Reactome | Cell surface interactions at the vascular wall

Cell surface interactions at the vascular wall

Stable Identifier

R-HSA-202733

DOI

10.3180/REACT_12051.1

Type

Pathway

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

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Cell surface interactions at the vascular wall

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Leukocyte extravasation is a rigorously controlled process that guides white cell movement from the vascular lumen to sites of tissue inflammation. The powerful adhesive interactions that are required for leukocytes to withstand local flow at the vessel wall is a multistep process mediated by different adhesion molecules. Platelets adhered to injured vessel walls form strong adhesive substrates for leukocytes. For instance, the initial tethering and rolling of leukocytes over the site of injury are mediated by reversible binding of selectins to their cognate cell-surface glycoconjugates.

Endothelial cells are tightly connected through various proteins, which regulate the organization of the junctional complex and bind to cytoskeletal proteins or cytoplasmic interaction partners that allow the transfer of intracellular signals. An important role for these junctional proteins in governing the transendothelial migration of leukocytes under normal or inflammatory conditions has been established.

This pathway describes some of the key interactions that assist in the process of platelet and leukocyte interaction with the endothelium, in response to injury.

Literature References

PubMed ID	Title	Journal	Year
14615387	Platelet-monocyte complexes support monocyte adhesion to endothelium by enhancing secondary tethering and cluster formation Ulfman, LH, Zwaginga, JJ, Hordijk, PL, van den Berk, N, Koenderman, L, da Costa Martins, P	Arterioscler Thromb Vasc Biol	2004
17525755	The role of junctional adhesion molecules in vascular inflammation Weber, C, Fraemohs, L, Dejana, E	Nat Rev Immunol	2007
16115029	Mechanisms of monocyte recruitment in vascular repair after injury Weber, C, Schober, A	Antioxid Redox Signal	2005
10798271	Endothelial function and hemostasis Heindl, B, Becker, BF, Kupatt, C, Zahler, S	Z Kardiol	2000
11282294	Platelets and the injured vessel wall-- "rolling into action": focus on glycoprotein Ib/V/IX and the platelet cytoskeleton Mistry, N, Jackson, SP, Yuan, Y	Trends Cardiovasc Med	2000
8578462	The molecular basis of platelet and endothelial cell interaction with neutrophils and monocytes: role of P-selectin and the P-selectin ligand, PSGL-1 Furie, B, Furie, BC	Thromb Haemost	1995