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11xCbxE-PROS1 [extracellular region]
Stable Identifier
R-HSA-202772
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
protein S
Locations in the PathwayBrowser
Expand all
Hemostasis (Homo sapiens)
Cell surface interactions at the vascular wall (Homo sapiens)
MERTK receptor binds ligands (Gas6 or Protein S) (Homo sapiens)
MERTK ligands [extracellular region] (Homo sapiens)
11xCbxE-PROS1 [extracellular region] (Homo sapiens)
MERTK:MERKT ligands [plasma membrane] (Homo sapiens)
MERTK ligands [extracellular region] (Homo sapiens)
11xCbxE-PROS1 [extracellular region] (Homo sapiens)
Formation of Fibrin Clot (Clotting Cascade) (Homo sapiens)
Intrinsic Pathway of Fibrin Clot Formation (Homo sapiens)
factor X -> factor Xa + factor X activation peptide (VIIIa:IXa catalyst) (Homo sapiens)
11xCbxE-PROS1 [extracellular region] (Homo sapiens)
FVIIIa:FIXa:PROS1 [plasma membrane] (Homo sapiens)
11xCbxE-PROS1 [extracellular region] (Homo sapiens)
Platelet activation, signaling and aggregation (Homo sapiens)
Response to elevated platelet cytosolic Ca2+ (Homo sapiens)
Platelet degranulation (Homo sapiens)
Exocytosis of platelet alpha granule contents (Homo sapiens)
Platelet alpha granule contents [extracellular region] (Homo sapiens)
11xCbxE-PROS1 [extracellular region] (Homo sapiens)
Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
Complement cascade (Homo sapiens)
Regulation of Complement cascade (Homo sapiens)
C4b binding protein binds Protein S (Homo sapiens)
11xCbxE-PROS1 [extracellular region] (Homo sapiens)
C4 binding protein:protein S [plasma membrane] (Homo sapiens)
11xCbxE-PROS1 [extracellular region] (Homo sapiens)
Literature References
PubMed ID
Title
Journal
Year
420821
Characterization of protein S, a gamma-carboxyglutamic acid containing protein from bovine and human plasma
DiScipio, RG
,
Davie, EW
Biochemistry
1979
External Reference Information
External Reference
UniProt:P07225 PROS1
Gene Names
PROS1, PROS
Chain
signal peptide:1-24, propeptide:25-41, chain:42-676
Reference Genes
BioGPS Gene:5627 PROS1
COSMIC (genes):PROS1 PROS1
CTD Gene:5627 PROS1
dbSNP Gene:5627 PROS1
ENSEMBL:ENSG00000184500.16 PROS1
HGNC:9456 PROS1
KEGG Gene (Homo sapiens):5627 PROS1
Monarch:5627 PROS1
NCBI Gene:5627 PROS1
OMIM:176880 PROS1
UCSC:P07225 PROS1
Reference Transcript
RefSeq:NM_000313.3 PROS1
RefSeq:NM_001314077.1 PROS1
Other Identifiers
0005550497
11720133_a_at
11720134_s_at
11720135_a_at
16956569
17123302
17123306
17123308
17123310
207808_PM_s_at
207808_s_at
2685269
2685271
2685273
2685275
2685277
2685278
2685280
2685282
2685287
2685291
2685293
2685295
2685305
2685306
2685307
2685308
2685309
2685310
2685311
2685313
2685314
2685315
2685316
2685317
2685319
2685321
2685322
2685323
2685324
2685328
2685337
2685338
2685339
35752_s_at
5627
8089011
8089015
A_21_P0012453
A_23_P73114
A_24_P383480
GE57827
GO:0000139
GO:0004866
GO:0005509
GO:0005515
GO:0005576
GO:0005615
GO:0005622
GO:0005737
GO:0005783
GO:0005789
GO:0005794
GO:0005796
GO:0005886
GO:0007596
GO:0007599
GO:0010951
GO:0030195
GO:0031093
GO:0031410
GO:0042060
GO:0042730
GO:0043226
GO:0050896
GO:0070062
GO:0072562
GO:0098772
HMNXSV003050726
ILMN_1671928
M14338_at
PH_hs_0003988
TC03001590.hg
TC03002992.hg
TC03002994.hg
g4506116_3p_a_at
Participates
as a member of
Platelet alpha granule contents [extracellular region] (Homo sapiens)
MERTK ligands [extracellular region] (Homo sapiens)
as a component of
FVIIIa:FIXa:PROS1 [plasma membrane] (Homo sapiens)
C4 binding protein:protein S [plasma membrane] (Homo sapiens)
as an input of
C4b binding protein binds Protein S (Homo sapiens)
Other forms of this molecule
11xCbxE-PROS1 [plasma membrane]
PROS1(25-676) [endoplasmic reticulum membrane]
11xCbxE-PROS1(25-676) [endoplasmic reticulum membrane]
11xCbxE-PROS1(25-676) [Golgi membrane]
PROS1(25-41) [Golgi lumen]
11xCbxE-PROS1 [Golgi membrane]
11xCbxE-PROS1 [platelet alpha granule lumen]
Inferred To
pros1 [extracellular region]
(Xenopus tropicalis)
Pros1 [extracellular region]
(Mus musculus)
Pros1 [extracellular region]
(Rattus norvegicus)
11xCbxE-PROS1 [extracellular region]
(Canis familiaris)
11xCbxE-PROS1 [extracellular region]
(Danio rerio)
PROS1 [extracellular region]
(Bos taurus)
PROS1 [extracellular region]
(Gallus gallus)
PROS1 [extracellular region]
(Sus scrofa)
Modified Residues
Name
L-gamma-carboxyglutamic acid at 77
Coordinate
77
PsiMod Name
L-gamma-carboxyglutamic acid [MOD:00041]
PsiMod Definition
A protein modification that effectively converts an L-glutamic acid residue to L-gamma-carboxyglutamic acid.
Name
L-gamma-carboxyglutamic acid at 73
Coordinate
73
PsiMod Name
L-gamma-carboxyglutamic acid [MOD:00041]
PsiMod Definition
A protein modification that effectively converts an L-glutamic acid residue to L-gamma-carboxyglutamic acid.
Name
L-gamma-carboxyglutamic acid at 70
Coordinate
70
PsiMod Name
L-gamma-carboxyglutamic acid [MOD:00041]
PsiMod Definition
A protein modification that effectively converts an L-glutamic acid residue to L-gamma-carboxyglutamic acid.
Name
L-gamma-carboxyglutamic acid at 67
Coordinate
67
PsiMod Name
L-gamma-carboxyglutamic acid [MOD:00041]
PsiMod Definition
A protein modification that effectively converts an L-glutamic acid residue to L-gamma-carboxyglutamic acid.
Name
L-gamma-carboxyglutamic acid at 66
Coordinate
66
PsiMod Name
L-gamma-carboxyglutamic acid [MOD:00041]
PsiMod Definition
A protein modification that effectively converts an L-glutamic acid residue to L-gamma-carboxyglutamic acid.
Name
L-gamma-carboxyglutamic acid at 61
Coordinate
61
PsiMod Name
L-gamma-carboxyglutamic acid [MOD:00041]
PsiMod Definition
A protein modification that effectively converts an L-glutamic acid residue to L-gamma-carboxyglutamic acid.
Name
L-gamma-carboxyglutamic acid at 60
Coordinate
60
PsiMod Name
L-gamma-carboxyglutamic acid [MOD:00041]
PsiMod Definition
A protein modification that effectively converts an L-glutamic acid residue to L-gamma-carboxyglutamic acid.
Name
L-gamma-carboxyglutamic acid at 57
Coordinate
57
PsiMod Name
L-gamma-carboxyglutamic acid [MOD:00041]
PsiMod Definition
A protein modification that effectively converts an L-glutamic acid residue to L-gamma-carboxyglutamic acid.
Name
L-gamma-carboxyglutamic acid at 55
Coordinate
55
PsiMod Name
L-gamma-carboxyglutamic acid [MOD:00041]
PsiMod Definition
A protein modification that effectively converts an L-glutamic acid residue to L-gamma-carboxyglutamic acid.
Name
L-gamma-carboxyglutamic acid at 48
Coordinate
48
PsiMod Name
L-gamma-carboxyglutamic acid [MOD:00041]
PsiMod Definition
A protein modification that effectively converts an L-glutamic acid residue to L-gamma-carboxyglutamic acid.
Name
L-gamma-carboxyglutamic acid at 47
Coordinate
47
PsiMod Name
L-gamma-carboxyglutamic acid [MOD:00041]
PsiMod Definition
A protein modification that effectively converts an L-glutamic acid residue to L-gamma-carboxyglutamic acid.
Cross References
RefSeq
NP_000304.2
,
NP_001301006.1
OpenTargets
ENSG00000184500
HPA
ENSG00000184500-PROS1
GeneCards
P07225
Ensembl
ENSP00000330021
,
ENSP00000377783
,
ENST00000348974
,
ENSG00000184500
,
ENST00000394236
PRO
P07225
Pharos - Targets
P07225
Orphanet
15148
PDB
1Z6C
HMDB Protein
HMDBP02003
Interactors (8)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q5SUL5 1A01
0.556
3
UniProt:P62937-2 P629372
0.556
3
UniProt:P61981 YWHAG
1
YWHAG [cytosol]
(R-HSA-380312)
0.556
3
UniProt:Q92993 KAT5
1
KAT5 [nucleoplasm]
(R-HSA-3321979)
0.556
3
UniProt:Q8TAP4-4 LMO3
0.556
3
UniProt:P17252 PRKCA
8
PRKCA [cytosol]
(R-HSA-58196)
pT497,T638,S657-PRKCA [plasma membrane]
(R-HSA-4332340)
p-T497,T638,S657-PRKCA [cytosol]
(R-HSA-4332337)
PRKCA [plasma membrane]
(R-HSA-156469)
p-T497-PRKCA [cytosol]
(R-HSA-5218731)
p-T497,T638,S657-PRKCA [nucleoplasm]
(R-HSA-5223292)
PRKCA [photoreceptor disc membrane]
(R-HSA-2648987)
PRKCA [nucleoplasm]
(R-HSA-450530)
0.556
3
UniProt:Q15047-2 SETDB1
0.556
3
UniProt:Q96CV9 OPTN
5
OPTN [recycling endosome membrane]
(R-HSA-8854141)
p-S177-OPTN [nucleoplasm]
(R-HSA-2562595)
p-S177-OPTN [cytosol]
(R-HSA-2562525)
OPTN [Golgi membrane]
(R-HSA-2161111)
OPTN [cytosol]
(R-HSA-9687907)
0.556
3
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