Reactome | p-S909,T1079-LATS1 [cytosol]

p-S909,T1079-LATS1 [cytosol]

Stable Identifier

R-HSA-2028551

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

p-LATS1, phosho-Serine/threonine-protein kinase LATS1, phospho-WARTS protein kinase

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Literature References

PubMed ID	Title	Journal	Year
15688006	The Ste20-like kinase Mst2 activates the human large tumor suppressor kinase Lats1 Chalamalasetty, RB, Nigg, EA, Nousiainen, M, Chan, EH, Silljé, HH, Schäfer, A	Oncogene	2005

External Reference Information

External Reference

UniProt:O95835 LATS1

Gene Names

LATS1, WARTS

Chain

chain:1-1130

Reference Genes

BioGPS Gene:9113 LATS1

COSMIC (genes):LATS1 LATS1

CTD Gene:9113 LATS1

dbSNP Gene:9113 LATS1

ENSEMBL:ENSG00000131023 LATS1

ENSEMBL_homo_sapiens_GENE:ENSG00000131023.13 LATS1

HGNC:6514 LATS1

KEGG Gene (Homo sapiens):9113 LATS1

Monarch:9113 LATS1

NCBI Gene:9113 LATS1

OMIM:603473 LATS1

UCSC:O95835 LATS1

Reference Transcript

Other Identifiers

11740127_a_at

11745334_a_at

11751496_a_at

1570425_PM_s_at

1570425_s_at

17024615

219813_PM_at

219813_at

227772_PM_at

227772_at

2978990

2978991

2978992

2978993

2978994

2978995

2978999

2979000

2979021

2979023

2979024

2979026

2979027

2979028

2979029

2979030

2979031

2979032

2979033

2979038

2979039

2979040

2979041

2979046

2979047

2979048

46129_at

8130116

9113

A_23_P366230

A_33_P3233764

GE58342

GO:0000082

GO:0000086

GO:0000166

GO:0000278

GO:0000287

GO:0000819

GO:0000922

GO:0001827

GO:0001828

GO:0003824

GO:0004672

GO:0004674

GO:0005515

GO:0005524

GO:0005634

GO:0005737

GO:0005813

GO:0005815

GO:0005816

GO:0005819

GO:0005829

GO:0005856

GO:0006468

GO:0007010

GO:0007049

GO:0007059

GO:0008104

GO:0009755

GO:0012501

GO:0016301

GO:0016310

GO:0016740

GO:0017015

GO:0019901

GO:0023052

GO:0030154

GO:0030163

GO:0030216

GO:0030331

GO:0030496

GO:0030833

GO:0033138

GO:0033146

GO:0035329

GO:0036211

GO:0043065

GO:0043226

GO:0043254

GO:0045454

GO:0045736

GO:0046620

GO:0046872

GO:0048856

GO:0050660

GO:0051220

GO:0051301

GO:0060644

GO:0065003

GO:0090090

GO:0106310

GO:0140096

GO:1900181

GO:2000058

HMNXSV003051946

Hs.250691.0.A1_3p_at

Hs2.250691.2.A1_3p_s_at

ILMN_1696921

ILMN_2108029

PH_hs_0040488

TC06002214.hg

g10862687_3p_at

g10862687_3p_x_at

Participates

as a component of

p-LATS1:p-MOB1 [cytosol] (Homo sapiens)

as a member of

p-LATS [cytosol] (Homo sapiens)

Other forms of this molecule

LATS1 [cytosol]

Inferred To

phospho-p-S909,T1079-LATS1 [cytosol] (Caenorhabditis elegans)

phospho-p-S909,T1079-LATS1 [cytosol] (Danio rerio)

phospho-p-S909,T1079-LATS1 [cytosol] (Drosophila melanogaster)

phospho-p-S909,T1079-LATS1 [cytosol] (Gallus gallus)

phospho-p-S909,T1079-LATS1 [cytosol] (Mus musculus)

phospho-p-S909,T1079-LATS1 [cytosol] (Xenopus tropicalis)

phospho-Lats1 [cytosol] (Rattus norvegicus)

phospho-LATS1 [cytosol] (Bos taurus)

phospho-LATS1 [cytosol] (Canis familiaris)

phospho-LATS1 [cytosol] (Sus scrofa)

Modified Residues

Name

O-phospho-L-serine at 909

Coordinate

909

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Name

O-phospho-L-threonine at 1079

Coordinate

1079

PsiMod Name

O-phospho-L-threonine [MOD:00047]

PsiMod Definition

A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.

Cross References

RefSeq

NP_001257448.1, NP_004681.1

ZINC - World Drugs

LATS1_HUMAN

Guide to Pharmacology - Targets

1515

OpenTargets

ENSG00000131023

ZINC - FDA approved

LATS1_HUMAN

ZINC - Substances

LATS1_HUMAN

ZINC - Biogenic

LATS1_HUMAN

ZINC target

O95835

PRO

O95835

PDB

5B5W, 5BRK, 4ZRK, 7LWH

ZINC - Investigational

LATS1_HUMAN

GeneCards

O95835

HPA

ENSG00000131023-LATS1

Ensembl

ENST00000253339, ENSP00000444678, ENST00000392273, ENSG00000131023, ENST00000543571, ENSP00000437550, ENSP00000253339

Pharos - Targets

O95835

Orphanet

24665

ZINC - Predictions - Purchasable

LATS1_HUMAN

HMDB Protein

HMDBP01499

Interactors (9)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P46937 YAP1	7	p-S127-YAP1 [cytosol] (R-HSA-2028553) p-5S-YAP1 [cytosol] (R-HSA-2028554) p-Y407-YAP1 [nucleoplasm] (R-HSA-8956661) p-Y-YAP1 [cytosol] (R-HSA-8937843) p-Y-YAP1 [nucleoplasm] (R-HSA-8937857) YAP1 [cytosol] (R-HSA-1253345) YAP1 [nucleoplasm] (R-HSA-1253322)	0.88	10
UniProt:Q9GZV5 WWTR1	3	p-S89-WWTR1 [cytosol] (R-HSA-2028665) WWTR1 [nucleoplasm] (R-HSA-1629775) WWTR1 [cytosol] (R-HSA-1629773)	0.641	5
UniProt:P06493 CDK1	11	CDK1 [endoplasmic reticulum membrane] (R-HSA-264424) p-Y4-CDK1 [cytosol] (R-HSA-9836187) p-T14,T161-CDK1 [nucleoplasm] (R-HSA-170078) p-T14-CDK1 [nucleoplasm] (R-HSA-170045) p-T14-CDK1 [cytosol] (R-HSA-170064) CDK1 [nucleoplasm] (R-HSA-68889) CDK1 [cytosol] (R-HSA-170075) p-T14,Y15,T161-CDK1 [cytosol] (R-HSA-170071) p-T161-CDK1 [cytosol] (R-HSA-157415) p-T14,Y15,T161-CDK1 [nucleoplasm] (R-HSA-170074) p-T161-CDK1 [nucleoplasm] (R-HSA-170066)	0.632	3
UniProt:P24941 CDK2	5	p-Y15-CDK2 [nucleoplasm] (R-HSA-187905) p-CDK2 [nucleoplasm] (R-HSA-68370) CDK2 [cytosol] (R-HSA-157440) CDK2 [nucleoplasm] (R-HSA-68365) p-T160-CDK2 [nucleoplasm] (R-HSA-187967)	0.576	4
UniProt:P35240 NF2	1	NF2 [plasma membrane] (R-HSA-5669168)	0.556	4
UniProt:P53667 LIMK1	3	p-S,T508-LIMK1 [cytosol] (R-HSA-419610) p-T508-LIMK1 [cytosol] (R-HSA-399816) LIMK1 [cytosol] (R-HSA-397785)	0.556	5
UniProt:P46662	1	Nf2 [plasma membrane] (R-MMU-5669168)	0.537	5
UniProt:Q15831 STK11	2	STK11 [cytosol] (R-HSA-380954) STK11 [nucleoplasm] (R-HSA-164119)	0.499	2
UniProt:P03372 ESR1	8	p-S118-ESR1 [nucleoplasm] (R-HSA-9024210) monoSUMO1-5K-ESR1 [nucleoplasm] (R-HSA-4090302) Me260-ESR1 [cytosol] (R-HSA-9632177) PalmS-ESR1 [cytosol] (R-HSA-9020974) PalmS-ESR1 [plasma membrane] (R-HSA-9021057) Me260-PalmS-ESR1 [plasma membrane] (R-HSA-9637788) ESR1 [nucleoplasm] (R-HSA-446168) ESR1 [cytosol] (R-HSA-9020968)	0.499	2

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