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p-S909,T1079-LATS1 [cytosol]
Stable Identifier
R-HSA-2028551
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
p-LATS1, phosho-Serine/threonine-protein kinase LATS1, phospho-WARTS protein kinase
Icon
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by Hippo (Homo sapiens)
Phosphorylation of LATS1 and 2 by p-STK3 (MST2)/N (Homo sapiens)
p-LATS:p-MOB [cytosol] (Homo sapiens)
p-LATS [cytosol] (Homo sapiens)
p-S909,T1079-LATS1 [cytosol] (Homo sapiens)
Phosphorylation of LATS1 and 2 by p-STK3 (p-MST2) (Homo sapiens)
p-LATS:p-MOB [cytosol] (Homo sapiens)
p-LATS [cytosol] (Homo sapiens)
p-S909,T1079-LATS1 [cytosol] (Homo sapiens)
Phosphorylation of LATS1 and 2 by p-STK4 (p-MST1) (Homo sapiens)
p-LATS:p-MOB [cytosol] (Homo sapiens)
p-LATS [cytosol] (Homo sapiens)
p-S909,T1079-LATS1 [cytosol] (Homo sapiens)
Phosphorylation of LATS1 and 2 by p-STK4(MST1)/N (Homo sapiens)
p-LATS:p-MOB [cytosol] (Homo sapiens)
p-LATS [cytosol] (Homo sapiens)
p-S909,T1079-LATS1 [cytosol] (Homo sapiens)
Phosphorylation of WWTR1 (TAZ) by LATS1 (Homo sapiens)
p-LATS1:p-MOB1 [cytosol] (Homo sapiens)
p-S909,T1079-LATS1 [cytosol] (Homo sapiens)
p-S909,T1079-LATS1 [cytosol] (Homo sapiens)
Phosphorylation of YAP by LATS1 (Homo sapiens)
p-LATS1:p-MOB1 [cytosol] (Homo sapiens)
p-S909,T1079-LATS1 [cytosol] (Homo sapiens)
p-S909,T1079-LATS1 [cytosol] (Homo sapiens)
Literature References
PubMed ID
Title
Journal
Year
15688006
The Ste20-like kinase Mst2 activates the human large tumor suppressor kinase Lats1
Chalamalasetty, RB
,
Nigg, EA
,
Nousiainen, M
,
Chan, EH
,
Silljé, HH
,
Schäfer, A
Oncogene
2005
External Reference Information
External Reference
UniProt:O95835 LATS1
Gene Names
LATS1, WARTS
Chain
chain:1-1130
Reference Genes
BioGPS Gene:9113 LATS1
COSMIC (genes):LATS1 LATS1
CTD Gene:9113 LATS1
dbSNP Gene:9113 LATS1
ENSEMBL:ENSG00000131023 LATS1
ENSEMBL_homo_sapiens_GENE:ENSG00000131023.13 LATS1
HGNC:6514 LATS1
KEGG Gene (Homo sapiens):9113 LATS1
Monarch:9113 LATS1
NCBI Gene:9113 LATS1
OMIM:603473 LATS1
UCSC:O95835 LATS1
Reference Transcript
RefSeq:NM_001270519.1 LATS1
RefSeq:NM_004690.3 LATS1
Other Identifiers
11740127_a_at
11745334_a_at
11751496_a_at
1570425_PM_s_at
1570425_s_at
17024615
219813_PM_at
219813_at
227772_PM_at
227772_at
2978990
2978991
2978992
2978993
2978994
2978995
2978999
2979000
2979021
2979023
2979024
2979026
2979027
2979028
2979029
2979030
2979031
2979032
2979033
2979038
2979039
2979040
2979041
2979046
2979047
2979048
46129_at
8130116
9113
A_23_P366230
A_33_P3233764
GE58342
GO:0000082
GO:0000086
GO:0000166
GO:0000278
GO:0000287
GO:0000819
GO:0000922
GO:0001827
GO:0001828
GO:0003824
GO:0004672
GO:0004674
GO:0005515
GO:0005524
GO:0005634
GO:0005737
GO:0005813
GO:0005815
GO:0005819
GO:0005829
GO:0005856
GO:0006468
GO:0007010
GO:0007049
GO:0007059
GO:0008104
GO:0009755
GO:0012501
GO:0016301
GO:0016310
GO:0016740
GO:0017015
GO:0019901
GO:0023052
GO:0030154
GO:0030163
GO:0030216
GO:0030331
GO:0030496
GO:0030833
GO:0033138
GO:0033146
GO:0035329
GO:0036211
GO:0043065
GO:0043226
GO:0043254
GO:0045454
GO:0045736
GO:0046620
GO:0046872
GO:0048856
GO:0050660
GO:0051220
GO:0051301
GO:0060644
GO:0065003
GO:0090090
GO:0106310
GO:0140096
GO:1900181
GO:2000058
HMNXSV003051946
Hs.250691.0.A1_3p_at
Hs2.250691.2.A1_3p_s_at
ILMN_1696921
ILMN_2108029
PH_hs_0040488
TC06002214.hg
g10862687_3p_at
g10862687_3p_x_at
Participates
as a component of
p-LATS1:p-MOB1 [cytosol] (Homo sapiens)
as a member of
p-LATS [cytosol] (Homo sapiens)
Other forms of this molecule
LATS1 [cytosol]
Inferred To
phospho-p-S909,T1079-LATS1 [cytosol]
(Caenorhabditis elegans)
phospho-p-S909,T1079-LATS1 [cytosol]
(Danio rerio)
phospho-p-S909,T1079-LATS1 [cytosol]
(Drosophila melanogaster)
phospho-p-S909,T1079-LATS1 [cytosol]
(Gallus gallus)
phospho-p-S909,T1079-LATS1 [cytosol]
(Mus musculus)
phospho-p-S909,T1079-LATS1 [cytosol]
(Xenopus tropicalis)
phospho-Lats1 [cytosol]
(Rattus norvegicus)
phospho-LATS1 [cytosol]
(Bos taurus)
phospho-LATS1 [cytosol]
(Canis familiaris)
phospho-LATS1 [cytosol]
(Sus scrofa)
Modified Residues
Name
O-phospho-L-serine at 909
Coordinate
909
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-threonine at 1079
Coordinate
1079
PsiMod Name
O-phospho-L-threonine [MOD:00047]
PsiMod Definition
A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.
Cross References
RefSeq
NP_001257448.1
,
NP_004681.1
ZINC - World Drugs
LATS1_HUMAN
Guide to Pharmacology - Targets
1515
OpenTargets
ENSG00000131023
ZINC - FDA approved
LATS1_HUMAN
ZINC - Substances
LATS1_HUMAN
ZINC target
O95835
ZINC - Biogenic
LATS1_HUMAN
PRO
O95835
PDB
7LWH
,
5B5W
,
5BRK
,
4ZRK
ZINC - Investigational
LATS1_HUMAN
HPA
ENSG00000131023-LATS1
GeneCards
O95835
Ensembl
ENSG00000131023
,
ENST00000543571
,
ENSP00000253339
,
ENSP00000437550
,
ENST00000392273
,
ENST00000253339
,
ENSP00000444678
Pharos - Targets
O95835
ZINC - Predictions - Purchasable
LATS1_HUMAN
HMDB Protein
HMDBP01499
Interactors (10)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P46937 YAP1
8
p-Y407-YAP1 [cytosol]
(R-HSA-9865208)
p-S127-YAP1 [cytosol]
(R-HSA-2028553)
p-5S-YAP1 [cytosol]
(R-HSA-2028554)
p-Y407-YAP1 [nucleoplasm]
(R-HSA-8956661)
p-Y-YAP1 [cytosol]
(R-HSA-8937843)
p-Y-YAP1 [nucleoplasm]
(R-HSA-8937857)
YAP1 [cytosol]
(R-HSA-1253345)
YAP1 [nucleoplasm]
(R-HSA-1253322)
0.88
10
UniProt:Q9GZV5 WWTR1
3
p-S89-WWTR1 [cytosol]
(R-HSA-2028665)
WWTR1 [cytosol]
(R-HSA-1629773)
WWTR1 [nucleoplasm]
(R-HSA-1629775)
0.641
5
UniProt:P06493 CDK1
11
CDK1 [endoplasmic reticulum membrane]
(R-HSA-264424)
p-Y4-CDK1 [cytosol]
(R-HSA-9836187)
p-T14,T161-CDK1 [nucleoplasm]
(R-HSA-170078)
p-T14-CDK1 [nucleoplasm]
(R-HSA-170045)
p-T14-CDK1 [cytosol]
(R-HSA-170064)
CDK1 [nucleoplasm]
(R-HSA-68889)
CDK1 [cytosol]
(R-HSA-170075)
p-T14,Y15,T161-CDK1 [cytosol]
(R-HSA-170071)
p-T161-CDK1 [cytosol]
(R-HSA-157415)
p-T14,Y15,T161-CDK1 [nucleoplasm]
(R-HSA-170074)
p-T161-CDK1 [nucleoplasm]
(R-HSA-170066)
0.632
3
UniProt:P24941 CDK2
5
p-Y15-CDK2 [nucleoplasm]
(R-HSA-187905)
p-CDK2 [nucleoplasm]
(R-HSA-68370)
CDK2 [cytosol]
(R-HSA-157440)
CDK2 [nucleoplasm]
(R-HSA-68365)
p-T160-CDK2 [nucleoplasm]
(R-HSA-187967)
0.576
4
UniProt:P35240 NF2
1
NF2 [plasma membrane]
(R-HSA-5669168)
0.556
4
UniProt:P53667 LIMK1
3
p-S,T508-LIMK1 [cytosol]
(R-HSA-419610)
p-T508-LIMK1 [cytosol]
(R-HSA-399816)
LIMK1 [cytosol]
(R-HSA-397785)
0.556
5
UniProt:P46662
1
Nf2 [plasma membrane]
(R-MMU-5669168)
0.537
5
UniProt:Q15831 STK11
2
STK11 [cytosol]
(R-HSA-380954)
STK11 [nucleoplasm]
(R-HSA-164119)
0.499
2
UniProt:P03372 ESR1
10
p-S118-ESR1 [nucleoplasm]
(R-HSA-9024210)
monoSUMO1-5K-ESR1 [nucleoplasm]
(R-HSA-4090302)
p-S167-ESR1 [nucleoplasm]
(R-HSA-9841867)
p-S167-ESR1 [cytosol]
(R-HSA-9841254)
Me260-ESR1 [cytosol]
(R-HSA-9632177)
PalmS-ESR1 [cytosol]
(R-HSA-9020974)
Me260-PalmS-ESR1 [plasma membrane]
(R-HSA-9637788)
PalmS-ESR1 [plasma membrane]
(R-HSA-9021057)
ESR1 [nucleoplasm]
(R-HSA-446168)
ESR1 [cytosol]
(R-HSA-9020968)
0.499
2
UniProt:P31946 YWHAB
1
YWHAB [cytosol]
(R-HSA-48888)
0.483
3
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