Reactome | p-S127-YAP1 [cytosol]

p-S127-YAP1 [cytosol]

Stable Identifier

R-HSA-2028553

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

p1-YAP1, monophospho-YAP1

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Literature References

PubMed ID	Title	Journal	Year
17974916	Inactivation of YAP oncoprotein by the Hippo pathway is involved in cell contact inhibition and tissue growth control Zheng, P, Halder, G, Ye, K, Lai, ZC, Yu, J, Wei, X, Guan, KL, Chinnaiyan, A, Xie, J, Yang, Q, Li, L, Kim, J, Li, W, Ikenoue, T, Udan, RS, Zhao, B	Genes Dev	2007

External Reference Information

External Reference

UniProt:P46937 YAP1

Gene Names

YAP1, YAP65

Chain

chain:1-504

Reference Genes

BioGPS Gene:10413 YAP1

COSMIC (genes):YAP1 YAP1

CTD Gene:10413 YAP1

dbSNP Gene:10413 YAP1

ENSEMBL:ENSG00000137693 YAP1

HGNC:16262 YAP1

KEGG:hsa:10413 YAP1

Monarch:10413 YAP1

NCBI Gene:10413 YAP1

OMIM:606608 YAP1

UCSC:P46937 YAP1

Reference Transcript

Other Identifiers

10413

11717920_a_at

11717921_x_at

11717922_a_at

11717923_s_at

11717924_a_at

11717925_s_at

11740548_a_at

11746496_a_at

16730503

213342_PM_at

213342_at

224894_PM_at

224894_at

224895_PM_at

224895_at

2929983

3346452

3346454

3346455

3346456

3346457

3346458

3346460

3346461

3346468

3346478

3346479

3346480

3346481

3346482

3346489

3346492

3346498

3346502

3346504

3346508

3346509

3346510

37979_at

46314_at

7943398

A_14_P102030

A_23_P104762

A_24_P273679

GE60063

GO:0000122

GO:0000902

GO:0000976

GO:0000978

GO:0001570

GO:0001674

GO:0001824

GO:0001829

GO:0001894

GO:0002067

GO:0003013

GO:0003015

GO:0003143

GO:0003677

GO:0003682

GO:0003712

GO:0003713

GO:0003714

GO:0005515

GO:0005634

GO:0005654

GO:0005667

GO:0005737

GO:0005829

GO:0005911

GO:0006355

GO:0006974

GO:0008283

GO:0008284

GO:0010468

GO:0010628

GO:0010629

GO:0010837

GO:0016020

GO:0030054

GO:0030154

GO:0030216

GO:0030307

GO:0030857

GO:0030859

GO:0030903

GO:0032570

GO:0035019

GO:0035265

GO:0035329

GO:0042060

GO:0042127

GO:0043226

GO:0045599

GO:0045669

GO:0045747

GO:0045893

GO:0045944

GO:0046622

GO:0048339

GO:0048368

GO:0048856

GO:0050673

GO:0050679

GO:0050767

GO:0060045

GO:0060070

GO:0060090

GO:0060449

GO:0060487

GO:0060575

GO:0060576

GO:0060828

GO:0061026

GO:0065003

GO:0070064

GO:0070102

GO:0070161

GO:0071300

GO:0071480

GO:0072091

GO:0072307

GO:0090263

GO:0097191

GO:0140110

GO:0140297

GO:0140552

GO:1900182

GO:1902018

GO:1902459

GO:1903703

GO:1904036

GO:2000737

GO:2001237

HMNXSV003031607

Hs.84520.0.S1_3p_at

Hs.84520.0.S2_3p_at

Hs.8939.0.A2_3p_at

ILMN_1709479

PH_hs_0022813

TC11000954.hg

X80507_at

Participates

as an input of

PP2A dephosphorylates serine-127 of YAP1 (Homo sapiens)

as a member of

p-YAP1 [cytosol] (Homo sapiens)

as an output of

Phosphorylation of YAP by LATS2 (Homo sapiens)

Other forms of this molecule

YAP1 [nucleoplasm]

YAP1 [cytosol]

p-5S-YAP1 [cytosol]

p-Y-YAP1 [nucleoplasm]

p-Y-YAP1 [cytosol]

p-Y407-YAP1 [nucleoplasm]

p-Y407-YAP1 [cytosol]

Inferred To

phospho-yap1 [cytosol] (Danio rerio)

phospho-yap1 [cytosol] (Xenopus tropicalis)

phospho-YAP1 [cytosol] (Bos taurus)

phospho-YAP1 [cytosol] (Sus scrofa)

phospho-yap-1 [cytosol] (Caenorhabditis elegans)

phospho-Yap1 [cytosol] (Mus musculus)

phospho-Yap1 [cytosol] (Rattus norvegicus)

phospho-p-S127-YAP1 [cytosol] (Canis familiaris)

phospho-p-S127-YAP1 [cytosol] (Gallus gallus)

Modified Residues

Name

O-phospho-L-serine at 127

Coordinate

127

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Cross References

RefSeq

NP_001269030.1, NP_001181973.1, NP_001269026.1, NP_001269027.1, NP_001269028.1, NP_001269029.1, NP_001181974.1, NP_001123617.1

OpenTargets

ENSG00000137693

ENSEMBL

ENSP00000435602, ENST00000524575, ENST00000531439, ENST00000629586, ENST00000526343, ENSP00000434134, ENSP00000445635, ENSP00000487519, ENST00000345877, ENST00000282441, ENSP00000478927, ENSP00000331023, ENST00000615667, ENSP00000431574, ENSP00000282441, ENST00000537274

HPA

ENSG00000137693-YAP1

PRO

P46937

Pharos - Targets

P46937

GlyGen

P46937

Orphanet

YAP1

PDB

2LAX, 2LAW, 2LAY, 5YDX, 5YDY, 4REX, 3KYS, 8C2F, 6GEG, 1K5R, 4RE1, 6GEI, 6G8K, 6G8L, 6GEE, 8A8R, 6G8I, 5OAQ, 6G8J, 6G6X, 6GE6, 6G8Q, 6GEK, 7O07, 6HIK, 3MHR, 6HIL, 6GEC, 6Q2X, 6GE5, 6GE4, 8A8Q, 6G8P, 1K9Q, 1K9R, 2LTW, 1JMQ, 6GE3, 2LTV

Interactors (52)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P28347 TEAD1	1	TEAD1 [nucleoplasm] (R-HSA-2032774)	0.94	11
UniProt:P61981 YWHAG	1	YWHAG [cytosol] (R-HSA-380312)	0.908	10
UniProt:P27348 YWHAQ	1	YWHAQ [cytosol] (R-HSA-1445116)	0.906	9
UniProt:Q15561 TEAD4	1	TEAD4 [nucleoplasm] (R-HSA-2032780)	0.897	12
UniProt:P31946 YWHAB	1	YWHAB [cytosol] (R-HSA-48888)	0.894	9
UniProt:Q04917 YWHAH	1	YWHAH [cytosol] (R-HSA-1445107)	0.894	11
UniProt:P63104 YWHAZ	2	YWHAZ [cytosol] (R-HSA-206099) YWHAZ [nucleoplasm] (R-HSA-450469)	0.882	11
UniProt:P35222 CTNNB1	20	CTNNB1 S45A [cytosol] (R-HSA-9663982) CTNNB1 S45F [cytosol] (R-HSA-4791268) CTNNB1 S45C [cytosol] (R-HSA-9663983) CTNNB1 S45Y [cytosol] (R-HSA-9663975) CTNNB1 S45N [cytosol] (R-HSA-9663984) CTNNB1 S45P [cytosol] (R-HSA-4791272) pT41,S45-CTNNB1 S37P [cytosol] (R-HSA-9663981) pT41,S45-CTNNB1 S37F [cytosol] (R-HSA-4839621) CTNNB1 [nucleoplasm] (R-HSA-3451168) CTNNB1 [cytosol] (R-HSA-448839) CTNNB1(1-115) [cytosol] (R-HSA-202930) CTNNB1(116-376) [cytosol] (R-HSA-202950) CTNNB1 [plasma membrane] (R-HSA-9038440) p-S33,S37,T41,S45 CTNNB1 [cytosol] (R-HSA-8942374) p-S37,T41,S45, CTNNB1 [cytosol] (R-HSA-8942369) p-T41,S45 CTNNB1 [cytosol] (R-HSA-8942367) p-S45 CTNNB1 [cytosol] (R-HSA-8942363) p-S552-CTNNB1 [cytosol] (R-HSA-3134933) p-S552-CTNNB1 [nucleoplasm] (R-HSA-3134926) p-Y-CTNNB1 [cytosol] (R-HSA-8876940)	0.881	14
UniProt:O95835 LATS1	2	LATS1 [cytosol] (R-HSA-2028562) p-S909,T1079-LATS1 [cytosol] (R-HSA-2028551)	0.88	10
UniProt:P62258 YWHAE	1	YWHAE [cytosol] (R-HSA-194368)	0.842	9
UniProt:Q15562 TEAD2	1	TEAD2 [nucleoplasm] (R-HSA-2032763)	0.823	9
UniProt:Q9BZD6 TMG4			0.815	5
UniProt:Q15678 PTPN14	1	PTPN14 [nucleoplasm] (R-HSA-9008917)	0.813	8
UniProt:Q15599 NHRF2			0.809	6
UniProt:Q4VCS5 AMOT			0.802	6
UniProt:Q969T9 WBP2			0.759	7
UniProt:O14745 NHRF1			0.753	9
UniProt:P97764 WBP1			0.74	13
UniProt:O15350 TP73	3	PolyUb-TP73 [cytosol] (R-HSA-8957256) TP73 [cytosol] (R-HSA-8957239) TP73 [nucleoplasm] (R-HSA-6798094)	0.73	5
UniProt:O15105 SMAD7	2	SMAD7 [nucleoplasm] (R-HSA-178197) SMAD7 [cytosol] (R-HSA-173478)	0.715	7
UniProt:Q99594 TEAD3	1	TEAD3 [nucleoplasm] (R-HSA-2032767)	0.68	5
UniProt:O75970 MPDZ			0.671	5
UniProt:Q8IY63 AMOTL1	1	AMOTL1 [cytosol] (R-HSA-2028603)	0.671	5
UniProt:Q9Y2J4 AMOTL2	1	AMOTL2 [cytosol] (R-HSA-2028606)	0.671	5
UniProt:Q8N3R9 MPP5	2	MPP5 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-9689606) MPP5 [plasma membrane] (R-HSA-419969)	0.671	5
UniProt:Q13625 TP53BP2	1	TP53BP2 [nucleoplasm] (R-HSA-6799780)	0.671	5
UniProt:Q9Y297 BTRC	2	BTRC [cytosol] (R-HSA-174237) BTRC [nucleoplasm] (R-HSA-3361753)	0.659	3
UniProt:O14669 TMG2			0.658	5
UniProt:O15350-1 TP73			0.65	7
UniProt:Q92841 DDX17	2	monoSUMO1-K50-DDX17 [nucleoplasm] (R-HSA-3900104) DDX17 [nucleoplasm] (R-HSA-3900090)	0.649	7
UniProt:P62136 PPP1CA	1	PPP1CA [cytosol] (R-HSA-163525)	0.643	3
UniProt:Q96G27 WBP1			0.623	4
UniProt:Q96PN7 TREF1			0.623	2
UniProt:Q9P2Y5 UVRAG	2	UVRAG [cytosol] (R-HSA-5668884) UVRAG [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-9730510)	0.623	2
UniProt:Q13625-2 TP53BP2			0.618	9
UniProt:Q9H3D4 TP63	1	TP63 [nucleoplasm] (R-HSA-2997585)	0.609	2
UniProt:Q8NI35 PATJ	1	PATJ [plasma membrane] (R-HSA-420011)	0.569	4
UniProt:Q13131 PRKAA1	3	p-T183-PRKAA1 [cytosol] (R-HSA-380964) PRKAA1 [cytosol] (R-HSA-380935) p-T183-PRKAA1 [nucleoplasm] (R-HSA-2151206)	0.564	3
UniProt:Q99593 TBX5	1	TBX5 [nucleoplasm] (R-HSA-2032786)	0.558	4
UniProt:Q15562-2 TEAD2			0.556	3
UniProt:Q02750 MAP2K1	20	MAP2K1(9-393) [cytosol] (R-HSA-5211353) MAP2K1(2-8) [cytosol] (R-HSA-5211342) MAP2K1 F53S [cytosol] (R-HSA-9652034) MAP2K1 D67N [cytosol] (R-HSA-9652016) p-S218,S222-MAP2K1 [cytosol] (R-HSA-109837) MAP2K1 [cytosol] (R-HSA-59502) p-S218,S222,T286,T292-MAP2K1 [cytosol] (R-HSA-112339) p-T286,T292-MAP2K1 [cytosol] (R-HSA-112374) p-S,218, S222,T292 MAP2K1 [cytosol] (R-HSA-5674490) MAP2K1 F53C [cytosol] (R-HSA-9652028) MAP2K1 P124Q [cytosol] (R-HSA-9652058) MAP2K1 L42_K57del [cytosol] (R-HSA-9652026) MAP2K1 F53Y [cytosol] (R-HSA-9652041) MAP2K1 P124L [cytosol] (R-HSA-9652056) MAP2K1 G128D [cytosol] (R-HSA-9652043) MAP2K1 D67Y [cytosol] (R-HSA-9652019) MAP2K1 F53V [cytosol] (R-HSA-9652038) MAP2K1 K57T [cytosol] (R-HSA-9652052) MAP2K1 K57N [cytosol] (R-HSA-9652050) MAP2K1 F53L [cytosol] (R-HSA-9652031)	0.556	3
UniProt:Q15797 SMAD1	4	p-S463,S465-SMAD1 [nucleoplasm] (R-HSA-201483) p-S463,S465-SMAD1 [cytosol] (R-HSA-201464) SMAD1 [cytosol] (R-HSA-201468) Ub-SMAD1 [cytosol] (R-HSA-6782768)	0.544	3
UniProt:Q9NUP9 LIN7C	2	LIN7C [plasma membrane] (R-HSA-5216165) LIN7C [transport vesicle membrane] (R-HSA-9610411)	0.527	3
UniProt:Q9Y4G8 RAPGEF2	1	RAPGEF2 [cytosol] (R-HSA-5672599)	0.527	2
UniProt:Q96FJ2 DYNLL2	4	DYNLL2 [cytosol] (R-HSA-2029024) DYNLL2 [plasma membrane] (R-HSA-140527) DYNLL2 [cilium] (R-HSA-5624865) DYNLL2 [ciliary tip] (R-HSA-5625337)	0.527	2
UniProt:A6NKD9 CC85C			0.527	3
UniProt:P35240 NF2	1	NF2 [plasma membrane] (R-HSA-5669168)	0.527	2
UniProt:O35625 Axin1	8	Phospho Axin1 [cytosol] (R-MMU-206175) phospho-Axin1 [cytosol] (R-MMU-3640864) phospho-Axin1 [cytosol] (R-MMU-3640841) Axin1 [cytosol] (R-MMU-4641133) Axin1 [cytosol] (R-MMU-205727) Phospho (3 sites) Axin1 [cytosol] (R-MMU-205737) phospho-Axin1 [cytosol] (R-MMU-206040) Axin1 [cytosol] (R-MMU-195249)	0.524	3
UniProt:O14544 SOCS6	1	SOCS6 [cytosol] (R-HSA-1469969)	0.524	2
UniProt:O15169 AXIN1	11	AXIN1 [cytosol] (R-HSA-195249) p-T481,S486,S493-AXIN1 [cytosol] (R-HSA-206040) ub-AXIN1 [cytosol] (R-HSA-4641133) RibC-AXIN1 [cytosol] (R-HSA-3640841) Ub-RibC-AXIN1 [cytosol] (R-HSA-3640864) AXIN1 P255S [cytosol] (R-HSA-5251505) AXIN1 P354L [cytosol] (R-HSA-5251511) AXIN1 W247* [cytosol] (R-HSA-5251512) AXIN1 E406* [cytosol] (R-HSA-5251500) AXIN1 Y346* [cytosol] (R-HSA-4839753) AXIN1 L396M [cytosol] (R-HSA-5251503)	0.499	11
UniProt:P31947 SFN	1	SFN [cytosol] (R-HSA-1445105)	0.471	2
IntAct:EBI-9253952 SUPER			0.462	3

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