Reactome | Phosphorylation of YAP by LATS2

Phosphorylation of YAP by LATS2

Stable Identifier

R-HSA-2028583

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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Cytosolic phospho-LATS2, complexed with MOB1, catalyzes the phosphorylation of YAP on serine residue 127 (and possibly other serine residues) (Zhao et al. 2007). This reaction is positively regulated by the angiomotin proteins AMOT (130 kd form), AMOTL1, and AMOTL2, which may function by physically bridging LATS2 and YAP (Paramasivam et al. 2011; Zhao et al. 2011).

Literature References

PubMed ID	Title	Journal	Year
21832154	Angiomotin family proteins are novel activators of the LATS2 kinase tumor suppressor Sarkeshik, A, Yates, JR 3rd, Paramasivam, M, McCollum, D, Fernandes, MJ	Mol Biol Cell	2011
21205866	Angiomotin is a novel Hippo pathway component that inhibits YAP oncoprotein Lei, Q, Guan, KL, Liu, CY, Li, L, Wang, LH, Lu, Q, Zhao, B	Genes Dev	2011
17974916	Inactivation of YAP oncoprotein by the Hippo pathway is involved in cell contact inhibition and tissue growth control Zheng, P, Halder, G, Ye, K, Lai, ZC, Yu, J, Wei, X, Guan, KL, Chinnaiyan, A, Xie, J, Yang, Q, Li, L, Kim, J, Li, W, Ikenoue, T, Udan, RS, Zhao, B	Genes Dev	2007