Phosphorylation of YAP by LATS2

Stable Identifier
Reaction [transition]
Homo sapiens
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Cytosolic phospho-LATS2, complexed with MOB1, catalyzes the phosphorylation of YAP on serine residue 127 (and possibly other serine residues) (Zhao et al. 2007). This reaction is positively regulated by the angiomotin proteins AMOT (130 kd form), AMOTL1, and AMOTL2, which may function by physically bridging LATS2 and YAP (Paramasivam et al. 2011; Zhao et al. 2011).

Literature References
PubMed ID Title Journal Year
21832154 Angiomotin family proteins are novel activators of the LATS2 kinase tumor suppressor

Sarkeshik, A, Yates, JR 3rd, Paramasivam, M, McCollum, D, Fernandes, MJ

Mol Biol Cell 2011
21205866 Angiomotin is a novel Hippo pathway component that inhibits YAP oncoprotein

Lei, Q, Guan, KL, Liu, CY, Li, L, Wang, LH, Lu, Q, Zhao, B

Genes Dev 2011
17974916 Inactivation of YAP oncoprotein by the Hippo pathway is involved in cell contact inhibition and tissue growth control

Zheng, P, Halder, G, Ye, K, Lai, ZC, Yu, J, Wei, X, Guan, KL, Chinnaiyan, A, Xie, J, Yang, Q, Li, L, Kim, J, Li, W, Ikenoue, T, Udan, RS, Zhao, B

Genes Dev 2007
Catalyst Activity

protein serine/threonine kinase activity of p-LATS2:p-MOB1 [cytosol]

This event is regulated
Positively by
Orthologous Events
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