Phosphorylation of LATS1 and 2 by p-STK3 (p-MST2)

Stable Identifier
Reaction [transition]
Homo sapiens
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Cytosolic LATS1 and LATS2 are phosphorylated by phospho-STK3 (p-MST2). LATS proteins are known to form complexes with MOB1 proteins and this reaction is annotated with LATS:MOB1 complexes as its substrate. Likewise, phosphorylated (active) STK3 (p-MST2) and SAV1 are known to form a complex and that complex is annotated as the catalyst of this reaction. Serine-909 and threonine-1097 have been identified as LATS1 residues phosphorylated by STK4 kinase (MST1); STK3 (MST2) is inferred to act similarly. The target residues of LATS2 have not been identified experimentally but are inferred to be serine-871 and threonine-1041 based on sequence similarity (Chan et al. 2005).

Literature References
PubMed ID Title Journal Year
15688006 The Ste20-like kinase Mst2 activates the human large tumor suppressor kinase Lats1

Chalamalasetty, RB, Nigg, EA, Nousiainen, M, Chan, EH, Silljé, HH, Schäfer, A

Oncogene 2005
Catalyst Activity

protein serine/threonine kinase activity of p-STK3:p-SAV1 [cytosol]

Orthologous Events
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