Phosphorylation of YAP by LATS1

Stable Identifier
R-HSA-2028598
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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Phosphorylation of YAP by LATS1
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Cytosolic phospho-LATS1, complexed with MOB1, catalyzes the phosphorylation of YAP on five serine residues (Hao et al. 2008).

Literature References
PubMed ID Title Journal Year
18158288 Tumor suppressor LATS1 is a negative regulator of oncogene YAP

Cheung, K, Rashidi, B, Yang, X, Hao, Y, Chun, A

J Biol Chem 2008
Participants
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Output
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Catalyst Activity

protein serine/threonine kinase activity of p-LATS1:p-MOB1 [cytosol]

Physical Entity
p-LATS1:p-MOB1 [cytosol] (Homo sapiens)
Activity
protein serine/threonine kinase activity (GO:0004674)
Orthologous Events
Phosphorylation of YAP by LATS1 (Bos taurus)
Phosphorylation of YAP by LATS1 (Caenorhabditis elegans)
Phosphorylation of YAP by LATS1 (Danio rerio)
Phosphorylation of YAP by LATS1 (Drosophila melanogaster)
Phosphorylation of YAP by LATS1 (Gallus gallus)
Phosphorylation of YAP by LATS1 (Mus musculus)
Phosphorylation of YAP by LATS1 (Rattus norvegicus)
Phosphorylation of YAP by LATS1 (Sus scrofa)
Authored
D'Eustachio, P  (2012-02-03)
Reviewed
Sudol, M  (2012-02-03)
Created
D'Eustachio, P  (2011-12-29)
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