Phosphorylation of MOB1A and B by p-STK4 (p-MST1)

Stable Identifier
R-HSA-2028629
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Phosphorylation of MOB1A and B by p-STK4 (p-MST1)
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Cytosolic MOB1A and MOB1B are phosphorylated by phospho-STK4 (p-MST1). Phosphorylated (active) STK4 (p-MST1) and SAV1 are known to form a complex and that complex is annotated as the catalyst of this reaction. Threonine residues 12 and 35 have been experimentally identifed as the targets of MOB1A phosphorylation; the homologous residues of MOB1B are inferred likewise to be targets (Praskova et al. 2008).
Literature References
PubMed ID Title Journal Year
18328708 MOBKL1A/MOBKL1B phosphorylation by MST1 and MST2 inhibits cell proliferation

Xia, F, Praskova, M, Avruch, J

Curr Biol 2008
Participants
Input
Output
Participates
as an event of
Catalyst Activity

protein serine/threonine kinase activity of p-STK4:p-SAV1 [cytosol]

Physical Entity
p-STK4:p-SAV1 [cytosol] (Homo sapiens)
Activity
protein serine/threonine kinase activity (GO:0004674)
Orthologous Events
Phosphorylation of MOB1A and B by p-STK4 (p-MST1) (Bos taurus)
Phosphorylation of MOB1A and B by p-STK4 (p-MST1) (Caenorhabditis elegans)
Phosphorylation of MOB1A and B by p-STK4 (p-MST1) (Canis familiaris)
Phosphorylation of MOB1A and B by p-STK4 (p-MST1) (Drosophila melanogaster)
Phosphorylation of MOB1A and B by p-STK4 (p-MST1) (Gallus gallus)
Phosphorylation of MOB1A and B by p-STK4 (p-MST1) (Mus musculus)
Phosphorylation of MOB1A and B by p-STK4 (p-MST1) (Rattus norvegicus)
Phosphorylation of MOB1A and B by p-STK4 (p-MST1) (Sus scrofa)
Phosphorylation of MOB1A and B by p-STK4 (p-MST1) (Xenopus tropicalis)
Authored
D'Eustachio, P  (2012-02-03)
Reviewed
Sudol, M  (2012-02-03)
Created
D'Eustachio, P  (2011-12-30)
Cite Us!