Reactome | Phosphorylation of WWTR1 (TAZ) by LATS2

Phosphorylation of WWTR1 (TAZ) by LATS2

Stable Identifier

R-HSA-2028661

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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Cytosolic phospho-LATS2, complexed with MOB1, catalyzes the phosphorylation of WWTR1 (TAZ) on serine residue 89 (Lei et al. 2008). This reaction is positively regulated by the angiomotin proteins AMOT (130 kd form), AMOTL1, and AMOTL2, which may function by physically bridging LATS2 and YAP (Zhao et al. 2011).

Literature References

PubMed ID	Title	Journal	Year
18227151	TAZ promotes cell proliferation and epithelial-mesenchymal transition and is inhibited by the hippo pathway Lei, Q, Guan, KL, Xiong, Y, Pei, XH, Zhang, H, Zha, ZY, Zhao, B, Bai, F, Zhao, S	Mol Cell Biol	2008
21205866	Angiomotin is a novel Hippo pathway component that inhibits YAP oncoprotein Lei, Q, Guan, KL, Liu, CY, Li, L, Wang, LH, Lu, Q, Zhao, B	Genes Dev	2011