Cytosolic phospho-LATS2, complexed with MOB1, catalyzes the phosphorylation of WWTR1 (TAZ) on serine residue 89 (Lei et al. 2008). This reaction is positively regulated by the angiomotin proteins AMOT (130 kd form), AMOTL1, and AMOTL2, which may function by physically bridging LATS2 and YAP (Zhao et al. 2011).
Lei, Q, Guan, KL, Xiong, Y, Pei, XH, Zhang, H, Zha, ZY, Zhao, B, Bai, F, Zhao, S
Lei, Q, Guan, KL, Liu, CY, Li, L, Wang, LH, Lu, Q, Zhao, B
protein serine/threonine kinase activity of p-LATS2:p-MOB1 [cytosol]
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