Reactome | STK4(327-487) [cytosol]

STK4(327-487) [cytosol]

Stable Identifier

R-HSA-2028668

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

STK4/C, Serine/threonine-protein kinase 4 18kDa subunit, MST1/C

Locations in the PathwayBrowser

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Literature References

PubMed ID	Title	Journal	Year
11278283	MST, a physiological caspase substrate, highly sensitizes apoptosis both upstream and downstream of caspase activation Tsubuki, S, Yajima, N, Lee, KK, Ohyama, T, Yonehara, S	J Biol Chem	2001
9545236	Caspase-mediated activation and induction of apoptosis by the mammalian Ste20-like kinase Mst1 Ambrose, DM, Krebs, EG, Han, DK, Gotoh, Y, Clark, EA, Draves, KE, Chernoff, J, Wright, M, Graves, JD	EMBO J	1998

External Reference Information

External Reference

UniProt:Q13043 STK4

Gene Names

STK4, KRS2, MST1

Chain

chain:1-487, chain:1-326, chain:327-487

Reference Genes

COSMIC (genes):MST1 STK4

COSMIC (genes):STK4 STK4

dbSNP Gene:6789 STK4

ENSEMBL:ENSG00000101109 STK4

Participates

as an output of

Cleavage of p-STK4 (p-MST1) by caspase 3 (Homo sapiens)

Other forms of this molecule

STK4(1-487) [cytosol]

p-T183-STK4(1-487) [cytosol]

p-T183-STK4(1-326) [cytosol]

Inferred To

STK4 [cytosol] (Canis familiaris)

STK4 [cytosol] (Gallus gallus)

STK4(327-487) [cytosol] (Bos taurus)

STK4(327-487) [cytosol] (Caenorhabditis elegans)

STK4(327-487) [cytosol] (Drosophila melanogaster)

STK4(327-487) [cytosol] (Mus musculus)

STK4(327-487) [cytosol] (Rattus norvegicus)

STK4(327-487) [cytosol] (Sus scrofa)

STK4(327-487) [cytosol] (Xenopus tropicalis)

Homologues of STK4(327-487) [cytosol] (Caenorhabditis elegans)

Interactors (34)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9H4B6 SAV1	2	p-SAV1 [cytosol] (R-HSA-2028276) SAV1 [cytosol] (R-HSA-2028283)	0.942	23
UniProt:P50749 RASF2			0.926	19
UniProt:Q13188 STK3	4	STK3(1-491) [cytosol] (R-HSA-2028280) p-T180-STK3(1-491) [cytosol] (R-HSA-2028274) STK3(323-491) [cytosol] (R-HSA-2028684) p-T180-STK3(1-322) [cytosol] (R-HSA-2028696)	0.914	20
UniProt:Q9NS23 RASF1			0.886	11
UniProt:Q8WWW0 RASF5			0.88	9
UniProt:Q9H2L5 RASF4			0.829	7
UniProt:Q86WH2 RASF3			0.823	7
UniProt:Q14BN4 SLMAP			0.787	8
UniProt:Q6ZTQ3 RASF6			0.779	6
UniProt:Q9H8S9 MOB1A	2	p-T12,T35-MOB1A [cytosol] (R-HSA-2028628) MOB1A [cytosol] (R-HSA-2028568)	0.747	9
UniProt:Q9NS23-2 RASSF1			0.729	4
UniProt:P46821 MAP1B	1	MAP1B(2-2206) [cytosol] (R-HSA-9836954)	0.725	4
UniProt:Q66K74 MAP1S			0.706	5
UniProt:Q9GZQ8 MAP1LC3B	3	MAP1LC3B [cytosol] (R-HSA-5205651) MAP1LC3B(2-121) [cytosol] (R-HSA-5682674) MAP1LC3B [autophagosome membrane] (R-HSA-5683641)	0.688	8
UniProt:Q13043 STK4	4	STK4(1-487) [cytosol] (R-HSA-201627) STK4(327-487) [cytosol] (R-HSA-2028668) p-T183-STK4(1-487) [cytosol] (R-HSA-2028258) p-T183-STK4(1-326) [cytosol] (R-HSA-2028682)	0.678	4
UniProt:Q06830 PRDX1	3	PRDX1 [cytosol] (R-HSA-3341270) HOOS-C52-PRDX1 [cytosol] (R-HSA-5629198) p-T90-PRDX1 [cytosol] (R-HSA-8868564)	0.66	11
UniProt:P61981 YWHAG	1	YWHAG [cytosol] (R-HSA-380312)	0.65	3
UniProt:Q9P0L0 VAPA	4	VAPA [azurophil granule membrane] (R-HSA-6799364) VAPA [plasma membrane] (R-HSA-6806269) VAPA [endoplasmic reticulum membrane] (R-HSA-429677) VAPA [cytosol] (R-HSA-9609920)	0.643	5
UniProt:Q7L9L4 MOB1B	2	p-T12,T35-MOB1B [cytosol] (R-HSA-2028643) MOB1B [cytosol] (R-HSA-2028569)	0.629	4
UniProt:P31749 AKT1	14	p-T308,S473-AKT1 [nucleoplasm] (R-HSA-198357) p-T308,S473-AKT1 [cytosol] (R-HSA-198356) p-S473-AKT1 [plasma membrane] (R-HSA-377265) AKT1 [plasma membrane] (R-HSA-199416) AKT1 [cytosol] (R-HSA-58252) p-T308-AKT1 [cytosol] (R-HSA-198634) p-Y315,Y326-AKT1 [cytosol] (R-HSA-8848757) p-T308,S473-AKT1 [plasma membrane] (R-HSA-199430) p-S473-AKT1 [cytosol] (R-HSA-9841264) AKT1 E17K [plasma membrane] (R-HSA-1500573) p-S473-AKT1 E17K [plasma membrane] (R-HSA-2243944) AKT1 E17K [cytosol] (R-HSA-2219526) p-T308,S473-AKT1 E17K [cytosol] (R-HSA-2243935) p-T308,S473-AKT1 E17K [nucleoplasm] (R-HSA-2399994)	0.619	13
UniProt:O43815 STRN	5	STRN [cytosol] (R-HSA-9037081) STRN(1-265)-PDGFRA(580-1089) fusion [cytosol] (R-HSA-9673902) p-11Y-STRN(1-265)-PDGFRA(580-1089) fusion [cytosol] (R-HSA-9673908) STRN(1-137)-ALK(1058-1620) fusion [cytosol] (R-HSA-9700485) STRN(1-137)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9700467)	0.615	4
UniProt:P35700 Prdx1	3	p-T90-Prdx1 [cytosol] (R-MMU-8868582) Prdx1 [cytosol] (R-MMU-5629198) Prdx1 [cytosol] (R-MMU-8868585)	0.611	3
UniProt:Q8WWW0-2 RASSF5			0.581	4
UniProt:Q99MK9 RASF1			0.564	2
UniProt:P60520 GABARAPL2	3	GABARAPL2 [cytosol] (R-HSA-5671758) GABARAPL2(1-117) [cytosol] (R-HSA-5682641) GABARAPL2 [autophagosome membrane] (R-HSA-5683633)	0.544	2
UniProt:O95166 GABARAP	3	GABARAP [cytosol] (R-HSA-975521) GABARAP(1-117) [cytosol] (R-HSA-5682696) GABARAP [autophagosome membrane] (R-HSA-5683634)	0.544	2
UniProt:Q9H0R8 GABARAPL1	3	GABARAPL1 [cytosol] (R-HSA-5671757) GABARAPL1(1-117) [cytosol] (R-HSA-5682659) GABARAPL1 [autophagosome membrane] (R-HSA-5683637)	0.544	2
UniProt:P04083 ANXA1	2	ANXA1 [cytosol] (R-HSA-5263630) ANXA1 [extracellular region] (R-HSA-444539)	0.527	2
UniProt:O95292 VAPB	2	VAPB [Golgi membrane] (R-HSA-9715115) VAPB [endoplasmic reticulum membrane] (R-HSA-429718)	0.527	4
UniProt:P11021 HSPA5	6	HSPA5 [lumenal side of endoplasmic reticulum membrane] (R-HSA-985498) HSPA5 [nucleoplasm] (R-HSA-5252042) HSPA5 [cytosol] (R-HSA-5252115) HSPA5 [endoplasmic reticulum membrane] (R-HSA-351315) HSPA5 [endoplasmic reticulum lumen] (R-HSA-387190) HSPA5 [extracellular region] (R-HSA-351322)	0.527	3
UniProt:Q91VJ4	1	STK38 [cytosol] (R-MMU-9715143)	0.525	2
UniProt:Q8WWW0-3 RASSF5			0.508	2
UniProt:Q9NVK5 FGFR1OP2	2	FGFR1OP(1-132)-FGFR1(429-822) fusion [cytosol] (R-HSA-1606443) FGFR1OP(1-132)-p-FGFR1(429-822) fusion [cytosol] (R-HSA-1838998)	0.483	2
UniProt:Q13033 STRN3			0.483	3