Phosphorylation of MOB1A and B by p-STK4(MST1)/N

Stable Identifier
R-HSA-2028670
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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Phosphorylation of MOB1A and B by p-STK4(MST1)/N
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Cytosolic MOB1A and MOB1B are phosphorylated by phospho-STK4(MST1)/N (Graves et al. 1998; Lee et al. 2001). Threonine residues 12 and 35 have been experimentally identifed as the targets of MOB1A phosphorylation; the homologous residues of MOB1B are inferred likewise to be targets.
Literature References
PubMed ID Title Journal Year
11278283 MST, a physiological caspase substrate, highly sensitizes apoptosis both upstream and downstream of caspase activation

Tsubuki, S, Yajima, N, Lee, KK, Ohyama, T, Yonehara, S

J Biol Chem 2001
9545236 Caspase-mediated activation and induction of apoptosis by the mammalian Ste20-like kinase Mst1

Ambrose, DM, Krebs, EG, Han, DK, Gotoh, Y, Clark, EA, Draves, KE, Chernoff, J, Wright, M, Graves, JD

EMBO J 1998
Participants
Input
Output
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as an event of
Catalyst Activity

protein serine/threonine kinase activity of p-STK4/N:p-SAV1 [cytosol]

Physical Entity
p-STK4/N:p-SAV1 [cytosol] (Homo sapiens)
Activity
protein serine/threonine kinase activity (GO:0004674)
Orthologous Events
Phosphorylation of MOB1A and B by p-STK4(MST1)/N (Bos taurus)
Phosphorylation of MOB1A and B by p-STK4(MST1)/N (Caenorhabditis elegans)
Phosphorylation of MOB1A and B by p-STK4(MST1)/N (Canis familiaris)
Phosphorylation of MOB1A and B by p-STK4(MST1)/N (Drosophila melanogaster)
Phosphorylation of MOB1A and B by p-STK4(MST1)/N (Gallus gallus)
Phosphorylation of MOB1A and B by p-STK4(MST1)/N (Mus musculus)
Phosphorylation of MOB1A and B by p-STK4(MST1)/N (Rattus norvegicus)
Phosphorylation of MOB1A and B by p-STK4(MST1)/N (Sus scrofa)
Phosphorylation of MOB1A and B by p-STK4(MST1)/N (Xenopus tropicalis)
Authored
D'Eustachio, P  (2012-02-03)
Reviewed
Sudol, M  (2012-02-03)
Created
D'Eustachio, P  (2011-12-31)
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