Phosphorylation of LATS1 and 2 by p-STK3 (MST2)/N

Stable Identifier
R-HSA-2028673
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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Phosphorylation of LATS1 and 2 by p-STK3 (MST2)/N
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Cytosolic LATS1 and LATS2 are phosphorylated by phospho-STK3 (MST2)/N (Lee et al. 2001). LATS proteins are known to form complexes with MOB1 proteins and this reaction is annotated with LATS:MOB1 complexes as its substrate. Serine-909 and threonine-1079 have been identified as LATS1 residues phosphorylated by STK4 (MST1) kinase; STK3(MST2)/N is inferred to act similarly. The target residues of LATS2 have not been identified experimentally but are inferred to be serine-872 and threonine-1041 based on sequence similarity.
Literature References
PubMed ID Title Journal Year
11278283 MST, a physiological caspase substrate, highly sensitizes apoptosis both upstream and downstream of caspase activation

Tsubuki, S, Yajima, N, Lee, KK, Ohyama, T, Yonehara, S

J Biol Chem 2001
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as an event of
Catalyst Activity

protein serine/threonine kinase activity of p-STK3/N:p-SAV1 [cytosol]

Physical Entity
p-STK3/N:p-SAV1 [cytosol] (Homo sapiens)
Activity
protein serine/threonine kinase activity (GO:0004674)
Orthologous Events
Phosphorylation of LATS1 and 2 by p-STK3 (MST2)/N (Bos taurus)
Phosphorylation of LATS1 and 2 by p-STK3 (MST2)/N (Caenorhabditis elegans)
Phosphorylation of LATS1 and 2 by p-STK3 (MST2)/N (Canis familiaris)
Phosphorylation of LATS1 and 2 by p-STK3 (MST2)/N (Danio rerio)
Phosphorylation of LATS1 and 2 by p-STK3 (MST2)/N (Drosophila melanogaster)
Phosphorylation of LATS1 and 2 by p-STK3 (MST2)/N (Gallus gallus)
Phosphorylation of LATS1 and 2 by p-STK3 (MST2)/N (Mus musculus)
Phosphorylation of LATS1 and 2 by p-STK3 (MST2)/N (Rattus norvegicus)
Phosphorylation of LATS1 and 2 by p-STK3 (MST2)/N (Sus scrofa)
Phosphorylation of LATS1 and 2 by p-STK3 (MST2)/N (Xenopus tropicalis)
Authored
D'Eustachio, P  (2012-02-03)
Reviewed
Sudol, M  (2012-02-03)
Created
D'Eustachio, P  (2011-12-31)
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