Reactome | Phosphorylation of LATS1 and 2 by p-STK4(MST1)/N

Phosphorylation of LATS1 and 2 by p-STK4(MST1)/N

Stable Identifier

R-HSA-2028679

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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Phosphorylation of LATS1 and 2 by p-STK4(MST1)/N

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Cytosolic LATS1 and LATS2 are phosphorylated by phospho-STK4(MST1)/N (Graves et al. 1998; Lee et al. 2001). LATS proteins are known to form complexes with MOB1 proteins and this reaction is annotated with LATS:MOB1 complexes as its substrate. Serine-909 and threonine-1097 have been identified as LATS1 residues phosphorylated by STK4 (MST1) kinase. The target residues of LATS2 have not been identified experiemntally but are inferred to be serine-871 and threonine-1041 based on sequence similarity.

Literature References

PubMed ID	Title	Journal	Year
11278283	MST, a physiological caspase substrate, highly sensitizes apoptosis both upstream and downstream of caspase activation Tsubuki, S, Yajima, N, Lee, KK, Ohyama, T, Yonehara, S	J Biol Chem	2001
9545236	Caspase-mediated activation and induction of apoptosis by the mammalian Ste20-like kinase Mst1 Ambrose, DM, Krebs, EG, Han, DK, Gotoh, Y, Clark, EA, Draves, KE, Chernoff, J, Wright, M, Graves, JD	EMBO J	1998