Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
ADD1(634-737) [cytosol]
Stable Identifier
R-HSA-202890
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Alpha adducin fragment (634-737)
Locations in the PathwayBrowser
Expand all
Programmed Cell Death (Homo sapiens)
Apoptosis (Homo sapiens)
Apoptotic execution phase (Homo sapiens)
Apoptotic cleavage of cellular proteins (Homo sapiens)
Caspase-mediated cleavage of cytoskeletal proteins (Homo sapiens)
Caspase-mediated cleavage of alpha adducin (Homo sapiens)
ADD1(634-737) [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P35611 ADD1
Gene Names
ADD1, ADDA
Chain
chain:1-737
Reference Genes
BioGPS Gene:118 ADD1
COSMIC (genes):ADD1 ADD1
CTD Gene:118 ADD1
dbSNP Gene:118 ADD1
ENSEMBL:ENSG00000087274 ADD1
ENSEMBL_homo_sapiens_GENE:ENSG00000087274.19 ADD1
HGNC:243 ADD1
KEGG Gene (Homo sapiens):118 ADD1
Monarch:118 ADD1
NCBI Gene:118 ADD1
OMIM:102680 ADD1
UCSC:P35611 ADD1
Reference Transcript
RefSeq:XM_017007710.1 ADD1
RefSeq:XM_017007708.1 ADD1
RefSeq:NM_001286645.1 ADD1
RefSeq:NM_014189.3 ADD1
RefSeq:NM_014190.3 ADD1
RefSeq:XM_017007706.1 ADD1
RefSeq:XM_017007709.1 ADD1
RefSeq:XM_017007707.1 ADD1
RefSeq:NM_001119.4 ADD1
RefSeq:NM_176801.2 ADD1
RefSeq:XM_005247937.2 ADD1
RefSeq:XM_017007704.1 ADD1
Other Identifiers
11716514_s_at
11716515_x_at
11716516_a_at
11716517_x_at
11747763_a_at
118
16964232
208030_PM_s_at
208030_s_at
214726_3p_x_at
214726_PM_x_at
214726_x_at
214736_PM_s_at
214736_s_at
2715633
2715635
2715636
2715647
2715648
2715651
2715652
2715660
2715661
2715663
2715666
2715668
2715680
2715681
2715682
2715683
2715687
2715689
2715691
2715700
2715703
2715706
2715711
2715712
2715713
2715714
2715715
2715716
2715717
2715719
32145_at
32146_s_at
8093643
A_14_P108022
A_14_P123088
A_23_P212768
A_24_P109272
GE80556
GO:0003723
GO:0003779
GO:0005515
GO:0005516
GO:0005634
GO:0005654
GO:0005737
GO:0005829
GO:0005856
GO:0005886
GO:0005912
GO:0005925
GO:0007010
GO:0008092
GO:0008290
GO:0014069
GO:0016020
GO:0016604
GO:0030036
GO:0030154
GO:0030507
GO:0032092
GO:0034330
GO:0042803
GO:0043226
GO:0045296
GO:0046982
GO:0046983
GO:0048856
GO:0051015
GO:0051016
GO:0051017
GO:0061629
GO:0065003
GO:0071277
GO:1903142
GO:1903393
HMNXSV003039979
Hs.183706.1.S1_3p_s_at
Hs.183706.2.S1_3p_s_at
ILMN_1759252
ILMN_2356786
L07261_s_at
PH_hs_0010830
TC04000039.hg
TC04001860.hg
Z68280_cds2_s_at
g7710113_3p_s_at
Participates
as an output of
Caspase-mediated cleavage of alpha adducin (Homo sapiens)
Other forms of this molecule
ADD1(1-633) [cytosol]
ADD1 [cytosol]
Inferred To
hts [cytosol]
(Drosophila melanogaster)
ahhA [cytosol]
(Dictyostelium discoideum)
ADD1 [cytosol]
(Bos taurus)
ADD1 [cytosol]
(Canis familiaris)
ADD1 [cytosol]
(Sus scrofa)
ADD1(634-737) [cytosol]
(Gallus gallus)
ADD1(634-737) [cytosol]
(Schizosaccharomyces pombe)
Add1 [cytosol]
(Mus musculus)
Add1 [cytosol]
(Rattus norvegicus)
add-1 [cytosol]
(Caenorhabditis elegans)
Cross References
RefSeq
NP_054908.2
,
XP_016863193.1
,
NP_001110.2
,
NP_054909.2
,
XP_016863199.1
,
XP_016863196.1
,
XP_016863197.1
,
NP_001273574.1
,
NP_789771.1
,
XP_016863198.1
,
XP_016863195.1
,
XP_005247994.1
OpenTargets
ENSG00000087274
HPA
ENSG00000087274-ADD1
GeneCards
P35611
Ensembl
ENST00000264758
,
ENSP00000348100
,
ENST00000651918
,
ENSP00000498269
,
ENSP00000381197
,
ENSP00000381191
,
ENST00000398123
,
ENST00000355842
,
ENSP00000264758
,
ENST00000398129
,
ENSP00000381193
,
ENST00000398125
,
ENSG00000087274
PRO
P35611
Pharos - Targets
P35611
Interactors (4)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P02489 CRYAA
0.556
3
UniProt:Q13153 PAK1
5
PAK1 [plasma membrane]
(R-HSA-3928409)
p-S144,T423-PAK1 [plasma membrane]
(R-HSA-3928472)
Active PAK1 [cytosol]
(R-HSA-8964622)
PAK1 [cytosol]
(R-HSA-162629)
p-S144,T423-PAK1 [cytosol]
(R-HSA-399819)
0.556
3
UniProt:P22670 RFX1
0.543
3
ChEBI:16618 1-PHOSPHATIDYL-1D-MYO-INOSITOL 3,4,5-TRISPHOSPHATE
0.462
2
© 2024
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text