Reactome | PLD1 [plasma membrane]

PLD1 [plasma membrane]

Stable Identifier

R-HSA-2028998

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Phospholipase D1, PLD1_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q13393 PLD1

Gene Names

PLD1

Chain

chain:1-1074

Reference Genes

BioGPS Gene:5337 PLD1

COSMIC (genes):PLD1 PLD1

CTD Gene:5337 PLD1

dbSNP Gene:5337 PLD1

ENSEMBL:ENSG00000075651 PLD1

HGNC:9067 PLD1

KEGG:hsa:5337 PLD1

Monarch:5337 PLD1

NCBI Gene:5337 PLD1

OMIM:602382 PLD1

UCSC:Q13393 PLD1

Reference Transcript

Other Identifiers

11723545_a_at

11723546_s_at

11737322_a_at

1557126_PM_a_at

1557126_a_at

16961551

177_PM_at

177_at

205203_PM_at

205203_at

215723_PM_s_at

215723_s_at

215724_PM_at

215724_at

226636_PM_at

226636_at

232530_PM_at

232530_at

2705444

2705446

2705447

2705448

2705449

2705450

2705451

2705453

2705455

2705456

2705458

2705459

2705465

2705466

2705468

2705473

2705475

2705476

2705481

2705482

2705483

2705484

2705487

2705488

2705490

2705491

2705492

2705493

2705496

2705498

2705500

2705501

2705504

2705505

2705506

2705507

2705508

2705509

2705510

2705511

2705512

2705513

2705514

2705515

2705521

2705522

2705523

2705524

2705525

2705526

2705527

2705528

2705529

2705532

2705533

5337

71119_at

8092134

89866_at

A_19_P00319323

A_19_P00319324

A_19_P00320889

A_19_P00321032

A_19_P00321033

A_19_P00321578

A_23_P155335

A_23_P398774

A_24_P123190

A_32_P112331

A_33_P3320062

GE81176

GO:0000139

GO:0003824

GO:0004630

GO:0005515

GO:0005737

GO:0005765

GO:0005768

GO:0005783

GO:0005789

GO:0005794

GO:0005886

GO:0006629

GO:0006654

GO:0006935

GO:0007264

GO:0007265

GO:0008289

GO:0009395

GO:0016020

GO:0016042

GO:0016324

GO:0016787

GO:0030139

GO:0031410

GO:0031670

GO:0031902

GO:0032534

GO:0035091

GO:0035556

GO:0035579

GO:0043226

GO:0043231

GO:0045727

GO:0048471

GO:0060627

GO:0070821

GO:0098693

GO:0098981

HMNXSV003044645

Hs.212533.0.S1_3p_at

Hs.82587.1.S1_3p_at

Hs.93837.2.A1_3p_at

Hs2.193001.1.S1_3p_s_at

ILMN_1719696

ILMN_1759344

PH_hs_0024328

TC03002001.hg

U38545_at

g4505872_3p_s_at

Participates

as a member of

as a candidate of

PLD [plasma membrane] (Homo sapiens)

Other forms of this molecule

PLD1 [tertiary granule membrane]

PLD1 [specific granule membrane]

PLD1 [endoplasmic reticulum membrane]

Inferred To

pldA [plasma membrane] (Dictyostelium discoideum)

Pld1 [plasma membrane] (Mus musculus)

Pld1 [plasma membrane] (Rattus norvegicus)

pldC [plasma membrane] (Dictyostelium discoideum)

Homologues of PLD1 [plasma membrane] (Dictyostelium discoideum)

PLD1 [plasma membrane] (Bos taurus)

PLD1 [plasma membrane] (Canis familiaris)

PLD1 [plasma membrane] (Dictyostelium discoideum)

PLD1 [plasma membrane] (Gallus gallus)

PLD1 [plasma membrane] (Sus scrofa)

SPO14 [plasma membrane] (Saccharomyces cerevisiae)

pld1 [plasma membrane] (Schizosaccharomyces pombe)

pld1 [plasma membrane] (Xenopus tropicalis)

Pld [plasma membrane] (Drosophila melanogaster)

pld-1 [plasma membrane] (Caenorhabditis elegans)

Cross References

RefSeq

XP_005247591.1, XP_005247590.1, NP_002653.1, XP_011511199.1

ZINC - World Drugs

PLD1_HUMAN

Guide to Pharmacology - Targets

1433

ENSEMBL

ENSP00000348681, ENST00000356327, ENST00000351298, ENSP00000342793

OpenTargets

ENSG00000075651

ZINC - FDA approved

PLD1_HUMAN

ZINC - Substances

PLD1_HUMAN

ZINC target

Q13393

PRO

Q13393

GlyGen

Q13393

PDB

6U8Z

IntEnz

3.1.4.4

HPA

ENSG00000075651-PLD1

Pharos - Targets

Q13393

ZINC - Predictions - Purchasable

PLD1_HUMAN

HMDB Protein

HMDBP00082

Interactors (5)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P23528 CFL1	3	CFL1 [cytosol] (R-HSA-350751) p-S3-CFL1 [cytosol] (R-HSA-399813) CFL1 [extracellular region] (R-HSA-350747)	0.571	4
UniProt:Q6NXG1 ESRP1	3	ESRP1(1-606)-RAF1(227-648) fusion [cytosol] (R-HSA-6802312) ESRP1(1-606)-p-RAF1(227-648) fusion [cytosol] (R-HSA-6802523) ESRP1 [nucleoplasm] (R-HSA-6803472)	0.556	3
UniProt:O15287 FANCG	2	FANCG [nucleoplasm] (R-HSA-419532) FANCG [cytosol] (R-HSA-420788)	0.556	3
UniProt:P05067 APP	20	APP(672-713) [extracellular region] (R-HSA-879340) APP(672-711) [cytosol] (R-HSA-877188) APP(672-711) [extracellular region] (R-HSA-976740) APP [endoplasmic reticulum lumen] (R-HSA-8956696) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP(18-770) [endosome lumen] (R-HSA-5229077) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-687) [extracellular region] (R-HSA-9010033) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) APP(18-770) [extracellular region] (R-HSA-49335) APP-C99 [cytosol] (R-HSA-9617603) APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136)	0.556	3
UniProt:Q12888 TP53BP1	3	TP53BP1 [nucleoplasm] (R-HSA-61175) p-S25,S1778-TP53BP1 [nucleoplasm] (R-HSA-5683418) monoSUMO1-K-TP53BP1 [nucleoplasm] (R-HSA-2997591)	0.556	3