Reactome | STX4 [phagocytic vesicle membrane]

STX4 [phagocytic vesicle membrane]

Stable Identifier

R-HSA-2029044

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

phagocytic vesicle membrane

Synonyms

Syntaxin 4

Locations in the PathwayBrowser for interactor UniProt:Q9Y228 T3JAM

Expand all

External Reference Information

External Reference

UniProt:Q12846 STX4

Gene Names

STX4, STX4A

Chain

chain:1-297

Reference Genes

BioGPS Gene:6810 STX4

COSMIC (genes):STX4 STX4

CTD Gene:6810 STX4

dbSNP Gene:6810 STX4

ENSEMBL:ENSG00000103496 STX4

ENSEMBL:ENSG00000103496.15 STX4

HGNC:11439 STX4

KEGG Gene (Homo sapiens):6810 STX4

Monarch:6810 STX4

NCBI Gene:6810 STX4

OMIM:186591 STX4

UCSC:Q12846 STX4

Reference Transcript

Other Identifiers

11725677_a_at

16818125

203530_PM_s_at

203530_s_at

3656761

3656762

3656763

3656764

3656765

3656766

3656767

3656768

3656770

3656772

3656774

3656775

3656776

3656777

3656779

3656781

3656782

37911_at

6810

7995017

A_23_P256375

GE58889

GO:0000149

GO:0000322

GO:0002376

GO:0002639

GO:0005484

GO:0005515

GO:0005576

GO:0005615

GO:0005737

GO:0005768

GO:0005773

GO:0005794

GO:0005802

GO:0005829

GO:0005886

GO:0006836

GO:0006886

GO:0006887

GO:0006906

GO:0007155

GO:0008284

GO:0009986

GO:0012501

GO:0012505

GO:0016020

GO:0016192

GO:0016230

GO:0016323

GO:0017157

GO:0023052

GO:0030027

GO:0030335

GO:0030670

GO:0031201

GO:0031410

GO:0032589

GO:0034394

GO:0034599

GO:0035493

GO:0035749

GO:0035774

GO:0036477

GO:0042581

GO:0042995

GO:0043005

GO:0043085

GO:0043197

GO:0043219

GO:0043226

GO:0043311

GO:0045202

GO:0045335

GO:0045785

GO:0048278

GO:0048284

GO:0048471

GO:0048870

GO:0050921

GO:0060090

GO:0060291

GO:0061024

GO:0065003

GO:0070062

GO:0071346

GO:0072659

GO:0098542

GO:0098772

GO:0098794

GO:0098978

GO:1902041

GO:1903078

GO:1903575

GO:2000010

HMNXSV003055143

ILMN_1680313

PH_hs_0004775

TC16000366.hg

U07158_at

g4759185_3p_a_at

Participates

as a component of

as an input of

SEC22B, CALR, STX4, TAP and TAPBP bind (Homo sapiens)

Other forms of this molecule

STX4 [plasma membrane]

STX4 [cytosol]

p-STX4 [cytosol]

Inferred To

Stx4 [phagocytic vesicle membrane] (Mus musculus)

Stx4 [phagocytic vesicle membrane] (Rattus norvegicus)

STX4 [phagocytic vesicle membrane] (Bos taurus)

STX4 [phagocytic vesicle membrane] (Canis familiaris)

STX4 [phagocytic vesicle membrane] (Danio rerio)

STX4 [phagocytic vesicle membrane] (Sus scrofa)

STX4 [phagocytic vesicle membrane] (Xenopus tropicalis)

syn1A [phagocytic vesicle membrane] (Dictyostelium discoideum)

Homologues of STX4 [phagocytic vesicle membrane] (Dictyostelium discoideum)

syn1B [phagocytic vesicle membrane] (Dictyostelium discoideum)

Cross References

RefSeq

NP_004595.2, NP_001259025.1

OpenTargets

ENSG00000103496

GeneCards

Q12846

HPA

ENSG00000103496-STX4

Ensembl

ENST00000394998, ENSP00000317714, ENSG00000103496, ENSP00000378447, ENST00000313843

PRO

Q12846

Pharos - Targets

Q12846

Interactors (52)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q15836 VAMP3	6	VAMP3 [recycling endosome membrane] (R-HSA-2029063) VAMP3 [phagocytic vesicle membrane] (R-HSA-2029013) VAMP3 [plasma membrane] (R-HSA-8867599) VAMP3 [trans-Golgi network membrane] (R-HSA-6814624) VAMP3 [transport vesicle] (R-HSA-6814625) VAMP3 [clathrin-coated endocytic vesicle membrane] (R-HSA-8869130)	0.846	9
UniProt:O43752 STX6	2	STX6 [trans-Golgi network membrane] (R-HSA-6811007) STX6 [Golgi membrane] (R-HSA-6811004)	0.831	8
UniProt:Q86Y82 STX12			0.831	8
UniProt:Q13277 STX3	1	STX3 [plasma membrane] (R-HSA-449131)	0.83	8
UniProt:O95183 VAMP5			0.782	7
UniProt:Q53TN4 CYBRD1	1	CYBRD1 [plasma membrane] (R-HSA-917788)	0.781	7
UniProt:O15400 STX7			0.781	7
UniProt:O75379 VAMP4	4	VAMP4 [transport vesicle] (R-HSA-6811023) VAMP4 [trans-Golgi network membrane] (R-HSA-6811021) VAMP4 [plasma membrane] (R-HSA-8864461) VAMP4 [clathrin-coated endocytic vesicle membrane] (R-HSA-8869133)	0.781	7
UniProt:Q9H115 NAPB	1	NAPB [cytosol] (R-HSA-5688553)	0.718	6
UniProt:Q9UNK0 STX8			0.718	6
UniProt:O15155 BET1	3	BET1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-5688142) BET1 [transport vesicle] (R-HSA-6808719) BET1 [Golgi membrane] (R-HSA-6807743)	0.718	6
UniProt:Q9UEU0 VTI1B	2	VTI1B [extracellular region] (R-HSA-8862983) VTI1B [platelet alpha granule lumen] (R-HSA-8862964)	0.718	6
UniProt:P63027 VAMP2	20	VAMP2 [clathrin-coated endocytic vesicle membrane] (R-HSA-8869129) VAMP2 [clathrin-sculpted monoamine transport vesicle membrane] (R-HSA-379363) VAMP2 [plasma membrane] (R-HSA-210516) VAMP2 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane] (R-HSA-917738) VAMP2 [clathrin-sculpted glutamate transport vesicle membrane] (R-HSA-210365) VAMP2 [synaptic vesicle membrane] (R-HSA-181517) VAMP2(59-116) [synaptic vesicle membrane] (R-HSA-5250891) VAMP2(2-58) [cytosol] (R-HSA-194815) VAMP2(2-76) [cytosol] (R-HSA-194802) VAMP2(77-116) [synaptic vesicle membrane] (R-HSA-5228355) VAMP2(60-116) [synaptic vesicle membrane] (R-HSA-5250615) VAMP2(2-59) [cytosol] (R-HSA-194797) VAMP2(82-116) [synaptic vesicle membrane] (R-HSA-5250961) VAMP2(2-81) [cytosol] (R-HSA-5250970) VAMP2 [secretory granule membrane] (R-HSA-376363) VAMP2 [cytosol] (R-HSA-9609882) VAMP2 [endoplasmic reticulum membrane] (R-HSA-9609886) VAMP2 [cytoplasmic vesicle membrane] (R-HSA-1449630) VAMP2 [lysosomal membrane] (R-HSA-432703) VAMP2 [Golgi membrane] (R-HSA-375425)	0.718	6
UniProt:Q13190 STX5	5	STX5 [endoplasmic reticulum membrane] (R-HSA-5689474) STX5 [ER to Golgi transport vesicle membrane] (R-HSA-5689838) STX5 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-5688157) STX5 [Golgi membrane] (R-HSA-6807771) STX5 [cytosol] (R-HSA-9613991)	0.718	6
UniProt:O14653 GOSR2	4	GOSR2 [endoplasmic reticulum membrane] (R-HSA-5689451) GOSR2 [ER to Golgi transport vesicle membrane] (R-HSA-5689800) GOSR2 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-535472) GOSR2 [Golgi membrane] (R-HSA-6807755)	0.718	6
UniProt:Q96IW7 SEC22A	3	SEC22A [ER to Golgi transport vesicle membrane] (R-HSA-5688560) SEC22A [endoplasmic reticulum membrane] (R-HSA-5216111) SEC22A [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-5688562)	0.718	6
UniProt:O75396 SEC22B	6	SEC22B [endoplasmic reticulum membrane] (R-HSA-5688150) SEC22B [ER to Golgi transport vesicle membrane] (R-HSA-5688565) SEC22B [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-5688566) SEC22B [phagocytic vesicle membrane] (R-HSA-8863938) SEC22B [transport vesicle] (R-HSA-6810994) SEC22B [Golgi membrane] (R-HSA-6810993)	0.675	4
UniProt:O75379-2 VAMP4			0.666	4
UniProt:P54920 NAPA	1	NAPA [cytosol] (R-HSA-264469)	0.632	3
UniProt:P0DTC3 3a	9	O-glycosyl 3a [virion membrane] (R-COV-9694395) O-glycosyl 3a [endocytic vesicle membrane] (R-COV-9694729) O-glycosyl 3a [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9694386) GalNAc-O-3a [endoplasmic reticulum-Golgi intermediate compartment] (R-COV-9694658) 3a [endoplasmic reticulum-Golgi intermediate compartment] (R-COV-9694716) 3a [endoplasmic reticulum lumen] (R-COV-9694584) O-glycosyl 3a [endolysosome membrane] (R-COV-9754541) O-glycosyl 3a [plasma membrane] (R-COV-9694433) O-glycosyl 3a [extracellular region] (R-COV-9694387)	0.602	4
UniProt:P32856-2 STX2			0.601	4
UniProt:P23763-3 VAMP1			0.556	3
UniProt:O60499-2 STX10			0.556	3
UniProt:Q9NZ43 USE1	1	USE1 [endoplasmic reticulum membrane] (R-HSA-2193119)	0.556	3
UniProt:Q8TGQ7 YP159			0.556	3
UniProt:Q8TDT2 GP152			0.556	3
UniProt:Q969S6 TM203			0.556	3
UniProt:Q5SQN1 SNP47			0.556	3
UniProt:Q96F15 GIMA5			0.556	3
UniProt:P50402 EMD	4	EMD [nuclear envelope] (R-HSA-201573) EMD [cytosol] (R-HSA-9613988) EMD [endoplasmic reticulum membrane] (R-HSA-9613998) EMD [endosome membrane] (R-HSA-9715092)	0.556	3
UniProt:P25788 PSMA3	2	PSMA3 [nucleoplasm] (R-HSA-174323) PSMA3 [cytosol] (R-HSA-68728)	0.556	3
UniProt:P23763 VAMP1	7	VAMP1(84-118) [synaptic vesicle membrane] (R-HSA-5250991) VAMP1(1-83) [cytosol] (R-HSA-5250967) VAMP1(1-61) [cytosol] (R-HSA-2976003) VAMP1(62-118) [synaptic vesicle membrane] (R-HSA-5250599) VAMP1(1-60) [cytosol] (R-HSA-2976004) VAMP1(61-118) [synaptic vesicle membrane] (R-HSA-5250888) VAMP1 [synaptic vesicle membrane] (R-HSA-2976040)	0.556	3
UniProt:P78317 RNF4	2	RNF4 [nucleoplasm] (R-HSA-5684076) RNF4 [cytosol] (R-HSA-975974)	0.556	3
UniProt:O75558 STX11			0.556	3
UniProt:P60201-2 PLP1			0.556	3
UniProt:P38736	1	GOS1 [Golgi membrane] (R-SCE-6807753)	0.556	3
UniProt:Q9Y228 T3JAM			0.556	3
UniProt:Q16623 STX1A	5	STX1A [plasma membrane] (R-HSA-449128) STX1A(?-288) [plasma membrane] (R-HSA-5246518) STX1A(1-?) [cytosol] (R-HSA-3065964) STX1A [cytosol] (R-HSA-9609866) STX1A [endoplasmic reticulum membrane] (R-HSA-9609878)	0.556	3
UniProt:Q8N511 TM199			0.556	3
UniProt:Q8N8B7-2 TCEANC			0.556	3
UniProt:P61266 STX1B	3	STX1B(1-?) [cytosol] (R-HSA-5246520) STX1B(?-288) [plasma membrane] (R-HSA-5246519) STX1B [plasma membrane] (R-HSA-181479)	0.556	3
UniProt:O14662-5 STX16			0.556	3
UniProt:O95470 SGPL1	1	PXLP-SGPL1 [endoplasmic reticulum membrane] (R-HSA-428661)	0.556	3
UniProt:O95159 ZFPL1			0.556	3
UniProt:O14662 STX16	2	STX16 [trans-Golgi network membrane] (R-HSA-6811002) STX16 [Golgi membrane] (R-HSA-6811001)	0.556	3
UniProt:Q96IV6 FXDC2			0.556	3
UniProt:Q08144	1	TLG2 [trans-Golgi network membrane] (R-SCE-6811002)	0.556	3
UniProt:Q9NYB9-2 ABI2			0.556	3
UniProt:Q9Y6X1 SERP1	2	SERP1 [endoplasmic reticulum membrane] (R-HSA-381045) SERP1 [cytosol] (R-HSA-5250574)	0.556	3
UniProt:Q86W74-2 ANKRD46			0.556	3
UniProt:P25385	4	BOS1 [Golgi membrane] (R-SCE-6807755) BOS1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-SCE-535472) BOS1 [ER to Golgi transport vesicle membrane] (R-SCE-5689800) BOS1 [endoplasmic reticulum membrane] (R-SCE-5689451)	0.556	3
UniProt:P21926 CD9	4	CD9 [plasma membrane] (R-HSA-51717) CD9 [endocytic vesicle membrane] (R-HSA-5334774) CD9 [clathrin-coated endocytic vesicle membrane] (R-HSA-5334779) CD9 [platelet alpha granule membrane] (R-HSA-114585)	0.462	2

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