Reactome | PLD2 [plasma membrane]

PLD2 [plasma membrane]

Stable Identifier

R-HSA-2029075

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Phospholipase D2, PLD2_HUMAN

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:O14939 PLD2

Gene Names

PLD2

Chain

chain:1-933

Reference Genes

BioGPS Gene:5338 PLD2

COSMIC (genes):PLD2 PLD2

CTD Gene:5338 PLD2

dbSNP Gene:5338 PLD2

ENSEMBL:ENSG00000129219 PLD2

ENSEMBL_homo_sapiens_GENE:ENSG00000129219.14 PLD2

HGNC:9068 PLD2

KEGG Gene (Homo sapiens):5338 PLD2

Monarch:5338 PLD2

NCBI Gene:5338 PLD2

OMIM:602384 PLD2

UCSC:O14939 PLD2

Reference Transcript

Other Identifiers

11748616_a_at

11757187_a_at

16829894

209643_PM_s_at

209643_s_at

3707218

3707219

3707220

3707221

3707222

3707224

3707225

3707226

3707228

3707229

3707231

3707232

3707233

3707234

3707235

3707236

3707237

3707239

3707241

3707243

3707245

3707246

3707247

3707248

3707249

3707250

3707253

3707254

3707255

3707256

3707257

41394_at

5338

8003962

A_23_P4308

A_33_P3286724

GE54324

GE81177

GO:0002376

GO:0003824

GO:0004630

GO:0005515

GO:0005783

GO:0005789

GO:0005886

GO:0006629

GO:0006654

GO:0007010

GO:0007264

GO:0008289

GO:0009395

GO:0016020

GO:0016042

GO:0016192

GO:0016787

GO:0023052

GO:0035091

GO:0035556

GO:0036465

GO:0038096

GO:0043226

GO:0043231

GO:0060627

GO:0070290

GO:0098793

HMNXSV003008076

HMNXSV003033601

ILMN_1697880

PH_hs_0005797

TC17000053.hg

g2645857_3p_a_at

Participates

as a member of

Other forms of this molecule

PLD2 [endoplasmic reticulum membrane]

Inferred To

pldC [plasma membrane] (Dictyostelium discoideum)

pld2 [plasma membrane] (Xenopus tropicalis)

PLD2 [plasma membrane] (Bos taurus)

PLD2 [plasma membrane] (Canis familiaris)

PLD2 [plasma membrane] (Sus scrofa)

SPO14 [plasma membrane] (Saccharomyces cerevisiae)

pld1 [plasma membrane] (Schizosaccharomyces pombe)

Pld2 [plasma membrane] (Mus musculus)

Pld2 [plasma membrane] (Rattus norvegicus)

Pld [plasma membrane] (Drosophila melanogaster)

pld-1 [plasma membrane] (Caenorhabditis elegans)

Cross References

RefSeq

NP_002654.3, NP_001230037.1

ZINC - World Drugs

PLD2_HUMAN

Guide to Pharmacology - Targets

1434

OpenTargets

ENSG00000129219

ZINC - FDA approved

PLD2_HUMAN

ZINC - Substances

PLD2_HUMAN

ZINC target

O14939

PRO

O14939

PDB

7SVP, 6OHO, 6OHP, 6OHQ, 6OHM, 6OHS

HPA

ENSG00000129219-PLD2

GeneCards

O14939

Ensembl

ENSP00000263088, ENST00000572940, ENSP00000459571, ENSG00000129219, ENST00000263088

Pharos - Targets

O14939

ZINC - Predictions - Purchasable

PLD2_HUMAN

HMDB Protein

HMDBP00080

Interactors (6)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P62993 GRB2	1	GRB2 [cytosol] (R-HSA-8983328)	0.635	4
UniProt:P05067 APP	20	APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136) APP-C99 [cytosol] (R-HSA-9617603) APP(18-770) [extracellular region] (R-HSA-49335) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) APP(18-687) [extracellular region] (R-HSA-9010033) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(18-770) [endosome lumen] (R-HSA-5229077) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP [endoplasmic reticulum lumen] (R-HSA-8956696) APP(672-711) [extracellular region] (R-HSA-976740) APP(672-711) [cytosol] (R-HSA-877188) APP(672-713) [extracellular region] (R-HSA-879340)	0.556	3
UniProt:P23528 CFL1	3	CFL1 [cytosol] (R-HSA-350751) p-S3-CFL1 [cytosol] (R-HSA-399813) CFL1 [extracellular region] (R-HSA-350747)	0.544	2
UniProt:Q8TDQ0 HAVCR2	1	HAVCR2 [plasma membrane] (R-HSA-5340408)	0.527	2
UniProt:P07437 TUBB	3	TUBB [cytosol] (R-HSA-9020816) TUBB [azurophil granule lumen] (R-HSA-6799370) TUBB [extracellular region] (R-HSA-380317)	0.527	3
UniProt:P20309 CHRM3	1	CHRM3 [plasma membrane] (R-HSA-399994)	0.527	2

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