Reactome | STX18 [endoplasmic reticulum membrane]

STX18 [endoplasmic reticulum membrane]

Stable Identifier

R-HSA-2029079

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

endoplasmic reticulum membrane

Synonyms

Syntaxin-18, STX18_HUMAN

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:Q9P2W9 STX18

Gene Names

STX18, GIG9

Chain

chain:1-335

Reference Genes

BioGPS Gene:53407 STX18

COSMIC (genes):STX18 STX18

CTD Gene:53407 STX18

dbSNP Gene:53407 STX18

ENSEMBL:ENSG00000168818 STX18

HGNC:15942 STX18

KEGG:hsa:53407 STX18

Monarch:53407 STX18

NCBI Gene:53407 STX18

OMIM:606046 STX18

UCSC:Q9P2W9 STX18

Reference Transcript

Other Identifiers

11718009_a_at

16973894

218763_PM_at

218763_at

2758734

2758735

2758736

2758737

2758738

2758740

2758741

2758742

2758743

2758747

2758749

2758750

2758751

2758757

2758758

2758759

2758760

2758762

2758777

2758778

3716318

3716330

3716332

53407

78425_at

8099121

A_23_P135616

A_24_P388622

GE58741

GO:0000139

GO:0005484

GO:0005515

GO:0005783

GO:0005789

GO:0005794

GO:0006886

GO:0006890

GO:0015031

GO:0016020

GO:0016192

GO:0019904

GO:0031201

GO:0060090

GO:0061024

GO:0061025

GO:0090158

GO:1902117

GO:1902953

GO:1903358

HMNXSV003029133

HMNXSV003047394

ILMN_1696126

PH_hs_0001290

TC04000990.hg

g8394375_3p_at

Participates

as an output of

NSF ATPase activity dissociates cis-SNARE at the ER (Homo sapiens)

as a component of

STX18:USE1L:BNIP1 [endoplasmic reticulum membrane] (Homo sapiens)

Inferred To

stx18 [endoplasmic reticulum membrane] (Danio rerio)

stx18 [endoplasmic reticulum membrane] (Xenopus tropicalis)

ufe1 [endoplasmic reticulum membrane] (Schizosaccharomyces pombe)

syx-18 [endoplasmic reticulum membrane] (Caenorhabditis elegans)

Syx18 [endoplasmic reticulum membrane] (Drosophila melanogaster)

UFE1 [endoplasmic reticulum membrane] (Saccharomyces cerevisiae)

STX18 [endoplasmic reticulum membrane] (Bos taurus)

STX18 [endoplasmic reticulum membrane] (Canis familiaris)

STX18 [endoplasmic reticulum membrane] (Dictyostelium discoideum)

STX18 [endoplasmic reticulum membrane] (Gallus gallus)

STX18 [endoplasmic reticulum membrane] (Sus scrofa)

Stx18 [endoplasmic reticulum membrane] (Mus musculus)

Stx18 [endoplasmic reticulum membrane] (Rattus norvegicus)

Cross References

RefSeq

NP_001333211.1, NP_001333210.1, NP_001333229.1, NP_058626.1

ENSEMBL

ENSG00000168818, ENSP00000305810, ENST00000306200

OpenTargets

ENSG00000168818

HPA

ENSG00000168818-STX18

GeneCards

STX18

PRO

Q9P2W9

Pharos - Targets

Q9P2W9

Interactors (31)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9NZ43 USE1	1	USE1 [endoplasmic reticulum membrane] (R-HSA-2193119)	0.853	12
UniProt:O43264 ZW10	1	ZW10 [cytosol] (R-HSA-377880)	0.837	8
UniProt:Q6NUQ1 RINT1	1	RINT1 [cytosol] (R-HSA-6810991)	0.837	8
UniProt:O75396 SEC22B	6	SEC22B [ER to Golgi transport vesicle membrane] (R-HSA-5688565) SEC22B [endoplasmic reticulum membrane] (R-HSA-5688150) SEC22B [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-5688566) SEC22B [phagocytic vesicle membrane] (R-HSA-8863938) SEC22B [transport vesicle] (R-HSA-6810994) SEC22B [Golgi membrane] (R-HSA-6810993)	0.823	7
UniProt:A2RRP1 NBAS	1	NBAS [cytosol] (R-HSA-6810973)	0.812	10
UniProt:Q8WVM8 SCFD1	1	SCFD1 [cytosol] (R-HSA-5688147)	0.788	7
UniProt:Q12981 BNIP1	1	BNIP1 [endoplasmic reticulum membrane] (R-HSA-6810950)	0.788	8
UniProt:P54920 NAPA	1	NAPA [cytosol] (R-HSA-264469)	0.725	5
UniProt:Q9Y5M8 SRPRB	1	SRPRB [endoplasmic reticulum membrane] (R-HSA-265002)	0.725	5
UniProt:O95721 SNAP29	3	SNAP29 [azurophil granule membrane] (R-HSA-6799359) SNAP29 [plasma membrane] (R-HSA-2029020) SNAP29 [Golgi membrane] (R-HSA-6810997)	0.725	5
UniProt:Q8WU76 SCFD2			0.725	5
UniProt:Q9NWB7 IFT57	2	IFT57 [cilium] (R-HSA-5610389) IFT57 [ciliary tip] (R-HSA-5625363)	0.643	3
UniProt:O15155 BET1	3	BET1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-5688142) BET1 [transport vesicle] (R-HSA-6808719) BET1 [Golgi membrane] (R-HSA-6807743)	0.643	4
UniProt:Q5SQN1 SNP47			0.643	4
UniProt:Q9BYC5 FUT8	1	FUT8 [Golgi membrane] (R-HSA-1028782)	0.643	3
UniProt:O95229 ZWINT	1	ZWINT [cytosol] (R-HSA-376254)	0.643	3
UniProt:Q9UEU0 VTI1B	2	VTI1B [platelet alpha granule lumen] (R-HSA-8862964) VTI1B [extracellular region] (R-HSA-8862983)	0.643	3
UniProt:Q9NRI5 DISC1			0.553	2
UniProt:Q9NYM9 BET1L	1	BET1L [Golgi membrane] (R-HSA-6807744)	0.527	3
UniProt:Q9NQ34 TMM9B			0.527	2
UniProt:Q9UNK0 STX8			0.527	4
UniProt:Q9UFG5 CS025			0.527	2
UniProt:O15482 TEX28			0.527	2
UniProt:Q8WV48 CC107			0.527	4
UniProt:Q99747 NAPG	1	NAPG [cytosol] (R-HSA-5688555)	0.527	2
UniProt:Q13190 STX5	5	STX5 [endoplasmic reticulum membrane] (R-HSA-5689474) STX5 [ER to Golgi transport vesicle membrane] (R-HSA-5689838) STX5 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-5688157) STX5 [Golgi membrane] (R-HSA-6807771) STX5 [cytosol] (R-HSA-9613991)	0.527	3
UniProt:Q86Y82 STX12			0.527	3
UniProt:Q6ICC9 RTL6			0.527	2
UniProt:O43752 STX6	2	STX6 [trans-Golgi network membrane] (R-HSA-6811007) STX6 [Golgi membrane] (R-HSA-6811004)	0.527	3
UniProt:Q9BV40 VAMP8	11	VAMP8 [specific granule membrane] (R-HSA-6799707) VAMP8 [plasma membrane] (R-HSA-376365) VAMP8 [azurophil granule membrane] (R-HSA-6799703) VAMP8 [tertiary granule membrane] (R-HSA-6801024) VAMP8 [recycling endosome membrane] (R-HSA-8863891) VAMP8 [phagocytic vesicle membrane] (R-HSA-8863896) VAMP8 [clathrin-coated endocytic vesicle membrane] (R-HSA-8869137) VAMP8 [lysosomal membrane] (R-HSA-432710) VAMP8 [Golgi membrane] (R-HSA-266201) VAMP8 [cytoplasmic vesicle membrane] (R-HSA-376373) VAMP8 [secretory granule membrane] (R-HSA-376368)	0.527	3
UniProt:P20309 CHRM3	1	CHRM3 [plasma membrane] (R-HSA-399994)	0.527	2

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