Caspase-mediated cleavage of Desmoglein 1

Stable Identifier
R-HSA-202917
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Caspase-mediated cleavage of Desmoglein 1
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Caspase mediated cleavage of desmoglein 1 leads to decreased expression at the cell surface and re-localization of its C terminus diffusely throughout the cytoplasm. Cleavage is thought to contribute to the dismantling of desmosomes during keratinocyte apoptosis (Dusek et al., 2006).
Literature References
PubMed ID Title Journal Year
16286477 The differentiation-dependent desmosomal cadherin desmoglein 1 is a novel caspase-3 target that regulates apoptosis in keratinocytes

Green, KJ, Getsios, S, Dusek, RL, Cryns, VL, Chen, F, Amargo, EV, Park, JK

J Biol Chem 2006
Participants
Input
Output
Participates
as an event of
Catalyst Activity

cysteine-type endopeptidase activity of Caspase-3 [cytosol]

Physical Entity
Caspase-3 [cytosol] (Homo sapiens)
Activity
cysteine-type endopeptidase activity (GO:0004197)
Orthologous Events
Caspase-mediated cleavage of Desmoglein 1 (Bos taurus)
Caspase-mediated cleavage of Desmoglein 1 (Caenorhabditis elegans)
Caspase-mediated cleavage of Desmoglein 1 (Canis familiaris)
Caspase-mediated cleavage of Desmoglein 1 (Danio rerio)
Caspase-mediated cleavage of Desmoglein 1 (Gallus gallus)
Caspase-mediated cleavage of Desmoglein 1 (Mus musculus)
Caspase-mediated cleavage of Desmoglein 1 (Rattus norvegicus)
Caspase-mediated cleavage of Desmoglein 1 (Sus scrofa)
Caspase-mediated cleavage of Desmoglein 1 (Xenopus tropicalis)
Authored
Schulze-Osthoff, K  (2007-09-03)
Reviewed
Ranganathan, S  (2008-06-11)
Created
Matthews, L  (2007-11-12)
Cite Us!