Caspase mediated cleavage of C-IAP1

Stable Identifier
R-HSA-202960
Type
Reaction
Species
Homo sapiens
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Caspase mediated cleavage of C-IAP1
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

c-IAP1 is cleaved by caspase-3 producing a proapoptotic C-terminal fragment.

Literature References
PubMed ID Title Journal Year
11106668 c-IAP1 is cleaved by caspases to produce a proapoptotic C-terminal fragment

Clem, RJ, Thornberry, NA, Duckett, CS, He, WW, Hardwick, JM, Richter, BW, Sheu, TT

J Biol Chem 2001
Participants
Input
Output
Participates
as an event of
Catalyst Activity

cysteine-type endopeptidase activity of Caspase-3 [cytosol]

Physical Entity
Caspase-3 [cytosol] (Homo sapiens)
Activity
cysteine-type endopeptidase activity (GO:0004197)
Orthologous Events
Caspase mediated cleavage of C-IAP1 (Canis familiaris)
Caspase mediated cleavage of C-IAP1 (Danio rerio)
Caspase mediated cleavage of C-IAP1 (Drosophila melanogaster)
Caspase mediated cleavage of C-IAP1 (Gallus gallus)
Caspase mediated cleavage of C-IAP1 (Mus musculus)
Caspase mediated cleavage of C-IAP1 (Rattus norvegicus)
Caspase mediated cleavage of C-IAP1 (Sus scrofa)
Caspase mediated cleavage of C-IAP1 (Xenopus tropicalis)
Authored
Schulze-Osthoff, K  (2007-09-03)
Reviewed
Ranganathan, S  (2007-11-23)
Created
Matthews, L  (2007-11-12)
Cite Us!