Caspase mediated cleavage of C-IAP1

Stable Identifier
R-HSA-202960
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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Caspase mediated cleavage of C-IAP1
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c-IAP1 is cleaved by caspase-3 producing a proapoptotic C-terminal fragment.
Literature References
PubMed ID Title Journal Year
11106668 c-IAP1 is cleaved by caspases to produce a proapoptotic C-terminal fragment

Clem, RJ, Sheu, TT, Richter, BW, He, WW, Thornberry, NA, Duckett, CS, Hardwick, JM

J Biol Chem 2001
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Output
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Catalyst Activity

cysteine-type endopeptidase activity of Caspase-3 [cytosol]

Physical Entity
Caspase-3 [cytosol] (Homo sapiens)
Activity
cysteine-type endopeptidase activity (GO:0004197)
Orthologous Events
Caspase mediated cleavage of C-IAP1 (Bos taurus)
Caspase mediated cleavage of C-IAP1 (Canis familiaris)
Caspase mediated cleavage of C-IAP1 (Danio rerio)
Caspase mediated cleavage of C-IAP1 (Drosophila melanogaster)
Caspase mediated cleavage of C-IAP1 (Gallus gallus)
Caspase mediated cleavage of C-IAP1 (Mus musculus)
Caspase mediated cleavage of C-IAP1 (Rattus norvegicus)
Caspase mediated cleavage of C-IAP1 (Sus scrofa)
Caspase mediated cleavage of C-IAP1 (Xenopus tropicalis)
Authored
Schulze-Osthoff, K  (2007-09-03)
Reviewed
Ranganathan, S  (2007-11-23)
Created
Matthews, L  (2007-11-12)
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