Caspase mediated cleavage of beta-catenin

Stable Identifier
R-HSA-202969
Type
Reaction [transition]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
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Apoptosis-induced cleavage of beta-catenin by caspase 3 results in reduced alpha catenin binding, relocalization to the cytoplasm and a reduction in cell-cell contact. In addition, the resulting proteolytic fragments have reduced transcription factor activity (Steinhusen et al., 2000 ).
Literature References
PubMed ID Title Journal Year
10748026 Apoptosis-induced cleavage of beta-catenin by caspase-3 results in proteolytic fragments with reduced transactivation potential

Bommert, K, Bauer, A, Steinhusen, U, Behrens, J, Wittman-Liebold, B, Badock, V, Dorken, B

J Biol Chem 2000
Participants
Participates
Catalyst Activity

cysteine-type endopeptidase activity of Caspase-3 [cytosol]

Orthologous Events
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