Caspase mediated cleavage of beta-catenin

Stable Identifier
R-HSA-202969
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Caspase mediated cleavage of beta-catenin
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Apoptosis-induced cleavage of beta-catenin by caspase 3 results in reduced alpha catenin binding, relocalization to the cytoplasm and a reduction in cell-cell contact. In addition, the resulting proteolytic fragments have reduced transcription factor activity (Steinhusen et al., 2000 ).
Literature References
PubMed ID Title Journal Year
10748026 Apoptosis-induced cleavage of beta-catenin by caspase-3 results in proteolytic fragments with reduced transactivation potential

Steinhusen, U, Badock, V, Bauer, A, Behrens, J, Wittman-Liebold, B, Dorken, B, Bommert, K

J Biol Chem 2000
Participants
Input
Output
Participates
as an event of
Catalyst Activity

cysteine-type endopeptidase activity of Caspase-3 [cytosol]

Physical Entity
Caspase-3 [cytosol] (Homo sapiens)
Activity
cysteine-type endopeptidase activity (GO:0004197)
Orthologous Events
Caspase mediated cleavage of beta-catenin (Bos taurus)
Caspase mediated cleavage of beta-catenin (Canis familiaris)
Caspase mediated cleavage of beta-catenin (Danio rerio)
Caspase mediated cleavage of beta-catenin (Drosophila melanogaster)
Caspase mediated cleavage of beta-catenin (Gallus gallus)
Caspase mediated cleavage of beta-catenin (Mus musculus)
Caspase mediated cleavage of beta-catenin (Rattus norvegicus)
Caspase mediated cleavage of beta-catenin (Sus scrofa)
Caspase mediated cleavage of beta-catenin (Xenopus tropicalis)
Authored
Schulze-Osthoff, K  (2007-09-03)
Reviewed
Ranganathan, S  (2008-06-11)
Created
Matthews, L  (2007-11-12)
Cite Us!