Association of profilin with monomeric actin

Stable Identifier
R-HSA-203070
Type
Reaction [binding]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
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Profilins PFN1 and PFN2 bind to monomeric actin (G-actin), forming a 1:1 complex and subsequently regulate actin filament barbed end assembly downstream of various signaling pathways (Pring et al. 1992, Korenbaum et al. 1998, Nodelman et al. 1999)
Literature References
PubMed ID Title Journal Year
10600384 X-ray structure determination of human profilin II: A comparative structural analysis of human profilins

Lindberg, U, Nodelman, IM, Schutt, CE, Bowman, GD

J Mol Biol 1999
1737036 Profilin-actin complexes directly elongate actin filaments at the barbed end

Bubb, MR, Weber, A, Pring, M

Biochemistry 1992
9649308 The role of profilin in actin polymerization and nucleotide exchange

Schutt, CE, Lindberg, U, Korenbaum, E, Karlsson, R, Björkegren-Sjögren, C, Nordberg, P

Biochemistry 1998
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