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eNOS binds NOSIP
Stable Identifier
R-HSA-203553
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol
,
plasma membrane
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
Metabolism (Homo sapiens)
Metabolism of nitric oxide: NOS3 activation and regulation (Homo sapiens)
NOSIP mediated eNOS trafficking (Homo sapiens)
eNOS binds NOSIP (Homo sapiens)
General
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
NOSIP (eNOS interacting protein) binds to the carboxyl-terminal region of the eNOS oxygenase domain. Note that the eNOS binding sites for caveolin and NOSIP overlap.
Literature References
PubMed ID
Title
Journal
Year
11149895
NOSIP, a novel modulator of endothelial nitric oxide synthase activity
Muller-Esterl, W
,
Wohlfart, P
,
Dedio, J
,
Konig, P
,
Schroeder, C
,
Kummer, W
FASEB J
2001
Participants
Input
NOSIP [cytosol]
(Homo sapiens)
palmitoylated, myristoylated eNOS dimer [plasma membrane]
(Homo sapiens)
Output
eNOS:NOSIP [plasma membrane]
(Homo sapiens)
Participates
as an event of
NOSIP mediated eNOS trafficking (Homo sapiens)
Orthologous Events
eNOS binds NOSIP (Bos taurus)
eNOS binds NOSIP (Dictyostelium discoideum)
eNOS binds NOSIP (Drosophila melanogaster)
eNOS binds NOSIP (Mus musculus)
eNOS binds NOSIP (Plasmodium falciparum)
eNOS binds NOSIP (Rattus norvegicus)
eNOS binds NOSIP (Sus scrofa)
Reviewed
Enikolopov, G (2008-02-28)
Created
Hemish, J (2007-10-19)
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