palmitoylation of eNOS

Stable Identifier
R-HSA-203567
Type
Reaction [transition]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
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DHHC-21 is a Golgi-localized acyl transferase that palmitoylates eNOS, which targets eNOS to plasmalemmal caveolae. Localization to this microdomain is likely to optimize eNOS activation and the extracellular release of nitric oxide.
Literature References
PubMed ID Title Journal Year
16864653 Identification of Golgi-localized acyl transferases that palmitoylate and regulate endothelial nitric oxide synthase

Sessa, WC, Bredt, DS, Bernatchez, PN, Fernandez-Hernando, C, Fukata, M, Lin, MI, Fukata, Y

J Cell Biol 2006
8692835 Targeting of nitric oxide synthase to endothelial cell caveolae via palmitoylation: implications for nitric oxide signaling

Schnitzer, JE, Liu, J, Sessa, WC, Garcia-Cardena, G, Oh, P

Proc Natl Acad Sci U S A 1996
Participants
Participates
Catalyst Activity

palmitoyltransferase activity of ZDHHC21 [Golgi membrane]

Orthologous Events
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