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Go!
MyrG-NOS3 [cytosol]
Stable Identifier
R-HSA-203687
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
N-myristoylated eNOS (Gly2)
Icon
Locations in the PathwayBrowser for interactor UniProt:Q12891 HYAL2
Expand all
Metabolism (Homo sapiens)
Metabolism of nitric oxide: NOS3 activation and regulation (Homo sapiens)
eNOS activation (Homo sapiens)
N-myristoylation of eNOS (Homo sapiens)
MyrG-NOS3 [cytosol] (Homo sapiens)
Palmitoylation of eNOS (Homo sapiens)
MyrG-NOS3 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P29474 NOS3
Gene Names
NOS3
Chain
initiator methionine:, chain:2-1203
Reference Genes
BioGPS Gene:4846 NOS3
COSMIC (genes):NOS3 NOS3
CTD Gene:4846 NOS3
dbSNP Gene:4846 NOS3
ENSEMBL:ENSG00000164867 NOS3
HGNC:7876 NOS3
KEGG:hsa:4846 NOS3
Monarch:4846 NOS3
NCBI Gene:4846 NOS3
UCSC:P29474 NOS3
Reference Transcript
RefSeq:NM_001160110.1 NOS3
RefSeq:NM_001160111.1 NOS3
RefSeq:NM_000603.4 NOS3
RefSeq:XM_017012232.1 NOS3
RefSeq:NM_001160109.1 NOS3
Other Identifiers
11725467_a_at
11745591_a_at
17053455
1961_f_at
205581_3p_s_at
205581_PM_s_at
205581_s_at
3031714
3031716
3031717
3031720
3031721
3031722
3031723
3031724
3031725
3031726
3031727
3031728
3031729
3031730
3031731
3031732
3031733
3031734
3031735
3031736
3031737
3031738
3031740
3031741
3031742
3031743
3031744
3031745
3031746
3031747
3031748
3031749
3031750
3031751
3031752
3031753
4846
576_at
77168_at
8137280
85472_at
A_14_P136875
A_14_P138990
A_21_P0000025
A_23_P70849
A_33_P3305790
GE57703
GE58153
GO:0000139
GO:0001525
GO:0001542
GO:0001701
GO:0001974
GO:0002028
GO:0003012
GO:0003013
GO:0003057
GO:0003100
GO:0003180
GO:0003184
GO:0003203
GO:0003785
GO:0003824
GO:0004517
GO:0005515
GO:0005516
GO:0005634
GO:0005737
GO:0005794
GO:0005829
GO:0005856
GO:0005886
GO:0005901
GO:0006520
GO:0006527
GO:0006809
GO:0006813
GO:0006816
GO:0007005
GO:0007263
GO:0008092
GO:0008217
GO:0008285
GO:0009408
GO:0009725
GO:0010181
GO:0010544
GO:0010628
GO:0014740
GO:0014806
GO:0016491
GO:0019430
GO:0020037
GO:0022414
GO:0030324
GO:0030666
GO:0031284
GO:0031644
GO:0031663
GO:0032496
GO:0034405
GO:0034617
GO:0034618
GO:0042311
GO:0043226
GO:0043267
GO:0043536
GO:0043542
GO:0045454
GO:0045747
GO:0045766
GO:0045776
GO:0046870
GO:0046872
GO:0048662
GO:0048856
GO:0048870
GO:0048873
GO:0050660
GO:0050661
GO:0050886
GO:0051649
GO:0051926
GO:0060412
GO:0070168
GO:0097110
GO:0097746
GO:0098754
GO:1902042
HMNXSV003009365
HMNXSV003039681
ILMN_1775224
M93718_at
PH_hs_0038843
TC07001009.hg
g10835160_3p_at
g10835160_3p_s_at
Participates
as an output of
N-myristoylation of eNOS (Homo sapiens)
as a component of
myristoylated eNOS dimer [cytosol] (Homo sapiens)
as an input of
Palmitoylation of eNOS (Homo sapiens)
Other forms of this molecule
2xPalmC-MyrG-p-S1177-NOS3 [plasma membrane]
2xPalmC-MyrG-NOS3 [plasma membrane]
2xPalmC-MyrG-NOS3 [Golgi membrane]
MyrG-NOS3 [Golgi membrane]
NOS3 [cytosol]
2xPalmC-MyrG-NOS3 [endocytic vesicle membrane]
2xPalmC-MyrG-p-S633-NOS3 [plasma membrane]
2xPalmC-MyrG-p-S1177,S1179-NOS3 [plasma membrane]
Inferred To
MyrG-NOS3 [cytosol]
(Bos taurus)
MyrG-NOS3 [cytosol]
(Dictyostelium discoideum)
MyrG-NOS3 [cytosol]
(Drosophila melanogaster)
MyrG-NOS3 [cytosol]
(Gallus gallus)
MyrG-NOS3 [cytosol]
(Mus musculus)
MyrG-NOS3 [cytosol]
(Plasmodium falciparum)
MyrG-NOS3 [cytosol]
(Rattus norvegicus)
MyrG-NOS3 [cytosol]
(Saccharomyces cerevisiae)
MyrG-NOS3 [cytosol]
(Schizosaccharomyces pombe)
MyrG-NOS3 [cytosol]
(Sus scrofa)
Modified Residues
Name
N-myristoylglycine at 2
Coordinate
2
PsiMod Name
N-myristoylglycine [MOD:00068]
PsiMod Definition
A protein modification that effectively converts a glycine residue to N-myristoylglycine.
Cross References
RefSeq
NP_001153581.1
,
NP_001153582.1
,
NP_001153583.1
,
NP_000594.2
,
XP_016867721.1
Guide to Pharmacology - Targets
1249
OpenTargets
ENSG00000164867
ENSEMBL
ENSP00000297494
,
ENSP00000420551
,
ENST00000467517
,
ENSP00000420215
,
ENST00000297494
,
ENST00000484524
HPA
ENSG00000164867-NOS3
ZINC target
P29474
PRO
P29474
Pharos - Targets
P29474
GlyGen
P29474
HMDB Protein
HMDBP00929
PDB
5VVB
,
6CIF
,
8UFT
,
6CIE
,
5XOF
,
6NH6
,
5UO8
,
7TSH
,
6PP2
,
6PP0
,
5VVD
,
8UFU
,
1NIW
,
7TSM
,
5UOC
,
3EAH
,
7TSO
,
5UOB
,
7TSG
,
4D1P
,
6NH4
,
8FGP
,
8FGR
,
6NH5
,
8FGT
,
8FGQ
,
6NH2
,
1M9K
,
1M9J
,
6NH3
,
2LL7
,
1M9M
,
6POV
,
6AV7
,
6AV6
,
8UFR
,
8UFS
,
6NHF
,
6NH7
,
7TSI
,
6PP4
,
6PP3
,
5VVC
,
6PP1
,
7UAO
,
3NOS
,
7TSK
,
7M56
,
7TSL
,
5UOA
,
5UO9
,
7TSP
,
7TSN
,
8FGU
,
6POZ
,
6POY
,
8FGN
,
8FGO
,
4D1O
,
6POX
,
1M9Q
,
8FGS
,
6POW
,
2N8J
,
6NH8
,
2MG5
,
6NH1
,
1M9R
,
6POU
Interactors (52)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q8IVI9 NOSTRIN
2
NOSTRIN [endocytic vesicle membrane]
(R-HSA-535014)
NOSTRIN [plasma membrane]
(R-HSA-202134)
0.729
9
UniProt:Q08379 GOLGA2
3
p-S37-GOLGA2 [Golgi membrane]
(R-HSA-2172179)
GOLGA2 [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-HSA-2167933)
GOLGA2 [Golgi membrane]
(R-HSA-6808764)
0.718
6
UniProt:Q16543 CDC37
1
CDC37 [cytosol]
(R-HSA-1221609)
0.582
4
UniProt:Q8IUI8 CRLF3
0.556
3
UniProt:Q7Z699 SPRED1
2
SPRED1 [plasma membrane]
(R-HSA-5658225)
SPRED1 [cytosol]
(R-HSA-5654207)
0.556
3
UniProt:Q7Z698 SPRED2
2
SPRED2 [cytosol]
(R-HSA-5654211)
SPRED2 [plasma membrane]
(R-HSA-5658229)
0.556
3
UniProt:Q9GZR2 REXO4
0.556
3
UniProt:O94851 MICA2
0.556
3
UniProt:Q9Y2M5 KLHL20
1
KLHL20 [cytosol]
(R-HSA-976032)
0.556
3
UniProt:O15381-5 O153815
0.556
3
UniProt:Q86WT6-2 TRIM69
0.556
3
UniProt:A4FUJ8 A4FUJ8
0.556
3
UniProt:Q71DI3 H3C15
20
2xAcK-HIST2H3A [nucleoplasm]
(R-HSA-427525)
Me1K5-HIST2H3A [nucleoplasm]
(R-HSA-9677679)
Me2aR27-HIST2H3A [nucleoplasm]
(R-HSA-5229057)
Me2aR18-HIST2H3A [nucleoplasm]
(R-HSA-5229063)
Me2sR9-HIST2H3A [nucleoplasm]
(R-HSA-5211327)
Me2sR3-HIST2H3A [nucleoplasm]
(R-HSA-5218930)
AcK9,14-p-S10-HIST2H3A [nucleoplasm]
(R-HSA-8870892)
AcK14,18,79-p-S10-HIST2H3A [nucleoplasm]
(R-HSA-8871273)
AcK9,14,18-p-S10,T11-HIST2H3A [nucleoplasm]
(R-HSA-8871304)
AcK14,18-p-S10,T11-HIST2H3A [nucleoplasm]
(R-HSA-8871292)
AcK9,14,18,79-p-S10,T11-HIST2H3A [nucleoplasm]
(R-HSA-8865607)
AcK14,18-p-S10-HIST2H3A [nucleoplasm]
(R-HSA-8871296)
AcK14,18,79-p-T11-HIST2H3A [nucleoplasm]
(R-HSA-8871290)
AcK14,18-p-T11-HIST2H3A [nucleoplasm]
(R-HSA-8871302)
AcK14,18,79-p-S10,T11-HIST2H3A [nucleoplasm]
(R-HSA-8871289)
Me2K28-HIST2H3A [nucleoplasm]
(R-HSA-4754197)
MeK37-HIST2H3A [nucleoplasm]
(R-HSA-4722131)
MeK80-HIST2H3A [nucleoplasm]
(R-HSA-5649805)
Me3K80-HIST2H3A [nucleoplasm]
(R-HSA-5649798)
Me2K80-HIST2H3A [nucleoplasm]
(R-HSA-5649803)
0.556
3
UniProt:Q9GZS3 SKIC8
2
WDR61 [cytosol]
(R-HSA-8931534)
WDR61 [nucleoplasm]
(R-HSA-8866696)
0.556
3
UniProt:Q8N6F8 MET27
0.556
3
UniProt:Q9NVV9 THAP1
0.556
3
UniProt:Q96D59 RN183
0.556
3
UniProt:Q96FT7-4 ASIC4
0.556
3
UniProt:Q96I34 PP16A
0.556
3
UniProt:Q8IUW3 SPA2L
0.556
3
UniProt:P61978 HNRNPK
2
HNRNPK [nucleoplasm]
(R-HSA-71945)
polySUMO2-K422-HNRNPK [nucleoplasm]
(R-HSA-4570532)
0.556
3
UniProt:O75925 PIAS1
1
PIAS1 [nucleoplasm]
(R-HSA-877307)
0.556
3
UniProt:Q9UNS2 COPS3
2
COPS3 [nucleoplasm]
(R-HSA-5697017)
COPS3 [cytosol]
(R-HSA-416973)
0.556
3
UniProt:Q8N6T3-3 ARFGAP1
0.556
3
UniProt:Q6DKI2 LEG9C
0.556
3
UniProt:Q9H347 UBQL3
0.556
3
UniProt:Q9NV79 PCMD2
0.556
3
UniProt:Q6X4W1-6 NSMF
0.556
3
UniProt:Q9BR01-2 Q9BR012
0.556
3
UniProt:P14079 TAX
0.556
3
IntAct:EBI-25831465 CCSB
0.556
3
UniProt:Q9UKT9 IKZF3
0.556
3
UniProt:Q8N6K7-2 SAMD3
0.556
3
UniProt:Q14525 KRT33B
1
KRT33B [cytosol]
(R-HSA-6809594)
0.556
3
UniProt:Q16549 PCSK7
0.556
3
UniProt:Q6ZMI0-5 PPP1R21
0.556
3
UniProt:Q9Y575-3 ASB3
0.556
3
UniProt:P63010-2 AP2B1
0.556
3
UniProt:P43364-2 MAGEA11
0.556
3
UniProt:O15287 FANCG
2
FANCG [nucleoplasm]
(R-HSA-419532)
FANCG [cytosol]
(R-HSA-420788)
0.556
3
UniProt:Q9NZC7-5 WWOX
0.556
3
UniProt:P58304 VSX2
0.556
3
UniProt:Q8N594 MPND
0.556
3
UniProt:P57052 RBM11
0.556
3
UniProt:Q5T2W1 NHRF3
0.556
3
UniProt:Q12891 HYAL2
1
HYAL2 [plasma membrane]
(R-HSA-2160919)
0.556
3
UniProt:Q9UNY5 ZN232
0.556
3
UniProt:Q5SZD1 CF141
0.556
3
UniProt:P69905 HBA1
4
HBA1 [extracellular region]
(R-HSA-2168862)
HBA1 [endocytic vesicle lumen]
(R-HSA-2230966)
HBA1 [cytosol]
(R-HSA-1008268)
CO-H+-HBA1 [cytosol]
(R-HSA-1237026)
0.544
2
UniProt:Q92947 GCDH
1
GCDH [mitochondrial matrix]
(R-HSA-71039)
0.524
3
UniProt:P50502 ST13
1
ST13 [cytosol]
(R-HSA-5255410)
0.482
3
UniProt:P35222 CTNNB1
20
CTNNB1 S45A [cytosol]
(R-HSA-9663982)
CTNNB1 S45F [cytosol]
(R-HSA-4791268)
CTNNB1 S45C [cytosol]
(R-HSA-9663983)
CTNNB1 S45Y [cytosol]
(R-HSA-9663975)
CTNNB1 S45N [cytosol]
(R-HSA-9663984)
CTNNB1 S45P [cytosol]
(R-HSA-4791272)
pT41,S45-CTNNB1 S37P [cytosol]
(R-HSA-9663981)
pT41,S45-CTNNB1 S37F [cytosol]
(R-HSA-4839621)
CTNNB1 [nucleoplasm]
(R-HSA-3451168)
CTNNB1 [cytosol]
(R-HSA-448839)
CTNNB1(1-115) [cytosol]
(R-HSA-202930)
CTNNB1(116-376) [cytosol]
(R-HSA-202950)
CTNNB1 [plasma membrane]
(R-HSA-9038440)
p-S33,S37,T41,S45 CTNNB1 [cytosol]
(R-HSA-8942374)
p-S37,T41,S45, CTNNB1 [cytosol]
(R-HSA-8942369)
p-T41,S45 CTNNB1 [cytosol]
(R-HSA-8942367)
p-S45 CTNNB1 [cytosol]
(R-HSA-8942363)
p-S552-CTNNB1 [cytosol]
(R-HSA-3134933)
p-S552-CTNNB1 [nucleoplasm]
(R-HSA-3134926)
p-Y-CTNNB1 [cytosol]
(R-HSA-8876940)
0.471
4
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