Reactome | LYPLA1 [cytosol]

LYPLA1 [cytosol]

Stable Identifier

R-HSA-203713

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

APT1

Locations in the PathwayBrowser

Expand all

Signal Transduction (Homo sapiens)

- MAPK family signaling cascades (Homo sapiens)
  - MAPK1/MAPK3 signaling (Homo sapiens)
    - RAF/MAP kinase cascade (Homo sapiens)
      - RAS processing (Homo sapiens)
        
        Palmostatin B binds RAS depalmitoylases (Homo sapiens)
        
        LYPLA1 dimer, ABHD17A,B,C [plasma membrane] (Homo sapiens)
        
        LYPLA1 dimer [cytosol] (Homo sapiens)
        
        LYPLA1 [cytosol] (Homo sapiens)
        
        Palmostatin B:LYPLA1 dimer, ABHD17A,B,C [cytosol] (Homo sapiens)
        
        LYPLA1 dimer, ABHD17A,B,C [plasma membrane] (Homo sapiens)
        
        LYPLA1 dimer [cytosol] (Homo sapiens)
        
        LYPLA1 [cytosol] (Homo sapiens)
        
        RAS proteins are depalmitoylated (Homo sapiens)
        
        LYPLA1 dimer, ABHD17A,B,C [plasma membrane] (Homo sapiens)
        
        LYPLA1 dimer [cytosol] (Homo sapiens)
        
        LYPLA1 [cytosol] (Homo sapiens)
        
        Palmostatin B:LYPLA1 dimer, ABHD17A,B,C [cytosol] (Homo sapiens)
        
        LYPLA1 dimer, ABHD17A,B,C [plasma membrane] (Homo sapiens)
        
        LYPLA1 dimer [cytosol] (Homo sapiens)
        
        LYPLA1 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:O75608 LYPLA1

Gene Names

LYPLA1, APT1, LPL1

Chain

chain:1-230

Reference Genes

BioGPS Gene:10434 LYPLA1

COSMIC (genes):LYPLA1 LYPLA1

CTD Gene:10434 LYPLA1

dbSNP Gene:10434 LYPLA1

ENSEMBL:ENSG00000120992 LYPLA1

HGNC:6737 LYPLA1

KEGG:hsa:10434 LYPLA1

Monarch:10434 LYPLA1

NCBI Gene:10434 LYPLA1

OMIM:605599 LYPLA1

UCSC:O75608 LYPLA1

Reference Transcript

Other Identifiers

10434

11718365_s_at

11749360_s_at

1560637_PM_at

1560637_at

17077244

203007_PM_x_at

203007_x_at

212449_PM_s_at

212449_s_at

2782029

2912968

2912969

2912970

3135566

3135568

3135569

3135572

3135573

3135574

3135575

3135576

3135577

3135580

3135582

3135584

3135585

3135592

3135593

3135594

3135595

3135596

3135597

39396_at

8150830

A_23_P19192

A_23_P214091

A_33_P3416762

GE54721

GO:0002084

GO:0003824

GO:0004620

GO:0004622

GO:0005515

GO:0005634

GO:0005654

GO:0005737

GO:0005739

GO:0005783

GO:0005829

GO:0005886

GO:0006629

GO:0006631

GO:0008474

GO:0015908

GO:0016020

GO:0016298

GO:0016787

GO:0030163

GO:0031965

GO:0042997

GO:0043226

GO:0052689

GO:0070062

GO:0098734

GO:0140096

GO:1905336

HMNXSV003017807

Hs.12540.2.A1_3p_a_at

ILMN_1666713

ILMN_2099798

PH_hs_0033558

TC08001218.hg

g4679009_3p_a_at

Participates

as a component of

LYPLA1 dimer [cytosol] (Homo sapiens)

Inferred To

Apt1 [cytosol] (Drosophila melanogaster)

Lypla1 [cytosol] (Mus musculus)

Lypla1 [cytosol] (Rattus norvegicus)

LYPLA1 [cytosol] (Bos taurus)

LYPLA1 [cytosol] (Dictyostelium discoideum)

LYPLA1 [cytosol] (Gallus gallus)

LYPLA1 [cytosol] (Saccharomyces cerevisiae)

LYPLA1 [cytosol] (Schizosaccharomyces pombe)

LYPLA1 [cytosol] (Sus scrofa)

ath-1 [cytosol] (Caenorhabditis elegans)

Homologues of LYPLA1 [cytosol] (Dictyostelium discoideum)

Homologues of LYPLA1 [cytosol] (Schizosaccharomyces pombe)

lypla1 [cytosol] (Danio rerio)

lypla1 [cytosol] (Xenopus tropicalis)

Cross References

RefSeq

NP_006321.1, NP_001266288.1, NP_001266289.1, NP_001266287.1, NP_001266286.1, NP_001266285.1

Guide to Pharmacology - Targets

3290

ENSEMBL

ENSP00000344477, ENST00000316963, ENST00000343231, ENSP00000320043

OpenTargets

ENSG00000120992

ZINC - Substances

LYPA1_HUMAN

ZINC target

O75608

PRO

O75608

GlyGen

O75608

PDB

6QGS, 1FJ2, 6QGQ, 6QGO, 5SYM, 6QGN

HPA

ENSG00000120992-LYPLA1

Pharos - Targets

O75608

ZINC - Predictions - Purchasable

LYPA1_HUMAN

HMDB Protein

HMDBP00056

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q08379 GOLGA2	3	p-S37-GOLGA2 [Golgi membrane] (R-HSA-2172179) GOLGA2 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-2167933) GOLGA2 [Golgi membrane] (R-HSA-6808764)	0.556	3