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About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
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Developer's Zone
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Content Service
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Pathway Diagrams
Icon Info
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FAQ
Linking to Us
Citing us
Tools
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Analyse gene list
Analyse gene expression
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Go!
CSK [cytosol]
Stable Identifier
R-HSA-203776
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Tyrosine-protein kinase CSK, C-Src kinase
Icon
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
Oncogenic MAPK signaling (Homo sapiens)
Paradoxical activation of RAF signaling by kinase inactive BRAF (Homo sapiens)
Activated MAP2Ks phosphorylate MAPKs downstream of inactive BRAF mutants (Homo sapiens)
RAS:GTP: inactive p-RAF:p-2S MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Homo sapiens)
p-Y530-SRC:CSK [cytosol] (Homo sapiens)
CSK [cytosol] (Homo sapiens)
RAS:GTP:inactive p-RAF:p-2S MAP2Ks:p-T,Y MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Homo sapiens)
p-Y530-SRC:CSK [cytosol] (Homo sapiens)
CSK [cytosol] (Homo sapiens)
Dissociation of paradoxically activated RAS:BRAF complexes (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Homo sapiens)
p-Y530-SRC:CSK [cytosol] (Homo sapiens)
CSK [cytosol] (Homo sapiens)
RAS:GTP:inactive p-RAF:p-2S MAP2Ks:p-T,Y MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Homo sapiens)
p-Y530-SRC:CSK [cytosol] (Homo sapiens)
CSK [cytosol] (Homo sapiens)
RAS:GTP:inactive p-RAF complexes phosphorylate MAP2Ks (Homo sapiens)
RAS:GTP: inactive p-RAF:p-2S MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Homo sapiens)
p-Y530-SRC:CSK [cytosol] (Homo sapiens)
CSK [cytosol] (Homo sapiens)
RAS:GTP:inactive p-RAF:MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Homo sapiens)
p-Y530-SRC:CSK [cytosol] (Homo sapiens)
CSK [cytosol] (Homo sapiens)
RAS:GTP:p-RAF complexes paradoxically bind MAP2Ks and MAPKs (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Homo sapiens)
p-Y530-SRC:CSK [cytosol] (Homo sapiens)
CSK [cytosol] (Homo sapiens)
RAS:GTP:inactive p-RAF:MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Homo sapiens)
p-Y530-SRC:CSK [cytosol] (Homo sapiens)
CSK [cytosol] (Homo sapiens)
Signaling by BRAF and RAF1 fusions (Homo sapiens)
Dissociation of BRAF/RAF fusion complex (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Homo sapiens)
p-Y530-SRC:CSK [cytosol] (Homo sapiens)
CSK [cytosol] (Homo sapiens)
p-BRAF/RAF fusion dimers:p-2S MAP2Ks:p-T,Y MAPKs:scaffold proteins [cytosol] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Homo sapiens)
p-Y530-SRC:CSK [cytosol] (Homo sapiens)
CSK [cytosol] (Homo sapiens)
MAPKs are phosphorylated downstream of BRAF and RAF fusion dimers (Homo sapiens)
p-BRAF/RAF fusion dimers:p-2S MAP2Ks:MAPKs:scaffold proteins [cytosol] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Homo sapiens)
p-Y530-SRC:CSK [cytosol] (Homo sapiens)
CSK [cytosol] (Homo sapiens)
p-BRAF/RAF fusion dimers:p-2S MAP2Ks:p-T,Y MAPKs:scaffold proteins [cytosol] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Homo sapiens)
p-Y530-SRC:CSK [cytosol] (Homo sapiens)
CSK [cytosol] (Homo sapiens)
p-BRAF and RAF fusion dimers bind MAP2Ks and MAPKs (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Homo sapiens)
p-Y530-SRC:CSK [cytosol] (Homo sapiens)
CSK [cytosol] (Homo sapiens)
p-BRAF/RAF fusion dimers:MAP2Ks:MAPKs:scaffold proteins [cytosol] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Homo sapiens)
p-Y530-SRC:CSK [cytosol] (Homo sapiens)
CSK [cytosol] (Homo sapiens)
p-BRAF and RAF fusion dimers phosphorylate MAP2Ks (Homo sapiens)
p-BRAF/RAF fusion dimers:MAP2Ks:MAPKs:scaffold proteins [cytosol] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Homo sapiens)
p-Y530-SRC:CSK [cytosol] (Homo sapiens)
CSK [cytosol] (Homo sapiens)
p-BRAF/RAF fusion dimers:p-2S MAP2Ks:MAPKs:scaffold proteins [cytosol] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Homo sapiens)
p-Y530-SRC:CSK [cytosol] (Homo sapiens)
CSK [cytosol] (Homo sapiens)
Signaling by RAF1 mutants (Homo sapiens)
Dissociation of RAS:RAF1 mutant complex (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Homo sapiens)
p-Y530-SRC:CSK [cytosol] (Homo sapiens)
CSK [cytosol] (Homo sapiens)
activated RAF1 mutant:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Homo sapiens)
p-Y530-SRC:CSK [cytosol] (Homo sapiens)
CSK [cytosol] (Homo sapiens)
MAP2Ks and MAPKs bind to the activated mutant RAF1 complex (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Homo sapiens)
p-Y530-SRC:CSK [cytosol] (Homo sapiens)
CSK [cytosol] (Homo sapiens)
activated RAF1 mutant:scaffold:MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Homo sapiens)
p-Y530-SRC:CSK [cytosol] (Homo sapiens)
CSK [cytosol] (Homo sapiens)
MAP2Ks phosphorylate MAPKs downstream of RAF1 mutants (Homo sapiens)
activated RAF1 mutant:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Homo sapiens)
p-Y530-SRC:CSK [cytosol] (Homo sapiens)
CSK [cytosol] (Homo sapiens)
activated RAF1 mutant:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Homo sapiens)
p-Y530-SRC:CSK [cytosol] (Homo sapiens)
CSK [cytosol] (Homo sapiens)
RAF1 mutant complexes phosphorylate MAP2K dimer (Homo sapiens)
activated RAF1 mutant:scaffold:MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Homo sapiens)
p-Y530-SRC:CSK [cytosol] (Homo sapiens)
CSK [cytosol] (Homo sapiens)
activated RAF1 mutant:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Homo sapiens)
p-Y530-SRC:CSK [cytosol] (Homo sapiens)
CSK [cytosol] (Homo sapiens)
Signaling by RAS mutants (Homo sapiens)
Signaling downstream of RAS mutants (Homo sapiens)
Activated MAP2Ks phosphorylate MAPKs downstream of oncogenic RAS (Homo sapiens)
mutant RAS:GTP:p-RAF:p-2S MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Homo sapiens)
p-Y530-SRC:CSK [cytosol] (Homo sapiens)
CSK [cytosol] (Homo sapiens)
mutant RAS:GTP:p-RAF:p-2S MAP2Ks:p-T,Y MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Homo sapiens)
p-Y530-SRC:CSK [cytosol] (Homo sapiens)
CSK [cytosol] (Homo sapiens)
Dissociation of oncogenic RAS:RAF complex (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Homo sapiens)
p-Y530-SRC:CSK [cytosol] (Homo sapiens)
CSK [cytosol] (Homo sapiens)
mutant RAS:GTP:p-RAF:p-2S MAP2Ks:p-T,Y MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Homo sapiens)
p-Y530-SRC:CSK [cytosol] (Homo sapiens)
CSK [cytosol] (Homo sapiens)
Mutant RAS:p-RAF complexes bind MAP2Ks and MAPKs (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Homo sapiens)
p-Y530-SRC:CSK [cytosol] (Homo sapiens)
CSK [cytosol] (Homo sapiens)
mutant RAS:GTP:p-RAF:MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Homo sapiens)
p-Y530-SRC:CSK [cytosol] (Homo sapiens)
CSK [cytosol] (Homo sapiens)
Mutant RAS:p-RAF complexes phosphorylate MAP2Ks (Homo sapiens)
mutant RAS:GTP:p-RAF:MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Homo sapiens)
p-Y530-SRC:CSK [cytosol] (Homo sapiens)
CSK [cytosol] (Homo sapiens)
mutant RAS:GTP:p-RAF:p-2S MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Homo sapiens)
p-Y530-SRC:CSK [cytosol] (Homo sapiens)
CSK [cytosol] (Homo sapiens)
Signaling by high-kinase activity BRAF mutants (Homo sapiens)
Activated MAP2Ks phosphorylate MAPKs downstream of high kinase activity BRAF mutants (Homo sapiens)
high kinase activity BRAF mutants:scaffold:p-2S MAP2K:MAPK complex [cytosol] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Homo sapiens)
p-Y530-SRC:CSK [cytosol] (Homo sapiens)
CSK [cytosol] (Homo sapiens)
high kinase activity BRAF mutants:scaffold:p-2S MAP2K:p-T,Y MAPK complex [cytosol] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Homo sapiens)
p-Y530-SRC:CSK [cytosol] (Homo sapiens)
CSK [cytosol] (Homo sapiens)
Dissociation of high activity BRAF complexes (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Homo sapiens)
p-Y530-SRC:CSK [cytosol] (Homo sapiens)
CSK [cytosol] (Homo sapiens)
high kinase activity BRAF mutants:scaffold:p-2S MAP2K:p-T,Y MAPK complex [cytosol] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Homo sapiens)
p-Y530-SRC:CSK [cytosol] (Homo sapiens)
CSK [cytosol] (Homo sapiens)
High kinase activity BRAF complexes phosphorylate MAP2Ks (Homo sapiens)
high kinase activity BRAF mutants:scaffold:MAP2K:MAPK complex [cytosol] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Homo sapiens)
p-Y530-SRC:CSK [cytosol] (Homo sapiens)
CSK [cytosol] (Homo sapiens)
high kinase activity BRAF mutants:scaffold:p-2S MAP2K:MAPK complex [cytosol] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Homo sapiens)
p-Y530-SRC:CSK [cytosol] (Homo sapiens)
CSK [cytosol] (Homo sapiens)
High kinase activity BRAF mutants bind MAP2Ks and MAPKs (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Homo sapiens)
p-Y530-SRC:CSK [cytosol] (Homo sapiens)
CSK [cytosol] (Homo sapiens)
high kinase activity BRAF mutants:scaffold:MAP2K:MAPK complex [cytosol] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Homo sapiens)
p-Y530-SRC:CSK [cytosol] (Homo sapiens)
CSK [cytosol] (Homo sapiens)
Signaling by moderate kinase activity BRAF mutants (Homo sapiens)
Activated MAP2Ks phosphorylate MAPKs downstream of moderate kinase activity BRAF mutants (Homo sapiens)
RAS:GTP:moderate kinase activity p-RAF:p-2S MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Homo sapiens)
p-Y530-SRC:CSK [cytosol] (Homo sapiens)
CSK [cytosol] (Homo sapiens)
RAS:GTP:moderate kinase activity p-RAF:p-2S MAP2Ks:p-T,Y MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Homo sapiens)
p-Y530-SRC:CSK [cytosol] (Homo sapiens)
CSK [cytosol] (Homo sapiens)
Dissociation of moderate activity BRAF complexes (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Homo sapiens)
p-Y530-SRC:CSK [cytosol] (Homo sapiens)
CSK [cytosol] (Homo sapiens)
RAS:GTP:moderate kinase activity p-RAF:p-2S MAP2Ks:p-T,Y MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Homo sapiens)
p-Y530-SRC:CSK [cytosol] (Homo sapiens)
CSK [cytosol] (Homo sapiens)
RAS:GTP:moderate kinase activity p-RAF complexes bind MAP2Ks and MAPKs (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Homo sapiens)
p-Y530-SRC:CSK [cytosol] (Homo sapiens)
CSK [cytosol] (Homo sapiens)
RAS:GTP:moderate kinase activity p-RAF:MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Homo sapiens)
p-Y530-SRC:CSK [cytosol] (Homo sapiens)
CSK [cytosol] (Homo sapiens)
RAS:GTP:moderate kinase activity p-RAF complexes phosphorylate MAP2Ks (Homo sapiens)
RAS:GTP:moderate kinase activity p-RAF:MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Homo sapiens)
p-Y530-SRC:CSK [cytosol] (Homo sapiens)
CSK [cytosol] (Homo sapiens)
RAS:GTP:moderate kinase activity p-RAF:p-2S MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Homo sapiens)
p-Y530-SRC:CSK [cytosol] (Homo sapiens)
CSK [cytosol] (Homo sapiens)
Hemostasis (Homo sapiens)
Platelet activation, signaling and aggregation (Homo sapiens)
Platelet Aggregation (Plug Formation) (Homo sapiens)
Integrin signaling (Homo sapiens)
Activated integrin alphaIIb beta3 binds SHC1 (Homo sapiens)
Integrin alphaIIb beta 3:p(Y530)-SRC:CSK:Talin:RIAM complex:SHC [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Homo sapiens)
p-Y530-SRC:CSK [cytosol] (Homo sapiens)
CSK [cytosol] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Homo sapiens)
p-Y530-SRC:CSK [cytosol] (Homo sapiens)
CSK [cytosol] (Homo sapiens)
Clustering of Integrin alphaIIb beta3 complexes (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Homo sapiens)
p-Y530-SRC:CSK [cytosol] (Homo sapiens)
CSK [cytosol] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Homo sapiens)
p-Y530-SRC:CSK [cytosol] (Homo sapiens)
CSK [cytosol] (Homo sapiens)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Homo sapiens)
p-Y530-SRC:CSK [cytosol] (Homo sapiens)
CSK [cytosol] (Homo sapiens)
Integrin alphaIIb beta3 activation (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Homo sapiens)
p-Y530-SRC:CSK [cytosol] (Homo sapiens)
CSK [cytosol] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Homo sapiens)
p-Y530-SRC:CSK [cytosol] (Homo sapiens)
CSK [cytosol] (Homo sapiens)
Interaction of integrin alphaIIb beta3 with Fibrinogen (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Homo sapiens)
p-Y530-SRC:CSK [cytosol] (Homo sapiens)
CSK [cytosol] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Homo sapiens)
p-Y530-SRC:CSK [cytosol] (Homo sapiens)
CSK [cytosol] (Homo sapiens)
Release of CSK from SRC (Homo sapiens)
CSK [cytosol] (Homo sapiens)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Homo sapiens)
p-Y530-SRC:CSK [cytosol] (Homo sapiens)
CSK [cytosol] (Homo sapiens)
SHC1 bound to integrin alphaIIb beta3 is phosphorylated somehow (Homo sapiens)
Integrin alpha IIb beta 3:p-Y530-SRC:CSK:Talin:RIAM complex:p-Y427-SHC [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Homo sapiens)
p-Y530-SRC:CSK [cytosol] (Homo sapiens)
CSK [cytosol] (Homo sapiens)
Integrin alphaIIb beta 3:p(Y530)-SRC:CSK:Talin:RIAM complex:SHC [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Homo sapiens)
p-Y530-SRC:CSK [cytosol] (Homo sapiens)
CSK [cytosol] (Homo sapiens)
SHC1 dissociates from integrin alphaIIb beta3 (Homo sapiens)
Integrin alpha IIb beta 3:p-Y530-SRC:CSK:Talin:RIAM complex:p-Y427-SHC [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Homo sapiens)
p-Y530-SRC:CSK [cytosol] (Homo sapiens)
CSK [cytosol] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Homo sapiens)
p-Y530-SRC:CSK [cytosol] (Homo sapiens)
CSK [cytosol] (Homo sapiens)
Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
Costimulation by the CD28 family (Homo sapiens)
PD-1 signaling (Homo sapiens)
Dephosphorylation of CD3-zeta by PD-1 bound phosphatases (Homo sapiens)
PTPN6,PTPN11:p-Y223,248-PDCD1:B7-DC,B7-H1 [plasma membrane] (Homo sapiens)
p-Y223,248-PDCD1:B7-DC,B7-H1 [plasma membrane] (Homo sapiens)
LCK, CSK [cytosol] (Homo sapiens)
CSK [cytosol] (Homo sapiens)
Interaction of SHP-1 or SHP-2 with phospho PD-1 (Homo sapiens)
PTPN6,PTPN11:p-Y223,248-PDCD1:B7-DC,B7-H1 [plasma membrane] (Homo sapiens)
p-Y223,248-PDCD1:B7-DC,B7-H1 [plasma membrane] (Homo sapiens)
LCK, CSK [cytosol] (Homo sapiens)
CSK [cytosol] (Homo sapiens)
p-Y223,248-PDCD1:B7-DC,B7-H1 [plasma membrane] (Homo sapiens)
LCK, CSK [cytosol] (Homo sapiens)
CSK [cytosol] (Homo sapiens)
Phosphorylation of PD-1 (Homo sapiens)
LCK, CSK [cytosol] (Homo sapiens)
CSK [cytosol] (Homo sapiens)
p-Y223,248-PDCD1:B7-DC,B7-H1 [plasma membrane] (Homo sapiens)
LCK, CSK [cytosol] (Homo sapiens)
CSK [cytosol] (Homo sapiens)
TCR signaling (Homo sapiens)
Phosphorylation of CD3 and TCR zeta chains (Homo sapiens)
Inactivation of Lck by Csk (Homo sapiens)
Csk:p-PAG [plasma membrane] (Homo sapiens)
CSK [cytosol] (Homo sapiens)
Interaction of Csk with PAG (Homo sapiens)
CSK [cytosol] (Homo sapiens)
Csk:p-PAG [plasma membrane] (Homo sapiens)
CSK [cytosol] (Homo sapiens)
PTPN22 dissociates from CSK (Homo sapiens)
CSK [cytosol] (Homo sapiens)
PTPN22:CSK [cytosol] (Homo sapiens)
CSK [cytosol] (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
FLT3 Signaling (Homo sapiens)
Negative regulation of FLT3 (Homo sapiens)
Active FLT3 binds to CSK (Homo sapiens)
CSK [cytosol] (Homo sapiens)
active FLT3:CSK [plasma membrane] (Homo sapiens)
CSK [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Integrin signaling (Homo sapiens)
Activated integrin alphaIIb beta3 binds SHC1 (Homo sapiens)
Integrin alphaIIb beta 3:p(Y530)-SRC:CSK:Talin:RIAM complex:SHC [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Homo sapiens)
p-Y530-SRC:CSK [cytosol] (Homo sapiens)
CSK [cytosol] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Homo sapiens)
p-Y530-SRC:CSK [cytosol] (Homo sapiens)
CSK [cytosol] (Homo sapiens)
Clustering of Integrin alphaIIb beta3 complexes (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Homo sapiens)
p-Y530-SRC:CSK [cytosol] (Homo sapiens)
CSK [cytosol] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Homo sapiens)
p-Y530-SRC:CSK [cytosol] (Homo sapiens)
CSK [cytosol] (Homo sapiens)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Homo sapiens)
p-Y530-SRC:CSK [cytosol] (Homo sapiens)
CSK [cytosol] (Homo sapiens)
Integrin alphaIIb beta3 activation (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Homo sapiens)
p-Y530-SRC:CSK [cytosol] (Homo sapiens)
CSK [cytosol] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Homo sapiens)
p-Y530-SRC:CSK [cytosol] (Homo sapiens)
CSK [cytosol] (Homo sapiens)
Interaction of integrin alphaIIb beta3 with Fibrinogen (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Homo sapiens)
p-Y530-SRC:CSK [cytosol] (Homo sapiens)
CSK [cytosol] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Homo sapiens)
p-Y530-SRC:CSK [cytosol] (Homo sapiens)
CSK [cytosol] (Homo sapiens)
Release of CSK from SRC (Homo sapiens)
CSK [cytosol] (Homo sapiens)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Homo sapiens)
p-Y530-SRC:CSK [cytosol] (Homo sapiens)
CSK [cytosol] (Homo sapiens)
SHC1 bound to integrin alphaIIb beta3 is phosphorylated somehow (Homo sapiens)
Integrin alpha IIb beta 3:p-Y530-SRC:CSK:Talin:RIAM complex:p-Y427-SHC [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Homo sapiens)
p-Y530-SRC:CSK [cytosol] (Homo sapiens)
CSK [cytosol] (Homo sapiens)
Integrin alphaIIb beta 3:p(Y530)-SRC:CSK:Talin:RIAM complex:SHC [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Homo sapiens)
p-Y530-SRC:CSK [cytosol] (Homo sapiens)
CSK [cytosol] (Homo sapiens)
SHC1 dissociates from integrin alphaIIb beta3 (Homo sapiens)
Integrin alpha IIb beta 3:p-Y530-SRC:CSK:Talin:RIAM complex:p-Y427-SHC [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Homo sapiens)
p-Y530-SRC:CSK [cytosol] (Homo sapiens)
CSK [cytosol] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Homo sapiens)
p-Y530-SRC:CSK [cytosol] (Homo sapiens)
CSK [cytosol] (Homo sapiens)
MAPK family signaling cascades (Homo sapiens)
MAPK1/MAPK3 signaling (Homo sapiens)
RAF/MAP kinase cascade (Homo sapiens)
MAP2K and MAPK activation (Homo sapiens)
Dissociation of RAS:RAF complex (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Homo sapiens)
p-Y530-SRC:CSK [cytosol] (Homo sapiens)
CSK [cytosol] (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Homo sapiens)
p-Y530-SRC:CSK [cytosol] (Homo sapiens)
CSK [cytosol] (Homo sapiens)
Dual mechanism MAP2K inhibitors bind MAP2Ks (Homo sapiens)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Homo sapiens)
p-Y530-SRC:CSK [cytosol] (Homo sapiens)
CSK [cytosol] (Homo sapiens)
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Homo sapiens)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Homo sapiens)
p-Y530-SRC:CSK [cytosol] (Homo sapiens)
CSK [cytosol] (Homo sapiens)
Dual mechanism MAPK inhibitors bind MAPKs (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Homo sapiens)
p-Y530-SRC:CSK [cytosol] (Homo sapiens)
CSK [cytosol] (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Homo sapiens)
p-Y530-SRC:CSK [cytosol] (Homo sapiens)
CSK [cytosol] (Homo sapiens)
MAP2Ks and MAPKs bind to the activated RAF complex (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Homo sapiens)
p-Y530-SRC:CSK [cytosol] (Homo sapiens)
CSK [cytosol] (Homo sapiens)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Homo sapiens)
p-Y530-SRC:CSK [cytosol] (Homo sapiens)
CSK [cytosol] (Homo sapiens)
MAP2Ks phosphorylate MAPKs (Homo sapiens)
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Homo sapiens)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Homo sapiens)
p-Y530-SRC:CSK [cytosol] (Homo sapiens)
CSK [cytosol] (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Homo sapiens)
p-Y530-SRC:CSK [cytosol] (Homo sapiens)
CSK [cytosol] (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Homo sapiens)
p-Y530-SRC:CSK [cytosol] (Homo sapiens)
CSK [cytosol] (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Homo sapiens)
p-Y530-SRC:CSK [cytosol] (Homo sapiens)
CSK [cytosol] (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Homo sapiens)
p-Y530-SRC:CSK [cytosol] (Homo sapiens)
CSK [cytosol] (Homo sapiens)
RAF phosphorylates MAP2K dimer (Homo sapiens)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Homo sapiens)
p-Y530-SRC:CSK [cytosol] (Homo sapiens)
CSK [cytosol] (Homo sapiens)
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Homo sapiens)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Homo sapiens)
p-Y530-SRC:CSK [cytosol] (Homo sapiens)
CSK [cytosol] (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Homo sapiens)
p-Y530-SRC:CSK [cytosol] (Homo sapiens)
CSK [cytosol] (Homo sapiens)
Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Homo sapiens)
p-Y530-SRC:CSK [cytosol] (Homo sapiens)
CSK [cytosol] (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Homo sapiens)
p-Y530-SRC:CSK [cytosol] (Homo sapiens)
CSK [cytosol] (Homo sapiens)
Single mechanism MAPK inhibitors bind phosphorylated MAPK (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Homo sapiens)
p-Y530-SRC:CSK [cytosol] (Homo sapiens)
CSK [cytosol] (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK:single mechanism MAPK inhibitors [plasma membrane] (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK:Talin:RIAM complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3:p-Y530-SRC:CSK [plasma membrane] (Homo sapiens)
p-Y530-SRC:CSK [cytosol] (Homo sapiens)
CSK [cytosol] (Homo sapiens)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Homo sapiens)
Signaling by Rho GTPases (Homo sapiens)
RHO GTPase cycle (Homo sapiens)
RHOH GTPase cycle (Homo sapiens)
RHOH binds effectors at the plasma membrane (Homo sapiens)
RHOH effectors [cytosol] (Homo sapiens)
CSK [cytosol] (Homo sapiens)
RHOH:GTP:RHOH effectors [plasma membrane] (Homo sapiens)
RHOH effectors [cytosol] (Homo sapiens)
CSK [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P41240 CSK
Gene Names
CSK
Chain
initiator methionine:, chain:2-450
Reference Genes
BioGPS Gene:1445 CSK
COSMIC (genes):CSK CSK
CTD Gene:1445 CSK
dbSNP Gene:1445 CSK
ENSEMBL:ENSG00000103653 CSK
ENSEMBL_homo_sapiens_GENE:ENSG00000103653.17 CSK
HGNC:2444 CSK
KEGG Gene (Homo sapiens):1445 CSK
Monarch:1445 CSK
NCBI Gene:1445 CSK
OMIM:124095 CSK
UCSC:P41240 CSK
Reference Transcript
RefSeq:NM_004383.2 CSK
RefSeq:XM_017021925.1 CSK
RefSeq:XM_005254165.4 CSK
RefSeq:NM_001127190.1 CSK
Other Identifiers
11724484_a_at
11724485_x_at
11740061_a_at
11751031_a_at
1445
16803059
1768_s_at
202329_PM_at
202329_at
3601851
3601852
3601853
3601854
3601855
3601856
3601859
3601861
3601862
3601865
3601867
3601868
3601870
3601871
3601873
3601875
3601876
3601877
3601878
3601880
3601881
3601883
3601884
3601885
7984871
A_23_P152024
GE59856
GO:0000166
GO:0002250
GO:0002376
GO:0003824
GO:0004672
GO:0004713
GO:0004715
GO:0005515
GO:0005524
GO:0005576
GO:0005615
GO:0005737
GO:0005829
GO:0005886
GO:0005911
GO:0006468
GO:0007155
GO:0008285
GO:0010989
GO:0016020
GO:0016192
GO:0016301
GO:0016310
GO:0016740
GO:0019903
GO:0023052
GO:0030154
GO:0031295
GO:0032715
GO:0034236
GO:0034330
GO:0034332
GO:0036211
GO:0042802
GO:0042997
GO:0043226
GO:0045779
GO:0046872
GO:0048709
GO:0048856
GO:0050765
GO:0050852
GO:0060368
GO:0070062
GO:0070064
GO:0070373
GO:0071375
GO:0072659
GO:0140096
GO:1990782
HMNXSV003034834
ILMN_1754121
PH_hs_0004489
TC15000685.hg
X59932_s_at
g4758077_3p_at
Participates
as a member of
RHOH effectors [cytosol] (Homo sapiens)
LCK, CSK [cytosol] (Homo sapiens)
as an output of
Release of CSK from SRC (Homo sapiens)
PTPN22 dissociates from CSK (Homo sapiens)
as a component of
active FLT3:CSK [plasma membrane] (Homo sapiens)
PTPN22:CSK [cytosol] (Homo sapiens)
Csk:p-PAG [plasma membrane] (Homo sapiens)
p-Y530-SRC:CSK [cytosol] (Homo sapiens)
as an input of
Active FLT3 binds to CSK (Homo sapiens)
Interaction of Csk with PAG (Homo sapiens)
Other forms of this molecule
CSK [plasma membrane]
Inferred To
CSK [cytosol]
(Bos taurus)
CSK [cytosol]
(Caenorhabditis elegans)
CSK [cytosol]
(Canis familiaris)
CSK [cytosol]
(Danio rerio)
CSK [cytosol]
(Drosophila melanogaster)
CSK [cytosol]
(Gallus gallus)
CSK [cytosol]
(Mus musculus)
CSK [cytosol]
(Rattus norvegicus)
CSK [cytosol]
(Sus scrofa)
CSK [cytosol]
(Xenopus tropicalis)
Cross References
RefSeq
NP_001120662.1
,
XP_016877414.1
,
NP_004374.1
,
XP_005254222.1
ZINC - World Drugs
CSK_HUMAN
Guide to Pharmacology - Targets
1994
OpenTargets
ENSG00000103653
ZINC - FDA approved
CSK_HUMAN
ZINC - Substances
CSK_HUMAN
ZINC - Biogenic
CSK_HUMAN
ZINC target
P41240
PRO
P41240
PDB
3EAC
,
3D7T
,
3EAZ
,
1BYG
,
1CSK
,
3D7U
ZINC - Investigational
CSK_HUMAN
IntEnz
2.7.10.2
GeneCards
P41240
HPA
ENSG00000103653-CSK
Ensembl
ENST00000220003
,
ENSP00000220003
,
ENST00000439220
,
ENSP00000414764
,
ENST00000567571
,
ENSP00000454906
,
ENSG00000103653
Pharos - Targets
P41240
ZINC - Predictions - Purchasable
CSK_HUMAN
Interactors (23)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9NWQ8 PAG1
2
PAG1 [plasma membrane]
(R-HSA-180500)
p-Y317-PAG1 [plasma membrane]
(R-HSA-180494)
0.823
6
UniProt:P00523 SRC
9
SRC [cytosol]
(R-GGA-9628701)
phospho-p-Y419-SRC [cytosol]
(R-GGA-8964276)
Src [cytosol]
(R-GGA-3928468)
MyrG-SRC [plasma membrane]
(R-GGA-8876922)
phospho-p-Y419-SRC [cytosol]
(R-GGA-377592)
phospho-MyrG,p-Y530-SRC [plasma membrane]
(R-GGA-377598)
SRC-1 [plasma membrane]
(R-GGA-65043)
phospho-MyrG-p-Y419-SRC [plasma membrane]
(R-GGA-1810408)
SRC-2 [cytosol]
(R-GGA-191648)
0.719
7
UniProt:P00533 EGFR
20
p-6Y-EGFR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869138)
p-5Y-EGFRvIII [plasma membrane]
(R-HSA-1248649)
EGFRvIII [plasma membrane]
(R-HSA-1214162)
p-6Y-EGFR E746_A750del;T790M [plasma membrane]
(R-HSA-1182985)
p-6Y-EGFR L858R;T790M [plasma membrane]
(R-HSA-1182984)
p-6Y-EGFR A767_V769dup [plasma membrane]
(R-HSA-1996343)
p-6Y-EGFR N771_H773dup [plasma membrane]
(R-HSA-1996342)
p-6Y-EGFR K739_I744dup [plasma membrane]
(R-HSA-1996346)
p-6Y-EGFR D770_N771insNPG [plasma membrane]
(R-HSA-1996335)
p-6Y-EGFR E746_A750del [plasma membrane]
(R-HSA-1181214)
p-6Y-EGFR L858R [plasma membrane]
(R-HSA-1173211)
p-6Y-EGFR G719S [plasma membrane]
(R-HSA-1169417)
p-6Y-EGFR L747_P753delinsS [plasma membrane]
(R-HSA-1228038)
p-6Y-EGFR L747_A750delinsP [plasma membrane]
(R-HSA-1228044)
p-6Y-EGFR L747_T751del [plasma membrane]
(R-HSA-1228041)
p-6Y-EGFR L747_S752del [plasma membrane]
(R-HSA-1228040)
p-6Y-EGFR L747_T751delinsP [plasma membrane]
(R-HSA-1228042)
p-6Y-EGFR E746_T751delinsA [plasma membrane]
(R-HSA-1228037)
p-6Y-EGFR E746_S752delinsV [plasma membrane]
(R-HSA-1228039)
p-6Y-EGFR L861Q [plasma membrane]
(R-HSA-1177541)
0.681
3
UniProt:Q63HR2 TENS2
0.671
4
UniProt:P42685 FRK
4
FRK [specific granule lumen]
(R-HSA-6801037)
FRK [extracellular region]
(R-HSA-6806235)
FRK [azurophil granule lumen]
(R-HSA-6799142)
p-Y387-FRK [cytosol]
(R-HSA-8847965)
0.643
3
UniProt:Q68CZ2 TNS3
1
TNS3 [cytosol]
(R-HSA-8875524)
0.643
4
UniProt:P08575 PTPRC
2
PTPRC [secretory granule membrane]
(R-HSA-6806150)
PTPRC [plasma membrane]
(R-HSA-197931)
0.623
3
UniProt:P49023 PXN
4
p-Y-PXN [plasma membrane]
(R-HSA-9031680)
PXN [plasma membrane]
(R-HSA-180493)
PXN [cytosol]
(R-HSA-210014)
p-Y31,Y118-PXN [cytosol]
(R-HSA-5218693)
0.623
4
UniProt:Q7VLE8 Q7VLE8
0.591
4
UniProt:P08069 IGF1R
3
IGF1R(741-1367) [plasma membrane]
(R-HSA-2404180)
IGF1R(31-736) [plasma membrane]
(R-HSA-2404169)
p-Y1161,Y1165,Y1166-IGF1R(741-1367) [plasma membrane]
(R-HSA-2404172)
0.567
8
UniProt:Q13283 G3BP1
1
G3BP1 [cytosol]
(R-HSA-9729517)
0.556
3
UniProt:Q5T7N3 KANK4
0.556
3
UniProt:Q96D03 DDT4L
0.556
3
UniProt:P42679 MATK
1
MATK [cytosol]
(R-HSA-1433581)
0.527
2
UniProt:P62993 GRB2
1
GRB2 [cytosol]
(R-HSA-8983328)
0.527
2
UniProt:Q9F220 Q9F220
0.524
2
ChEBI:39112 BOSUTINIB
0.499
2
UniProt:Q6UWF3 SCIMP
0.499
3
ChEBI:49375 DASATINIB
0.499
2
UniProt:O15530 PDPK1
3
p-S241-PDPK1 [cytosol]
(R-HSA-9860799)
PDPK1 [cytosol]
(R-HSA-202210)
PDPK1 [plasma membrane]
(R-HSA-61459)
0.488
2
UniProt:P61981 YWHAG
1
YWHAG [cytosol]
(R-HSA-380312)
0.483
2
UniProt:Q8NHL6 LILRB1
1
LILRB1 [plasma membrane]
(R-HSA-197721)
0.482
2
ChEBI:16851 1-PHOSPHATIDYL-1D-MYO-INOSITOL 3,5-BISPHOSPHATE
0.462
2
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