Reactome | DUSP7 [nucleoplasm]

DUSP7 [nucleoplasm]

Stable Identifier

R-HSA-203791

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Dual specificity protein phosphatase 7, DUS7_HUMAN

Locations in the PathwayBrowser

Expand all

Immune System (Homo sapiens)

- Cytokine Signaling in Immune system (Homo sapiens)
  - Signaling by Interleukins (Homo sapiens)
    - Interleukin-17 signaling (Homo sapiens)
      - MAP kinase activation (Homo sapiens)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Homo sapiens)
        
        ERK/MAPK targets (Homo sapiens)
        
        ERKs are inactivated (Homo sapiens)
        
        ERKs are inactivated by dual-specific phosphatases (DUSPs) (Homo sapiens)
        
        ERK-specific DUSP [nucleoplasm] (Homo sapiens)
        
        DUSP7 [nucleoplasm] (Homo sapiens)
- Innate Immune System (Homo sapiens)
  - Toll-like Receptor Cascades (Homo sapiens)
    - Toll Like Receptor 10 (TLR10) Cascade (Homo sapiens)
      - MyD88 cascade initiated on plasma membrane (Homo sapiens)
        
        MAP kinase activation (Homo sapiens)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Homo sapiens)
        
        ERK/MAPK targets (Homo sapiens)
        
        ERKs are inactivated (Homo sapiens)
        
        ERKs are inactivated by dual-specific phosphatases (DUSPs) (Homo sapiens)
        
        ERK-specific DUSP [nucleoplasm] (Homo sapiens)
        
        DUSP7 [nucleoplasm] (Homo sapiens)
    - Toll Like Receptor 2 (TLR2) Cascade (Homo sapiens)
      - Toll Like Receptor TLR1:TLR2 Cascade (Homo sapiens)
        
        MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
        
        MAP kinase activation (Homo sapiens)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Homo sapiens)
        
        ERK/MAPK targets (Homo sapiens)
        
        ERKs are inactivated (Homo sapiens)
        
        ERKs are inactivated by dual-specific phosphatases (DUSPs) (Homo sapiens)
        
        ERK-specific DUSP [nucleoplasm] (Homo sapiens)
        
        DUSP7 [nucleoplasm] (Homo sapiens)
      - Toll Like Receptor TLR6:TLR2 Cascade (Homo sapiens)
        
        MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
        
        MAP kinase activation (Homo sapiens)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Homo sapiens)
        
        ERK/MAPK targets (Homo sapiens)
        
        ERKs are inactivated (Homo sapiens)
        
        ERKs are inactivated by dual-specific phosphatases (DUSPs) (Homo sapiens)
        
        ERK-specific DUSP [nucleoplasm] (Homo sapiens)
        
        DUSP7 [nucleoplasm] (Homo sapiens)
    - Toll Like Receptor 3 (TLR3) Cascade (Homo sapiens)
      - MAP kinase activation (Homo sapiens)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Homo sapiens)
        
        ERK/MAPK targets (Homo sapiens)
        
        ERKs are inactivated (Homo sapiens)
        
        ERKs are inactivated by dual-specific phosphatases (DUSPs) (Homo sapiens)
        
        ERK-specific DUSP [nucleoplasm] (Homo sapiens)
        
        DUSP7 [nucleoplasm] (Homo sapiens)
    - Toll Like Receptor 4 (TLR4) Cascade (Homo sapiens)
      - MyD88-independent TLR4 cascade (Homo sapiens)
        
        TRIF (TICAM1)-mediated TLR4 signaling (Homo sapiens)
        
        MAP kinase activation (Homo sapiens)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Homo sapiens)
        
        ERK/MAPK targets (Homo sapiens)
        
        ERKs are inactivated (Homo sapiens)
        
        ERKs are inactivated by dual-specific phosphatases (DUSPs) (Homo sapiens)
        
        ERK-specific DUSP [nucleoplasm] (Homo sapiens)
        
        DUSP7 [nucleoplasm] (Homo sapiens)
      - MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
        
        MAP kinase activation (Homo sapiens)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Homo sapiens)
        
        ERK/MAPK targets (Homo sapiens)
        
        ERKs are inactivated (Homo sapiens)
        
        ERKs are inactivated by dual-specific phosphatases (DUSPs) (Homo sapiens)
        
        ERK-specific DUSP [nucleoplasm] (Homo sapiens)
        
        DUSP7 [nucleoplasm] (Homo sapiens)
    - Toll Like Receptor 5 (TLR5) Cascade (Homo sapiens)
      - MyD88 cascade initiated on plasma membrane (Homo sapiens)
        
        MAP kinase activation (Homo sapiens)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Homo sapiens)
        
        ERK/MAPK targets (Homo sapiens)
        
        ERKs are inactivated (Homo sapiens)
        
        ERKs are inactivated by dual-specific phosphatases (DUSPs) (Homo sapiens)
        
        ERK-specific DUSP [nucleoplasm] (Homo sapiens)
        
        DUSP7 [nucleoplasm] (Homo sapiens)
    - Toll Like Receptor 7/8 (TLR7/8) Cascade (Homo sapiens)
      - MyD88 dependent cascade initiated on endosome (Homo sapiens)
        
        TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Homo sapiens)
        
        MAP kinase activation (Homo sapiens)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Homo sapiens)
        
        ERK/MAPK targets (Homo sapiens)
        
        ERKs are inactivated (Homo sapiens)
        
        ERKs are inactivated by dual-specific phosphatases (DUSPs) (Homo sapiens)
        
        ERK-specific DUSP [nucleoplasm] (Homo sapiens)
        
        DUSP7 [nucleoplasm] (Homo sapiens)
    - Toll Like Receptor 9 (TLR9) Cascade (Homo sapiens)
      - MyD88 dependent cascade initiated on endosome (Homo sapiens)
        
        TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Homo sapiens)
        
        MAP kinase activation (Homo sapiens)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Homo sapiens)
        
        ERK/MAPK targets (Homo sapiens)
        
        ERKs are inactivated (Homo sapiens)
        
        ERKs are inactivated by dual-specific phosphatases (DUSPs) (Homo sapiens)
        
        ERK-specific DUSP [nucleoplasm] (Homo sapiens)
        
        DUSP7 [nucleoplasm] (Homo sapiens)

Signal Transduction (Homo sapiens)

- Signaling by Receptor Tyrosine Kinases (Homo sapiens)
  - Signaling by NTRKs (Homo sapiens)
    - Signaling by NTRK1 (TRKA) (Homo sapiens)
      - Nuclear Events (kinase and transcription factor activation) (Homo sapiens)
        
        ERK/MAPK targets (Homo sapiens)
        
        ERKs are inactivated (Homo sapiens)
        
        ERKs are inactivated by dual-specific phosphatases (DUSPs) (Homo sapiens)
        
        ERK-specific DUSP [nucleoplasm] (Homo sapiens)
        
        DUSP7 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q16829 DUSP7

Gene Names

DUSP7, PYST2

Chain

chain:1-419

Reference Genes

BioGPS Gene:1849 DUSP7

COSMIC (genes):DUSP7 DUSP7

CTD Gene:1849 DUSP7

dbSNP Gene:1849 DUSP7

ENSEMBL:ENSG00000164086 DUSP7

HGNC:3073 DUSP7

KEGG:hsa:1849 DUSP7

Monarch:1849 DUSP7

NCBI Gene:1849 DUSP7

OMIM:602749 DUSP7

UCSC:Q16829 DUSP7

Reference Transcript

RefSeq:NM_001947.3 DUSP7

Other Identifiers

11756121_a_at

16954697

1849

213848_PM_at

213848_at

214793_PM_at

214793_at

2675924

2675926

2675927

2675928

2675929

2675930

2675931

2675932

2675933

39932_at

39933_at

8087833

A_24_P51855

GE60163

GE768258

GO:0000165

GO:0003824

GO:0004721

GO:0004722

GO:0004725

GO:0005515

GO:0005654

GO:0005737

GO:0005829

GO:0006470

GO:0008138

GO:0008330

GO:0016311

GO:0016787

GO:0017017

GO:0017018

GO:0033550

GO:0035335

GO:0043407

GO:0043409

GO:0070371

GO:0140096

HMNXSV003005918

Hs.296938.0.S1_3p_at

Hs.3843.0.A1_3p_at

Hs.3843.0.A1_3p_x_at

ILMN_1782581

PH_hs_0030901

TC03001445.hg

X93921_at

Participates

as a member of

ERK-specific DUSP [nucleoplasm] (Homo sapiens)

Other forms of this molecule

DUSP7 [cytosol]

Inferred To

mpl2 [nucleoplasm] (Dictyostelium discoideum)

mpl1 [nucleoplasm] (Dictyostelium discoideum)

Homologues of DUSP7 [nucleoplasm] (Caenorhabditis elegans)

Homologues of DUSP7 [nucleoplasm] (Dictyostelium discoideum)

Mkp3 [nucleoplasm] (Drosophila melanogaster)

lip-1 [nucleoplasm] (Caenorhabditis elegans)

mpl3 [nucleoplasm] (Dictyostelium discoideum)

DUSP7 [nucleoplasm] (Bos taurus)

DUSP7 [nucleoplasm] (Caenorhabditis elegans)

DUSP7 [nucleoplasm] (Dictyostelium discoideum)

DUSP7 [nucleoplasm] (Gallus gallus)

DUSP7 [nucleoplasm] (Mus musculus)

DUSP7 [nucleoplasm] (Plasmodium falciparum)

DUSP7 [nucleoplasm] (Rattus norvegicus)

DUSP7 [nucleoplasm] (Sus scrofa)

dusp7 [nucleoplasm] (Xenopus tropicalis)

Cross References

RefSeq

NP_001938.2

ENSEMBL

ENST00000495880, ENSP00000417183

OpenTargets

ENSG00000164086

HPA

ENSG00000164086-DUSP7

PRO

Q16829

Pharos - Targets

Q16829

HMDB Protein

HMDBP08914

PDB

4Y2E

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P28482 MAPK1	18	p-T185,Y187-MAPK1 [nucleoplasm] (R-HSA-112354) p-T185,Y187-MAPK1 [cytosol] (R-HSA-109853) MAPK1 [cytosol] (R-HSA-59282) MAPK1 [nucleoplasm] (R-HSA-199960) p-T185-MAPK1 [cytosol] (R-HSA-9635773) p-T185,Y187 MAPK1 P58G [cytosol] (R-HSA-9652802) p-T185,Y187 MAPK1 E322A [cytosol] (R-HSA-9652794) p-T185,Y187 MAPK1 D321N [cytosol] (R-HSA-9652785) p-T185,Y187 MAPK1 D321V [cytosol] (R-HSA-9652791) p-T185,Y187 MAPK1 P58L [cytosol] (R-HSA-9652806) p-T185,Y187 MAPK1 S142L [cytosol] (R-HSA-9652808) p-T185,Y187 MAPK1 E81K [cytosol] (R-HSA-9652799) p-T185,Y187 MAPK1 E322K [cytosol] (R-HSA-9652175) p-T185,Y187 MAPK1 E322V [cytosol] (R-HSA-9652797) MAPK1 [azurophil granule lumen] (R-HSA-6799225) MAPK1 [extracellular region] (R-HSA-6806250) MAPK1 [ficolin-1-rich granule lumen] (R-HSA-6800964) MAPK1 [endoplasmic reticulum lumen] (R-HSA-9636293)	0.59	2
UniProt:Q16539 MAPK14	7	MAPK14 [ficolin-1-rich granule lumen] (R-HSA-6803280) MAPK14 [extracellular region] (R-HSA-6806453) MAPK14 [secretory granule lumen] (R-HSA-6803300) MAPK14 [nucleoplasm] (R-HSA-446223) MAPK14 [cytosol] (R-HSA-428933) p-T180,Y182-MAPK14 [cytosol] (R-HSA-428935) p-T180,Y182-MAPK14 [nucleoplasm] (R-HSA-446227)	0.59	2
UniProt:P10912 GHR	7	GHR activated [plasma membrane] (R-HSA-1168385) GHR(19-638) [plasma membrane] (R-HSA-982779) GHR(19-256) [extracellular region] (R-HSA-1168821) GHR(19-638) [endosome lumen] (R-HSA-1169263) p-5Y-GHR(19-638) [plasma membrane] (R-HSA-1168904) GHR(257-638) [plasma membrane] (R-HSA-1168803) p-Y332,Y487,Y627-GHR(19-638) [plasma membrane] (R-HSA-1169226)	0.558	2