p-6Y-FGFR3 805fs*141 [plasma membrane]

Stable Identifier
R-HSA-2038360
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
p-FGFR3 805fs*141
Icon
p-6Y-FGFR3 805fs*141 [plasma membrane] icon
p-6Y-FGFR3 805fs*141 [plasma membrane] icon
Locations in the PathwayBrowser
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Literature References
PubMed ID Title Journal Year
7647778 Stop codon FGFR3 mutations in thanatophoric dwarfism type 1

Rousseau, F, Saugier, P, Le Merrer, M, Munnich, A, Delezoide, AL, Maroteaux, P, Bonaventure, J, Narcy, F, Sanak, M

Nat Genet 1995
11157491 Activated fibroblast growth factor receptor 3 is an oncogene that contributes to tumor progression in multiple myeloma

Chesi, M, Brents, LA, Ely, SA, Bais, C, Robbiani, DF, Mesri, EA, Kuehl, WM, Bergsagel, PL

Blood 2001
External Reference Information
External Reference
UniProt:P22607 FGFR3
Gene Names
FGFR3, JTK4
Chain
signal peptide:1-22, chain:23-806
Reference Genes
BioGPS Gene:2261 FGFR3
COSMIC (genes):FGFR3 FGFR3
CTD Gene:2261 FGFR3
dbSNP Gene:2261 FGFR3
ENSEMBL:ENSG00000068078 FGFR3
HGNC:3690 FGFR3
KEGG:hsa:2261 FGFR3
Monarch:2261 FGFR3
NCBI Gene:2261 FGFR3
OMIM:134934 FGFR3
UCSC:P22607 FGFR3
Reference Transcript
Participates
as a component of
Other forms of this molecule
FGFR3(23-760)-TACC3(612-838) fusion [plasma membrane]
FGFR3(23-760)-BAIAP2L1(18-522) fusion [plasma membrane]
FGFR3(23-793)-TACC3(143-838) fusion [plasma membrane]
FGFR3(23-758)-TACC3(549-838) fusion [plasma membrane]
FGFR3(23-758)-TACC3(649-838) fusion [plasma membrane]
FGFR3(23-760)-TACC3(647-838) fusion [plasma membrane]
FGFR3 K650T [plasma membrane]
FGFR3 K650N [plasma membrane]
FGFR3 K650M [plasma membrane]
FGFR3 K650Q [plasma membrane]
FGFR3 A391E [plasma membrane]
FGFR3 K650E [plasma membrane]
FGFR3 G380R [plasma membrane]
FGFR3 G382D [plasma membrane]
FGFR3 805fs*141 [plasma membrane]
p-6Y-FGFR3 A391E [plasma membrane]
p-6Y-FGFR3 K650T [plasma membrane]
p-6Y-FGFR3 G382D [plasma membrane]
p-6Y-FGFR3 G380R [plasma membrane]
p-6Y-FGFR3 K650M [plasma membrane]
p-6Y-FGFR3 K650E [plasma membrane]
p-6Y-FGFR3 K650N [plasma membrane]
p-6Y-FGFR3 K650Q [plasma membrane]
pY-FGFR3 [plasma membrane]
p-6Y-FGFR3 R248C [plasma membrane]
p-6Y-FGFR3 Y373C [plasma membrane]
p-4Y-FGFR3(23-760)-BAIAP2L1(18-522) fusion [plasma membrane]
p-4Y-FGFR3(23-758)-TACC3(649-838) fusion [plasma membrane]
p-4Y-FGFR3(23-758)-TACC3(549-838) fusion [plasma membrane]
p-4Y-FGFR3(23-793)-TACC3(143-838) fusion [plasma membrane]
p-4Y-FGFR3(23-760)-TACC3(647-838) fusion [plasma membrane]
p-4Y-FGFR3(23-760)-TACC3(612-838) fusion [plasma membrane]
p-6Y-FGFR3 G370C [plasma membrane]
p-6Y-FGFR3 S371C [plasma membrane]
FGFR3 R248C [plasma membrane]
FGFR3 G370C [plasma membrane]
FGFR3 Y373C [plasma membrane]
FGFR3 S371C [plasma membrane]
FGFR3 [plasma membrane]
Modified Residues
Name
O4'-phospho-L-tyrosine at unknown position
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at unknown position
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at unknown position
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at unknown position
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at unknown position
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at unknown position
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
Replacement of residues 806 to 806 by TRATGPQQCEGSLAAHPAAGAQPLPGMRLSADGETATQSFGLCVCVCVCVCVCTSACACVRAHLASRCRGTLGVPAAVQRSPDWCCSTEGPLGWGDPVQNVSGPTRWDPRGAGSWARHGSGLCLCTTGHHRVGLGPSHTQS
Disease
Cross References
RefSeq
ZINC - World Drugs
Guide to Pharmacology - Targets
OpenTargets
ENSEMBL
Mondo
ZINC - FDA approved
ZINC - Substances
ZINC - Biogenic
ZINC target
PRO
GlyGen
PDB
ZINC - Investigational
GeneCards
HPA
Pharos - Targets
Orphanet
ZINC - Predictions - Purchasable
HMDB Protein
Interactors (55)
Accession #Entities Entities Confidence Score Evidence (IntAct)
 UniProt:P08238 HSP90AB1  6 0.667 4
 UniProt:O95674 CDS2  1 0.659 4
 UniProt:Q86WV5 TEN1  1 0.556 3
 UniProt:Q96EZ8 MCRS1  1 0.556 3
 UniProt:Q9H2A9 CHST8  1 0.556 3
 UniProt:O14544 SOCS6  1 0.556 3
 UniProt:Q9UJU6 DBNL  7 0.556 3
 UniProt:P22692 IGFBP4  5 0.556 3
 UniProt:P55318 FOXA3  1 0.556 3
 UniProt:O14641 DVL2  5 0.556 3
 UniProt:Q9Y2Y0 ARL2BP  2 0.556 3
 UniProt:Q6N021 TET2  1 0.556 3
 UniProt:O15534 PER1  4 0.556 3
 UniProt:A0AVK6 E2F8  1 0.556 3
 UniProt:P19388 POLR2E  2 0.556 3
 UniProt:Q15814 TBCC  1 0.556 3
 UniProt:P01106 MYC  2 0.556 3
 UniProt:Q9UBX5 FBLN5  1 0.556 3
 UniProt:O43504 LAMTOR5  1 0.556 3
 UniProt:Q96T60 PNKP  1 0.556 3
 UniProt:Q13573 SNW1  1 0.556 3
 UniProt:Q16621 NFE2  1 0.556 3
 UniProt:Q9UKV8 AGO2  2 0.556 3
 UniProt:P10809 HSPD1  6 0.556 3
 UniProt:P22415 USF1  2 0.556 3
 UniProt:Q9H147 DNTTIP1  1 0.556 3
 UniProt:P23771 GATA3  2 0.556 3
 UniProt:Q8N5V2 NGEF  2 0.556 3
 UniProt:Q9BVC3 DSCC1  1 0.556 3
 UniProt:P41134 ID1  1 0.556 3
 UniProt:Q13352 ITGB3BP  2 0.556 3
 UniProt:Q06323 PSME1  1 0.556 3
 UniProt:P17275 JUNB  1 0.556 3
 UniProt:Q99743 NPAS2  2 0.556 3
 UniProt:Q9NZH6 IL37  6 0.556 3
 UniProt:Q9GZQ8 MAP1LC3B  4 0.556 3
 UniProt:Q9BXU0 TEX12  1 0.556 3
 UniProt:Q07869 PPARA  2 0.556 3
 UniProt:P38936 CDKN1A  5 0.556 3
 UniProt:P05412 JUN  4 0.556 3
 UniProt:Q99075 HBEGF  8 0.556 3
 UniProt:Q06547-2 GABPB1  1 0.556 3
 UniProt:Q7Z7J5 DPPA2  1 0.556 3
 UniProt:P14618 PKM  4 0.556 3
 UniProt:Q8WUX9 CHMP7  2 0.556 3
 UniProt:P24941 CDK2  5 0.556 3
 UniProt:Q06547-3 GABPB1  1 0.556 3
 UniProt:Q6IAA8 LAMTOR1  5 0.556 3
 UniProt:P62244 RPS15A  2 0.556 3
 UniProt:P62333 PSMC6  2 0.556 3
 UniProt:Q8N3R9 PALS1  2 0.556 3
 UniProt:Q6NXG1 ESRP1  3 0.556 3
 UniProt:Q12824 SMARCB1  1 0.556 3
 UniProt:Q04206 RELA  7 0.556 3
 UniProt:Q00994 BEX3  1 0.556 3
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