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WWC1 [cytosol]
Stable Identifier
R-HSA-2038400
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
KIBRA
Locations in the PathwayBrowser for interactor UniProt:Q9UKE5 TNIK
Expand all
Signal Transduction (Homo sapiens)
Signaling by Hippo (Homo sapiens)
KIBRA (WWC1) binds LATS proteins (Homo sapiens)
WWC1 [cytosol] (Homo sapiens)
Signaling by NOTCH (Homo sapiens)
Signaling by NOTCH3 (Homo sapiens)
NOTCH3 Intracellular Domain Regulates Transcription (Homo sapiens)
WWC1 (Kibra) gene expression is stimulated by NOTCH3 (Homo sapiens)
WWC1 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q8IX03 WWC1
Gene Names
WWC1, KIAA0869, KIBRA
Chain
chain:1-1113
Reference Genes
COSMIC (genes):WWC1 WWC1
dbSNP Gene:23286 WWC1
ENSEMBL:ENSG00000113645 WWC1
Participates
as a component of
KIBRA:LATS [cytosol] (Homo sapiens)
as an input of
KIBRA (WWC1) binds LATS proteins (Homo sapiens)
as an output of
WWC1 (Kibra) gene expression is stimulated by NOTCH3 (Homo sapiens)
Inferred To
WWC1 [cytosol]
(Bos taurus)
WWC1 [cytosol]
(Canis familiaris)
WWC1 [cytosol]
(Gallus gallus)
WWC1 [cytosol]
(Sus scrofa)
wwc1 [cytosol]
(Xenopus tropicalis)
Dmel\CG10508 [cytosol]
(Drosophila melanogaster)
kibra [cytosol]
(Drosophila melanogaster)
Wwc1 [cytosol]
(Mus musculus)
Wwc1 [cytosol]
(Rattus norvegicus)
Homologues of WWC1 [cytosol]
(Drosophila melanogaster)
Interactors (13)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P61981 YWHAG
1
YWHAG [cytosol]
(R-HSA-380312)
0.725
4
UniProt:Q04917 YWHAH
1
YWHAH [cytosol]
(R-HSA-1445107)
0.643
3
UniProt:Q96FJ2 DYNLL2
4
DYNLL2 [cytosol]
(R-HSA-2029024)
DYNLL2 [plasma membrane]
(R-HSA-140527)
DYNLL2 [cilium]
(R-HSA-5624865)
DYNLL2 [ciliary tip]
(R-HSA-5625337)
0.643
3
UniProt:Q4VCS5 AMOT
0.615
3
UniProt:Q9UKE5 TNIK
1
TNIK [cytosol]
(R-HSA-3214889)
0.553
2
UniProt:P63167 DYNLL1
6
DYNLL1 [cytosol]
(R-HSA-387105)
DYNLL1 [plasma membrane]
(R-HSA-54017)
DYNLL1 [ficolin-1-rich granule membrane]
(R-HSA-6801518)
DYNLL1 [tertiary granule membrane]
(R-HSA-6801482)
DYNLL1 [cilium]
(R-HSA-5624863)
DYNLL1 [ciliary tip]
(R-HSA-5625335)
0.527
2
UniProt:P62258 YWHAE
1
YWHAE [cytosol]
(R-HSA-194368)
0.527
2
UniProt:Q9UKB1 FBXW11
1
FBXW11 [cytosol]
(R-HSA-976035)
0.527
2
UniProt:Q9Y2J2 EPB41L3
1
EPB41L3 [cytosol]
(R-HSA-6797563)
0.527
2
UniProt:O43491 EPB41L2
1
EPB41L2 [cytosol]
(R-HSA-6797548)
0.527
2
UniProt:Q15678 PTPN14
1
PTPN14 [nucleoplasm]
(R-HSA-9008917)
0.527
2
UniProt:Q05513 PRKCZ
5
pS, p-T410-PRKCZ [cytosol]
(R-HSA-9632824)
PRKCZ [cytosol]
(R-HSA-58218)
p-T410,T563-PRKCZ [cytosol]
(R-HSA-5218698)
p-T410-PRKCZ [cytosol]
(R-HSA-437181)
PRKCZ [cell junction]
(R-HSA-2134483)
0.527
4
UniProt:Q9Y297 BTRC
2
BTRC [cytosol]
(R-HSA-174237)
BTRC [nucleoplasm]
(R-HSA-3361753)
0.527
2
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