Reactome | PDK3(?-406) [mitochondrial matrix]

PDK3(?-406) [mitochondrial matrix]

Stable Identifier

R-HSA-203940

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

mitochondrial matrix

Synonyms

PDK3, Pyruvate dehydrogenase kinase isoform 3

Locations in the PathwayBrowser

Expand all

Metabolism (Homo sapiens)

- Aerobic respiration and respiratory electron transport (Homo sapiens)
  - Pyruvate metabolism (Homo sapiens)
    - Regulation of pyruvate metabolism (Homo sapiens)
      - Regulation of pyruvate dehydrogenase (PDH) complex (Homo sapiens)
        
        PDK isozymes phosphorylate PDHC subunit E1 (Homo sapiens)
        
        PDK isozyme dimers [mitochondrial matrix] (Homo sapiens)
        
        PDK3 dimer [mitochondrial matrix] (Homo sapiens)
        
        PDK3(?-406) [mitochondrial matrix] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q15120 PDK3

Gene Names

PDK3, PDHK3

Chain

transit peptide:1-, chain:-406

Reference Genes

BioGPS Gene:5165 PDK3

COSMIC (genes):PDK3 PDK3

CTD Gene:5165 PDK3

dbSNP Gene:5165 PDK3

ENSEMBL:ENSG00000067992 PDK3

HGNC:8811 PDK3

KEGG:hsa:5165 PDK3

Monarch:5165 PDK3

NCBI Gene:5165 PDK3

OMIM:300906 PDK3

UCSC:Q15120 PDK3

Reference Transcript

Other Identifiers

11730952_a_at

17102210

206347_PM_at

206347_at

206348_PM_s_at

206348_s_at

221957_PM_at

221957_at

228959_PM_at

228959_at

230085_PM_at

230085_at

36718_s_at

36719_r_at

36720_at

3972026

3972027

3972038

3972039

3972040

3972041

3972043

3972051

3972054

3972055

3972056

3972057

3972058

3972059

3972060

3972061

3972062

3972064

3972066

3972068

3972070

5165

76511_at

8166511

90797_at

A_23_P250478

A_24_P340112

A_24_P941666

A_32_P214503

GE611979

GE62944

GO:0003824

GO:0004672

GO:0004674

GO:0004740

GO:0005515

GO:0005524

GO:0005730

GO:0005739

GO:0005759

GO:0010510

GO:0010906

GO:0016301

GO:0016740

GO:0018105

GO:0035357

GO:0043226

GO:0071333

GO:0071398

GO:0097411

GO:0140096

GO:2000377

HMNXSV003011365

Hs.193124.1.A1_3p_at

Hs.193124.2.S1_3p_at

Hs.296031.0.A1_3p_at

ILMN_1776582

ILMN_1827736

L42452_at

PH_hs_0011385

PH_hs_0015321

TC0X000118.hg

TC0X001627.hg

g4885544_3p_at

Participates

as a component of

PDK3 dimer [mitochondrial matrix] (Homo sapiens)

Inferred To

PDK3 [mitochondrial matrix] (Bos taurus)

PDK3 [mitochondrial matrix] (Canis familiaris)

PDK3 [mitochondrial matrix] (Gallus gallus)

PDK3 [mitochondrial matrix] (Sus scrofa)

PDK3(?-406) [mitochondrial matrix] (Caenorhabditis elegans)

PDK3(?-406) [mitochondrial matrix] (Drosophila melanogaster)

PDK3(?-406) [mitochondrial matrix] (Mus musculus)

PDK3(?-406) [mitochondrial matrix] (Rattus norvegicus)

PDK3(?-406) [mitochondrial matrix] (Schizosaccharomyces pombe)

pdk3 [mitochondrial matrix] (Xenopus tropicalis)

Cross References

RefSeq

NP_005382.1, NP_001135858.1

Guide to Pharmacology - Targets

2143

ENSEMBL

ENST00000568479, ENST00000379162, ENSP00000498864, ENST00000648777, ENSP00000368460, ENSP00000497727

OpenTargets

ENSG00000067992

ZINC - Substances

PDK3_HUMAN

ZINC target

Q15120

PRO

Q15120

PDB

1Y8P, 2Q8I, 1Y8N, 1Y8O, 2PNR

IntEnz

2.7.11.2

HPA

ENSG00000067992-PDK3

Pharos - Targets

Q15120

Orphanet

PDK3

ZINC - Predictions - Purchasable

PDK3_HUMAN

HMDB Protein

HMDBP01508

Interactors (7)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P10515 DLAT	4	Lipo-K259-DLAT [mitochondrial matrix] (R-HSA-69969) AcetyllipoH2-K132,K259-DLAT [mitochondrial matrix] (R-HSA-9861594) LipoH2-K259-DLAT [mitochondrial matrix] (R-HSA-9861664) DLAT [mitochondrial matrix] (R-HSA-6792585)	0.688	3
UniProt:Q15119 PDK2	1	PDK2(?-407) [mitochondrial matrix] (R-HSA-203943)	0.643	3
UniProt:Q16654 PDK4	1	PDK4(?-411) [mitochondrial matrix] (R-HSA-203941)	0.643	4
UniProt:P10809 HSPD1	6	HSPD1(1-573) [cytosol] (R-HSA-1267989) HSPD1(1-573) [mitochondrial intermembrane space] (R-HSA-1267963) HSPD1(1-26) [mitochondrial matrix] (R-HSA-8986171) HSPD1(1-573) [mitochondrial inner membrane] (R-HSA-1299442) HSPD1 [mitochondrial inner membrane] (R-HSA-1299455) HSPD1 [mitochondrial matrix] (R-HSA-1299448)	0.615	3
UniProt:P00533 EGFR	20	p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR A767_V769dup [plasma membrane] (R-HSA-1996343) p-6Y-EGFR N771_H773dup [plasma membrane] (R-HSA-1996342) p-6Y-EGFR K739_I744dup [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541)	0.553	2
UniProt:P42229 STAT5A	4	STAT5A [cytosol] (R-HSA-380747) p-Y694-STAT5A [cytosol] (R-HSA-507936) p-Y694-STAT5A [nucleoplasm] (R-HSA-507995) STAT5A [nucleoplasm] (R-HSA-9701901)	0.527	3
UniProt:P17987 TCP1	1	TCP1 [cytosol] (R-HSA-390448)	0.527	2

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