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PDK2(?-407) [mitochondrial matrix]
Stable Identifier
R-HSA-203943
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
mitochondrial matrix
Synonyms
PDK2, Pyruvate dehydrogenase kinase isoform 2
Locations in the PathwayBrowser
Expand all
Metabolism (Homo sapiens)
Aerobic respiration and respiratory electron transport (Homo sapiens)
Pyruvate metabolism (Homo sapiens)
Regulation of pyruvate metabolism (Homo sapiens)
Regulation of pyruvate dehydrogenase (PDH) complex (Homo sapiens)
DCA binds PDK2 (Homo sapiens)
DCA:PDK2 [mitochondrial matrix] (Homo sapiens)
PDK2(?-407) [mitochondrial matrix] (Homo sapiens)
PDK2(?-407) [mitochondrial matrix] (Homo sapiens)
PDK isozymes phosphorylate PDHC subunit E1 (Homo sapiens)
DCA:PDK2 [mitochondrial matrix] (Homo sapiens)
PDK2(?-407) [mitochondrial matrix] (Homo sapiens)
PDK isozyme dimers [mitochondrial matrix] (Homo sapiens)
PDK1:PDK2 [mitochondrial matrix] (Homo sapiens)
PDK2(?-407) [mitochondrial matrix] (Homo sapiens)
PDK2 dimer [mitochondrial matrix] (Homo sapiens)
PDK2(?-407) [mitochondrial matrix] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Nuclear Receptors (Homo sapiens)
Signaling by Retinoic Acid (Homo sapiens)
PDK isozymes phosphorylate PDHC subunit E1 (Homo sapiens)
DCA:PDK2 [mitochondrial matrix] (Homo sapiens)
PDK2(?-407) [mitochondrial matrix] (Homo sapiens)
PDK isozyme dimers [mitochondrial matrix] (Homo sapiens)
PDK1:PDK2 [mitochondrial matrix] (Homo sapiens)
PDK2(?-407) [mitochondrial matrix] (Homo sapiens)
PDK2 dimer [mitochondrial matrix] (Homo sapiens)
PDK2(?-407) [mitochondrial matrix] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q15119 PDK2
Gene Names
PDK2, PDHK2
Chain
transit peptide:1-, chain:-407
Reference Genes
BioGPS Gene:5164 PDK2
COSMIC (genes):PDK2 PDK2
CTD Gene:5164 PDK2
dbSNP Gene:5164 PDK2
ENSEMBL:ENSG00000005882 PDK2
ENSEMBL_homo_sapiens_GENE:ENSG00000005882.12 PDK2
HGNC:8810 PDK2
KEGG Gene (Homo sapiens):5164 PDK2
Monarch:5164 PDK2
NCBI Gene:5164 PDK2
OMIM:602525 PDK2
UCSC:Q15119 PDK2
Reference Transcript
RefSeq:NM_001199899.1 PDK2
RefSeq:NM_002611.4 PDK2
RefSeq:NM_001199898.1 PDK2
Other Identifiers
11719555_a_at
11719556_a_at
11747205_a_at
16835711
202590_PM_s_at
202590_s_at
213724_PM_s_at
213724_s_at
3726210
3726212
3726213
3726214
3726215
3726216
3726218
3726219
3726224
3726225
3726227
3726229
3726230
3726231
3726233
3726234
38844_at
38845_at
5164
8008263
87983_at
A_23_P207517
GE552475
GE57775
GO:0000166
GO:0003824
GO:0004672
GO:0004740
GO:0005515
GO:0005524
GO:0005634
GO:0005654
GO:0005739
GO:0005759
GO:0005829
GO:0005967
GO:0005975
GO:0006006
GO:0006111
GO:0006629
GO:0006790
GO:0006885
GO:0008286
GO:0010510
GO:0010565
GO:0010906
GO:0012501
GO:0016301
GO:0016310
GO:0016740
GO:0023052
GO:0031670
GO:0034614
GO:0042593
GO:0042803
GO:0043226
GO:0050848
GO:0055086
GO:0072332
GO:0140096
GO:1901135
HMNXSV003041970
HMNXSV003048460
Hs.92261.0.A2_3p_s_at
Hs.92261.1.A1_3p_s_at
ILMN_1705397
L42451_at
PH_hs_0005113
TC17000655.hg
Participates
as an input of
DCA binds PDK2 (Homo sapiens)
as a component of
DCA:PDK2 [mitochondrial matrix] (Homo sapiens)
PDK1:PDK2 [mitochondrial matrix] (Homo sapiens)
PDK2 dimer [mitochondrial matrix] (Homo sapiens)
Inferred To
pdk4 [mitochondrial matrix]
(Xenopus tropicalis)
PDK2(?-407) [mitochondrial matrix]
(Caenorhabditis elegans)
PDK2(?-407) [mitochondrial matrix]
(Drosophila melanogaster)
PDK2(?-407) [mitochondrial matrix]
(Gallus gallus)
PDK2(?-407) [mitochondrial matrix]
(Mus musculus)
PDK2(?-407) [mitochondrial matrix]
(Rattus norvegicus)
PDK2(?-407) [mitochondrial matrix]
(Schizosaccharomyces pombe)
PDK2 [mitochondrial matrix]
(Bos taurus)
PDK2 [mitochondrial matrix]
(Canis familiaris)
PDK2 [mitochondrial matrix]
(Sus scrofa)
si:rp71-57j15.4 [mitochondrial matrix]
(Danio rerio)
Cross References
RefSeq
NP_002602.2
,
NP_001186827.1
,
NP_001186828.1
Guide to Pharmacology - Targets
2142
OpenTargets
ENSG00000005882
GeneCards
Q15119
HPA
ENSG00000005882-PDK2
ZINC - Substances
PDK2_HUMAN
Ensembl
ENSP00000007708
,
ENSG00000005882
,
ENST00000614357
,
ENSP00000420927
,
ENST00000007708
,
ENST00000503176
,
ENSP00000481915
ZINC target
Q15119
PRO
Q15119
Pharos - Targets
Q15119
ZINC - Predictions - Purchasable
PDK2_HUMAN
PDB
5M4N
,
2BU7
,
2BU8
,
6LIN
,
5M4P
,
6LIO
,
4MPC
,
4V25
,
4MP2
,
2BU5
,
5M4K
,
5M4M
,
4MP7
,
4V26
,
6LIL
,
2BU6
,
6TN0
,
7VBX
,
6TN2
,
7EBH
,
2BU2
,
7EA0
,
6TMZ
,
5J71
,
2BTZ
,
7VBU
,
7EAS
,
6TMP
,
4MPE
,
5J6A
,
4MPN
,
7VBV
,
6TMQ
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P42858 HTT
1
HTT [nucleoplasm]
(R-HSA-9023590)
0.666
10
UniProt:Q15118 PDK1
1
PDK1 [mitochondrial matrix]
(R-HSA-203944)
0.615
3
UniProt:Q15120 PDK3
1
PDK3(?-406) [mitochondrial matrix]
(R-HSA-203940)
0.527
2
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