Reactome | PDK2(?-407) [mitochondrial matrix]

PDK2(?-407) [mitochondrial matrix]

Stable Identifier

R-HSA-203943

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

mitochondrial matrix

Synonyms

PDK2, Pyruvate dehydrogenase kinase isoform 2

Locations in the PathwayBrowser for interactor UniProt:P42229 STAT5A

Expand all

Metabolism (Homo sapiens)

- Aerobic respiration and respiratory electron transport (Homo sapiens)
  - Pyruvate metabolism (Homo sapiens)
    - Regulation of pyruvate metabolism (Homo sapiens)
      - Regulation of pyruvate dehydrogenase (PDH) complex (Homo sapiens)
        
        DCA binds PDK2 (Homo sapiens)
        
        PDK2(?-407) [mitochondrial matrix] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q15119 PDK2

Gene Names

PDK2, PDHK2

Chain

transit peptide:1-, chain:-407

Reference Genes

BioGPS Gene:5164 PDK2

COSMIC (genes):PDK2 PDK2

CTD Gene:5164 PDK2

dbSNP Gene:5164 PDK2

ENSEMBL:ENSG00000005882 PDK2

HGNC:8810 PDK2

KEGG:hsa:5164 PDK2

Monarch:5164 PDK2

NCBI Gene:5164 PDK2

OMIM:602525 PDK2

UCSC:Q15119 PDK2

Reference Transcript

Other Identifiers

11719555_a_at

11719556_a_at

11747205_a_at

16835711

202590_PM_s_at

202590_s_at

213724_PM_s_at

213724_s_at

3726210

3726212

3726213

3726214

3726215

3726216

3726218

3726219

3726220

3726221

3726222

3726223

3726224

3726225

3726226

3726227

3726228

3726229

3726230

3726231

3726232

3726233

3726234

38844_at

38845_at

5164

8008263

87983_at

A_14_P136364

A_21_P0000146

A_23_P207517

GE552475

GE57775

GO:0003824

GO:0004672

GO:0004740

GO:0005515

GO:0005524

GO:0005654

GO:0005739

GO:0005759

GO:0005829

GO:0005975

GO:0006006

GO:0006111

GO:0006885

GO:0008286

GO:0010510

GO:0010565

GO:0010906

GO:0016301

GO:0016740

GO:0031670

GO:0034614

GO:0042593

GO:0042803

GO:0043226

GO:0045254

GO:0050848

GO:0072332

GO:0140096

HMNXSV003041970

HMNXSV003048460

Hs.92261.0.A2_3p_s_at

Hs.92261.1.A1_3p_s_at

ILMN_1705397

L42451_at

PH_hs_0005113

TC17000655.hg

Participates

as an input of

DCA binds PDK2 (Homo sapiens)

as a component of

Inferred To

pdk4 [mitochondrial matrix] (Danio rerio)

pdk4 [mitochondrial matrix] (Xenopus tropicalis)

PDK2(?-407) [mitochondrial matrix] (Caenorhabditis elegans)

PDK2(?-407) [mitochondrial matrix] (Drosophila melanogaster)

PDK2(?-407) [mitochondrial matrix] (Gallus gallus)

PDK2(?-407) [mitochondrial matrix] (Mus musculus)

PDK2(?-407) [mitochondrial matrix] (Rattus norvegicus)

PDK2(?-407) [mitochondrial matrix] (Schizosaccharomyces pombe)

PDK2 [mitochondrial matrix] (Bos taurus)

PDK2 [mitochondrial matrix] (Canis familiaris)

PDK2 [mitochondrial matrix] (Sus scrofa)

Cross References

RefSeq

NP_001186827.1, NP_001186828.1, NP_002602.2

Guide to Pharmacology - Targets

2142

OpenTargets

ENSG00000005882

ENSEMBL

ENST00000503176, ENSP00000481915, ENST00000614357, ENST00000007708, ENSP00000007708, ENSP00000420927

HPA

ENSG00000005882-PDK2

ZINC - Substances

PDK2_HUMAN

ZINC target

Q15119

PRO

Q15119

Pharos - Targets

Q15119

ZINC - Predictions - Purchasable

PDK2_HUMAN

PDB

2BU2, 4MPN, 7VBX, 6TN2, 7EA0, 7VBU, 2BTZ, 4MPC, 6TMQ, 5M4N, 2BU7, 2BU5, 7VBV, 2BU6, 2BU8, 4MPE, 5M4P, 5J71, 5M4K, 7EBH, 6LIL, 4MP7, 6TMP, 5J6A, 4MP2, 6TN0, 6LIN, 6TMZ, 6LIO, 5M4M, 4V26, 8ZM2, 4V25, 8ZM1, 7EAS

Interactors (8)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q15118 PDK1	1	PDK1 [mitochondrial matrix] (R-HSA-203944)	0.706	5
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.666	10
UniProt:Q15120 PDK3	1	PDK3(?-406) [mitochondrial matrix] (R-HSA-203940)	0.643	3
UniProt:Q16654 PDK4	1	PDK4(?-411) [mitochondrial matrix] (R-HSA-203941)	0.527	2
UniProt:Q8IV01 SYT12	1	SYT12 [synaptic vesicle membrane] (R-HSA-6789229)	0.527	3
UniProt:Q12950 FOXD4			0.527	3
UniProt:Q9H845 ACAD9	1	ACAD9 [mitochondrial inner membrane] (R-HSA-5689049)	0.527	2
UniProt:P42229 STAT5A	4	STAT5A [cytosol] (R-HSA-380747) p-Y694-STAT5A [cytosol] (R-HSA-507936) p-Y694-STAT5A [nucleoplasm] (R-HSA-507995) STAT5A [nucleoplasm] (R-HSA-9701901)	0.527	2