Reactome | SEC24C [endoplasmic reticulum membrane]

SEC24C [endoplasmic reticulum membrane]

Stable Identifier

R-HSA-203987

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

endoplasmic reticulum membrane

Synonyms

Protein transport protein Sec24C, S24C_HUMAN

Locations in the PathwayBrowser

Expand all

Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - Viral Infection Pathways (Homo sapiens)
    - SARS-CoV Infections (Homo sapiens)
      - SARS-CoV-2 Infection (Homo sapiens)
        
        SARS-CoV-2-host interactions (Homo sapiens)
        
        SARS-CoV-2 activates/modulates innate and adaptive immune responses (Homo sapiens)
        
        Capturing cargo and formation of prebudding complex (Homo sapiens)
        
        SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC24C [endoplasmic reticulum membrane] (Homo sapiens)
        
        Sar1p:GTP:Sec23p:Sec24p:Ag bound MHC class I [lumenal side of endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC24C [endoplasmic reticulum membrane] (Homo sapiens)

Immune System (Homo sapiens)

- Adaptive Immune System (Homo sapiens)
  - Class I MHC mediated antigen processing & presentation (Homo sapiens)
    - Antigen Presentation: Folding, assembly and peptide loading of class I MHC (Homo sapiens)
      - Budding of COPII coated vesicle (Homo sapiens)
        
        COPII vesicle with MHC class I [lumenal side of endoplasmic reticulum membrane] (Homo sapiens)
        
        Sar1p:GTP:Sec23p:Sec24p:Ag bound MHC class I [lumenal side of endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC24C [endoplasmic reticulum membrane] (Homo sapiens)
      - Capturing cargo and formation of prebudding complex (Homo sapiens)
        
        SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC24C [endoplasmic reticulum membrane] (Homo sapiens)
        
        Sar1p:GTP:Sec23p:Sec24p:Ag bound MHC class I [lumenal side of endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC24C [endoplasmic reticulum membrane] (Homo sapiens)
      - Coat Assembly (Homo sapiens)
        
        SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC24C [endoplasmic reticulum membrane] (Homo sapiens)
      - Recruitment of Sec31p:Sec13p to prebudding complex and formation of COPII vesicle (Homo sapiens)
        
        COPII vesicle with MHC class I [lumenal side of endoplasmic reticulum membrane] (Homo sapiens)
        
        Sar1p:GTP:Sec23p:Sec24p:Ag bound MHC class I [lumenal side of endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC24C [endoplasmic reticulum membrane] (Homo sapiens)
        
        Sar1p:GTP:Sec23p:Sec24p:Ag bound MHC class I [lumenal side of endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC24C [endoplasmic reticulum membrane] (Homo sapiens)
  - MHC class II antigen presentation (Homo sapiens)
    - Formation of COPII vesicle (Homo sapiens)
      - COPII [endoplasmic reticulum membrane] (Homo sapiens)
        
        SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC24C [endoplasmic reticulum membrane] (Homo sapiens)
      - Nonameric complex in COPII vesicle [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        COPII [endoplasmic reticulum membrane] (Homo sapiens)
        
        SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC24C [endoplasmic reticulum membrane] (Homo sapiens)
    - Fusion of COPII vesicle with Golgi complex (Homo sapiens)
      - COPII [endoplasmic reticulum membrane] (Homo sapiens)
        
        SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC24C [endoplasmic reticulum membrane] (Homo sapiens)
      - Nonameric complex in COPII vesicle [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        COPII [endoplasmic reticulum membrane] (Homo sapiens)
        
        SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC24C [endoplasmic reticulum membrane] (Homo sapiens)

Metabolism (Homo sapiens)

- Metabolism of lipids (Homo sapiens)
  - Metabolism of steroids (Homo sapiens)
    - Regulation of cholesterol biosynthesis by SREBP (SREBF) (Homo sapiens)
      - SREBP1A,1C,2:SCAP binds CopII Coat Complex (Homo sapiens)
        
        SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC24C [endoplasmic reticulum membrane] (Homo sapiens)
        
        SREBP1A,1C,2:SCAP:Cop II Coat [endoplasmic reticulum membrane] (Homo sapiens)
        
        SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC24C [endoplasmic reticulum membrane] (Homo sapiens)
      - SREBP1A,1C,2:SCAP translocates to the Golgi (Homo sapiens)
        
        SREBP1A,1C,2:SCAP:Cop II Coat [endoplasmic reticulum membrane] (Homo sapiens)
        
        SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC23:SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC24 [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC24C [endoplasmic reticulum membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:P53992 SEC24C

Gene Names

SEC24C, KIAA0079

Chain

chain:1-1094

Reference Genes

BioGPS Gene:9632 SEC24C

COSMIC (genes):SEC24C SEC24C

CTD Gene:9632 SEC24C

dbSNP Gene:9632 SEC24C

ENSEMBL:ENSG00000176986 SEC24C

HGNC:10705 SEC24C

KEGG:hsa:9632 SEC24C

Monarch:9632 SEC24C

NCBI Gene:9632 SEC24C

OMIM:607185 SEC24C

UCSC:P53992 SEC24C

Reference Transcript

Other Identifiers

11718639_a_at

11753200_a_at

11755383_a_at

16706082

202361_PM_at

202361_at

3251849

3251850

3251851

3251852

3251853

3251854

3251856

3251857

3251858

3251859

3251860

3251861

3251862

3251863

3251864

3251865

3251866

3251867

3251868

3251869

3251871

3251872

3251873

3251874

3251875

3251876

3251878

3251879

3251881

3251882

3251883

3251885

3251887

3251888

3251889

3251890

3251891

3251892

3251893

3251894

3251895

3251896

3251897

3251898

3251899

3251900

3251901

3251902

3251903

3251904

3251905

3251906

38117_at

7928369

7928395

9632

A_14_P104672

A_14_P200272

A_24_P255338

A_33_P3317123

D38555_at

GE57198

GO:0000149

GO:0001701

GO:0005515

GO:0005737

GO:0005783

GO:0005789

GO:0005829

GO:0006886

GO:0006888

GO:0008270

GO:0012507

GO:0015031

GO:0016020

GO:0016192

GO:0030127

GO:0031410

GO:0043226

GO:0046872

GO:0048856

GO:0070971

GO:0090110

HMNXSV003000764

HMNXSV003043041

ILMN_1676600

ILMN_1706758

PH_hs_0031363

TC10000468.hg

g4758633_3p_at

g4758633_3p_x_at

Participates

as a component of

as an input of

SREBP2:SCAP Binds CopII Coat Complex (Cricetulus griseus)

as a member of

SEC24 [endoplasmic reticulum membrane] (Homo sapiens)

Other forms of this molecule

SEC24C [cytosol]

SEC24C [ER to Golgi transport vesicle membrane]

p-SEC24C [cytosol]

Inferred To

Sec24CD [endoplasmic reticulum membrane] (Drosophila melanogaster)

sec24c [endoplasmic reticulum membrane] (Xenopus tropicalis)

Sec24c [endoplasmic reticulum membrane] (Mus musculus)

Sec24c [endoplasmic reticulum membrane] (Rattus norvegicus)

SFB3 [endoplasmic reticulum membrane] (Saccharomyces cerevisiae)

SEC24C [endoplasmic reticulum membrane] (Bos taurus)

SEC24C [endoplasmic reticulum membrane] (Canis familiaris)

SEC24C [endoplasmic reticulum membrane] (Gallus gallus)

SEC24C [endoplasmic reticulum membrane] (Plasmodium falciparum)

SEC24C [endoplasmic reticulum membrane] (Schizosaccharomyces pombe)

SEC24C [endoplasmic reticulum membrane] (Sus scrofa)

sec-24.1 [endoplasmic reticulum membrane] (Caenorhabditis elegans)

sec24l [endoplasmic reticulum membrane] (Dictyostelium discoideum)

Cross References

RefSeq

XP_047281990.1, XP_054223205.1, NP_004913.2, XP_047281989.1, NP_940999.1, XP_054223204.1

OpenTargets

ENSG00000176986

ENSEMBL

ENSP00000321845, ENST00000339365, ENSG00000176986, ENST00000345254, ENSP00000343405

HPA

ENSG00000176986-SEC24C

GeneCards

SEC24C

PRO

P53992

Pharos - Targets

P53992

Orphanet

SEC24C

GlyGen

P53992

PDB

3EH2, 8CL3, 6PU1

Interactors (8)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q15436 SEC23A	4	SEC23A [endoplasmic reticulum membrane] (R-HSA-203976) SEC23A [cytosol] (R-HSA-203972) SEC23A [ER to Golgi transport vesicle membrane] (R-HSA-204024) p-S738,T744 SEC23A [cytosol] (R-HSA-5685740)	0.811	8
UniProt:Q15437 SC23B			0.804	6
UniProt:P00540 MOS			0.666	4
UniProt:P20081	1	FPR1 [cytosol] (R-SCE-2026007)	0.556	3
UniProt:P53829 CAF40			0.556	3
UniProt:O43516 WIPF1	1	WIPF1 [cytosol] (R-HSA-201874)	0.556	3
UniProt:Q96PV0 SYNGAP1	1	SYNGAP1 [cytosol] (R-HSA-5658217)	0.527	3
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.483	7

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