Reactome | SLC16A1 [plasma membrane]

SLC16A1 [plasma membrane]

Stable Identifier

R-HSA-204387

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Monocarboxylate transporter 1, MOT1_HUMAN, MCT1

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:P53985 SLC16A1

Gene Names

SLC16A1, MCT1

Chain

chain:1-500

Reference Genes

BioGPS Gene:6566 SLC16A1

COSMIC (genes):SLC16A1 SLC16A1

CTD Gene:6566 SLC16A1

dbSNP Gene:6566 SLC16A1

ENSEMBL:ENSG00000155380 SLC16A1

HGNC:10922 SLC16A1

KEGG:hsa:6566 SLC16A1

Monarch:6566 SLC16A1

NCBI Gene:6566 SLC16A1

OMIM:600682 SLC16A1

UCSC:P53985 SLC16A1

Reference Transcript

Other Identifiers

11718656_at

11748355_a_at

1557918_PM_s_at

1557918_s_at

16691023

202234_PM_s_at

202234_s_at

202235_PM_at

202235_at

202236_PM_s_at

202236_s_at

209900_PM_s_at

209900_s_at

2428492

2428493

2428494

2428495

2428502

2428503

2428504

2428505

2428506

2428507

2428508

2428509

2428510

2428511

2428512

2428515

2428516

2428517

2428518

2428520

2428521

2428522

2428523

36206_at

49197_at

6566

73253_at

7918622

A_23_P126825

A_33_P3282434

GE81228

GO:0003013

GO:0005215

GO:0005515

GO:0005813

GO:0005815

GO:0005886

GO:0006629

GO:0007098

GO:0008028

GO:0009925

GO:0015129

GO:0015130

GO:0015141

GO:0015293

GO:0015295

GO:0015650

GO:0015718

GO:0015728

GO:0016020

GO:0016323

GO:0016324

GO:0016328

GO:0022857

GO:0030054

GO:0032094

GO:0035873

GO:0035879

GO:0042593

GO:0042802

GO:0042867

GO:0043226

GO:0043231

GO:0045202

GO:0046943

GO:0050796

GO:0051780

GO:0055085

GO:0070062

GO:0071407

GO:0071422

GO:0097159

GO:0150104

GO:1901475

GO:1902600

GO:1905039

HMNXSV003030050

Hs.75231.0.S3_3p_at

Hs2.407205.1.S1_3p_s_at

ILMN_1757052

L31801_at

PH_hs_0031315

TC01003001.hg

g4506982_3p_a_at

g7328161_3p_a_at

Participates

as a component of

as a member of

Monocarboxylate Transporter Set (MCT) [plasma membrane] (Homo sapiens)

Other forms of this molecule

SLC16A1 G472R [plasma membrane]

SLC16A1 K204E [plasma membrane]

Inferred To

slcf-1 [plasma membrane] (Caenorhabditis elegans)

mct-5 [plasma membrane] (Caenorhabditis elegans)

slc16a1 [plasma membrane] (Xenopus tropicalis)

Dmel\CG8468 [plasma membrane] (Drosophila melanogaster)

mct-2 [plasma membrane] (Caenorhabditis elegans)

Homologues of SLC16A1 [plasma membrane] (Caenorhabditis elegans)

Homologues of SLC16A1 [plasma membrane] (Drosophila melanogaster)

Targ [plasma membrane] (Drosophila melanogaster)

mct-4 [plasma membrane] (Caenorhabditis elegans)

mct-6 [plasma membrane] (Caenorhabditis elegans)

Dmel\CG13907 [plasma membrane] (Drosophila melanogaster)

Mct1 [plasma membrane] (Drosophila melanogaster)

SLC16A1 [plasma membrane] (Bos taurus)

SLC16A1 [plasma membrane] (Gallus gallus)

SLC16A1 [plasma membrane] (Mus musculus)

SLC16A1 [plasma membrane] (Rattus norvegicus)

SLC16A1 [plasma membrane] (Sus scrofa)

mct-3 [plasma membrane] (Caenorhabditis elegans)

LOC100686848 [plasma membrane] (Canis familiaris)

Cross References

Guide to Pharmacology - Targets

988

OpenTargets

ENSG00000155380

ENSEMBL

ENST00000628110, ENST00000630362, ENSP00000399104, ENSP00000397106, ENSP00000486000, ENSP00000505879, ENSP00000416167, ENST00000443580, ENST00000679803, ENSP00000358640, ENSP00000485688, ENST00000429288, ENST00000458229, ENST00000538576, ENSP00000441065, ENST00000369626

ZINC - Substances

MOT1_HUMAN

ZINC - Biogenic

MOT1_HUMAN

ZINC target

P53985

PRO

P53985

GlyGen

P53985

PDB

7CKO, 7DA5, 7CKR, 6LYY, 7YR5, 6LZ0

HPA

ENSG00000155380-SLC16A1

Pharos - Targets

P53985

Orphanet

SLC16A1

ZINC - Predictions - Purchasable

MOT1_HUMAN

HMDB Protein

HMDBP01111

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.483	10

Cite Us!