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ITGA6(24-1130) [plasma membrane]
Stable Identifier
R-HSA-204439
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Integrin alpha-6, ITA6_HUMAN, ITGA6
Locations in the PathwayBrowser
Expand all
Cell-Cell communication (Homo sapiens)
Cell junction organization (Homo sapiens)
Type I hemidesmosome assembly (Homo sapiens)
BP180 interacts extracellularly with Laminin 332 (Homo sapiens)
Integrin alpha 6:beta 4:Plectin:BP180:Laminin-322 complex [plasma membrane] (Homo sapiens)
Integrin alpha 6:beta 4:Plectin complex [plasma membrane] (Homo sapiens)
Integrin alpha6beta4 [plasma membrane] (Homo sapiens)
ITGA6(24-1130) [plasma membrane] (Homo sapiens)
Integrin alpha6:beta4:Plectin:BP180 complex [plasma membrane] (Homo sapiens)
Integrin alpha 6:beta 4:Plectin complex [plasma membrane] (Homo sapiens)
Integrin alpha6beta4 [plasma membrane] (Homo sapiens)
ITGA6(24-1130) [plasma membrane] (Homo sapiens)
BP180 interacts intracellularly with plectin and integrin beta4 (Homo sapiens)
Integrin alpha 6:beta 4:Plectin complex [plasma membrane] (Homo sapiens)
Integrin alpha6beta4 [plasma membrane] (Homo sapiens)
ITGA6(24-1130) [plasma membrane] (Homo sapiens)
Integrin alpha6:beta4:Plectin:BP180 complex [plasma membrane] (Homo sapiens)
Integrin alpha 6:beta 4:Plectin complex [plasma membrane] (Homo sapiens)
Integrin alpha6beta4 [plasma membrane] (Homo sapiens)
ITGA6(24-1130) [plasma membrane] (Homo sapiens)
BP230 interacts with keretin K5/K14 (Homo sapiens)
CD151:BP230:BP180:Plectin:Integrin alpha 6 beta 4: Laminin [plasma membrane] (Homo sapiens)
BP230:BP180:Plectin:integrin alpha 6 beta 4:Laminin 332 [plasma membrane] (Homo sapiens)
Integrin alpha 6:beta 4:Plectin:BP180:Laminin-322 complex [plasma membrane] (Homo sapiens)
Integrin alpha 6:beta 4:Plectin complex [plasma membrane] (Homo sapiens)
Integrin alpha6beta4 [plasma membrane] (Homo sapiens)
ITGA6(24-1130) [plasma membrane] (Homo sapiens)
Type II hemidesmosome [plasma membrane] (Homo sapiens)
CD151:BP230:BP180:Plectin:Integrin alpha 6 beta 4: Laminin [plasma membrane] (Homo sapiens)
BP230:BP180:Plectin:integrin alpha 6 beta 4:Laminin 332 [plasma membrane] (Homo sapiens)
Integrin alpha 6:beta 4:Plectin:BP180:Laminin-322 complex [plasma membrane] (Homo sapiens)
Integrin alpha 6:beta 4:Plectin complex [plasma membrane] (Homo sapiens)
Integrin alpha6beta4 [plasma membrane] (Homo sapiens)
ITGA6(24-1130) [plasma membrane] (Homo sapiens)
BP230 is recruited to the hemidesmosome (Homo sapiens)
BP230:BP180:Plectin:integrin alpha 6 beta 4:Laminin 332 [plasma membrane] (Homo sapiens)
Integrin alpha 6:beta 4:Plectin:BP180:Laminin-322 complex [plasma membrane] (Homo sapiens)
Integrin alpha 6:beta 4:Plectin complex [plasma membrane] (Homo sapiens)
Integrin alpha6beta4 [plasma membrane] (Homo sapiens)
ITGA6(24-1130) [plasma membrane] (Homo sapiens)
Integrin alpha 6:beta 4:Plectin:BP180:Laminin-322 complex [plasma membrane] (Homo sapiens)
Integrin alpha 6:beta 4:Plectin complex [plasma membrane] (Homo sapiens)
Integrin alpha6beta4 [plasma membrane] (Homo sapiens)
ITGA6(24-1130) [plasma membrane] (Homo sapiens)
CD151 interacts with BP180 and the integrin alpha 6 subunit (Homo sapiens)
BP230:BP180:Plectin:integrin alpha 6 beta 4:Laminin 332 [plasma membrane] (Homo sapiens)
Integrin alpha 6:beta 4:Plectin:BP180:Laminin-322 complex [plasma membrane] (Homo sapiens)
Integrin alpha 6:beta 4:Plectin complex [plasma membrane] (Homo sapiens)
Integrin alpha6beta4 [plasma membrane] (Homo sapiens)
ITGA6(24-1130) [plasma membrane] (Homo sapiens)
CD151:BP230:BP180:Plectin:Integrin alpha 6 beta 4: Laminin [plasma membrane] (Homo sapiens)
BP230:BP180:Plectin:integrin alpha 6 beta 4:Laminin 332 [plasma membrane] (Homo sapiens)
Integrin alpha 6:beta 4:Plectin:BP180:Laminin-322 complex [plasma membrane] (Homo sapiens)
Integrin alpha 6:beta 4:Plectin complex [plasma membrane] (Homo sapiens)
Integrin alpha6beta4 [plasma membrane] (Homo sapiens)
ITGA6(24-1130) [plasma membrane] (Homo sapiens)
Interaction of Plectin with Integrin beta 4 (Homo sapiens)
Integrin alpha 6:beta 4:Plectin complex [plasma membrane] (Homo sapiens)
Integrin alpha6beta4 [plasma membrane] (Homo sapiens)
ITGA6(24-1130) [plasma membrane] (Homo sapiens)
Integrin alpha6beta4 [plasma membrane] (Homo sapiens)
ITGA6(24-1130) [plasma membrane] (Homo sapiens)
Developmental Biology (Homo sapiens)
Developmental Cell Lineages (Homo sapiens)
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin (Homo sapiens)
Keratinocyte stem cell differentiates into transit amplifying cell in the basal layer of interfollicular epidermis (Homo sapiens)
keratinocyte stem cell of skin epidermis basal layer (Homo sapiens)
ITGA6(24-1130) [plasma membrane] (Homo sapiens)
transit-amplifying cell of epidermis basal layer (Homo sapiens)
ITGA6(24-1130) [plasma membrane] (Homo sapiens)
Transit-amplifying cell of basal layer differentiates into keratinocyte of spinosum layer in interfollicular epidermis (Homo sapiens)
transit-amplifying cell of epidermis basal layer (Homo sapiens)
ITGA6(24-1130) [plasma membrane] (Homo sapiens)
Extracellular matrix organization (Homo sapiens)
Collagen formation (Homo sapiens)
Assembly of collagen fibrils and other multimeric structures (Homo sapiens)
Hemidesmosome formation (Homo sapiens)
Collagen type XVII fibril:Integrin alpha6beta4 [plasma membrane] (Homo sapiens)
Integrin alpha6beta4 [plasma membrane] (Homo sapiens)
ITGA6(24-1130) [plasma membrane] (Homo sapiens)
Type I hemidesmosome complex [extracellular region] (Homo sapiens)
Collagen type XVII fibril:Integrin alpha6beta4 [plasma membrane] (Homo sapiens)
Integrin alpha6beta4 [plasma membrane] (Homo sapiens)
ITGA6(24-1130) [plasma membrane] (Homo sapiens)
Integrin cell surface interactions (Homo sapiens)
AGRN binds Integrins alphaVbeta1 (Other beta1-containing integrins) (Homo sapiens)
Agrin:Integrin alphaVbeta1 (other beta1) [plasma membrane] (Homo sapiens)
Integrins alphaVbeta1 (other beta 1) [plasma membrane] (Homo sapiens)
Integrin alpha6beta1 [plasma membrane] (Homo sapiens)
ITGA6(24-1130) [plasma membrane] (Homo sapiens)
Integrins alphaVbeta1 (other beta 1) [plasma membrane] (Homo sapiens)
Integrin alpha6beta1 [plasma membrane] (Homo sapiens)
ITGA6(24-1130) [plasma membrane] (Homo sapiens)
BSG (basigin) binds Integrin alpha3beta1, alpha6beta1 (Homo sapiens)
BSG:Integrin alpha3beta1, alpha6beta1 [plasma membrane] (Homo sapiens)
Integrin alpha3beta1, alpha6beta1 [plasma membrane] (Homo sapiens)
Integrin alpha6beta1 [plasma membrane] (Homo sapiens)
ITGA6(24-1130) [plasma membrane] (Homo sapiens)
Integrin alpha3beta1, alpha6beta1 [plasma membrane] (Homo sapiens)
Integrin alpha6beta1 [plasma membrane] (Homo sapiens)
ITGA6(24-1130) [plasma membrane] (Homo sapiens)
Laminin interactions (Homo sapiens)
Integrin alpha6beta1 binds laminin-322, 512, 521, 211, 221, 411 (Homo sapiens)
Integrin alpha6beta1 [plasma membrane] (Homo sapiens)
ITGA6(24-1130) [plasma membrane] (Homo sapiens)
Integrin alpha6beta1:Laminin-211, 221, 332, 411, 512, 521 [plasma membrane] (Homo sapiens)
Integrin alpha6beta1 [plasma membrane] (Homo sapiens)
ITGA6(24-1130) [plasma membrane] (Homo sapiens)
Integrin alpha6beta1, alpha7beta1, alpha1beta1, alpha2beta1 bind laminin-111 (Homo sapiens)
Integrin alpha6beta1, alpha7beta1, alpha1beta1, alpha2beta1, alphaVbeta1 [plasma membrane] (Homo sapiens)
Integrin alpha6beta1 [plasma membrane] (Homo sapiens)
ITGA6(24-1130) [plasma membrane] (Homo sapiens)
Integrin alpha6beta1, alpha7beta1, alpha1beta1, alpha2beta1, alphaVbeta1:Laminin-111 [plasma membrane] (Homo sapiens)
Integrin alpha6beta1, alpha7beta1, alpha1beta1, alpha2beta1, alphaVbeta1 [plasma membrane] (Homo sapiens)
Integrin alpha6beta1 [plasma membrane] (Homo sapiens)
ITGA6(24-1130) [plasma membrane] (Homo sapiens)
Integrins alpha3beta1, alpha6beta4 bind laminin-332, 511, 521, (211, 221) (Homo sapiens)
Integrin alpha3beta1, alpha6beta4 [plasma membrane] (Homo sapiens)
Integrin alpha6beta4 [plasma membrane] (Homo sapiens)
ITGA6(24-1130) [plasma membrane] (Homo sapiens)
Integrin alpha3beta1, alpha6beta4:Laminins-332, 511, 521, (211, 221) [plasma membrane] (Homo sapiens)
Integrin alpha3beta1, alpha6beta4 [plasma membrane] (Homo sapiens)
Integrin alpha6beta4 [plasma membrane] (Homo sapiens)
ITGA6(24-1130) [plasma membrane] (Homo sapiens)
Non-integrin membrane-ECM interactions (Homo sapiens)
Syndecan interactions (Homo sapiens)
Syndecan-1 binds Integrins alpha2beta1, (alpha6beta4) (Homo sapiens)
Integrin alpha2beta1, (alpha6beta4) [plasma membrane] (Homo sapiens)
Integrin alpha6beta4 [plasma membrane] (Homo sapiens)
ITGA6(24-1130) [plasma membrane] (Homo sapiens)
Syndecan-1:Integrin alpha2beta1 (alpha6beta4) [plasma membrane] (Homo sapiens)
Integrin alpha2beta1, (alpha6beta4) [plasma membrane] (Homo sapiens)
Integrin alpha6beta4 [plasma membrane] (Homo sapiens)
ITGA6(24-1130) [plasma membrane] (Homo sapiens)
Hemostasis (Homo sapiens)
Cell surface interactions at the vascular wall (Homo sapiens)
Basigin interactions (Homo sapiens)
BSG (basigin) binds Integrin alpha3beta1, alpha6beta1 (Homo sapiens)
BSG:Integrin alpha3beta1, alpha6beta1 [plasma membrane] (Homo sapiens)
Integrin alpha3beta1, alpha6beta1 [plasma membrane] (Homo sapiens)
Integrin alpha6beta1 [plasma membrane] (Homo sapiens)
ITGA6(24-1130) [plasma membrane] (Homo sapiens)
Integrin alpha3beta1, alpha6beta1 [plasma membrane] (Homo sapiens)
Integrin alpha6beta1 [plasma membrane] (Homo sapiens)
ITGA6(24-1130) [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P23229 ITGA6
Gene Names
ITGA6
Chain
signal peptide:1-23, chain:24-1130, chain:24-938, chain:636-1130, chain:942-1130
Reference Genes
BioGPS Gene:3655 ITGA6
COSMIC (genes):ITGA6 ITGA6
CTD Gene:3655 ITGA6
dbSNP Gene:3655 ITGA6
ENSEMBL:ENSG00000091409 ITGA6
HGNC:6142 ITGA6
KEGG:hsa:3655 ITGA6
Monarch:3655 ITGA6
NCBI Gene:3655 ITGA6
OMIM:147556 ITGA6
UCSC:P23229 ITGA6
Reference Transcript
RefSeq:NM_001079818.2 ITGA6
RefSeq:NM_001316306.1 ITGA6
RefSeq:NM_000210.3 ITGA6
Other Identifiers
11736029_a_at
11739860_a_at
11739861_s_at
16887702
201656_PM_at
201656_at
2077_at
215177_PM_s_at
215177_s_at
2515625
2515626
2515628
2515629
2515643
2515645
2515646
2515650
2515653
2515654
2515655
2515656
2515657
2515658
2515659
2515661
2515662
2515663
2515664
2515665
2515666
2515667
2515668
2515669
2515670
2515671
2515672
2515673
2515674
2515675
2515677
2515679
2515680
2515681
2515682
2515683
2515684
2515685
2515686
2515687
2515688
2515700
2515706
33410_at
33411_g_at
3655
41266_at
8046380
A_14_P112374
A_14_P115063
A_21_P0002620
A_23_P210176
A_33_P3231447
GE62367
GO:0002376
GO:0005178
GO:0005515
GO:0005886
GO:0005912
GO:0005925
GO:0006355
GO:0007044
GO:0007155
GO:0007160
GO:0007229
GO:0008305
GO:0009897
GO:0009986
GO:0010668
GO:0010811
GO:0010976
GO:0016020
GO:0030154
GO:0030175
GO:0030335
GO:0031589
GO:0031994
GO:0033627
GO:0034330
GO:0034675
GO:0034676
GO:0035878
GO:0038132
GO:0042327
GO:0043065
GO:0043236
GO:0043547
GO:0043589
GO:0044877
GO:0045296
GO:0045944
GO:0046872
GO:0048856
GO:0048870
GO:0050900
GO:0071407
GO:0098609
GO:2001237
HMNXSV003013336
HMNXSV003047483
Hs.227730.2.A1_3p_a_at
ILMN_2267488
ILMN_2359287
PH_hs_0023084
TC02001030.hg
X53586_rna1_at
g4557674_3p_at
p21267
Participates
as a protein marker of
transit-amplifying cell of epidermis basal layer (Homo sapiens)
keratinocyte stem cell of skin epidermis basal layer (Homo sapiens)
as a component of
Integrin alpha6beta4 [plasma membrane] (Homo sapiens)
Integrin alpha6beta1 [plasma membrane] (Homo sapiens)
Inferred To
ITGA6 [plasma membrane]
(Bos taurus)
ITGA6 [plasma membrane]
(Canis familiaris)
ITGA6 [plasma membrane]
(Sus scrofa)
Itga6 [plasma membrane]
(Rattus norvegicus)
ItgaPS5 [plasma membrane]
(Drosophila melanogaster)
itga6b [plasma membrane]
(Danio rerio)
ITGA6(24-1130) [plasma membrane]
(Gallus gallus)
ITGA6(24-1130) [plasma membrane]
(Mus musculus)
itga6 [plasma membrane]
(Xenopus tropicalis)
ina-1 [plasma membrane]
(Caenorhabditis elegans)
Homologues of ITGA6(24-1130) [plasma membrane]
(Drosophila melanogaster)
ItgaPS4 [plasma membrane]
(Drosophila melanogaster)
mew [plasma membrane]
(Drosophila melanogaster)
scb [plasma membrane]
(Drosophila melanogaster)
Cross References
RefSeq
NP_000201.2
,
NP_001303235.1
,
NP_001073286.1
Guide to Pharmacology - Targets
2445
ENSEMBL
ENSP00000386896
,
ENST00000409080
,
ENST00000409532
,
ENST00000442250
,
ENST00000684293
,
ENST00000458358
,
ENSP00000386614
,
ENSP00000394169
,
ENSP00000508249
,
ENSP00000406694
OpenTargets
ENSG00000091409
HPA
ENSG00000091409-ITGA6
PRO
P23229
Pharos - Targets
P23229
GlyGen
P23229
Orphanet
ITGA6
PDB
7CEC
,
7CEB
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P48509 CD151
2
CD151 [cytosol]
(R-HSA-446072)
CD151 [plasma membrane]
(R-HSA-913947)
0.695
5
UniProt:P21926 CD9
4
CD9 [plasma membrane]
(R-HSA-51717)
CD9 [endocytic vesicle membrane]
(R-HSA-5334774)
CD9 [clathrin-coated endocytic vesicle membrane]
(R-HSA-5334779)
CD9 [platelet alpha granule membrane]
(R-HSA-114585)
0.597
3
UniProt:P05556 ITGB1
2
ITGB1 [plasma membrane]
(R-HSA-57596)
ITGB1 [endosome membrane]
(R-HSA-9611157)
0.564
2
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