Reactome | ITGA3(33-1051) [plasma membrane]

ITGA3(33-1051) [plasma membrane]

Stable Identifier

R-HSA-204441

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Integrin alpha-3, ITA3_HUMAN, ITGA3

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Locations in the PathwayBrowser

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Signal Transduction (Homo sapiens)

- Signaling by Receptor Tyrosine Kinases (Homo sapiens)
  - Signaling by MET (Homo sapiens)
    - MET promotes cell motility (Homo sapiens)
      - MET activates PTK2 signaling (Homo sapiens)
        
        PTK2 binds activated MET (Homo sapiens)
        
        Integrin alpha2beta1,alpha3:beta1:(collagen,laminin,fibronectin) [plasma membrane] (Homo sapiens)
        
        Integrin alpha2beta1,alpha3beta1 [plasma membrane] (Homo sapiens)
        
        Integrin alpha3beta1 [plasma membrane] (Homo sapiens)
        
        ITGA3(33-1051) [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:P26006 ITGA3

Gene Names

ITGA3, MSK18

Chain

signal peptide:1-32, chain:33-1051, chain:33-872, chain:876-1051

Reference Genes

BioGPS Gene:3675 ITGA3

COSMIC (genes):ITGA3 ITGA3

CTD Gene:3675 ITGA3

dbSNP Gene:3675 ITGA3

ENSEMBL:ENSG00000005884 ITGA3

HGNC:6139 ITGA3

KEGG:hsa:3675 ITGA3

Monarch:3675 ITGA3

NCBI Gene:3675 ITGA3

OMIM:605025 ITGA3

UCSC:P26006 ITGA3

Reference Transcript

RefSeq:NM_002204.4 ITGA3

Participates

as a component of

Integrin alpha3beta1 [plasma membrane] (Homo sapiens)

Inferred To

ItgaPS5 [plasma membrane] (Drosophila melanogaster)

ina-1 [plasma membrane] (Caenorhabditis elegans)

Homologues of ITGA3(33-1051) [plasma membrane] (Drosophila melanogaster)

ItgaPS4 [plasma membrane] (Drosophila melanogaster)

itga3 [plasma membrane] (Xenopus tropicalis)

mew [plasma membrane] (Drosophila melanogaster)

ITGA3 [plasma membrane] (Bos taurus)

ITGA3 [plasma membrane] (Canis familiaris)

ITGA3 [plasma membrane] (Gallus gallus)

ITGA3 [plasma membrane] (Sus scrofa)

itga3b [plasma membrane] (Danio rerio)

scb [plasma membrane] (Drosophila melanogaster)

Itga3 [plasma membrane] (Mus musculus)

Itga3 [plasma membrane] (Rattus norvegicus)

Cross References

RefSeq

NP_002195.1

Guide to Pharmacology - Targets

2442

ENSEMBL

ENST00000007722, ENSP00000007722, ENSG00000005884, ENST00000320031, ENSP00000315190

OpenTargets

ENSG00000005884

ZINC - Substances

ITA3_HUMAN

ZINC target

P26006

PRO

P26006

GlyGen

P26006

GeneCards

ITGA3

HPA

ENSG00000005884-ITGA3

Pharos - Targets

P26006

Orphanet

ITGA3

ZINC - Predictions - Purchasable

ITA3_HUMAN

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P48509 CD151	2	CD151 [cytosol] (R-HSA-446072) CD151 [plasma membrane] (R-HSA-913947)	0.76	7
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279)	0.527	12
UniProt:P21926 CD9	4	CD9 [plasma membrane] (R-HSA-51717) CD9 [endocytic vesicle membrane] (R-HSA-5334774) CD9 [clathrin-coated endocytic vesicle membrane] (R-HSA-5334779) CD9 [platelet alpha granule membrane] (R-HSA-114585)	0.462	6