Reactome | ITGA3(33-1051) [plasma membrane]

ITGA3(33-1051) [plasma membrane]

Stable Identifier

R-HSA-204441

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Integrin alpha-3, ITA3_HUMAN, ITGA3

Locations in the PathwayBrowser

Expand all

Signal Transduction (Homo sapiens)

- Signaling by Receptor Tyrosine Kinases (Homo sapiens)
  - Signaling by MET (Homo sapiens)
    - MET promotes cell motility (Homo sapiens)
      - MET activates PTK2 signaling (Homo sapiens)
        
        PTK2 binds activated MET (Homo sapiens)
        
        Integrin alpha2beta1,alpha3:beta1:(collagen,laminin,fibronectin) [plasma membrane] (Homo sapiens)
        
        Integrin alpha2beta1,alpha3beta1 [plasma membrane] (Homo sapiens)
        
        Integrin alpha3beta1 [plasma membrane] (Homo sapiens)
        
        ITGA3(33-1051) [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:P26006 ITGA3

Gene Names

ITGA3, MSK18

Chain

signal peptide:1-32, chain:33-1051, chain:33-872, chain:876-1051

Reference Genes

BioGPS Gene:3675 ITGA3

COSMIC (genes):ITGA3 ITGA3

CTD Gene:3675 ITGA3

dbSNP Gene:3675 ITGA3

ENSEMBL:ENSG00000005884 ITGA3

ENSEMBL_homo_sapiens_GENE:ENSG00000005884.18 ITGA3

HGNC:6139 ITGA3

KEGG Gene (Homo sapiens):3675 ITGA3

Monarch:3675 ITGA3

NCBI Gene:3675 ITGA3

OMIM:605025 ITGA3

UCSC:P26006 ITGA3

Reference Transcript

RefSeq:NM_002204.3 ITGA3

Other Identifiers

11739145_a_at

11749035_a_at

11756790_a_at

16835672

3675

3726155

3726156

3726157

3726161

3726162

3726163

3726164

3726166

3726167

3726168

3726170

3726171

3726172

3726173

3726174

3726176

3726177

3726178

3726179

3726180

3726182

3726183

3726184

3726185

3726186

3726187

3726188

3726189

3726191

3726195

3726196

3726198

3726199

3726200

3726201

3726202

3726203

3726204

3726205

3726206

8008237

884_at

885_g_at

A_23_P55251

GE63379

GO:0001764

GO:0001968

GO:0002020

GO:0002376

GO:0003014

GO:0005178

GO:0005515

GO:0005518

GO:0005576

GO:0005615

GO:0005886

GO:0005925

GO:0007155

GO:0007160

GO:0007229

GO:0007266

GO:0007507

GO:0007613

GO:0008305

GO:0009410

GO:0009897

GO:0009986

GO:0010628

GO:0010634

GO:0010811

GO:0010976

GO:0016020

GO:0016323

GO:0017015

GO:0019904

GO:0022414

GO:0023052

GO:0030111

GO:0030154

GO:0030324

GO:0030426

GO:0030510

GO:0031345

GO:0031527

GO:0031594

GO:0033627

GO:0034330

GO:0034667

GO:0034698

GO:0035024

GO:0035640

GO:0042995

GO:0043226

GO:0043235

GO:0043236

GO:0043588

GO:0044877

GO:0045202

GO:0045211

GO:0046872

GO:0046982

GO:0048333

GO:0048471

GO:0048787

GO:0048856

GO:0048870

GO:0050877

GO:0050900

GO:0060076

GO:0060135

GO:0070062

GO:0070161

GO:0071944

GO:0072006

GO:0072659

GO:0097060

GO:0097062

GO:0097205

GO:0098609

GO:0098978

GO:0099173

GO:0099560

GO:1903078

GO:1990812

HMNXSV003014501

ILMN_1654074

M59911_at

TC17000654.hg

g4504746_3p_a_at

Participates

as a component of

Integrin alpha3beta1 [plasma membrane] (Homo sapiens)

Inferred To

ItgaPS5 [plasma membrane] (Drosophila melanogaster)

ina-1 [plasma membrane] (Caenorhabditis elegans)

im:7155971 [plasma membrane] (Danio rerio)

Homologues of ITGA3(33-1051) [plasma membrane] (Drosophila melanogaster)

ItgaPS4 [plasma membrane] (Drosophila melanogaster)

itga3 [plasma membrane] (Xenopus tropicalis)

mew [plasma membrane] (Drosophila melanogaster)

ITGA3 [plasma membrane] (Canis familiaris)

ITGA3 [plasma membrane] (Sus scrofa)

ITGA3(33-1051) [plasma membrane] (Bos taurus)

ITGA3(33-1051) [plasma membrane] (Gallus gallus)

scb [plasma membrane] (Drosophila melanogaster)

Itga3 [plasma membrane] (Mus musculus)

Itga3 [plasma membrane] (Rattus norvegicus)

Cross References

RefSeq

NP_002195.1

Guide to Pharmacology - Targets

2442

OpenTargets

ENSG00000005884

GeneCards

P26006

HPA

ENSG00000005884-ITGA3

ZINC - Substances

ITA3_HUMAN

ZINC target

P26006

Ensembl

ENSP00000315190, ENST00000320031, ENSG00000005884, ENSP00000007722, ENST00000007722

PRO

P26006

Pharos - Targets

P26006

ZINC - Predictions - Purchasable

ITA3_HUMAN

Orphanet

21420

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P48509 CD151	2	CD151 [cytosol] (R-HSA-446072) CD151 [plasma membrane] (R-HSA-913947)	0.69	6
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.527	12
UniProt:P21926 CD9	4	CD9 [plasma membrane] (R-HSA-51717) CD9 [endocytic vesicle membrane] (R-HSA-5334774) CD9 [clathrin-coated endocytic vesicle membrane] (R-HSA-5334779) CD9 [platelet alpha granule membrane] (R-HSA-114585)	0.462	6