Reactome | Basigin binds CyPA

Basigin binds CyPA

Stable Identifier

R-HSA-204485

Type

Reaction [binding]

Species

Homo sapiens

Compartment

extracellular region, plasma membrane

ReviewStatus

5/5

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Cyclophilin A (CyPA)1 is an intracellular protein belonging to the immunophilin family and is recognized as the major target for the potent immunosuppressive drug cyclosporin A. CD147 is the natural cell surface receptor for CyPA. It is demonstrated that CD147 is an essential component in the CyPA-initiated signaling cascade that culminates in ERK activation.

Literature References

PubMed ID	Title	Journal	Year
11943775	Active site residues of cyclophilin A are crucial for its signaling activity via CD147 Gallay, P, Toole, B, Bukrinsky, M, Hung, HC, O'Connor, M, Sherry, B, Yurchenko, V, Franchin, G, Hao, T, Dai, WW, Guo, H, Zybarth, G	J Biol Chem	2002