Reactome | SCP2 [peroxisomal matrix]

SCP2 [peroxisomal matrix]

Stable Identifier

R-HSA-2046067

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

peroxisomal matrix

Synonyms

SCPx thiolase (SCPX), Non-specific lipid-transfer protein, NLTP_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P22307 SCP2

Gene Names

SCP2

Chain

chain:1-547

Reference Genes

BioGPS Gene:6342 P223073

COSMIC (genes):SCP2 CTDSP2

CTD Gene:6342 P223073

dbSNP Gene:6342 P223073

ENSEMBL:ENSG00000116171 SCP2

HGNC:10606 P223073

KEGG:hsa:6342 P223073

Monarch:6342 P223073

NCBI Gene:6342 P223073

OMIM:184755 P223073

UCSC:P22307 P223073

Reference Transcript

Participates

as an input of

TYSND1 cleaves SCP2 (Homo sapiens)

as a member of

Cargo proteins containing PTS1 [peroxisomal matrix] (Homo sapiens)

Other forms of this molecule

SCP2 [cytosol]

SCP2(1-424) [peroxisomal matrix]

SCP2(425-547) [peroxisomal matrix]

Inferred To

SCP2-1 [peroxisomal matrix] (Danio rerio)

SCP2-1 [peroxisomal matrix] (Gallus gallus)

Scp2 [peroxisomal matrix] (Rattus norvegicus)

ScpX [peroxisomal matrix] (Drosophila melanogaster)

SCP2 [peroxisomal matrix] (Bos taurus)

SCP2 [peroxisomal matrix] (Canis familiaris)

Scp2(1-547) [peroxisomal matrix] (Mus musculus)

Cross References

OpenTargets

ENSG00000116171

ENSEMBL

ENST00000371514, ENST00000371513, ENST00000430330, ENSP00000406636, ENSP00000386214, ENST00000435345, ENST00000528311, ENSP00000360568, ENSP00000434132, ENSP00000384569, ENSP00000360564, ENSP00000396413, ENSP00000435783, ENST00000371509, ENSG00000116171, ENST00000408941, ENST00000488965, ENST00000407246, ENSP00000360569

ZINC - Substances

NLTP_HUMAN

ZINC target

P22307

PRO

P22307

PDB

2C0L, 1QND

IntEnz

2.3.1.176, 2.3.1.16

HPA

ENSG00000116171-SCP2

GeneCards

SCP2

Pharos - Targets

P22307

Orphanet

SCP2

ZINC - Predictions - Purchasable

NLTP_HUMAN

HMDB Protein

HMDBP00440

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q15645 PCH2			0.666	4
UniProt:P49817 Cav1	6	caveolin-1 [lipid droplet] (R-MMU-163603) Cav1 [endocytic vesicle membrane] (R-MMU-535009) Cav1 [lipid droplet] (R-MMU-163510) Cav1 [early endosome membrane] (R-MMU-5368451) Cav1 [plasma membrane] (R-MMU-534994) Cav1 [Golgi membrane] (R-MMU-204504)	0.463	3
UniProt:Q03135 CAV1	5	CAV1 [Golgi membrane] (R-HSA-204504) CAV1 [plasma membrane] (R-HSA-534994) CAV1 [early endosome membrane] (R-HSA-5368451) CAV1 [lipid droplet] (R-HSA-163510) CAV1 [endocytic vesicle membrane] (R-HSA-535009)	0.454	3

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