Reactome | Desaturation of Linoleoyl-CoA to gamma-linolenoyl-CoA

Desaturation of Linoleoyl-CoA to gamma-linolenoyl-CoA

Stable Identifier

R-HSA-2046096

Type

Reaction [transition]

Species

Homo sapiens

Compartment

endoplasmic reticulum membrane, endoplasmic reticulum lumen

ReviewStatus

5/5

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Desaturation of Linoleoyl-CoA to gamma-linolenoyl-CoA

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The first major step in the metabolism of linoleic acid (LA) is desaturation of delta 9,12-octadecadienoyl CoA/linoleoyl CoA (LA-CoA) to delta 6,9,12-octodecatrienoyl CoA/gamma-lenoleoyl CoA (GLA-CoA). This step is catalyzed by delta-6-destaurase (fatty acid desaturase-2, FADS2) which introduces a cis-double bond between carbons 6 and 7. This is the rate limiting step in LA metabolism (Horrobin 1993).

Literature References

PubMed ID	Title	Journal	Year
12562861	Regulation of human delta-6 desaturase gene transcription: identification of a functional direct repeat-1 element Nakamura, MT, Cho, HP, Tang, C, Clarke, SD	J Lipid Res	2003
12713571	Identification of the delta-6 desaturase of human sebaceous glands: expression and enzyme activity Prouty, SM, Gordon, JS, Ge, L, Hsuan, C, Stenn, K	J Invest Dermatol	2003
11988075	The same rat Delta6-desaturase not only acts on 18- but also on 24-carbon fatty acids in very-long-chain polyunsaturated fatty acid biosynthesis Jan, S, d'Andréa, S, Catheline, D, Bouriel, M, Thibault, JN, Legrand, P, Rioux, V, Guillou, H	Biochem J	2002