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SOCS1 [cytosol]
Stable Identifier
R-HSA-204910
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Suppressor of cytokine signaling 1, SOCS-1
Locations in the PathwayBrowser for interactor UniProt:Q99961 SH3GL1
Expand all
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Signaling by CSF3 (G-CSF) (Homo sapiens)
Inactivation of CSF3 (G-CSF) signaling (Homo sapiens)
p-Y-STAT1,3,5 dimer enhances expression of SOCS1 (Homo sapiens)
SOCS1 [cytosol] (Homo sapiens)
Signaling by Interleukins (Homo sapiens)
Interleukin-4 and Interleukin-13 signaling (Homo sapiens)
Expression of SOCS1 (Homo sapiens)
SOCS1 [cytosol] (Homo sapiens)
Innate Immune System (Homo sapiens)
Toll-like Receptor Cascades (Homo sapiens)
Toll Like Receptor 2 (TLR2) Cascade (Homo sapiens)
Toll Like Receptor TLR1:TLR2 Cascade (Homo sapiens)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
MyD88 forms a complex with TIRAP:activated TLR2/4 (Homo sapiens)
SOCS1 [cytosol] (Homo sapiens)
Toll Like Receptor TLR6:TLR2 Cascade (Homo sapiens)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
MyD88 forms a complex with TIRAP:activated TLR2/4 (Homo sapiens)
SOCS1 [cytosol] (Homo sapiens)
Toll Like Receptor 4 (TLR4) Cascade (Homo sapiens)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
MyD88 forms a complex with TIRAP:activated TLR2/4 (Homo sapiens)
SOCS1 [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by SCF-KIT (Homo sapiens)
Regulation of KIT signaling (Homo sapiens)
SOCS1 as a regulator of KIT signaling (Homo sapiens)
SOCS1 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:O15524 SOCS1
Gene Names
SOCS1, SSI1, TIP3
Chain
chain:1-211
Reference Genes
BioGPS Gene:8651 SOCS1
COSMIC (genes):SOCS1 SOCS1
CTD Gene:8651 SOCS1
dbSNP Gene:8651 SOCS1
ENSEMBL:ENSG00000185338 SOCS1
ENSEMBL_homo_sapiens_GENE:ENSG00000185338.7 SOCS1
HGNC:19383 SOCS1
KEGG Gene (Homo sapiens):8651 SOCS1
Monarch:8651 SOCS1
NCBI Gene:8651 SOCS1
OMIM:603597 SOCS1
Reference Transcript
RefSeq:NM_003745.1 SOCS1
Other Identifiers
11737146_a_at
11754269_a_at
16823866
209999_PM_x_at
209999_x_at
210001_PM_s_at
210001_s_at
3680215
3680216
3680217
3680218
3680219
3680220
3680221
41592_at
48838_s_at
7999423
8651
A_23_P420196
A_24_P48014
GE53021
GO:0001817
GO:0001932
GO:0002376
GO:0004860
GO:0005159
GO:0005515
GO:0005634
GO:0005654
GO:0005737
GO:0005829
GO:0005942
GO:0006629
GO:0007155
GO:0007259
GO:0009968
GO:0016567
GO:0019210
GO:0019221
GO:0019901
GO:0023052
GO:0030154
GO:0030225
GO:0031410
GO:0035556
GO:0036211
GO:0036464
GO:0042509
GO:0042532
GO:0043226
GO:0043372
GO:0043377
GO:0045444
GO:0045591
GO:0046425
GO:0046426
GO:0046627
GO:0046854
GO:0046935
GO:0048856
GO:0071230
GO:0098772
HMNXSV003013528
Hs.50640.0.A1_3p_a_at
ILMN_1774733
PH_hs_0003492
TC16000862.hg
g2443364_3p_a_at
Participates
as a candidate of
SOCS5,(SOCS1) [cytosol] (Homo sapiens)
as an output of
Expression of SOCS1 (Homo sapiens)
p-Y-STAT1,3,5 dimer enhances expression of SOCS1 (Homo sapiens)
as a member of
CISH,SOCS1,SOCS2 [cytosol] (Homo sapiens)
SOCS [cytosol] (Homo sapiens)
CIS, SOCS1-3 [cytosol] (Homo sapiens)
SOCS-1 and SOCS-3 [cytosol] (Homo sapiens)
as a component of
SOCS1:p-KIT complex [plasma membrane] (Homo sapiens)
as an input of
SOCS1 as a regulator of KIT signaling (Homo sapiens)
This entity regulates
Negatively
MyD88 forms a complex with TIRAP:activated TLR2/4
(Homo sapiens)
Inferred To
SOCS1 [cytosol]
(Bos taurus)
SOCS1 [cytosol]
(Gallus gallus)
SOCS1 [cytosol]
(Sus scrofa)
Socs1 [cytosol]
(Mus musculus)
Socs1 [cytosol]
(Rattus norvegicus)
socs1 [cytosol]
(Xenopus tropicalis)
socs1a [cytosol]
(Danio rerio)
Cross References
RefSeq
NP_003736.1
OpenTargets
ENSG00000185338
HPA
ENSG00000185338-SOCS1
GeneCards
O15524
Ensembl
ENST00000644787
,
ENST00000332029
,
ENSP00000496577
,
ENSP00000329418
,
ENSG00000185338
PRO
O15524
Pharos - Targets
O15524
Interactors (7)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q15369 ELOC
2
TCEB1 [nucleoplasm]
(R-HSA-112422)
ELOC [cytosol]
(R-HSA-180535)
0.678
4
UniProt:Q99961 SH3GL1
1
SH3GL1 [cytosol]
(R-HSA-8867732)
0.556
3
UniProt:Q77YG1 Q77YG1
0.524
5
UniProt:Q8N668 COMMD1
2
COMMD1 [nucleoplasm]
(R-HSA-8955094)
COMMD1 [cytosol]
(R-HSA-8955110)
0.524
3
UniProt:P27986-2 PIK3R1
0.488
2
UniProt:P46108-2 CRK
0.488
2
UniProt:P46109 CRKL
2
CRKL [cytosol]
(R-HSA-354384)
p-CRKL [cytosol]
(R-HSA-9024730)
0.488
2
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