Reactome | HDAC1 [nucleoplasm]

HDAC1 [nucleoplasm]

Stable Identifier

R-HSA-205021

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

HDA1_HUMAN, Histone deacetylase 1

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Locations in the PathwayBrowser for interactor UniProt:Q9H9B1 EHMT1

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Disease (Homo sapiens)

- Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
  - Signaling by ALK in cancer (Homo sapiens)
    - Signaling by ALK fusions and activated point mutants (Homo sapiens)
      - Nuclear events stimulated by ALK signaling in cancer (Homo sapiens)
        
        STAT3, DNMT1 and HDAC1 bind PTPN6 gene (Homo sapiens)
        
        HDAC1 [nucleoplasm] (Homo sapiens)

Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - SUMOylation (Homo sapiens)
    - SUMO E3 ligases SUMOylate target proteins (Homo sapiens)
      - SUMOylation of chromatin organization proteins (Homo sapiens)
        
        SUMOylation of HDAC1 with SUMO1 (Homo sapiens)
        
        HDAC1 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q13547 HDAC1

Gene Names

HDAC1, RPD3L1

Chain

chain:1-482

Reference Genes

BioGPS Gene:3065 HDAC1

COSMIC (genes):HDAC1 HDAC1

CTD Gene:3065 HDAC1

dbSNP Gene:3065 HDAC1

ENSEMBL:ENSG00000116478 HDAC1

HGNC:4852 HDAC1

KEGG:hsa:3065 HDAC1

Monarch:3065 HDAC1

NCBI Gene:3065 HDAC1

OMIM:601241 HDAC1

UCSC:Q13547 HDAC1

Reference Transcript

RefSeq:NM_004964.2 HDAC1

Other Identifiers

11747406_a_at

11755718_s_at

11761287_a_at

16662077

201209_PM_at

201209_at

2328869

2328870

2328872

2328873

2328878

2328879

2328880

2328881

2328882

2328883

2328884

2328885

2328886

2328887

2328888

2328889

2328890

2328891

2328892

2328893

2328894

2328895

2328896

2328897

2328898

2328900

2328901

2328903

2381219

2927725

3065

38771_at

476_s_at

7899774

A_14_P113469

A_14_P114672

A_23_P114656

D50405_at

GE57241

GO:0000118

GO:0000122

GO:0000785

GO:0000792

GO:0000976

GO:0000978

GO:0000979

GO:0001046

GO:0001222

GO:0002039

GO:0003677

GO:0003682

GO:0003714

GO:0003824

GO:0004407

GO:0005515

GO:0005634

GO:0005654

GO:0005667

GO:0005737

GO:0005829

GO:0006325

GO:0006338

GO:0006346

GO:0006355

GO:0006357

GO:0006476

GO:0007492

GO:0007623

GO:0008284

GO:0009913

GO:0010628

GO:0010629

GO:0016581

GO:0016787

GO:0017053

GO:0019899

GO:0021766

GO:0030154

GO:0030182

GO:0030336

GO:0030512

GO:0031492

GO:0031507

GO:0032922

GO:0032991

GO:0033558

GO:0035851

GO:0036120

GO:0042475

GO:0042659

GO:0042733

GO:0042826

GO:0043025

GO:0043066

GO:0043124

GO:0043226

GO:0043922

GO:0045814

GO:0045892

GO:0045893

GO:0045944

GO:0046872

GO:0048511

GO:0048661

GO:0048709

GO:0048714

GO:0048856

GO:0051059

GO:0060090

GO:0060766

GO:0060789

GO:0061029

GO:0061198

GO:0061629

GO:0070822

GO:0070888

GO:0090090

GO:0140096

GO:0140110

GO:0140297

GO:0160008

GO:0160009

GO:1902455

GO:1902459

GO:1990841

GO:2000273

GO:2000736

GO:2001243

HMNXSV003006637

ILMN_1727458

PH_hs_0004954

TC01000427.hg

U50079_s_at

g13128859_3p_at

Participates

as a component of

as an input of

as an output of

as a member of

This entity regulates

Negatively

FOXD3 gene expression (Homo sapiens)

Other forms of this molecule

monoSUMO1-K444,K476-HDAC1 [nucleoplasm]

Inferred To

Hdac1 [nucleoplasm] (Mus musculus)

Hdac1 [nucleoplasm] (Rattus norvegicus)

clr6 [nucleoplasm] (Schizosaccharomyces pombe)

HDAC1 [nucleoplasm] (Bos taurus)

HDAC1 [nucleoplasm] (Caenorhabditis elegans)

HDAC1 [nucleoplasm] (Canis familiaris)

HDAC1 [nucleoplasm] (Dictyostelium discoideum)

HDAC1 [nucleoplasm] (Drosophila melanogaster)

HDAC1 [nucleoplasm] (Gallus gallus)

HDAC1 [nucleoplasm] (Plasmodium falciparum)

HDAC1 [nucleoplasm] (Sus scrofa)

HDAC1 [nucleoplasm] (Xenopus tropicalis)

RPD3 [nucleoplasm] (Saccharomyces cerevisiae)

Ghost homologue of HDAC1 [nucleoplasm] (Danio rerio)

Cross References

RefSeq

NP_004955.2

ZINC - World Drugs

HDAC1_HUMAN

Guide to Pharmacology - Targets

2658

OpenTargets

ENSG00000116478

ENSEMBL

ENST00000373548, ENSP00000362649

ZINC - FDA approved

HDAC1_HUMAN

ZINC - Substances

HDAC1_HUMAN

ZINC - Biogenic

HDAC1_HUMAN

ZINC target

Q13547

PRO

Q13547

GlyGen

Q13547

PDB

5ICN, 6Z2J, 6Z2K, 7AOA, 7AO9, 7SME, 7AO8, 4BKX

ZINC - Investigational

HDAC1_HUMAN

HPA

ENSG00000116478-HDAC1

Pharos - Targets

Q13547

ZINC - Predictions - Purchasable

HDAC1_HUMAN

Interactors (173)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P06400 RB1	20	RB1 R661W [nucleoplasm] (R-HSA-9659801) RB1 C706F [nucleoplasm] (R-HSA-9659812) RB1 N480del [nucleoplasm] (R-HSA-9659792) RB1 C706Y [nucleoplasm] (R-HSA-9659821) RB1 R661Q [nucleoplasm] (R-HSA-9659807) RB1 I703_E737del [nucleoplasm] (R-HSA-9661065) RB1 R830_G887del [cytosol] (R-HSA-9661059) RB1 K791* [cytosol] (R-HSA-9662284) RB1 Q176* [cytosol] (R-HSA-9661774) RB1 S114* [cytosol] (R-HSA-9661775) RB1 K765* [cytosol] (R-HSA-9662281) RB1 W99* [cytosol] (R-HSA-9661769) RB1 S149* [cytosol] (R-HSA-9661770) RB1 E166* [cytosol] (R-HSA-9661767) RB1 G100* [cytosol] (R-HSA-9661763) RB1 E125* [cytosol] (R-HSA-9661784) RB1 Q121* [cytosol] (R-HSA-9661780) RB1 E184* [cytosol] (R-HSA-9661781) RB1 E137* [cytosol] (R-HSA-9661782) RB1 K745* [cytosol] (R-HSA-9662288)	0.955	18
UniProt:O94776 MTA2	1	MTA2 [nucleoplasm] (R-HSA-4657009)	0.951	19
UniProt:Q92769 HDAC2	2	HDAC2 [nucleoplasm] (R-HSA-205135) monoSUMO1-K462-HDAC2 [nucleoplasm] (R-HSA-4615958)	0.946	21
UniProt:Q9UKL0 RCOR1	1	RCOR1 [nucleoplasm] (R-HSA-996766)	0.945	15
UniProt:Q13330 MTA1	2	MTA1 [nucleoplasm] (R-HSA-3465550) polySUMO2,3-K509-MTA1 [nucleoplasm] (R-HSA-3465537)	0.929	16
UniProt:Q8N108 MIER1			0.926	12
UniProt:Q14839 CHD4	1	CHD4 [nucleoplasm] (R-HSA-3702078)	0.924	15
UniProt:Q96ST3 SIN3A	2	SIN3A [nucleoplasm] (R-HSA-351657) monoSUMO1-SIN3A [nucleoplasm] (R-HSA-4086071)	0.918	13
UniProt:Q09028 RBBP4	1	RBBP4 [nucleoplasm] (R-HSA-212223)	0.916	14
UniProt:Q16576 RBBP7	1	RBBP7 [nucleoplasm] (R-HSA-212227)	0.909	12
UniProt:O95983 MBD3	1	MBD3 [nucleoplasm] (R-HSA-4657010)	0.899	10
UniProt:Q9UBB5 MBD2	1	MBD2 [nucleoplasm] (R-HSA-427367)	0.894	10
UniProt:Q8WXI9 GATAD2B	1	GATAD2B [nucleoplasm] (R-HSA-3702079)	0.877	10
UniProt:O60341 KDM1A	1	KDM1A [nucleoplasm] (R-HSA-996769)	0.855	12
UniProt:Q92618 ZN516			0.84	12
UniProt:Q86YP4 GATAD2A	1	GATAD2A [nucleoplasm] (R-HSA-3702077)	0.837	8
UniProt:Q5PSV4 BRM1L			0.837	8
UniProt:Q6PJG2 MDEAS			0.837	9
UniProt:O75446 SAP30	1	SAP30 [nucleoplasm] (R-HSA-351693)	0.837	9
UniProt:Q9H7L9 SUDS3	2	K63polyUb-SUDS3 [nucleoplasm] (R-HSA-6782790) SUDS3 [nucleoplasm] (R-HSA-351696)	0.837	8
UniProt:Q9NP66 HM20A			0.837	9
UniProt:Q9BTC8 MTA3	1	MTA3 [nucleoplasm] (R-HSA-4657013)	0.837	9
UniProt:Q9H147 TDIF1			0.837	10
UniProt:Q14865 ARID5B	1	ARID5B [nucleoplasm] (R-HSA-5423050)	0.835	9
UniProt:Q9NP50 SHCAF			0.835	10
UniProt:Q9HCU9 BRMS1	1	BRMS1 [nucleoplasm] (R-HSA-4650034)	0.832	8
UniProt:Q12873 CHD3	2	CHD3 [nucleoplasm] (R-HSA-4657012) monoSUMO1-K1971-CHD3 [nucleoplasm] (R-HSA-8956372)	0.805	9
UniProt:Q96KQ7 EHMT2	1	EHMT2 [nucleoplasm] (R-HSA-212151)	0.794	9
UniProt:O75182 SIN3B	1	SIN3B [nucleoplasm] (R-HSA-3006450)	0.788	7
UniProt:Q14687 GSE1			0.788	7
UniProt:Q9P0W2 HMG20B	1	HMG20B [nucleoplasm] (R-HSA-996745)	0.788	7
UniProt:P78371 CCT2	3	CCT2 [azurophil granule lumen] (R-HSA-6799356) CCT2 [extracellular region] (R-HSA-6806220) CCT2 [cytosol] (R-HSA-390464)	0.788	8
UniProt:P50991 CCT4	1	CCT4 [cytosol] (R-HSA-390458)	0.788	7
UniProt:Q7Z589 EMSY			0.788	7
UniProt:Q9UBW7 ZMYM2	6	ZMYM2(1-1057)-FLT3(586-993) fusion [cytosol] (R-HSA-9703311) ZMYM2(1-1059)-FLT3(594-993) fusion [cytosol] (R-HSA-9703310) ZMYM2(1-1057)-p-5Y-FLT3(586-993) fusion [cytosol] (R-HSA-9703319) ZMYM2(1-1059)-p-4Y-FLT3(594-993) fusion [cytosol] (R-HSA-9703309) ZMYM2(1-913)-FGFR1(429-822) fusion [cytosol] (R-HSA-1604544) ZMYM2(1-913)-p-FGFR1(429-822) fusion [cytosol] (R-HSA-1839016)	0.788	6
UniProt:O14519 CDKA1			0.788	8
UniProt:O75362 ZNF217	1	ZNF217 [nucleoplasm] (R-HSA-9011738)	0.788	7
UniProt:P17987 TCP1	1	TCP1 [cytosol] (R-HSA-390448)	0.788	7
UniProt:Q96N64 PWP2A			0.787	8
UniProt:Q6PH81 CP087			0.773	8
UniProt:P68400 CSNK2A1	2	CSNK2A1 [cytosol] (R-HSA-201713) CSNK2A1 [nucleoplasm] (R-HSA-6805057)	0.759	4
UniProt:Q99832 CCT7	1	CCT7 [cytosol] (R-HSA-390451)	0.725	6
UniProt:Q92766 RREB1			0.725	6
UniProt:Q9HAJ7 SAP30L	1	SAP30L [nucleoplasm] (R-HSA-351698)	0.725	6
UniProt:P48643 CCT5	1	CCT5 [cytosol] (R-HSA-390447)	0.725	5
UniProt:O15417 TNC18			0.725	5
UniProt:Q9H9B1 EHMT1	1	EHMT1 [nucleoplasm] (R-HSA-1183226)	0.725	4
UniProt:Q96QT6 PHF12			0.725	7
UniProt:Q9P2R6 RERE			0.725	6
UniProt:Q9H0E3 SAP130	1	SAP130 [nucleoplasm] (R-HSA-3006732)	0.725	6
UniProt:Q14202 ZMYM3			0.725	6
UniProt:Q9P2K3 RCOR3			0.725	6
UniProt:P49368 CCT3	1	CCT3 [cytosol] (R-HSA-390463)	0.725	7
UniProt:Q8WUU5 GATD1			0.725	5
UniProt:Q96PN7 TREF1			0.725	6
UniProt:Q8N680 ZBTB2			0.725	5
UniProt:P61964 WDR5	1	WDR5 [nucleoplasm] (R-HSA-1629838)	0.725	4
UniProt:Q9H160 ING2	2	monoSUMO1-K195-ING2 [nucleoplasm] (R-HSA-4086075) ING2 [nucleoplasm] (R-HSA-3215167)	0.725	6
UniProt:Q13363 CTBP1	3	CTBP1 [nucleoplasm] (R-HSA-212372) polySUMO2,3-K428-CTBP1 [nucleoplasm] (R-HSA-3108226) monoSUMO1-K428-CTBP1 [nucleoplasm] (R-HSA-3108200)	0.725	8
UniProt:P04637 TP53	20	Unfolded TP53 [cytosol] (R-HSA-6813797) TP53 [cytosol] (R-HSA-8869337) PolyUb-TP53 [nucleoplasm] (R-HSA-6782509) polySUMO2,3-K386-TP53 [nucleoplasm] (R-HSA-2997661) TP53 F341C [nucleoplasm] (R-HSA-9726318) TP53 G334V [nucleoplasm] (R-HSA-9726126) TP53 L330H [nucleoplasm] (R-HSA-9726124) TP53 A347T [nucleoplasm] (R-HSA-9726339) TP53 R337C [nucleoplasm] (R-HSA-9726118) TP53 L344P [nucleoplasm] (R-HSA-9726075) TP53 L344R [nucleoplasm] (R-HSA-9726073) TP53 R337H [nucleoplasm] (R-HSA-9726169) TP53 R337P [nucleoplasm] (R-HSA-9726168) TP53 L330P [nucleoplasm] (R-HSA-9726136) TP53 L348S [nucleoplasm] (R-HSA-9726366) TP53 R337L [nucleoplasm] (R-HSA-9726163) TP53 K351E [nucleoplasm] (R-HSA-9726258) TP53 F338I [nucleoplasm] (R-HSA-9726358) TP53 R342P [nucleoplasm] (R-HSA-9726101) TP53 L330R [nucleoplasm] (R-HSA-9726133)	0.713	7
UniProt:Q05516 ZBTB16	1	ZBTB16 [cytosol] (R-HSA-976047)	0.702	6
UniProt:Q9C0K0 BC11B			0.695	5
UniProt:P01106 MYC	2	MYC [nucleoplasm] (R-HSA-188379) PolyUb-MYC [nucleoplasm] (R-HSA-6783169)	0.69	4
UniProt:P62805 H4C1	17	HIST1H4 [nucleoplasm] (R-HSA-181902) Me2K21-HIST1H4 [nucleoplasm] (R-HSA-5651652) MeK21-HIST1H4 [nucleoplasm] (R-HSA-5423110) AcK-HIST1H4 [nucleoplasm] (R-HSA-3451124) AcK9-HIST1H4 [nucleoplasm] (R-HSA-4568758) AcK6-HIST1H4 [nucleoplasm] (R-HSA-4568748) AcK17-HIST1H4 [nucleoplasm] (R-HSA-427469) HIST1H4A [extracellular region] (R-HSA-977569) Me3K21-HIST1H4 [nucleoplasm] (R-HSA-5651656) MeR4-HIST1H4 [nucleoplasm] (R-HSA-4754240) Me2sR4-HIST1H4 [nucleoplasm] (R-HSA-4754243) Me2aR4-HIST1H4 [nucleoplasm] (R-HSA-5229015) AcK13-HIST1H4 [nucleoplasm] (R-HSA-4568744) AcK5,12-HIST1H4A [nucleoplasm] (R-HSA-212078) 4xAcK-HIST1H4A [nucleoplasm] (R-HSA-427390) monoSUMO1-HIST1H4 [nucleoplasm] (R-HSA-4570518) polySUMO3-HIST1H4 [nucleoplasm] (R-HSA-4570531)	0.688	3
UniProt:Q04206 RELA	7	RELA [nucleoplasm] (R-HSA-177676) RELA [cytosol] (R-HSA-168172) p-S276-RELA [nucleoplasm] (R-HSA-5624468) p-S276,5xAcK-RELA [nucleoplasm] (R-HSA-5660642) polySUMO3-K37,K122,K123-RELA [nucleoplasm] (R-HSA-4755466) p-S536-RELA [nucleoplasm] (R-HSA-9861499) MeK310-RELA [nucleoplasm] (R-HSA-8865233)	0.656	6
UniProt:P19838 NFKB1	8	3xUb-p-S927,S932-NFKB1(1-968) [cytosol] (R-HSA-451619) p-S927,S932-NFKB1(1-968) [cytosol] (R-HSA-451611) NFKB1(1-968) [cytosol] (R-HSA-451607) NFKB1(1-433) [nucleoplasm] (R-HSA-177655) NFKB1(1-433) [cytosol] (R-HSA-168168) NFKB1(1-968) [specific granule lumen] (R-HSA-6799557) NFKB1(1-968) [extracellular region] (R-HSA-6806304) NFKB1(1-968) [secretory granule lumen] (R-HSA-6801004)	0.646	5
UniProt:P52294 KPNA1	2	KPNA1 [cytosol] (R-HSA-180612) KPNA1 [nucleoplasm] (R-HSA-188865)	0.643	3
UniProt:P85037 FOXK1	1	FOXK1 [nucleoplasm] (R-HSA-5689673)	0.643	3
UniProt:Q8IZ40 RCOR2			0.643	5
UniProt:O15014 ZN609			0.643	3
UniProt:Q96BD5 PHF21A	1	PHF21A [nucleoplasm] (R-HSA-996754)	0.643	5
UniProt:Q99471 PFDN5	1	PFDN5 [cytosol] (R-HSA-379548)	0.643	4
UniProt:O95785 WIZ			0.643	3
UniProt:Q8IWI9 MGA	1	MGA [nucleoplasm] (R-HSA-8953093)	0.643	5
UniProt:P50990 CCT8	5	CCT8 [secretory granule lumen] (R-HSA-6801035) CCT8 [extracellular region] (R-HSA-6806238) CCT8 [azurophil granule lumen] (R-HSA-6799369) CCT8 [ficolin-1-rich granule lumen] (R-HSA-6800894) CCT8 [cytosol] (R-HSA-390449)	0.643	4
UniProt:Q8N344 MIER2			0.643	5
UniProt:Q9H165 BCL11A	2	BCL11A(1-219)insDHPPA-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9713447) BCL11A(1-219)insDHPPA-ALK(1058-1620) fusion [cytosol] (R-HSA-9713444)	0.643	4
UniProt:P0C0S8 H2AC11	11	Ack-HIST1H2AG [nucleoplasm] (R-HSA-4551311) HIST1H2AG [nucleoplasm] (R-HSA-212084) MeR12-HIST1H2AG [nucleoplasm] (R-HSA-5229206) Me2aR12-HIST1H2AG [nucleoplasm] (R-HSA-5229305) MeR4-HIST1H2AG [nucleoplasm] (R-HSA-5244623) Me2aR4-HIST1H2AG [nucleoplasm] (R-HSA-5244587) MeR30-HIST1H2AG [nucleoplasm] (R-HSA-5244560) Me2aR30-HIST1H2AG [nucleoplasm] (R-HSA-5244582) Ack6-HIST1H2AG [nucleoplasm] (R-HSA-4568595) Ub-HIST1H2AG [nucleoplasm] (R-HSA-6782508) K63polyUb-HIST1H2AG [nucleoplasm] (R-HSA-6783237)	0.643	3
UniProt:Q4LE39 ARID4B	1	ARID4B [nucleoplasm] (R-HSA-2976647)	0.643	5
UniProt:Q9ULU4 ZMYD8			0.643	3
UniProt:Q9P281 BAHC1			0.643	3
UniProt:P61758 VBP1	1	VBP1 [cytosol] (R-HSA-379543)	0.643	3
UniProt:Q96KM6 ZNF512B	1	ZNF512B [cytosol] (R-HSA-9715175)	0.643	3
UniProt:P29374 ARID4A	1	ARID4A [nucleoplasm] (R-HSA-4650032)	0.643	5
UniProt:Q7Z3K6 MIER3			0.643	5
UniProt:O00629 KPNA4	2	KPNA4 [cytosol] (R-HSA-1176066) KPNA4 [nucleoplasm] (R-HSA-1176058)	0.643	3
UniProt:Q8N1G0 ZN687			0.643	3
UniProt:O75461 E2F6	2	E2F6 [nucleoplasm] (R-HSA-8953089) p-S12-E2F6 [nucleoplasm] (R-HSA-9007536)	0.643	4
UniProt:Q14186 TFDP1	1	TFDP1 [nucleoplasm] (R-HSA-68652)	0.643	4
UniProt:Q9BYE7 PCGF6	1	PCGF6 [nucleoplasm] (R-HSA-8953572)	0.643	5
UniProt:Q96K83 ZNF521	1	ZNF521 [nucleoplasm] (R-HSA-3222324)	0.643	3
UniProt:O60315 ZEB2	1	ZEB2 [nucleoplasm] (R-HSA-3108222)	0.643	10
UniProt:O95863 SNAI1	1	SNAI1 [nucleoplasm] (R-HSA-2980903)	0.642	3
UniProt:Q2TB10 ZN800			0.615	3
UniProt:P03372 ESR1	10	ESR1 [cytosol] (R-HSA-9020968) ESR1 [nucleoplasm] (R-HSA-446168) Me260-PalmS-ESR1 [plasma membrane] (R-HSA-9637788) PalmS-ESR1 [plasma membrane] (R-HSA-9021057) PalmS-ESR1 [cytosol] (R-HSA-9020974) Me260-ESR1 [cytosol] (R-HSA-9632177) p-S167-ESR1 [cytosol] (R-HSA-9841254) p-S167-ESR1 [nucleoplasm] (R-HSA-9841867) monoSUMO1-5K-ESR1 [nucleoplasm] (R-HSA-4090302) p-S118-ESR1 [nucleoplasm] (R-HSA-9024210)	0.597	4
UniProt:P26358 DNMT1	2	DNMT1 [nucleoplasm] (R-HSA-212181) monoSUMO1-K-DNMT1 [nucleoplasm] (R-HSA-4655353)	0.597	7
UniProt:Q01094 E2F1	2	E2F1 [nucleoplasm] (R-HSA-68639) p-E2F1 [nucleoplasm] (R-HSA-187911)	0.589	2
UniProt:Q9Y618 NCOR2	2	NCOR2 [nucleoplasm] (R-HSA-442469) monoSUMO1-K672-NCOR2 [nucleoplasm] (R-HSA-3927904)	0.589	2
UniProt:Q9NQX1 PRDM5			0.576	3
UniProt:P17844 DDX5	4	DDX5 [nucleoplasm] (R-HSA-3900136) DDX5 [cytosol] (R-HSA-9682643) polySUMO2-K53-DDX5 [nucleoplasm] (R-HSA-3900186) monoSUMO1-K53-DDX5 [nucleoplasm] (R-HSA-3900041)	0.576	4
UniProt:O60341-1 KDM1A			0.564	2
UniProt:O95365 ZBT7A			0.564	2
UniProt:P08047 SP1	1	SP1 [nucleoplasm] (R-HSA-1592223)	0.564	2
UniProt:P17542 TAL1	1	TAL1 [nucleoplasm] (R-HSA-8956511)	0.558	5
UniProt:Q9UJW3 DNMT3L	1	DNMT3L [nucleoplasm] (R-HSA-5334123)	0.544	3
UniProt:Q99497 PARK7	7	PolyUb-Misfolded PARK7 [lysosomal lumen] (R-HSA-9659997) PolyUb-Misfolded PARK7 [cytosol] (R-HSA-9641128) Ub-Misfolded PARK7 [cytosol] (R-HSA-9641123) Misfolded PARK7 [cytosol] (R-HSA-9641100) PolyUb-Misfolded PARK7 [late endosome lumen] (R-HSA-9660005) PARK7 [nucleoplasm] (R-HSA-3900141) monoSUMO1-K130-PARK7 [nucleoplasm] (R-HSA-4085351)	0.537	4
UniProt:P22670 RFX1			0.534	2
UniProt:Q8N5A5 ZGPAT			0.532	3
UniProt:Q17R98 ZN827			0.527	2
UniProt:Q9NSC2 SALL1	1	SALL1 [nucleoplasm] (R-HSA-452500)	0.527	2
UniProt:Q9P2K3-3 RCOR3			0.527	2
UniProt:Q8IV32 CCD71			0.527	3
UniProt:Q969G3 SMARCE1	1	SMARCE1 [nucleoplasm] (R-HSA-389258)	0.527	2
UniProt:Q6NUJ5 PWP2B			0.527	2
UniProt:Q92526 CCT6B	1	CCT6B [cytosol] (R-HSA-5216201)	0.527	3
UniProt:Q14839-2 CHD4			0.527	2
UniProt:P56545 CTBP2	1	CTBP2 [nucleoplasm] (R-HSA-5333990)	0.527	2
UniProt:Q4LE39-2 ARID4B			0.527	2
UniProt:Q9UHF7 TRPS1			0.527	2
UniProt:Q9R190 Mta2	1	Mta2 [nucleoplasm] (R-MMU-5096453)	0.527	2
UniProt:Q9UHV9 PFDN2	1	PFDN2 [cytosol] (R-HSA-379544)	0.527	2
UniProt:P40227 CCT6A	1	CCT6A [cytosol] (R-HSA-390454)	0.527	3
UniProt:O60925 PFDN1	1	PFDN1 [cytosol] (R-HSA-379541)	0.527	2
UniProt:Q9UK53 ING1			0.527	4
UniProt:P29375-2 KDM5A			0.527	2
UniProt:Q9Y232-2 CDYL			0.527	2
UniProt:Q96BD5-2 PHF21A			0.527	2
UniProt:Q9H2P0 ADNP			0.527	2
UniProt:Q8WY36 BBX			0.527	2
UniProt:Q9ULD9 ZN608			0.527	2
UniProt:IL2 ENSG00000109471			0.527	3
UniProt:O75182-2 SIN3B			0.527	2
UniProt:Q09028-2 RBBP4			0.527	2
UniProt:Q5T5X7 BEND3			0.527	2
UniProt:Q92610 ZN592			0.527	2
UniProt:Q8WWY6 MB3L1			0.527	3
UniProt:Q96EK2 PF21B			0.527	3
UniProt:Q9P2Y4 ZN219			0.527	5
UniProt:O15212 PFDN6	1	PFDN6 [cytosol] (R-HSA-379547)	0.527	2
UniProt:Q8TDI0 CHD5			0.527	4
UniProt:Q8TBE0 BAHD1			0.527	3
UniProt:Q96A08 H2BC1	9	HIST1H2BA [nucleoplasm] (R-HSA-181916) Ub-122-HIST1H2BA [nucleoplasm] (R-HSA-3364020) AcK22-HIST1H2BA [nucleoplasm] (R-HSA-4568647) AcK17-HIST1H2BA [nucleoplasm] (R-HSA-4568631) AcK14-HIST1H2BA [nucleoplasm] (R-HSA-4568615) AcK7-HIST1H2BA [nucleoplasm] (R-HSA-4568624) HIST1H2BA [extracellular region] (R-HSA-977582) AcK-HIST1H2BA [nucleoplasm] (R-HSA-4549263) Ub-HIST1H2BA [nucleoplasm] (R-HSA-6782561)	0.527	4
UniProt:Q96KQ7-2 EHMT2			0.527	2
UniProt:Q9UHJ3 SMBT1			0.527	2
UniProt:P29375 KDM5A	1	KDM5A [nucleoplasm] (R-HSA-3215029)	0.527	3
UniProt:O60684 KPNA6	2	KPNA6 [nucleoplasm] (R-HSA-9734665) KPNA6 [cytosol] (R-HSA-9734672)	0.527	2
UniProt:Q9Y232 CDYL			0.527	4
UniProt:O75530 EED	1	EED [nucleoplasm] (R-HSA-212278)	0.527	3
UniProt:Q8N4J0 CARNMT1	1	CARNMT1 [cytosol] (R-HSA-8876689)	0.527	3
UniProt:Q969R5 L3MBTL2	2	L3MBTL2 [nucleoplasm] (R-HSA-6804477) polySUMO2-K675,K700-L3MBTL2 [nucleoplasm] (R-HSA-6804480)	0.527	4
UniProt:Q9UKL3 CASP8AP2	2	monoSUMO1-K1813-CASP8AP2 [nucleoplasm] (R-HSA-3927850) CASP8AP2 [nucleoplasm] (R-HSA-3927945)	0.527	3
UniProt:P43355 MAGA1			0.524	2
UniProt:Q92841-4 DDX17			0.524	3
UniProt:O00422 SAP18	1	SAP18 [nucleoplasm] (R-HSA-351694)	0.524	2
UniProt:P03129 VE7			0.524	2
UniProt:Q66K89 E4F1			0.524	3
UniProt:P29128 ICP0			0.524	2
UniProt:O43463 SUV39H1	1	SUV39H1 [nucleoplasm] (R-HSA-427517)	0.524	3
UniProt:P06748 NPM1	11	NPM1 [cytosol] (R-HSA-3008211) p-S4-NPM1 [cytosol] (R-HSA-6801679) NPM1 [nucleoplasm] (R-HSA-606320) NPM1 [granular component] (R-HSA-9017702) NPM1(1-117)-ALK(1058-1620) fusion [cytosol] (R-HSA-9699834) NPM1(1-117)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9699861) NPM1(1-117)-ALK(1068-1620) fusion [cytosol] (R-HSA-9730697) NPM1(1-117)-p-7Y-ALK(1068-1620) fusion [cytosol] (R-HSA-9730703) NPM1(1-117)-p-7Y-ALK(1058-1620) fusion [nucleoplasm] (R-HSA-9725010) polySUMO2,3-K263-NPM1 [nucleoplasm] (R-HSA-4086056) monoSUMO1-K263-NPM1 [nucleoplasm] (R-HSA-4086039)	0.524	2
UniProt:O15379 HDAC3	2	HDAC3 [nucleoplasm] (R-HSA-442464) Unfolded HDAC3 [cytosol] (R-HSA-6813777)	0.524	2
UniProt:Q9UIS9 MBD1	2	MBD1 [nucleoplasm] (R-HSA-417134) monoSUMO1-K499,K538-MBD1 [nucleoplasm] (R-HSA-4090331)	0.524	2
UniProt:P51858 HDGF	1	HDGF [nucleoplasm] (R-HSA-535593)	0.512	4
UniProt:Q92949 FOXJ1			0.508	2
IntAct:EBI-2694074 MDM2			0.499	2
UniProt:Q15466 NR0B2	1	NR0B2 [nucleoplasm] (R-HSA-376312)	0.499	2
UniProt:Q13227 GPS2	1	GPS2 [nucleoplasm] (R-HSA-351642)	0.499	2
UniProt:Q9UER7 DAXX	13	DAXX [nucleoplasm] (R-HSA-3222068) DAXX A36Qfs108 [nucleoplasm] (R-HSA-9673105) DAXX K56 [nucleoplasm] (R-HSA-9673089) DAXX A103Sfs40 [nucleoplasm] (R-HSA-9673121) DAXX C106 [nucleoplasm] (R-HSA-9673079) DAXX E72Nfs72 [nucleoplasm] (R-HSA-9673110) DAXX E104 [nucleoplasm] (R-HSA-9673078) DAXX H26Tfs118 [nucleoplasm] (R-HSA-9673114) DAXX S138 [nucleoplasm] (R-HSA-9673081) DAXX C74* [nucleoplasm] (R-HSA-9673096) DAXX R48Vfs93 [nucleoplasm] (R-HSA-9673103) DAXX L98Vfs13 [nucleoplasm] (R-HSA-9673102) monoSUMO1-K630,K631-DAXX [nucleoplasm] (R-HSA-4086086)	0.499	2
UniProt:Q99684 GFI1	1	GFI1 [nucleoplasm] (R-HSA-2980932)	0.499	4
UniProt:P51610 HCFC1	2	K48polyUb,K63polyUb-HCFC1 [nucleoplasm] (R-HSA-5690821) HCFC1 [nucleoplasm] (R-HSA-1592209)	0.499	2
UniProt:Q9UKG1 APPL1	1	APPL1 [endosome membrane] (R-HSA-373630)	0.483	2
UniProt:A4PIW0 A4PIW0			0.462	3
UniProt:P23771 GATA3	2	GATA3 [nucleoplasm] (R-HSA-996768) PolyUb-GATA3 [nucleoplasm] (R-HSA-6783009)	0.462	4
UniProt:P46531 NOTCH1	20	NOTCH1 L1678P S2 cleavage fragment [extracellular region] (R-HSA-2730745) NOTCH1 I1680N S2 cleavage fragment [extracellular region] (R-HSA-2730744) NOTCH1 I1718T S2 cleavage fragment [extracellular region] (R-HSA-2730757) NOTCH1 A1701P S2 cleavage fragment [plasma membrane] (R-HSA-2730742) NOTCH1 V1676D S2 cleavage fragment [extracellular region] (R-HSA-2730755) NOTCH1 I1680N Transmembrane Fragment [plasma membrane] (R-HSA-2684869) NOTCH1 I1718T Transmembrane Fragment [plasma membrane] (R-HSA-2684881) NOTCH1 I1616T Extracellular Fragment [extracellular region] (R-HSA-2684866) NOTCH1 L1596H Extracellular Fragment [extracellular region] (R-HSA-2684853) NOTCH1 L1678P Transmembrane Fragment [plasma membrane] (R-HSA-1485591) NOTCH1 A1701P Transmembrane Fragment [plasma membrane] (R-HSA-1485585) NOTCH1 I1616N Extracellular Fragment [extracellular region] (R-HSA-2684862) NOTCH1 L1593P Extracellular Fragment [extracellular region] (R-HSA-1485584) NOTCH1 R1598P Extracellular Fragment [extracellular region] (R-HSA-1485592) NOTCH1 V1576E Extracellular Fragment [extracellular region] (R-HSA-2684852) NOTCH1 V1676D Transmembrane Fragment [plasma membrane] (R-HSA-2684874) NOTCH1 F1592S Extracellular Fragment [extracellular region] (R-HSA-2684847) NOTCH1 L1574Q Extracellular Fragment [extracellular region] (R-HSA-2691203) p-NICD1 Q2440* [nucleoplasm] (R-HSA-2902207) p-NICD1 Q2395* [nucleoplasm] (R-HSA-2902205)	0.462	2

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