Reactome | AATF [cytosol]

AATF [cytosol]

Stable Identifier

R-HSA-205071

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

CHE1, Protein AATF, AATF_HUMAN

Locations in the PathwayBrowser for interactor UniProt:Q8NEH6 MNS1

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External Reference Information

External Reference

UniProt:Q9NY61 AATF

Gene Names

AATF, CHE1, DED, HSPC277

Chain

initiator methionine:, chain:2-560

Reference Genes

BioGPS Gene:26574 AATF

CTD Gene:26574 AATF

dbSNP Gene:26574 AATF

ENSEMBL:ENSG00000275700 AATF

HGNC:19235 AATF

KEGG:hsa:26574 AATF

Monarch:26574 AATF

NCBI Gene:26574 AATF

OMIM:608463 AATF

UCSC:Q9NY61 AATF

Reference Transcript

RefSeq:NM_012138.3 AATF

Other Identifiers

11732137_at

16833518

209165_PM_at

209165_at

26574

32117_at

3719363

3719364

3719365

3719366

3719367

3719368

3719369

3719370

3719371

3719372

3719373

3719377

3719379

3719380

3719381

3719382

3719390

3719391

3719392

3719393

3719394

3719395

3719399

3719400

3719401

3719402

3719403

3719404

3719405

3719406

3719407

3719408

8006690

A_14_P113500

A_14_P113553

A_23_P89460

A_24_P262395

GE55294

GO:0003723

GO:0005515

GO:0005634

GO:0005654

GO:0005667

GO:0005730

GO:0005737

GO:0006355

GO:0006357

GO:0007155

GO:0007346

GO:0008092

GO:0019901

GO:0032040

GO:0040016

GO:0042254

GO:0042274

GO:0042985

GO:0043066

GO:0043226

GO:0043522

GO:0045893

GO:0048156

GO:2001234

HMNXSV003044137

ILMN_1703743

PH_hs_0023719

TC17000444.hg

g5813798_3p_at

Participates

as a component of

NGF ligand:p75NTR:NRAGE:CHE1 [plasma membrane] (Homo sapiens)

as an input of

NRAGE sequesters CHE1 in the cytoplasm (Homo sapiens)

Cross References

RefSeq

NP_036270.1

OpenTargets

ENSG00000275700

ENSEMBL

ENST00000619387, ENSP00000477848, ENSP00000481894, ENST00000620004

HPA

ENSG00000275700-AATF

PRO

Q9NY61

Pharos - Targets

Q9NY61

GlyGen

Q9NY61

PDB

7MQ9, 7MQ8, 5W6A

Interactors (23)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q8NEJ9 NGDN			0.806	6
UniProt:O96017 CHEK2	3	p-S,3T-CHEK2 [nucleoplasm] (R-HSA-5683784) CHEK2 [nucleoplasm] (R-HSA-113824) p-T68-CHEK2 [nucleoplasm] (R-HSA-113825)	0.602	4
UniProt:P27986-2 PIK3R1			0.556	3
UniProt:P63000 RAC1	6	RAC1 [plasma membrane] (R-HSA-351141) RAC1 [cytosol] (R-HSA-442615) GGC-PalmC-RAC1 [plasma membrane] (R-HSA-2316446) RAC1 [ficolin-1-rich granule membrane] (R-HSA-6804802) RAC1 [secretory granule membrane] (R-HSA-6804770) RAC1 [endoplasmic reticulum membrane] (R-HSA-5672076)	0.556	3
UniProt:P05067 APP	20	APP(672-713) [extracellular region] (R-HSA-879340) APP(672-711) [cytosol] (R-HSA-877188) APP(672-711) [extracellular region] (R-HSA-976740) APP [endoplasmic reticulum lumen] (R-HSA-8956696) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP(18-770) [endosome lumen] (R-HSA-5229077) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-687) [extracellular region] (R-HSA-9010033) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) APP(18-770) [extracellular region] (R-HSA-49335) APP-C99 [cytosol] (R-HSA-9617603) APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136)	0.556	3
UniProt:Q8NEH6 MNS1			0.556	3
UniProt:Q13315 ATM	5	ATM [cytosol] (R-HSA-9665171) ATM [peroxisomal matrix] (R-HSA-9665169) p-S1981,Ac-K3016-ATM [nucleoplasm] (R-HSA-5693527) ATM [nucleoplasm] (R-HSA-69484) Ac-K3016-ATM [nucleoplasm] (R-HSA-5682043)	0.544	3
UniProt:P08047 SP1	1	SP1 [nucleoplasm] (R-HSA-1592223)	0.544	2
UniProt:Q86TJ2 TADA2B	1	TADA2B [nucleoplasm] (R-HSA-3322963)	0.543	4
UniProt:O75478 TADA2A	1	TADA2A [nucleoplasm] (R-HSA-3662284)	0.543	4
UniProt:Q92830 KAT2A	1	KAT2A [nucleoplasm] (R-HSA-3006516)	0.543	4
UniProt:P15880 RPS2	3	RPS2 [cytosol] (R-HSA-72347) Me2aR-RPS2 [cytosol] (R-HSA-8879138) RPS2 [nucleoplasm] (R-HSA-6790655)	0.527	3
UniProt:P0DTC9 N	13	SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [cytosol] (R-COV-9729340) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9729341) ADPr-p-11S,2T-metR95,177-N [cytosol] (R-COV-9729275) p-11S,2T-metR95,177-N [cytosol] (R-COV-9729308) p-11S,2T-N [cytosol] (R-COV-9729264) p-8S,2T-N [cytosol] (R-COV-9729277) p-8S-N [cytosol] (R-COV-9729335) p-S188,206-N [cytosol] (R-COV-9729324) N [cytosol] (R-COV-9694300) SUMO1-K62,ADPr-,p-11S,2T,met-R95,177,Ac-K375-N [cytosol] (R-COV-9756489) N [plasma membrane] (R-COV-9694356) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [nucleolus] (R-COV-9729339) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [plasma membrane] (R-COV-9729325)	0.527	2
UniProt:P0DTD1-PRO_0000449626 REP			0.527	2
UniProt:Q04206 RELA	7	RELA [nucleoplasm] (R-HSA-177676) RELA [cytosol] (R-HSA-168172) p-S276-RELA [nucleoplasm] (R-HSA-5624468) p-S276,5xAcK-RELA [nucleoplasm] (R-HSA-5660642) polySUMO3-K37,K122,K123-RELA [nucleoplasm] (R-HSA-4755466) p-S536-RELA [nucleoplasm] (R-HSA-9861499) MeK310-RELA [nucleoplasm] (R-HSA-8865233)	0.524	3
UniProt:Q99708 RBBP8	4	p-S327,T847-RBBP8 [nucleoplasm] (R-HSA-5684083) RBBP8 [nucleoplasm] (R-HSA-912399) Ac-K-RBBP8 [nucleoplasm] (R-HSA-5685955) p-S327,T847,T859-RBBP8 [nucleoplasm] (R-HSA-5684138)	0.508	3
UniProt:Q6ZWQ9 Q6ZWQ9			0.508	3
UniProt:O75528 TADA3	1	TADA3 [nucleoplasm] (R-HSA-3322966)	0.508	2
UniProt:P52435 POLR2J	1	POLR2J [nucleoplasm] (R-HSA-63531)	0.508	2
UniProt:Q8WYQ5 DGCR8	1	DGCR8 [nucleoplasm] (R-HSA-1482509)	0.483	2
UniProt:P06748 NPM1	11	NPM1 [cytosol] (R-HSA-3008211) p-S4-NPM1 [cytosol] (R-HSA-6801679) NPM1 [nucleoplasm] (R-HSA-606320) NPM1 [granular component] (R-HSA-9017702) NPM1(1-117)-ALK(1058-1620) fusion [cytosol] (R-HSA-9699834) NPM1(1-117)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9699861) NPM1(1-117)-ALK(1068-1620) fusion [cytosol] (R-HSA-9730697) NPM1(1-117)-p-7Y-ALK(1068-1620) fusion [cytosol] (R-HSA-9730703) NPM1(1-117)-p-7Y-ALK(1058-1620) fusion [nucleoplasm] (R-HSA-9725010) polySUMO2,3-K263-NPM1 [nucleoplasm] (R-HSA-4086056) monoSUMO1-K263-NPM1 [nucleoplasm] (R-HSA-4086039)	0.483	2
UniProt:P62753 RPS6	4	RPS6 [cytosol] (R-HSA-72381) p-5S-RPS6 [cytosol] (R-HSA-165727) 3OHR147-RPS6 [cytosol] (R-HSA-9629876) RPS6 [nucleoplasm] (R-HSA-6790606)	0.483	3
UniProt:P10636 MAPT	3	MAPT(422-758) [cytosol] (R-HSA-350642) MAPT(2-421) [cytosol] (R-HSA-350628) MAPT [cytosol] (R-HSA-201574)	0.471	2

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