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Interaction of Src family kinases with p-KIT
Stable Identifier
R-HSA-205205
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane
,
cytosol
,
extracellular region
ReviewStatus
5/5
Locations in the PathwayBrowser
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Signal Transduction (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by SCF-KIT (Homo sapiens)
Interaction of Src family kinases with p-KIT (Homo sapiens)
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Binding of SCF to KIT induces the activation and rapid increase in kinase activity of multiple Src family kinases (SFK), including Src, Lck, Tec, Fyn, and Lyn (Timokhina et al. 1998, Krystal et al. 1998, Linnekin et al. 1997, Lennartsson et al. 1999, Tang et al. 1994, Samayawardhena et al. 2007). The tyrosine residues Y568 and Y570 in KIT juxtamembrane region are involved in the association of SFKs (Price et al. 1997).
SFKs recruited to KIT induce proliferation and chemotaxis in primary hematopoietic progenitor cells or bone marrow derived mast cells (O'Laughlin-Bunner et al. 2001). SCF activated SFKs also mediate a critical signal for lymphocyte development (Agosti et al. 2004). Timokhina et al. demonstrated that Src kinase and PI3-kinase signaling pathways converge to activate Rac1 and JNK after SCF stimulation in BMMC, promoting cell proliferation (Timokhina et al., 1998, Reber et al. 2006 ).
Participants
Input
p-7Y-KIT:sSCF dimer:p-7Y-KIT [plasma membrane]
(Homo sapiens)
Src family tyrosine kinases (SFKs) [cytosol]
(Homo sapiens)
Output
SFKs:p-KIT complex [plasma membrane]
(Homo sapiens)
Participates
as an event of
Signaling by SCF-KIT (Homo sapiens)
Inferred From
Interaction of Src kinases with c-Kit (Mus musculus)
Authored
Garapati, P V (2011-07-11)
Reviewed
Rönnstrand, L (2011-08-22)
Created
Garapati, P V (2007-12-10)
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