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p-7Y-KIT [plasma membrane]
Stable Identifier
R-HSA-205207
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
autophosphorylated Kit
Icon
Locations in the PathwayBrowser
Expand all
Developmental Biology (Homo sapiens)
MITF-M-regulated melanocyte development (Homo sapiens)
Transcriptional and post-translational regulation of MITF-M expression and activity (Homo sapiens)
MAPK-dependent phosphorylation of KARS (Homo sapiens)
p-7Y-KIT:sSCF dimer:p-7Y-KIT [plasma membrane] (Homo sapiens)
p-7Y-KIT [plasma membrane] (Homo sapiens)
MAPK1-dependent phosphorylation of MITF-M (Homo sapiens)
p-7Y-KIT:sSCF dimer:p-7Y-KIT [plasma membrane] (Homo sapiens)
p-7Y-KIT [plasma membrane] (Homo sapiens)
RPS6KA1-dependent phosphorylation of MITF-M (Homo sapiens)
p-7Y-KIT:sSCF dimer:p-7Y-KIT [plasma membrane] (Homo sapiens)
p-7Y-KIT [plasma membrane] (Homo sapiens)
Disease (Homo sapiens)
Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
PI3K/AKT Signaling in Cancer (Homo sapiens)
Constitutive Signaling by Aberrant PI3K in Cancer (Homo sapiens)
PI3K inhibitors block PI3K catalytic activity (Homo sapiens)
PI3K Inhibitors:PI3K [cytosol] (Homo sapiens)
PI3K mutants,Activator:PI3K [plasma membrane] (Homo sapiens)
Activator:PI3K [plasma membrane] (Homo sapiens)
PI3K:p-KIT:sSCF dimer:p-KIT [plasma membrane] (Homo sapiens)
p-7Y-KIT:sSCF dimer:p-7Y-KIT [plasma membrane] (Homo sapiens)
p-7Y-KIT [plasma membrane] (Homo sapiens)
PI3K mutants,Activator:PI3K [plasma membrane] (Homo sapiens)
Activator:PI3K [plasma membrane] (Homo sapiens)
PI3K:p-KIT:sSCF dimer:p-KIT [plasma membrane] (Homo sapiens)
p-7Y-KIT:sSCF dimer:p-7Y-KIT [plasma membrane] (Homo sapiens)
p-7Y-KIT [plasma membrane] (Homo sapiens)
Signal Transduction (Homo sapiens)
Intracellular signaling by second messengers (Homo sapiens)
PIP3 activates AKT signaling (Homo sapiens)
Negative regulation of the PI3K/AKT network (Homo sapiens)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Homo sapiens)
PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
Activator:PI3K [plasma membrane] (Homo sapiens)
PI3K:p-KIT:sSCF dimer:p-KIT [plasma membrane] (Homo sapiens)
p-7Y-KIT:sSCF dimer:p-7Y-KIT [plasma membrane] (Homo sapiens)
p-7Y-KIT [plasma membrane] (Homo sapiens)
PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
Activator:PI3K [plasma membrane] (Homo sapiens)
PI3K:p-KIT:sSCF dimer:p-KIT [plasma membrane] (Homo sapiens)
p-7Y-KIT:sSCF dimer:p-7Y-KIT [plasma membrane] (Homo sapiens)
p-7Y-KIT [plasma membrane] (Homo sapiens)
MAPK family signaling cascades (Homo sapiens)
MAPK1/MAPK3 signaling (Homo sapiens)
RAF/MAP kinase cascade (Homo sapiens)
RAS GEFs promote RAS nucleotide exchange (Homo sapiens)
RAS GEFs [plasma membrane] (Homo sapiens)
GRB2:SOS1:p-KIT complex [plasma membrane] (Homo sapiens)
p-7Y-KIT:sSCF dimer:p-7Y-KIT [plasma membrane] (Homo sapiens)
p-7Y-KIT [plasma membrane] (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by SCF-KIT (Homo sapiens)
Activation of RAS by p-KIT bound SOS1 (Homo sapiens)
GRB2:SOS1:p-KIT complex [plasma membrane] (Homo sapiens)
p-7Y-KIT:sSCF dimer:p-7Y-KIT [plasma membrane] (Homo sapiens)
p-7Y-KIT [plasma membrane] (Homo sapiens)
Autophosphorylation of KIT (Homo sapiens)
p-7Y-KIT:sSCF dimer:p-7Y-KIT [plasma membrane] (Homo sapiens)
p-7Y-KIT [plasma membrane] (Homo sapiens)
Dimerization of STATs (Homo sapiens)
p-JAK2:SFKs:p-KIT complex:p-STAT dimers [plasma membrane] (Homo sapiens)
SFKs:p-KIT complex [plasma membrane] (Homo sapiens)
p-7Y-KIT:sSCF dimer:p-7Y-KIT [plasma membrane] (Homo sapiens)
p-7Y-KIT [plasma membrane] (Homo sapiens)
p-JAK2:SFKs:p-KIT complex:p-STATs [plasma membrane] (Homo sapiens)
SFKs:p-KIT complex [plasma membrane] (Homo sapiens)
p-7Y-KIT:sSCF dimer:p-7Y-KIT [plasma membrane] (Homo sapiens)
p-7Y-KIT [plasma membrane] (Homo sapiens)
Direct recruitment of PI3K to p-KIT (Homo sapiens)
PI3K:p-KIT:sSCF dimer:p-KIT [plasma membrane] (Homo sapiens)
p-7Y-KIT:sSCF dimer:p-7Y-KIT [plasma membrane] (Homo sapiens)
p-7Y-KIT [plasma membrane] (Homo sapiens)
p-7Y-KIT:sSCF dimer:p-7Y-KIT [plasma membrane] (Homo sapiens)
p-7Y-KIT [plasma membrane] (Homo sapiens)
Disassociation and translocation of STATs to the nucleus (Homo sapiens)
p-JAK2:SFKs:p-KIT complex [plasma membrane] (Homo sapiens)
SFKs:p-KIT complex [plasma membrane] (Homo sapiens)
p-7Y-KIT:sSCF dimer:p-7Y-KIT [plasma membrane] (Homo sapiens)
p-7Y-KIT [plasma membrane] (Homo sapiens)
p-JAK2:SFKs:p-KIT complex:p-STAT dimers [plasma membrane] (Homo sapiens)
SFKs:p-KIT complex [plasma membrane] (Homo sapiens)
p-7Y-KIT:sSCF dimer:p-7Y-KIT [plasma membrane] (Homo sapiens)
p-7Y-KIT [plasma membrane] (Homo sapiens)
GRB2 is indirectly recruited to p-KIT through SHP2 (Homo sapiens)
GRB2:p-SHP2:p-KIT complex [plasma membrane] (Homo sapiens)
p-SHP2:p-KIT complex [plasma membrane] (Homo sapiens)
SFKs:p-KIT complex [plasma membrane] (Homo sapiens)
p-7Y-KIT:sSCF dimer:p-7Y-KIT [plasma membrane] (Homo sapiens)
p-7Y-KIT [plasma membrane] (Homo sapiens)
p-SHP2:p-KIT complex [plasma membrane] (Homo sapiens)
SFKs:p-KIT complex [plasma membrane] (Homo sapiens)
p-7Y-KIT:sSCF dimer:p-7Y-KIT [plasma membrane] (Homo sapiens)
p-7Y-KIT [plasma membrane] (Homo sapiens)
GRB2:SOS interacts with p-KIT (Homo sapiens)
GRB2:SOS1:p-KIT complex [plasma membrane] (Homo sapiens)
p-7Y-KIT:sSCF dimer:p-7Y-KIT [plasma membrane] (Homo sapiens)
p-7Y-KIT [plasma membrane] (Homo sapiens)
p-7Y-KIT:sSCF dimer:p-7Y-KIT [plasma membrane] (Homo sapiens)
p-7Y-KIT [plasma membrane] (Homo sapiens)
Indirect recruitment of GAB2 to p-KIT (Homo sapiens)
GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Homo sapiens)
GRB2:p-SHP2:p-KIT complex [plasma membrane] (Homo sapiens)
p-SHP2:p-KIT complex [plasma membrane] (Homo sapiens)
SFKs:p-KIT complex [plasma membrane] (Homo sapiens)
p-7Y-KIT:sSCF dimer:p-7Y-KIT [plasma membrane] (Homo sapiens)
p-7Y-KIT [plasma membrane] (Homo sapiens)
GRB2:p-SHP2:p-KIT complex [plasma membrane] (Homo sapiens)
p-SHP2:p-KIT complex [plasma membrane] (Homo sapiens)
SFKs:p-KIT complex [plasma membrane] (Homo sapiens)
p-7Y-KIT:sSCF dimer:p-7Y-KIT [plasma membrane] (Homo sapiens)
p-7Y-KIT [plasma membrane] (Homo sapiens)
Indirect recruitment of PI3K to KIT via p(Y)-GAB2 (Homo sapiens)
PI3K:p(Y)-GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Homo sapiens)
GRB2:p-SHP2:p-KIT complex [plasma membrane] (Homo sapiens)
p-SHP2:p-KIT complex [plasma membrane] (Homo sapiens)
SFKs:p-KIT complex [plasma membrane] (Homo sapiens)
p-7Y-KIT:sSCF dimer:p-7Y-KIT [plasma membrane] (Homo sapiens)
p-7Y-KIT [plasma membrane] (Homo sapiens)
p(Y)-GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Homo sapiens)
GRB2:p-SHP2:p-KIT complex [plasma membrane] (Homo sapiens)
p-SHP2:p-KIT complex [plasma membrane] (Homo sapiens)
SFKs:p-KIT complex [plasma membrane] (Homo sapiens)
p-7Y-KIT:sSCF dimer:p-7Y-KIT [plasma membrane] (Homo sapiens)
p-7Y-KIT [plasma membrane] (Homo sapiens)
Interaction of Src family kinases with p-KIT (Homo sapiens)
SFKs:p-KIT complex [plasma membrane] (Homo sapiens)
p-7Y-KIT:sSCF dimer:p-7Y-KIT [plasma membrane] (Homo sapiens)
p-7Y-KIT [plasma membrane] (Homo sapiens)
p-7Y-KIT:sSCF dimer:p-7Y-KIT [plasma membrane] (Homo sapiens)
p-7Y-KIT [plasma membrane] (Homo sapiens)
Interaction of other adapter proteins with p-KIT (Homo sapiens)
Adapter proteins:p-KIT complex [plasma membrane] (Homo sapiens)
p-7Y-KIT:sSCF dimer:p-7Y-KIT [plasma membrane] (Homo sapiens)
p-7Y-KIT [plasma membrane] (Homo sapiens)
p-7Y-KIT:sSCF dimer:p-7Y-KIT [plasma membrane] (Homo sapiens)
p-7Y-KIT [plasma membrane] (Homo sapiens)
Interaction of other tyrosine kinases with p-KIT (Homo sapiens)
Tyrosine kinases:p-KIT complex [plasma membrane] (Homo sapiens)
p-7Y-KIT:sSCF dimer:p-7Y-KIT [plasma membrane] (Homo sapiens)
p-7Y-KIT [plasma membrane] (Homo sapiens)
p-7Y-KIT:sSCF dimer:p-7Y-KIT [plasma membrane] (Homo sapiens)
p-7Y-KIT [plasma membrane] (Homo sapiens)
JAK2 binds to p-KIT (Homo sapiens)
JAK2:SFKS:p-KIT complex [plasma membrane] (Homo sapiens)
SFKs:p-KIT complex [plasma membrane] (Homo sapiens)
p-7Y-KIT:sSCF dimer:p-7Y-KIT [plasma membrane] (Homo sapiens)
p-7Y-KIT [plasma membrane] (Homo sapiens)
SFKs:p-KIT complex [plasma membrane] (Homo sapiens)
p-7Y-KIT:sSCF dimer:p-7Y-KIT [plasma membrane] (Homo sapiens)
p-7Y-KIT [plasma membrane] (Homo sapiens)
Phosphorylation and activation of VAV1 (Homo sapiens)
SFKs:p-KIT complex [plasma membrane] (Homo sapiens)
p-7Y-KIT:sSCF dimer:p-7Y-KIT [plasma membrane] (Homo sapiens)
p-7Y-KIT [plasma membrane] (Homo sapiens)
Phosphorylation of GAB2 by SFKs (Homo sapiens)
GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Homo sapiens)
GRB2:p-SHP2:p-KIT complex [plasma membrane] (Homo sapiens)
p-SHP2:p-KIT complex [plasma membrane] (Homo sapiens)
SFKs:p-KIT complex [plasma membrane] (Homo sapiens)
p-7Y-KIT:sSCF dimer:p-7Y-KIT [plasma membrane] (Homo sapiens)
p-7Y-KIT [plasma membrane] (Homo sapiens)
p(Y)-GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Homo sapiens)
GRB2:p-SHP2:p-KIT complex [plasma membrane] (Homo sapiens)
p-SHP2:p-KIT complex [plasma membrane] (Homo sapiens)
SFKs:p-KIT complex [plasma membrane] (Homo sapiens)
p-7Y-KIT:sSCF dimer:p-7Y-KIT [plasma membrane] (Homo sapiens)
p-7Y-KIT [plasma membrane] (Homo sapiens)
Phosphorylation of JAK2 (Homo sapiens)
JAK2:SFKS:p-KIT complex [plasma membrane] (Homo sapiens)
SFKs:p-KIT complex [plasma membrane] (Homo sapiens)
p-7Y-KIT:sSCF dimer:p-7Y-KIT [plasma membrane] (Homo sapiens)
p-7Y-KIT [plasma membrane] (Homo sapiens)
p-JAK2:SFKs:p-KIT complex [plasma membrane] (Homo sapiens)
SFKs:p-KIT complex [plasma membrane] (Homo sapiens)
p-7Y-KIT:sSCF dimer:p-7Y-KIT [plasma membrane] (Homo sapiens)
p-7Y-KIT [plasma membrane] (Homo sapiens)
Phosphorylation of SHP2 by SFKs (Homo sapiens)
SHP2:SFKs:p-KIT:sSCF dimer:p-KIT [plasma membrane] (Homo sapiens)
SFKs:p-KIT complex [plasma membrane] (Homo sapiens)
p-7Y-KIT:sSCF dimer:p-7Y-KIT [plasma membrane] (Homo sapiens)
p-7Y-KIT [plasma membrane] (Homo sapiens)
p-SHP2:p-KIT complex [plasma membrane] (Homo sapiens)
SFKs:p-KIT complex [plasma membrane] (Homo sapiens)
p-7Y-KIT:sSCF dimer:p-7Y-KIT [plasma membrane] (Homo sapiens)
p-7Y-KIT [plasma membrane] (Homo sapiens)
Phosphorylation of STATs (Homo sapiens)
p-JAK2:SFKs:p-KIT complex:STATs [plasma membrane] (Homo sapiens)
SFKs:p-KIT complex [plasma membrane] (Homo sapiens)
p-7Y-KIT:sSCF dimer:p-7Y-KIT [plasma membrane] (Homo sapiens)
p-7Y-KIT [plasma membrane] (Homo sapiens)
p-JAK2:SFKs:p-KIT complex:p-STATs [plasma membrane] (Homo sapiens)
SFKs:p-KIT complex [plasma membrane] (Homo sapiens)
p-7Y-KIT:sSCF dimer:p-7Y-KIT [plasma membrane] (Homo sapiens)
p-7Y-KIT [plasma membrane] (Homo sapiens)
Phosphorylation of p-KIT on Y900 by Src kinases (Homo sapiens)
SFKs:p-KIT complex [plasma membrane] (Homo sapiens)
p-7Y-KIT:sSCF dimer:p-7Y-KIT [plasma membrane] (Homo sapiens)
p-7Y-KIT [plasma membrane] (Homo sapiens)
Recruitment of STATs (Homo sapiens)
p-JAK2:SFKs:p-KIT complex [plasma membrane] (Homo sapiens)
SFKs:p-KIT complex [plasma membrane] (Homo sapiens)
p-7Y-KIT:sSCF dimer:p-7Y-KIT [plasma membrane] (Homo sapiens)
p-7Y-KIT [plasma membrane] (Homo sapiens)
p-JAK2:SFKs:p-KIT complex:STATs [plasma membrane] (Homo sapiens)
SFKs:p-KIT complex [plasma membrane] (Homo sapiens)
p-7Y-KIT:sSCF dimer:p-7Y-KIT [plasma membrane] (Homo sapiens)
p-7Y-KIT [plasma membrane] (Homo sapiens)
Regulation of KIT signaling (Homo sapiens)
Downregulation of c-Kit signaling by SOCS6 (Homo sapiens)
SOCS6:p-c-Kit:sSCF dimer:p-c-Kit [plasma membrane] (Homo sapiens)
p-7Y-KIT:sSCF dimer:p-7Y-KIT [plasma membrane] (Homo sapiens)
p-7Y-KIT [plasma membrane] (Homo sapiens)
p-7Y-KIT:sSCF dimer:p-7Y-KIT [plasma membrane] (Homo sapiens)
p-7Y-KIT [plasma membrane] (Homo sapiens)
Interaction of APS and p-KIT (Homo sapiens)
APS dimer:p-c-Kit:SFKs complex [plasma membrane] (Homo sapiens)
SFKs:p-KIT complex [plasma membrane] (Homo sapiens)
p-7Y-KIT:sSCF dimer:p-7Y-KIT [plasma membrane] (Homo sapiens)
p-7Y-KIT [plasma membrane] (Homo sapiens)
SFKs:p-KIT complex [plasma membrane] (Homo sapiens)
p-7Y-KIT:sSCF dimer:p-7Y-KIT [plasma membrane] (Homo sapiens)
p-7Y-KIT [plasma membrane] (Homo sapiens)
Interaction of SHP1 and KIT (Homo sapiens)
PTPN6:p-c-Kit complex [plasma membrane] (Homo sapiens)
p-7Y-KIT:sSCF dimer:p-7Y-KIT [plasma membrane] (Homo sapiens)
p-7Y-KIT [plasma membrane] (Homo sapiens)
p-7Y-KIT:sSCF dimer:p-7Y-KIT [plasma membrane] (Homo sapiens)
p-7Y-KIT [plasma membrane] (Homo sapiens)
LNK binds to p-KIT and inhibit downstream signaling (Homo sapiens)
LNK:p-7Y-KIT:sSCF dimer:p-7Y-KIT [plasma membrane] (Homo sapiens)
p-7Y-KIT:sSCF dimer:p-7Y-KIT [plasma membrane] (Homo sapiens)
p-7Y-KIT [plasma membrane] (Homo sapiens)
p-7Y-KIT:sSCF dimer:p-7Y-KIT [plasma membrane] (Homo sapiens)
p-7Y-KIT [plasma membrane] (Homo sapiens)
Phosphorylation of APS (Homo sapiens)
APS dimer:p-c-Kit:SFKs complex [plasma membrane] (Homo sapiens)
SFKs:p-KIT complex [plasma membrane] (Homo sapiens)
p-7Y-KIT:sSCF dimer:p-7Y-KIT [plasma membrane] (Homo sapiens)
p-7Y-KIT [plasma membrane] (Homo sapiens)
p-APS dimer:p-KIT complex [plasma membrane] (Homo sapiens)
SFKs:p-KIT complex [plasma membrane] (Homo sapiens)
p-7Y-KIT:sSCF dimer:p-7Y-KIT [plasma membrane] (Homo sapiens)
p-7Y-KIT [plasma membrane] (Homo sapiens)
Recruitment of CBL to KIT (Homo sapiens)
CBL:Grb2/p-APS:p-c-Kit complex [plasma membrane] (Homo sapiens)
Grb2:SOS:p-c-Kit/p-APS:p-c-Kit complex [plasma membrane] (Homo sapiens)
GRB2:SOS1:p-KIT complex [plasma membrane] (Homo sapiens)
p-7Y-KIT:sSCF dimer:p-7Y-KIT [plasma membrane] (Homo sapiens)
p-7Y-KIT [plasma membrane] (Homo sapiens)
p-APS dimer:p-KIT complex [plasma membrane] (Homo sapiens)
SFKs:p-KIT complex [plasma membrane] (Homo sapiens)
p-7Y-KIT:sSCF dimer:p-7Y-KIT [plasma membrane] (Homo sapiens)
p-7Y-KIT [plasma membrane] (Homo sapiens)
Grb2:SOS:p-c-Kit/p-APS:p-c-Kit complex [plasma membrane] (Homo sapiens)
GRB2:SOS1:p-KIT complex [plasma membrane] (Homo sapiens)
p-7Y-KIT:sSCF dimer:p-7Y-KIT [plasma membrane] (Homo sapiens)
p-7Y-KIT [plasma membrane] (Homo sapiens)
p-APS dimer:p-KIT complex [plasma membrane] (Homo sapiens)
SFKs:p-KIT complex [plasma membrane] (Homo sapiens)
p-7Y-KIT:sSCF dimer:p-7Y-KIT [plasma membrane] (Homo sapiens)
p-7Y-KIT [plasma membrane] (Homo sapiens)
SOCS1 as a regulator of KIT signaling (Homo sapiens)
SOCS1:p-KIT complex [plasma membrane] (Homo sapiens)
p-7Y-KIT:sSCF dimer:p-7Y-KIT [plasma membrane] (Homo sapiens)
p-7Y-KIT [plasma membrane] (Homo sapiens)
p-7Y-KIT:sSCF dimer:p-7Y-KIT [plasma membrane] (Homo sapiens)
p-7Y-KIT [plasma membrane] (Homo sapiens)
SHP2 interacts with p-KIT (Homo sapiens)
SFKs:p-KIT complex [plasma membrane] (Homo sapiens)
p-7Y-KIT:sSCF dimer:p-7Y-KIT [plasma membrane] (Homo sapiens)
p-7Y-KIT [plasma membrane] (Homo sapiens)
SHP2:SFKs:p-KIT:sSCF dimer:p-KIT [plasma membrane] (Homo sapiens)
SFKs:p-KIT complex [plasma membrane] (Homo sapiens)
p-7Y-KIT:sSCF dimer:p-7Y-KIT [plasma membrane] (Homo sapiens)
p-7Y-KIT [plasma membrane] (Homo sapiens)
Synthesis of PIP3 from PIP2 by PI3K (Homo sapiens)
PI3K:p-KIT:sSCF dimer:p-KIT,PI3K:p(Y)-GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Homo sapiens)
PI3K:p(Y)-GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Homo sapiens)
GRB2:p-SHP2:p-KIT complex [plasma membrane] (Homo sapiens)
p-SHP2:p-KIT complex [plasma membrane] (Homo sapiens)
SFKs:p-KIT complex [plasma membrane] (Homo sapiens)
p-7Y-KIT:sSCF dimer:p-7Y-KIT [plasma membrane] (Homo sapiens)
p-7Y-KIT [plasma membrane] (Homo sapiens)
PI3K:p-KIT:sSCF dimer:p-KIT [plasma membrane] (Homo sapiens)
p-7Y-KIT:sSCF dimer:p-7Y-KIT [plasma membrane] (Homo sapiens)
p-7Y-KIT [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P10721 KIT
Gene Names
KIT, SCFR
Chain
signal peptide:1-25, chain:26-976
Reference Genes
BioGPS Gene:3815 KIT
COSMIC (genes):KIT KIT
CTD Gene:3815 KIT
dbSNP Gene:3815 KIT
ENSEMBL:ENSG00000157404 KIT
ENSEMBL_homo_sapiens_GENE:ENSG00000157404.17 KIT
HGNC:6342 KIT
KEGG Gene (Homo sapiens):3815 KIT
Monarch:3815 KIT
NCBI Gene:3815 KIT
OMIM:164920 KIT
UCSC:P10721 KIT
Reference Transcript
RefSeq:NM_000222.2 KIT
RefSeq:NM_001093772.1 KIT
Other Identifiers
11721613_a_at
11721614_a_at
11746065_a_at
16966855
1888_s_at
205051_PM_s_at
205051_s_at
2727601
2727602
2727616
2727620
2727621
2727624
2727625
2727626
2727628
2727631
2727633
2727634
2727635
2727636
2727637
2727638
2727639
2727640
2727641
2727642
2727643
2727644
2727645
2727646
2727647
2727648
3815
8095110
A_14_P122291
A_14_P130973
A_14_P135100
A_23_P110253
A_33_P3303245
A_33_P3407034
GE59676
GO:0000166
GO:0001541
GO:0001650
GO:0001669
GO:0002020
GO:0002244
GO:0002318
GO:0002320
GO:0002327
GO:0002376
GO:0002551
GO:0002732
GO:0003012
GO:0003824
GO:0004672
GO:0004713
GO:0004714
GO:0005020
GO:0005515
GO:0005524
GO:0005576
GO:0005615
GO:0005634
GO:0005730
GO:0005737
GO:0005886
GO:0005911
GO:0006351
GO:0006355
GO:0006468
GO:0006629
GO:0006687
GO:0006954
GO:0007010
GO:0007155
GO:0007165
GO:0007169
GO:0007283
GO:0007286
GO:0008283
GO:0008284
GO:0008354
GO:0008360
GO:0008542
GO:0008584
GO:0009314
GO:0009897
GO:0009898
GO:0009986
GO:0010628
GO:0010863
GO:0012501
GO:0016020
GO:0016192
GO:0016301
GO:0016310
GO:0016740
GO:0019221
GO:0019827
GO:0019838
GO:0019955
GO:0022414
GO:0023052
GO:0030032
GO:0030036
GO:0030097
GO:0030154
GO:0030183
GO:0030217
GO:0030218
GO:0030318
GO:0030335
GO:0031274
GO:0031401
GO:0031410
GO:0032765
GO:0035019
GO:0035162
GO:0035234
GO:0035556
GO:0035701
GO:0035855
GO:0036211
GO:0038093
GO:0038109
GO:0038162
GO:0042127
GO:0042169
GO:0042531
GO:0042803
GO:0043069
GO:0043226
GO:0043235
GO:0043303
GO:0043410
GO:0043473
GO:0043586
GO:0045747
GO:0045937
GO:0046427
GO:0046686
GO:0046777
GO:0046872
GO:0048066
GO:0048170
GO:0048565
GO:0048584
GO:0048856
GO:0048863
GO:0048870
GO:0050673
GO:0050877
GO:0050910
GO:0051091
GO:0051093
GO:0051897
GO:0060089
GO:0060326
GO:0060374
GO:0070662
GO:0070668
GO:0097324
GO:0097326
GO:0120072
GO:0140096
GO:1901135
GO:1904251
GO:1904343
GO:1904349
GO:1905065
GO:2000242
HMNXSV003047477
HMNXSV003050311
ILMN_1790160
PH_hs_0004671
TC04000313.hg
X06182_s_at
g4557694_3p_a_at
Participates
as a component of
p-7Y-KIT:sSCF dimer:p-7Y-KIT [plasma membrane] (Homo sapiens)
Other forms of this molecule
KIT C443Y [plasma membrane]
KIT T417_D419delinsY [plasma membrane]
KIT S476I [plasma membrane]
KIT K509I [plasma membrane]
KIT D419A [plasma membrane]
KIT D419del [plasma membrane]
KIT S501_A502dup [plasma membrane]
KIT D419G [plasma membrane]
KIT N505_F508dup [plasma membrane]
KIT C443S [plasma membrane]
KIT D419N [plasma membrane]
KIT S476N [plasma membrane]
KIT D419H [plasma membrane]
KIT V560_L576del [plasma membrane]
KIT Y823N [plasma membrane]
KIT Y823C [plasma membrane]
p6Y-KIT Y823D [plasma membrane]
p7Y-KIT D816V [plasma membrane]
p7Y-KIT K642E [plasma membrane]
p7Y-KIT N822K [plasma membrane]
p7Y-KIT N822D [plasma membrane]
p7Y-KIT N822S [plasma membrane]
p-7Y KIT V654E [plasma membrane]
p7Y-KIT N822I [plasma membrane]
p7Y-KIT D816N [plasma membrane]
p7Y-KIT A829P [plasma membrane]
p7Y-KIT D816H [plasma membrane]
p6Y-KIT Y823C [plasma membrane]
p7Y-KIT K642Q [plasma membrane]
p6Y-KIT Y823N [plasma membrane]
p7Y-KIT D816A [plasma membrane]
p7Y-KIT N822H [plasma membrane]
p7Y-KIT D816F [plasma membrane]
p-7Y KIT V654A [plasma membrane]
p7Y-KIT N822T [plasma membrane]
p7Y-KIT D816E [plasma membrane]
p7Y-KIT D816Y [plasma membrane]
p7Y-KIT N822Y [plasma membrane]
p7Y-KIT V559D [plasma membrane]
p-7Y-KIT K550I;P551_V555del [plasma membrane]
p-7Y KIT W557_K558del [plasma membrane]
p-5Y KIT V560_L576del [plasma membrane]
p7Y-KIT L576P [plasma membrane]
p7Y-KIT V559_V560del [plasma membrane]
p7Y-KIT P551_V555del [plasma membrane]
p7Y-KIT V560G [plasma membrane]
p7Y-KIT K550_K558del [plasma membrane]
p7Y-KIT V560E [plasma membrane]
p7Y-KIT V560D [plasma membrane]
p7Y-KIT V559A [plasma membrane]
p7Y-KIT V559I [plasma membrane]
p7Y-KIT W557R [plasma membrane]
p7Y-KIT V559G [plasma membrane]
p7Y-KIT W557G [plasma membrane]
p7Y-KIT K509I [plasma membrane]
p-7Y-KIT A502_Y503dup [plasma membrane]
p7Y-KIT S476I [plasma membrane]
p7Y-KIT C443Y [plasma membrane]
p7Y-KIT D419A [plasma membrane]
p-7Y-KIT T417_D419delinsY [plasma membrane]
p7Y-KIT D419H [plasma membrane]
p-7Y-KIT S501_A502dup [plasma membrane]
p7Y-KIT D419del [plasma membrane]
p-7Y-KIT N505_F508dup [plasma membrane]
p7Y-KIT D419N [plasma membrane]
p7Y-KIT C443S [plasma membrane]
p7Y-KIT S476N [plasma membrane]
p7Y-KIT D419G [plasma membrane]
KIT A829P [plasma membrane]
KIT N822D [plasma membrane]
KIT V654E [plasma membrane]
KIT W557R [plasma membrane]
KIT W557G [plasma membrane]
KIT V559A [plasma membrane]
KIT K550I;P551_V555del [plasma membrane]
KIT L576P [plasma membrane]
KIT V559_V560del [plasma membrane]
KIT P551_V555del [plasma membrane]
KIT V559I [plasma membrane]
KIT K550_K558del [plasma membrane]
KIT V559G [plasma membrane]
KIT V559D [plasma membrane]
KIT W557_K558del [plasma membrane]
KIT Y823D [plasma membrane]
KIT D816V [plasma membrane]
KIT N822Y [plasma membrane]
KIT T670I [plasma membrane]
KIT D820E [plasma membrane]
KIT V654A [plasma membrane]
KIT D816H [plasma membrane]
KIT K642E [plasma membrane]
KIT V560D [plasma membrane]
KIT N822H [plasma membrane]
KIT A502_Y503dup [plasma membrane]
KIT N822K [plasma membrane]
KIT D816Y [plasma membrane]
KIT D820A [plasma membrane]
KIT N822T [plasma membrane]
KIT D816F [plasma membrane]
KIT K642Q [plasma membrane]
KIT D816E [plasma membrane]
KIT N822I [plasma membrane]
KIT V560E [plasma membrane]
KIT N822S [plasma membrane]
KIT D816N [plasma membrane]
KIT D816A [plasma membrane]
KIT V560G [plasma membrane]
p-8Y-KIT [plasma membrane]
p-S741,S746-KIT [plasma membrane]
KIT [plasma membrane]
Inferred To
Homologues of p-7Y-KIT [plasma membrane]
(Caenorhabditis elegans)
phospho-kin-36 [plasma membrane]
(Caenorhabditis elegans)
phospho-p-7Y-KIT [plasma membrane]
(Bos taurus)
phospho-p-7Y-KIT [plasma membrane]
(Caenorhabditis elegans)
phospho-p-7Y-KIT [plasma membrane]
(Canis familiaris)
phospho-p-7Y-KIT [plasma membrane]
(Danio rerio)
phospho-p-7Y-KIT [plasma membrane]
(Drosophila melanogaster)
phospho-p-7Y-KIT [plasma membrane]
(Gallus gallus)
phospho-p-7Y-KIT [plasma membrane]
(Mus musculus)
phospho-p-7Y-KIT [plasma membrane]
(Rattus norvegicus)
phospho-p-7Y-KIT [plasma membrane]
(Sus scrofa)
phospho-p-7Y-KIT [plasma membrane]
(Xenopus tropicalis)
Modified Residues
Name
O4'-phospho-L-tyrosine at 568
Coordinate
568
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 570
Coordinate
570
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 703
Coordinate
703
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 721
Coordinate
721
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 730
Coordinate
730
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 823
Coordinate
823
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 936
Coordinate
936
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Cross References
RefSeq
NP_000213.1
,
NP_001087241.1
ZINC - World Drugs
KIT_HUMAN
Guide to Pharmacology - Targets
1805
OpenTargets
ENSG00000157404
ZINC - FDA approved
KIT_HUMAN
ZINC - Substances
KIT_HUMAN
ZINC target
P10721
ZINC - Biogenic
KIT_HUMAN
PRO
P10721
PDB
8PQE
,
8DFQ
,
6GQL
,
6ITT
,
6GQM
,
7KHG
,
1T46
,
8PQF
,
6KLA
,
4PGZ
,
1PKG
,
8PQG
,
6XV9
,
8PQ9
,
7KHK
,
7KHJ
,
2E9W
,
6ITV
,
2VIF
,
6XVA
,
7ZY6
,
6HH1
,
8PQA
,
4K94
,
3G0E
,
7ZW8
,
3G0F
,
8PQB
,
2EC8
,
6XVB
,
8PQC
,
6MOB
,
6GQJ
,
2IUH
,
4HVS
,
4K9E
,
8DFM
,
4U0I
,
6GQK
,
8PQD
,
1T45
,
8DFP
ZINC - Investigational
KIT_HUMAN
IntEnz
2.7.10.1
GeneCards
P10721
HPA
ENSG00000157404-KIT
Ensembl
ENST00000687295
,
ENSP00000509450
,
ENSP00000288135
,
ENST00000288135
,
ENSG00000157404
Pharos - Targets
P10721
Orphanet
16308
ZINC - Predictions - Purchasable
KIT_HUMAN
HMDB Protein
HMDBP01513
Interactors (12)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P27986 PIK3R1
16
p-Y-PIK3R1 [cytosol]
(R-HSA-9680647)
PIK3R1 G376R [plasma membrane]
(R-HSA-2399717)
PIK3R1 K379E [plasma membrane]
(R-HSA-8944148)
PIK3R1 Y463_L466del [plasma membrane]
(R-HSA-2399546)
PIK3R1 H450_E451del [plasma membrane]
(R-HSA-2399545)
PIK3R1 R574_T576del [plasma membrane]
(R-HSA-2399544)
PIK3R1 D560Y [plasma membrane]
(R-HSA-2399421)
PIK3R1 N564D [plasma membrane]
(R-HSA-2399427)
PIK3R1 K459del [plasma membrane]
(R-HSA-2399554)
PIK3R1 N564K [plasma membrane]
(R-HSA-2399431)
PIK3R1 D560H [plasma membrane]
(R-HSA-2399432)
PIK3R1 R574I [plasma membrane]
(R-HSA-2399536)
PIK3R1 R574T [plasma membrane]
(R-HSA-2399540)
K63polyUb-PIK3R1 [cytosol]
(R-HSA-3080572)
PIK3R1 [cytosol]
(R-HSA-74789)
PIK3R1 [plasma membrane]
(R-HSA-198365)
0.749
19
UniProt:P62993 GRB2
1
GRB2 [cytosol]
(R-HSA-8983328)
0.743
6
UniProt:P19174 PLCG1
6
p-Y-PLCG1 [cytosol]
(R-HSA-9029082)
p-4Y-PLCG1 [plasma membrane]
(R-HSA-167679)
PLCG1 [cytosol]
(R-HSA-202320)
PLCG1 [plasma membrane]
(R-HSA-167682)
p-Y771,Y783,Y1254-PLCG1 [cytosol]
(R-HSA-202357)
p-Y771,Y783-PLCG1 [plasma membrane]
(R-HSA-1169084)
0.675
31
UniProt:O00459 PIK3R2
3
PIK3R2 [cytosol]
(R-HSA-74791)
K63polyUb-PIK3R2 [cytosol]
(R-HSA-3080554)
p-Y464-PIK3R2 [cytosol]
(R-HSA-9860512)
0.59
19
UniProt:Q14451 GRB7
1
GRB7 [cytosol]
(R-HSA-204819)
0.59
4
UniProt:P46108 CRK
1
CRK [cytosol]
(R-HSA-2980677)
0.59
4
UniProt:P21583 KITLG
0.544
2
UniProt:P35235 Ptpn11
5
p-Y546,Y584-Shp2 [cytosol]
(R-MMU-443116)
Ptpn11 [cytosol]
(R-MMU-210002)
PTPN11 [nucleoplasm]
(R-MMU-8937745)
PTPN11 [cytosol]
(R-MMU-162563)
phospho-p-Y542,Y580-PTPN11 [cytosol]
(R-MMU-162573)
0.524
2
UniProt:Q8VBX6 MPDZ
0.508
4
ChEBI:39112 BOSUTINIB
0.499
2
ChEBI:45783 IMATINIB
0.499
3
ChEBI:49375 DASATINIB
0.499
2
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