Reactome | Indirect recruitment of GAB2 to p-KIT

Indirect recruitment of GAB2 to p-KIT

Stable Identifier

R-HSA-205234

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane, cytosol, extracellular region

ReviewStatus

5/5

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The scaffolding adapter GAB2 plays a role in KIT dependent PI3K/AKT activation. GAB2 interacts with KIT indirectly via the adapter protein GRB2 which is bound to KIT on phosphorylated Y703 and Y936 (Sun et al. 2008, Yu et al. 2006).

Literature References

PubMed ID	Title	Journal	Year
16873377	The scaffolding adapter Gab2, via Shp-2, regulates kit-evoked mast cell proliferation by activating the Rac/JNK pathway Yu, M, Luo, J, Gu, H, Yang, W, Neel, BG, Wang, Y, Besmer, P, Mizuki, M, Kanakura, Y	J Biol Chem	2006
18697750	Gab2 is involved in differential phosphoinositide 3-kinase signaling by two splice forms of c-Kit Sun, J, Pedersen, M, Rönnstrand, L	J Biol Chem	2008