Reactome | Direct recruitment of PI3K to p-KIT

Direct recruitment of PI3K to p-KIT

Stable Identifier

R-HSA-205262

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane, cytosol, extracellular region

ReviewStatus

5/5

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The regulatory subunit (p85) of PI3K interacts directly with phosphorylated Y721 of KIT via one of its SH2 domains. This binding leads to the activation of the catalytic domain (p110) of PI3K. SCF-induced PI3K recruitment mediates AKT activation through phospholipids at the membrane and to subsequent phosphorylation of the pro-apoptotic factor Bad as well as Fox3a.
PI3K activation mediates SCF-induced cell proliferation, survival, differentiation, adhesion, secretion and actin cytoskeletal organization.

Literature References

PubMed ID	Title	Journal	Year
15526160	Signal transduction via the stem cell factor receptor/c-Kit Rönnstrand, L	Cell Mol Life Sci	2004
16483568	Stem cell factor and its receptor c-Kit as targets for inflammatory diseases Frossard, N, Da Silva, CA, Reber, L	Eur J Pharmacol	2006
11520784	Phosphatidylinositol 3 kinase contributes to the transformation of hematopoietic cells by the D816V c-Kit mutant Young, S, Leonard, E, Chian, R, Ferrao, P, Danilkovitch-Miagkova, A, Linnekin, D, Ashman, L, Rönnstrand, L	Blood	2001