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p-7Y-KIT:sSCF dimer:p-7Y-KIT [plasma membrane]
Stable Identifier
R-HSA-205310
Type
Complex
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
p-KIT complex
Locations in the PathwayBrowser
Expand all
Developmental Biology (Homo sapiens)
MITF-M-regulated melanocyte development (Homo sapiens)
Transcriptional and post-translational regulation of MITF-M expression and activity (Homo sapiens)
MAPK-dependent phosphorylation of KARS (Homo sapiens)
p-7Y-KIT:sSCF dimer:p-7Y-KIT [plasma membrane] (Homo sapiens)
MAPK1-dependent phosphorylation of MITF-M (Homo sapiens)
p-7Y-KIT:sSCF dimer:p-7Y-KIT [plasma membrane] (Homo sapiens)
RPS6KA1-dependent phosphorylation of MITF-M (Homo sapiens)
p-7Y-KIT:sSCF dimer:p-7Y-KIT [plasma membrane] (Homo sapiens)
Disease (Homo sapiens)
Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
PI3K/AKT Signaling in Cancer (Homo sapiens)
Constitutive Signaling by Aberrant PI3K in Cancer (Homo sapiens)
PI3K inhibitors block PI3K catalytic activity (Homo sapiens)
PI3K Inhibitors:PI3K [cytosol] (Homo sapiens)
PI3K mutants,Activator:PI3K [plasma membrane] (Homo sapiens)
Activator:PI3K [plasma membrane] (Homo sapiens)
PI3K:p-KIT:sSCF dimer:p-KIT [plasma membrane] (Homo sapiens)
p-7Y-KIT:sSCF dimer:p-7Y-KIT [plasma membrane] (Homo sapiens)
PI3K mutants,Activator:PI3K [plasma membrane] (Homo sapiens)
Activator:PI3K [plasma membrane] (Homo sapiens)
PI3K:p-KIT:sSCF dimer:p-KIT [plasma membrane] (Homo sapiens)
p-7Y-KIT:sSCF dimer:p-7Y-KIT [plasma membrane] (Homo sapiens)
Signal Transduction (Homo sapiens)
Intracellular signaling by second messengers (Homo sapiens)
PIP3 activates AKT signaling (Homo sapiens)
Negative regulation of the PI3K/AKT network (Homo sapiens)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Homo sapiens)
PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
Activator:PI3K [plasma membrane] (Homo sapiens)
PI3K:p-KIT:sSCF dimer:p-KIT [plasma membrane] (Homo sapiens)
p-7Y-KIT:sSCF dimer:p-7Y-KIT [plasma membrane] (Homo sapiens)
PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
Activator:PI3K [plasma membrane] (Homo sapiens)
PI3K:p-KIT:sSCF dimer:p-KIT [plasma membrane] (Homo sapiens)
p-7Y-KIT:sSCF dimer:p-7Y-KIT [plasma membrane] (Homo sapiens)
MAPK family signaling cascades (Homo sapiens)
MAPK1/MAPK3 signaling (Homo sapiens)
RAF/MAP kinase cascade (Homo sapiens)
RAS GEFs promote RAS nucleotide exchange (Homo sapiens)
RAS GEFs [plasma membrane] (Homo sapiens)
GRB2:SOS1:p-KIT complex [plasma membrane] (Homo sapiens)
p-7Y-KIT:sSCF dimer:p-7Y-KIT [plasma membrane] (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by SCF-KIT (Homo sapiens)
Activation of RAS by p-KIT bound SOS1 (Homo sapiens)
GRB2:SOS1:p-KIT complex [plasma membrane] (Homo sapiens)
p-7Y-KIT:sSCF dimer:p-7Y-KIT [plasma membrane] (Homo sapiens)
Autophosphorylation of KIT (Homo sapiens)
p-7Y-KIT:sSCF dimer:p-7Y-KIT [plasma membrane] (Homo sapiens)
Dimerization of STATs (Homo sapiens)
p-JAK2:SFKs:p-KIT complex:p-STAT dimers [plasma membrane] (Homo sapiens)
SFKs:p-KIT complex [plasma membrane] (Homo sapiens)
p-7Y-KIT:sSCF dimer:p-7Y-KIT [plasma membrane] (Homo sapiens)
p-JAK2:SFKs:p-KIT complex:p-STATs [plasma membrane] (Homo sapiens)
SFKs:p-KIT complex [plasma membrane] (Homo sapiens)
p-7Y-KIT:sSCF dimer:p-7Y-KIT [plasma membrane] (Homo sapiens)
Direct recruitment of PI3K to p-KIT (Homo sapiens)
PI3K:p-KIT:sSCF dimer:p-KIT [plasma membrane] (Homo sapiens)
p-7Y-KIT:sSCF dimer:p-7Y-KIT [plasma membrane] (Homo sapiens)
p-7Y-KIT:sSCF dimer:p-7Y-KIT [plasma membrane] (Homo sapiens)
Disassociation and translocation of STATs to the nucleus (Homo sapiens)
p-JAK2:SFKs:p-KIT complex [plasma membrane] (Homo sapiens)
SFKs:p-KIT complex [plasma membrane] (Homo sapiens)
p-7Y-KIT:sSCF dimer:p-7Y-KIT [plasma membrane] (Homo sapiens)
p-JAK2:SFKs:p-KIT complex:p-STAT dimers [plasma membrane] (Homo sapiens)
SFKs:p-KIT complex [plasma membrane] (Homo sapiens)
p-7Y-KIT:sSCF dimer:p-7Y-KIT [plasma membrane] (Homo sapiens)
GRB2 is indirectly recruited to p-KIT through SHP2 (Homo sapiens)
GRB2:p-SHP2:p-KIT complex [plasma membrane] (Homo sapiens)
p-SHP2:p-KIT complex [plasma membrane] (Homo sapiens)
SFKs:p-KIT complex [plasma membrane] (Homo sapiens)
p-7Y-KIT:sSCF dimer:p-7Y-KIT [plasma membrane] (Homo sapiens)
p-SHP2:p-KIT complex [plasma membrane] (Homo sapiens)
SFKs:p-KIT complex [plasma membrane] (Homo sapiens)
p-7Y-KIT:sSCF dimer:p-7Y-KIT [plasma membrane] (Homo sapiens)
GRB2:SOS interacts with p-KIT (Homo sapiens)
GRB2:SOS1:p-KIT complex [plasma membrane] (Homo sapiens)
p-7Y-KIT:sSCF dimer:p-7Y-KIT [plasma membrane] (Homo sapiens)
p-7Y-KIT:sSCF dimer:p-7Y-KIT [plasma membrane] (Homo sapiens)
Indirect recruitment of GAB2 to p-KIT (Homo sapiens)
GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Homo sapiens)
GRB2:p-SHP2:p-KIT complex [plasma membrane] (Homo sapiens)
p-SHP2:p-KIT complex [plasma membrane] (Homo sapiens)
SFKs:p-KIT complex [plasma membrane] (Homo sapiens)
p-7Y-KIT:sSCF dimer:p-7Y-KIT [plasma membrane] (Homo sapiens)
GRB2:p-SHP2:p-KIT complex [plasma membrane] (Homo sapiens)
p-SHP2:p-KIT complex [plasma membrane] (Homo sapiens)
SFKs:p-KIT complex [plasma membrane] (Homo sapiens)
p-7Y-KIT:sSCF dimer:p-7Y-KIT [plasma membrane] (Homo sapiens)
Indirect recruitment of PI3K to KIT via p(Y)-GAB2 (Homo sapiens)
PI3K:p(Y)-GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Homo sapiens)
GRB2:p-SHP2:p-KIT complex [plasma membrane] (Homo sapiens)
p-SHP2:p-KIT complex [plasma membrane] (Homo sapiens)
SFKs:p-KIT complex [plasma membrane] (Homo sapiens)
p-7Y-KIT:sSCF dimer:p-7Y-KIT [plasma membrane] (Homo sapiens)
p(Y)-GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Homo sapiens)
GRB2:p-SHP2:p-KIT complex [plasma membrane] (Homo sapiens)
p-SHP2:p-KIT complex [plasma membrane] (Homo sapiens)
SFKs:p-KIT complex [plasma membrane] (Homo sapiens)
p-7Y-KIT:sSCF dimer:p-7Y-KIT [plasma membrane] (Homo sapiens)
Interaction of Src family kinases with p-KIT (Homo sapiens)
SFKs:p-KIT complex [plasma membrane] (Homo sapiens)
p-7Y-KIT:sSCF dimer:p-7Y-KIT [plasma membrane] (Homo sapiens)
p-7Y-KIT:sSCF dimer:p-7Y-KIT [plasma membrane] (Homo sapiens)
Interaction of other adapter proteins with p-KIT (Homo sapiens)
Adapter proteins:p-KIT complex [plasma membrane] (Homo sapiens)
p-7Y-KIT:sSCF dimer:p-7Y-KIT [plasma membrane] (Homo sapiens)
p-7Y-KIT:sSCF dimer:p-7Y-KIT [plasma membrane] (Homo sapiens)
Interaction of other tyrosine kinases with p-KIT (Homo sapiens)
Tyrosine kinases:p-KIT complex [plasma membrane] (Homo sapiens)
p-7Y-KIT:sSCF dimer:p-7Y-KIT [plasma membrane] (Homo sapiens)
p-7Y-KIT:sSCF dimer:p-7Y-KIT [plasma membrane] (Homo sapiens)
JAK2 binds to p-KIT (Homo sapiens)
JAK2:SFKS:p-KIT complex [plasma membrane] (Homo sapiens)
SFKs:p-KIT complex [plasma membrane] (Homo sapiens)
p-7Y-KIT:sSCF dimer:p-7Y-KIT [plasma membrane] (Homo sapiens)
SFKs:p-KIT complex [plasma membrane] (Homo sapiens)
p-7Y-KIT:sSCF dimer:p-7Y-KIT [plasma membrane] (Homo sapiens)
Phosphorylation and activation of VAV1 (Homo sapiens)
SFKs:p-KIT complex [plasma membrane] (Homo sapiens)
p-7Y-KIT:sSCF dimer:p-7Y-KIT [plasma membrane] (Homo sapiens)
Phosphorylation of GAB2 by SFKs (Homo sapiens)
GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Homo sapiens)
GRB2:p-SHP2:p-KIT complex [plasma membrane] (Homo sapiens)
p-SHP2:p-KIT complex [plasma membrane] (Homo sapiens)
SFKs:p-KIT complex [plasma membrane] (Homo sapiens)
p-7Y-KIT:sSCF dimer:p-7Y-KIT [plasma membrane] (Homo sapiens)
p(Y)-GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Homo sapiens)
GRB2:p-SHP2:p-KIT complex [plasma membrane] (Homo sapiens)
p-SHP2:p-KIT complex [plasma membrane] (Homo sapiens)
SFKs:p-KIT complex [plasma membrane] (Homo sapiens)
p-7Y-KIT:sSCF dimer:p-7Y-KIT [plasma membrane] (Homo sapiens)
Phosphorylation of JAK2 (Homo sapiens)
JAK2:SFKS:p-KIT complex [plasma membrane] (Homo sapiens)
SFKs:p-KIT complex [plasma membrane] (Homo sapiens)
p-7Y-KIT:sSCF dimer:p-7Y-KIT [plasma membrane] (Homo sapiens)
p-JAK2:SFKs:p-KIT complex [plasma membrane] (Homo sapiens)
SFKs:p-KIT complex [plasma membrane] (Homo sapiens)
p-7Y-KIT:sSCF dimer:p-7Y-KIT [plasma membrane] (Homo sapiens)
Phosphorylation of SHP2 by SFKs (Homo sapiens)
SHP2:SFKs:p-KIT:sSCF dimer:p-KIT [plasma membrane] (Homo sapiens)
SFKs:p-KIT complex [plasma membrane] (Homo sapiens)
p-7Y-KIT:sSCF dimer:p-7Y-KIT [plasma membrane] (Homo sapiens)
p-SHP2:p-KIT complex [plasma membrane] (Homo sapiens)
SFKs:p-KIT complex [plasma membrane] (Homo sapiens)
p-7Y-KIT:sSCF dimer:p-7Y-KIT [plasma membrane] (Homo sapiens)
Phosphorylation of STATs (Homo sapiens)
p-JAK2:SFKs:p-KIT complex:STATs [plasma membrane] (Homo sapiens)
SFKs:p-KIT complex [plasma membrane] (Homo sapiens)
p-7Y-KIT:sSCF dimer:p-7Y-KIT [plasma membrane] (Homo sapiens)
p-JAK2:SFKs:p-KIT complex:p-STATs [plasma membrane] (Homo sapiens)
SFKs:p-KIT complex [plasma membrane] (Homo sapiens)
p-7Y-KIT:sSCF dimer:p-7Y-KIT [plasma membrane] (Homo sapiens)
Phosphorylation of p-KIT on Y900 by Src kinases (Homo sapiens)
SFKs:p-KIT complex [plasma membrane] (Homo sapiens)
p-7Y-KIT:sSCF dimer:p-7Y-KIT [plasma membrane] (Homo sapiens)
Recruitment of STATs (Homo sapiens)
p-JAK2:SFKs:p-KIT complex [plasma membrane] (Homo sapiens)
SFKs:p-KIT complex [plasma membrane] (Homo sapiens)
p-7Y-KIT:sSCF dimer:p-7Y-KIT [plasma membrane] (Homo sapiens)
p-JAK2:SFKs:p-KIT complex:STATs [plasma membrane] (Homo sapiens)
SFKs:p-KIT complex [plasma membrane] (Homo sapiens)
p-7Y-KIT:sSCF dimer:p-7Y-KIT [plasma membrane] (Homo sapiens)
Regulation of KIT signaling (Homo sapiens)
Downregulation of c-Kit signaling by SOCS6 (Homo sapiens)
SOCS6:p-c-Kit:sSCF dimer:p-c-Kit [plasma membrane] (Homo sapiens)
p-7Y-KIT:sSCF dimer:p-7Y-KIT [plasma membrane] (Homo sapiens)
p-7Y-KIT:sSCF dimer:p-7Y-KIT [plasma membrane] (Homo sapiens)
Interaction of APS and p-KIT (Homo sapiens)
APS dimer:p-c-Kit:SFKs complex [plasma membrane] (Homo sapiens)
SFKs:p-KIT complex [plasma membrane] (Homo sapiens)
p-7Y-KIT:sSCF dimer:p-7Y-KIT [plasma membrane] (Homo sapiens)
SFKs:p-KIT complex [plasma membrane] (Homo sapiens)
p-7Y-KIT:sSCF dimer:p-7Y-KIT [plasma membrane] (Homo sapiens)
Interaction of SHP1 and KIT (Homo sapiens)
PTPN6:p-c-Kit complex [plasma membrane] (Homo sapiens)
p-7Y-KIT:sSCF dimer:p-7Y-KIT [plasma membrane] (Homo sapiens)
p-7Y-KIT:sSCF dimer:p-7Y-KIT [plasma membrane] (Homo sapiens)
LNK binds to p-KIT and inhibit downstream signaling (Homo sapiens)
LNK:p-7Y-KIT:sSCF dimer:p-7Y-KIT [plasma membrane] (Homo sapiens)
p-7Y-KIT:sSCF dimer:p-7Y-KIT [plasma membrane] (Homo sapiens)
p-7Y-KIT:sSCF dimer:p-7Y-KIT [plasma membrane] (Homo sapiens)
Phosphorylation of APS (Homo sapiens)
APS dimer:p-c-Kit:SFKs complex [plasma membrane] (Homo sapiens)
SFKs:p-KIT complex [plasma membrane] (Homo sapiens)
p-7Y-KIT:sSCF dimer:p-7Y-KIT [plasma membrane] (Homo sapiens)
p-APS dimer:p-KIT complex [plasma membrane] (Homo sapiens)
SFKs:p-KIT complex [plasma membrane] (Homo sapiens)
p-7Y-KIT:sSCF dimer:p-7Y-KIT [plasma membrane] (Homo sapiens)
Recruitment of CBL to KIT (Homo sapiens)
CBL:Grb2/p-APS:p-c-Kit complex [plasma membrane] (Homo sapiens)
Grb2:SOS:p-c-Kit/p-APS:p-c-Kit complex [plasma membrane] (Homo sapiens)
GRB2:SOS1:p-KIT complex [plasma membrane] (Homo sapiens)
p-7Y-KIT:sSCF dimer:p-7Y-KIT [plasma membrane] (Homo sapiens)
p-APS dimer:p-KIT complex [plasma membrane] (Homo sapiens)
SFKs:p-KIT complex [plasma membrane] (Homo sapiens)
p-7Y-KIT:sSCF dimer:p-7Y-KIT [plasma membrane] (Homo sapiens)
Grb2:SOS:p-c-Kit/p-APS:p-c-Kit complex [plasma membrane] (Homo sapiens)
GRB2:SOS1:p-KIT complex [plasma membrane] (Homo sapiens)
p-7Y-KIT:sSCF dimer:p-7Y-KIT [plasma membrane] (Homo sapiens)
p-APS dimer:p-KIT complex [plasma membrane] (Homo sapiens)
SFKs:p-KIT complex [plasma membrane] (Homo sapiens)
p-7Y-KIT:sSCF dimer:p-7Y-KIT [plasma membrane] (Homo sapiens)
SOCS1 as a regulator of KIT signaling (Homo sapiens)
SOCS1:p-KIT complex [plasma membrane] (Homo sapiens)
p-7Y-KIT:sSCF dimer:p-7Y-KIT [plasma membrane] (Homo sapiens)
p-7Y-KIT:sSCF dimer:p-7Y-KIT [plasma membrane] (Homo sapiens)
SHP2 interacts with p-KIT (Homo sapiens)
SFKs:p-KIT complex [plasma membrane] (Homo sapiens)
p-7Y-KIT:sSCF dimer:p-7Y-KIT [plasma membrane] (Homo sapiens)
SHP2:SFKs:p-KIT:sSCF dimer:p-KIT [plasma membrane] (Homo sapiens)
SFKs:p-KIT complex [plasma membrane] (Homo sapiens)
p-7Y-KIT:sSCF dimer:p-7Y-KIT [plasma membrane] (Homo sapiens)
Synthesis of PIP3 from PIP2 by PI3K (Homo sapiens)
PI3K:p-KIT:sSCF dimer:p-KIT,PI3K:p(Y)-GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Homo sapiens)
PI3K:p(Y)-GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Homo sapiens)
GRB2:p-SHP2:p-KIT complex [plasma membrane] (Homo sapiens)
p-SHP2:p-KIT complex [plasma membrane] (Homo sapiens)
SFKs:p-KIT complex [plasma membrane] (Homo sapiens)
p-7Y-KIT:sSCF dimer:p-7Y-KIT [plasma membrane] (Homo sapiens)
PI3K:p-KIT:sSCF dimer:p-KIT [plasma membrane] (Homo sapiens)
p-7Y-KIT:sSCF dimer:p-7Y-KIT [plasma membrane] (Homo sapiens)
Participants
components
x 2
p-7Y-KIT [plasma membrane]
(Homo sapiens)
sSCF dimer [extracellular region]
(Homo sapiens)
Participates
as a component of
Tyrosine kinases:p-KIT complex [plasma membrane] (Homo sapiens)
Adapter proteins:p-KIT complex [plasma membrane] (Homo sapiens)
SOCS6:p-c-Kit:sSCF dimer:p-c-Kit [plasma membrane] (Homo sapiens)
PTPN6:p-c-Kit complex [plasma membrane] (Homo sapiens)
LNK:p-7Y-KIT:sSCF dimer:p-7Y-KIT [plasma membrane] (Homo sapiens)
SOCS1:p-KIT complex [plasma membrane] (Homo sapiens)
SFKs:p-KIT complex [plasma membrane] (Homo sapiens)
GRB2:SOS1:p-KIT complex [plasma membrane] (Homo sapiens)
PI3K:p-KIT:sSCF dimer:p-KIT [plasma membrane] (Homo sapiens)
as an input of
Interaction of other tyrosine kinases with p-KIT (Homo sapiens)
Interaction of other adapter proteins with p-KIT (Homo sapiens)
Interaction of Src family kinases with p-KIT (Homo sapiens)
Downregulation of c-Kit signaling by SOCS6 (Homo sapiens)
Interaction of SHP1 and KIT (Homo sapiens)
LNK binds to p-KIT and inhibit downstream signaling (Homo sapiens)
SOCS1 as a regulator of KIT signaling (Homo sapiens)
GRB2:SOS interacts with p-KIT (Homo sapiens)
Direct recruitment of PI3K to p-KIT (Homo sapiens)
as an output of
Autophosphorylation of KIT (Homo sapiens)
This entity regulates
Positively
RPS6KA1-dependent phosphorylation of MITF-M
(Homo sapiens)
MAPK-dependent phosphorylation of KARS
(Homo sapiens)
MAPK1-dependent phosphorylation of MITF-M
(Homo sapiens)
Inferred To
p-7Y-KIT:sSCF dimer:p-7Y-KIT [plasma membrane]
(Bos taurus)
p-7Y-KIT:sSCF dimer:p-7Y-KIT [plasma membrane]
(Caenorhabditis elegans)
p-7Y-KIT:sSCF dimer:p-7Y-KIT [plasma membrane]
(Canis familiaris)
p-7Y-KIT:sSCF dimer:p-7Y-KIT [plasma membrane]
(Danio rerio)
p-7Y-KIT:sSCF dimer:p-7Y-KIT [plasma membrane]
(Drosophila melanogaster)
p-7Y-KIT:sSCF dimer:p-7Y-KIT [plasma membrane]
(Gallus gallus)
p-7Y-KIT:sSCF dimer:p-7Y-KIT [plasma membrane]
(Mus musculus)
p-7Y-KIT:sSCF dimer:p-7Y-KIT [plasma membrane]
(Rattus norvegicus)
p-7Y-KIT:sSCF dimer:p-7Y-KIT [plasma membrane]
(Sus scrofa)
p-7Y-KIT:sSCF dimer:p-7Y-KIT [plasma membrane]
(Xenopus tropicalis)
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