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PPM1A [nucleoplasm]
Stable Identifier
R-HSA-205813
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Protein phosphatase 1A
Locations in the PathwayBrowser
Expand all
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer (Homo sapiens)
Downregulation of SMAD2/3:SMAD4 transcriptional activity (Homo sapiens)
PPM1A dephosphorylates nuclear SMAD2/3 (Homo sapiens)
PPM1A [nucleoplasm] (Homo sapiens)
p-2S-SMAD2,3:SMAD4:PPM1A [nucleoplasm] (Homo sapiens)
PPM1A [nucleoplasm] (Homo sapiens)
PPM1A protein phosphatase binds phosphorylated SMAD2/3 (Homo sapiens)
PPM1A [nucleoplasm] (Homo sapiens)
p-2S-SMAD2,3:SMAD4:PPM1A [nucleoplasm] (Homo sapiens)
PPM1A [nucleoplasm] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by TGFB family members (Homo sapiens)
Signaling by TGF-beta Receptor Complex (Homo sapiens)
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer (Homo sapiens)
Downregulation of SMAD2/3:SMAD4 transcriptional activity (Homo sapiens)
PPM1A dephosphorylates nuclear SMAD2/3 (Homo sapiens)
PPM1A [nucleoplasm] (Homo sapiens)
p-2S-SMAD2,3:SMAD4:PPM1A [nucleoplasm] (Homo sapiens)
PPM1A [nucleoplasm] (Homo sapiens)
PPM1A protein phosphatase binds phosphorylated SMAD2/3 (Homo sapiens)
PPM1A [nucleoplasm] (Homo sapiens)
p-2S-SMAD2,3:SMAD4:PPM1A [nucleoplasm] (Homo sapiens)
PPM1A [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:P35813 PPM1A
Gene Names
PPM1A, PPPM1A
Chain
initiator methionine:, chain:2-382
Reference Genes
BioGPS Gene:5494 PPM1A
COSMIC (genes):PPM1A PPM1A
CTD Gene:5494 PPM1A
dbSNP Gene:5494 PPM1A
ENSEMBL:ENSG00000100614 PPM1A
HGNC:9275 PPM1A
KEGG:hsa:5494 PPM1A
Monarch:5494 PPM1A
NCBI Gene:5494 PPM1A
OMIM:606108 PPM1A
UCSC:P35813 PPM1A
Reference Transcript
RefSeq:XM_017021384.1 PPM1A
RefSeq:NM_177952.2 PPM1A
RefSeq:XM_011536879.2 PPM1A
RefSeq:XM_011536878.1 PPM1A
RefSeq:XM_011536881.2 PPM1A
RefSeq:XM_011536882.2 PPM1A
RefSeq:XM_017021385.1 PPM1A
RefSeq:XM_017021386.1 PPM1A
RefSeq:XM_011536880.2 PPM1A
RefSeq:XM_011536884.1 PPM1A
RefSeq:XM_005267781.1 PPM1A
RefSeq:NM_177951.2 PPM1A
RefSeq:XM_005267779.1 PPM1A
RefSeq:XM_017021387.1 PPM1A
RefSeq:XM_011536883.1 PPM1A
RefSeq:NM_021003.4 PPM1A
Other Identifiers
11720672_a_at
11720673_a_at
11720674_a_at
11726945_at
11726946_at
16784909
203966_PM_s_at
203966_s_at
210407_PM_at
210407_at
227728_PM_at
227728_at
229027_PM_at
229027_at
235344_PM_at
235344_at
3538556
3538558
3538559
3538560
3538561
3538563
3538565
3538569
3538570
3538571
3538572
3538573
3538574
3538575
3538576
3538577
3538578
3538579
3538580
3538581
3538582
3538583
3538584
3538585
3538586
3538587
36435_at
36501_at
50725_at
53315_at
5494
60213_at
7974781
857_at
A_14_P135788
A_23_P151679
A_23_P409553
A_24_P407323
A_24_P688133
GE58830
GE88748
GO:0000122
GO:0000287
GO:0003824
GO:0004721
GO:0004722
GO:0005515
GO:0005634
GO:0005654
GO:0005737
GO:0005829
GO:0005886
GO:0006355
GO:0006470
GO:0006499
GO:0006611
GO:0006886
GO:0006913
GO:0016020
GO:0016311
GO:0016787
GO:0017018
GO:0030145
GO:0030512
GO:0030514
GO:0033192
GO:0035970
GO:0043123
GO:0043124
GO:0043169
GO:0043226
GO:0045893
GO:0046827
GO:0046872
GO:0051726
GO:0070412
GO:0071560
GO:0090263
GO:0140096
GO:1901223
HMNXSV003040552
HMNXSV003041535
Hs.108829.0.A1_3p_at
Hs.56022.0.A1_3p_at
Hs.86022.0.A1_3p_at
ILMN_1690077
ILMN_1727127
ILMN_1903159
ILMN_2296045
ILMN_2410516
PH_hs_0022431
PH_hs_0037349
S87759_at
TC14000362.hg
TC14001719.hg
TC14001720.hg
g10337594_3p_at
g3372871_3p_at
Participates
as an input of
PPM1A protein phosphatase binds phosphorylated SMAD2/3 (Homo sapiens)
as an output of
PPM1A dephosphorylates nuclear SMAD2/3 (Homo sapiens)
as a component of
p-2S-SMAD2,3:SMAD4:PPM1A [nucleoplasm] (Homo sapiens)
Other forms of this molecule
PPM1A [cytosol]
Inferred To
PPM1A [nucleoplasm]
(Bos taurus)
PPM1A [nucleoplasm]
(Caenorhabditis elegans)
PPM1A [nucleoplasm]
(Canis familiaris)
PPM1A [nucleoplasm]
(Gallus gallus)
PPM1A [nucleoplasm]
(Mus musculus)
PPM1A [nucleoplasm]
(Rattus norvegicus)
PPM1A [nucleoplasm]
(Sus scrofa)
alph [nucleoplasm]
(Drosophila melanogaster)
Cross References
RefSeq
XP_016876874.1
,
XP_005267838.1
,
XP_016876873.1
,
NP_066283.1
,
XP_016876876.1
,
XP_005267836.1
,
NP_808821.2
,
NP_808820.1
,
XP_016876875.1
,
XP_011535180.1
,
XP_011535181.1
,
XP_011535186.1
,
XP_011535182.1
,
XP_011535184.1
,
XP_011535185.1
,
XP_011535183.1
OpenTargets
ENSG00000100614
ENSEMBL
ENST00000325642
,
ENSP00000327255
,
ENST00000325658
,
ENSP00000314850
,
ENSP00000378514
,
ENST00000395076
ZINC - Substances
PPM1A_HUMAN
ZINC target
P35813
PRO
P35813
GlyGen
P35813
PDB
3FXM
,
6B67
,
4RA2
,
3FXL
,
1A6Q
,
3FXK
,
4RAF
,
3FXJ
,
3FXO
,
4RAG
IntEnz
3.1.3.16
HPA
ENSG00000100614-PPM1A
Pharos - Targets
P35813
ZINC - Predictions - Purchasable
PPM1A_HUMAN
HMDB Protein
HMDBP08792
Interactors (26)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P28482 MAPK1
18
p-T185,Y187-MAPK1 [nucleoplasm]
(R-HSA-112354)
p-T185,Y187-MAPK1 [cytosol]
(R-HSA-109853)
MAPK1 [cytosol]
(R-HSA-59282)
MAPK1 [nucleoplasm]
(R-HSA-199960)
p-T185-MAPK1 [cytosol]
(R-HSA-9635773)
p-T185,Y187 MAPK1 P58G [cytosol]
(R-HSA-9652802)
p-T185,Y187 MAPK1 E322A [cytosol]
(R-HSA-9652794)
p-T185,Y187 MAPK1 D321N [cytosol]
(R-HSA-9652785)
p-T185,Y187 MAPK1 D321V [cytosol]
(R-HSA-9652791)
p-T185,Y187 MAPK1 P58L [cytosol]
(R-HSA-9652806)
p-T185,Y187 MAPK1 S142L [cytosol]
(R-HSA-9652808)
p-T185,Y187 MAPK1 E81K [cytosol]
(R-HSA-9652799)
p-T185,Y187 MAPK1 E322K [cytosol]
(R-HSA-9652175)
p-T185,Y187 MAPK1 E322V [cytosol]
(R-HSA-9652797)
MAPK1 [azurophil granule lumen]
(R-HSA-6799225)
MAPK1 [extracellular region]
(R-HSA-6806250)
MAPK1 [ficolin-1-rich granule lumen]
(R-HSA-6800964)
MAPK1 [endoplasmic reticulum lumen]
(R-HSA-9636293)
0.611
19
UniProt:Q9H6Z4 RANB3
0.602
4
UniProt:Q9GZN4 BSSP4
0.564
3
UniProt:P04792 HSBP1
3
HSPB1 [cytosol]
(R-HSA-450563)
p-S15,S78,S82-HSP27 [cytosol]
(R-HSA-5218697)
p-S78,S82 HSPB1 [cytosol]
(R-HSA-5687009)
0.553
2
UniProt:Q15796 SMAD2
20
Ub-SMAD2 [cytosol]
(R-HSA-6782774)
p-S465,S467-SMAD2 P305L [cytosol]
(R-HSA-3315471)
p-S465,S467-SMAD2 D300A [cytosol]
(R-HSA-3315064)
p-S465,S467-SMAD2 D300N [cytosol]
(R-HSA-3315066)
p-S465,S467-SMAD2 A354T [cytosol]
(R-HSA-3315474)
p-S465,S467-SMAD2 P305Q [cytosol]
(R-HSA-3315070)
p-S465,S467-SMAD2 [nucleoplasm]
(R-HSA-3009185)
p-S465,S467-SMAD2 [cytosol]
(R-HSA-3009186)
SMAD2 [cytosol]
(R-HSA-3006353)
p-T220,S465,S467-SMAD2 [nucleoplasm]
(R-HSA-3009189)
Ub,p-T220,S465,S467-SMAD2 [nucleoplasm]
(R-HSA-9773843)
SMAD2 [nucleoplasm]
(R-HSA-3006352)
p-S250-SMAD2 [cytosol]
(R-HSA-9731121)
SMAD2 Q429* [cytosol]
(R-HSA-9668727)
SMAD2 S467P [cytosol]
(R-HSA-3304375)
SMAD2 L315* [cytosol]
(R-HSA-9668725)
SMAD2 E439* [cytosol]
(R-HSA-9668724)
SMAD2 Q455* [cytosol]
(R-HSA-9668731)
SMAD2 S306* [cytosol]
(R-HSA-9668730)
SMAD2 S296* [cytosol]
(R-HSA-9668729)
0.544
2
UniProt:P10636-8 MAPT
3
MAPT-8 [cytosol]
(R-HSA-9619519)
p-S262,S356,S396-MAPT-8 [cytosol]
(R-HSA-9619521)
p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol]
(R-HSA-9836400)
0.527
4
UniProt:O15357 INPPL1
1
INPPL1 [cytosol]
(R-HSA-913354)
0.527
2
UniProt:P47897 QARS1
2
QARS [cytosol]
(R-HSA-379615)
QARS [mitochondrial matrix]
(R-HSA-379592)
0.527
2
UniProt:P43353 ALDH3B1
3
ALDH3B1 [secretory granule membrane]
(R-HSA-6801023)
ALDH3B1 [plasma membrane]
(R-HSA-5696096)
ALDH3B1 [specific granule membrane]
(R-HSA-6799510)
0.527
2
UniProt:Q8N1E6 FBXL14
1
FBXL14 [cytosol]
(R-HSA-8862603)
0.527
2
UniProt:Q49AM1 MTEF2
0.527
2
UniProt:O95813 CER1
2
CER1 [exocytic vesicle]
(R-HSA-9921118)
CER1 [extracellular region]
(R-HSA-201831)
0.527
2
UniProt:O75146 HIP1R
3
HIP1R [cytosol]
(R-HSA-8868155)
HIP1R [Golgi membrane]
(R-HSA-434348)
HIP1R [cytoplasmic vesicle membrane]
(R-HSA-434201)
0.527
2
UniProt:O15040 TCPR2
0.527
2
UniProt:Q9Y581 INSL6
0.527
3
UniProt:Q5GAN3 RNS13
0.527
2
UniProt:Q7Z6J8 UBE3D
1
UBE3D [cytosol]
(R-HSA-8851647)
0.527
2
UniProt:Q9H8X9 ZDHHC11
1
ZDHHC11 [Golgi membrane]
(R-HSA-9774147)
0.527
2
UniProt:Q9NR23 GDF3
0.527
3
UniProt:Q9NYQ3 HAO2
2
HAO2 [cytosol]
(R-HSA-9033093)
HAO2 [peroxisomal matrix]
(R-HSA-6787806)
0.527
2
UniProt:P00533 EGFR
20
p-6Y-EGFR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869138)
p-5Y-EGFRvIII [plasma membrane]
(R-HSA-1248649)
EGFRvIII [plasma membrane]
(R-HSA-1214162)
p-6Y-EGFR E746_A750del;T790M [plasma membrane]
(R-HSA-1182985)
p-6Y-EGFR L858R;T790M [plasma membrane]
(R-HSA-1182984)
p-6Y-EGFR A767_V769dup [plasma membrane]
(R-HSA-1996343)
p-6Y-EGFR N771_H773dup [plasma membrane]
(R-HSA-1996342)
p-6Y-EGFR K739_I744dup [plasma membrane]
(R-HSA-1996346)
p-6Y-EGFR D770_N771insNPG [plasma membrane]
(R-HSA-1996335)
p-6Y-EGFR E746_A750del [plasma membrane]
(R-HSA-1181214)
p-6Y-EGFR L858R [plasma membrane]
(R-HSA-1173211)
p-6Y-EGFR G719S [plasma membrane]
(R-HSA-1169417)
p-6Y-EGFR L747_P753delinsS [plasma membrane]
(R-HSA-1228038)
p-6Y-EGFR L747_A750delinsP [plasma membrane]
(R-HSA-1228044)
p-6Y-EGFR L747_T751del [plasma membrane]
(R-HSA-1228041)
p-6Y-EGFR L747_S752del [plasma membrane]
(R-HSA-1228040)
p-6Y-EGFR L747_T751delinsP [plasma membrane]
(R-HSA-1228042)
p-6Y-EGFR E746_T751delinsA [plasma membrane]
(R-HSA-1228037)
p-6Y-EGFR E746_S752delinsV [plasma membrane]
(R-HSA-1228039)
p-6Y-EGFR L861Q [plasma membrane]
(R-HSA-1177541)
0.508
2
UniProt:P08069 IGF1R
3
p-Y1161,Y1165,Y1166-IGF1R(741-1367) [plasma membrane]
(R-HSA-2404172)
IGF1R(31-736) [plasma membrane]
(R-HSA-2404169)
IGF1R(741-1367) [plasma membrane]
(R-HSA-2404180)
0.508
2
UniProt:P32121 ARRB2
3
ARRB2 [cytosol]
(R-HSA-416464)
PolyUb-ARRB2 [cytosol]
(R-HSA-6783000)
ARRB2 [endocytic vesicle membrane]
(R-HSA-9910881)
0.499
3
UniProt:P49407 ARRB1
6
ARRB1 [cytosol]
(R-HSA-264470)
PolyUb-ARRB1 [cytosol]
(R-HSA-6783186)
ARRB1 [endocytic vesicle membrane]
(R-HSA-9910882)
ARRB1 [lysosomal membrane]
(R-HSA-432701)
ARRB1 [Golgi membrane]
(R-HSA-350831)
ARRB1 [cytoplasmic vesicle membrane]
(R-HSA-351187)
0.499
4
UniProt:O15169 AXIN1
11
AXIN1 [cytosol]
(R-HSA-195249)
p-T481,S486,S493-AXIN1 [cytosol]
(R-HSA-206040)
ub-AXIN1 [cytosol]
(R-HSA-4641133)
RibC-AXIN1 [cytosol]
(R-HSA-3640841)
Ub-RibC-AXIN1 [cytosol]
(R-HSA-3640864)
AXIN1 P255S [cytosol]
(R-HSA-5251505)
AXIN1 P354L [cytosol]
(R-HSA-5251511)
AXIN1 W247* [cytosol]
(R-HSA-5251512)
AXIN1 E406* [cytosol]
(R-HSA-5251500)
AXIN1 Y346* [cytosol]
(R-HSA-4839753)
AXIN1 L396M [cytosol]
(R-HSA-5251503)
0.499
2
UniProt:Q49MI3 CERKL
0.499
3
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