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CSNK1E [cytosol]
Stable Identifier
R-HSA-205877
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
CKIepsilon, Casein kinase I isoform epsilon
Icon
Locations in the PathwayBrowser for interactor UniProt:O15055 PER2
Expand all
Metabolism of RNA (Homo sapiens)
rRNA processing (Homo sapiens)
rRNA processing in the nucleus and cytosol (Homo sapiens)
Major pathway of rRNA processing in the nucleolus and cytosol (Homo sapiens)
18SE pre-rRNA in pre-40S particles is nucleolytically processed during translocation from the nucleus to the cytosol (Homo sapiens)
CSNK1E [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by WNT (Homo sapiens)
TCF dependent signaling in response to WNT (Homo sapiens)
WNT mediated activation of DVL (Homo sapiens)
WNT signaling stimulates CSNK1-dependent phosphorylation of DVL (Homo sapiens)
CSNK1E [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P49674 CSNK1E
Gene Names
CSNK1E
Chain
chain:1-416
Reference Genes
BioGPS Gene:102800317 CSNK1E
BioGPS Gene:1454 CSNK1E
COSMIC (genes):CSNK1E CSNK1E
CTD Gene:102800317 CSNK1E
CTD Gene:1454 CSNK1E
dbSNP Gene:102800317 CSNK1E
dbSNP Gene:1454 CSNK1E
ENSEMBL:ENSG00000213923 CSNK1E
HGNC:2453 CSNK1E
KEGG:hsa:102800317 CSNK1E
KEGG:hsa:1454 CSNK1E
Monarch:102800317 CSNK1E
Monarch:1454 CSNK1E
NCBI Gene:102800317 CSNK1E
NCBI Gene:1454 CSNK1E
OMIM:600863 CSNK1E
UCSC:P49674 CSNK1E
Reference Transcript
RefSeq:NM_152221.2 CSNK1E
RefSeq:NM_001894.4 CSNK1E
RefSeq:NM_001289912.1 CSNK1E
Other Identifiers
11727001_a_at
11727002_a_at
11727003_x_at
11741873_a_at
1454
202332_PM_at
202332_at
222015_PM_at
222015_at
225756_PM_at
225756_at
226858_PM_at
226858_at
38019_at
3960480
3960481
3960482
3960483
3960484
3960485
3960486
3960487
3960488
3960489
3960490
3960491
3960492
3960493
3960494
3960495
3960497
3960498
3960499
3960500
3960501
3960502
3960503
3960504
3960505
3960506
3960507
3960508
3960509
3960510
3960511
3960512
3960513
3960514
3960515
3960517
3960518
3960527
3960528
3960529
3960530
47542_at
50075_at
52939_at
65131_s_at
8076056
90001_s_at
A_23_P29263
A_23_P40664
A_24_P918436
A_33_P3265180
A_33_P3265185
A_33_P3368495
GE53668
GE84513
GE86394
GO:0003723
GO:0003824
GO:0004672
GO:0004674
GO:0005515
GO:0005524
GO:0005634
GO:0005654
GO:0005737
GO:0005829
GO:0006281
GO:0006468
GO:0006897
GO:0007165
GO:0008104
GO:0016020
GO:0016192
GO:0016740
GO:0030177
GO:0030178
GO:0030426
GO:0032091
GO:0032436
GO:0032880
GO:0032922
GO:0042752
GO:0043025
GO:0043226
GO:0048511
GO:0048512
GO:0060070
GO:0090263
GO:0106310
GO:0140096
GO:1902004
GO:1990090
GO:1990904
GO:2000052
HMNXSV003004036
HMNXSV003029637
HMNXSV003057183
Hs.118078.0.A1_3p_at
Hs.5722.1.S1_3p_at
Hs.79658.1.S1_3p_at
ILMN_1708858
ILMN_1808913
ILMN_2415235
L37043_at
PH_hs_0028220
TC22001493.hg
g4503092_3p_at
p25219
Participates
as a component of
centrosome without CEP164, CCP110 or CEP97 [cytosol] (Homo sapiens)
mother centriole [cytosol] (Homo sapiens)
Nlp-depleted centrosome [cytosol] (Homo sapiens)
centrosome containing phosphorylated Nlp [cytosol] (Homo sapiens)
cNAP-1 depleted centrosome [cytosol] (Homo sapiens)
centrosome [cytosol] (Homo sapiens)
as an output of
18SE pre-rRNA in pre-40S particles is nucleolytically processed during translocation from the nucleus to the cytosol (Homo sapiens)
as a member of
CSNK1E,CSNK1D [cytosol] (Homo sapiens)
This entity regulates
Positively
18SE pre-rRNA in pre-40S particles is nucleolytically processed during translocation from the nucleus to the cytosol
(Homo sapiens)
Other forms of this molecule
CSNK1E [nucleoplasm]
Inferred To
Ghost homologue of CSNK1E [cytosol]
(Canis familiaris)
CSNK1E [cytosol]
(Bos taurus)
CSNK1E [cytosol]
(Caenorhabditis elegans)
CSNK1E [cytosol]
(Danio rerio)
CSNK1E [cytosol]
(Drosophila melanogaster)
CSNK1E [cytosol]
(Gallus gallus)
CSNK1E [cytosol]
(Mus musculus)
CSNK1E [cytosol]
(Rattus norvegicus)
CSNK1E [cytosol]
(Sus scrofa)
CSNK1E [cytosol]
(Xenopus tropicalis)
Cross References
RefSeq
NP_001276841.1
,
NP_689407.1
,
NP_001885.1
ZINC - World Drugs
KC1E_HUMAN
Guide to Pharmacology - Targets
1998
OpenTargets
ENSG00000213923
ENSEMBL
ENST00000396832
,
ENSP00000352929
,
ENSP00000380044
,
ENST00000359867
,
ENST00000403904
,
ENSP00000384074
ZINC - FDA approved
KC1E_HUMAN
ZINC - Substances
KC1E_HUMAN
ZINC - Biogenic
KC1E_HUMAN
ZINC target
P49674
PRO
P49674
PDB
4HOK
,
4HNI
ZINC - Investigational
KC1E_HUMAN
IntEnz
2.7.11.1
HPA
ENSG00000213923-CSNK1E
Pharos - Targets
P49674
ZINC - Predictions - Purchasable
KC1E_HUMAN
HMDB Protein
HMDBP09459
Interactors (59)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P23508 CRCM
0.891
9
UniProt:O15055 PER2
4
Ub-p-S-PER2 [cytosol]
(R-HSA-517835)
PER2 [cytosol]
(R-HSA-400399)
p-S-PER2 [nucleoplasm]
(R-HSA-3325591)
p-S-PER2 [cytosol]
(R-HSA-400331)
0.854
9
UniProt:Q6ZRV2 FA83H
0.85
10
UniProt:O15534 PER1
4
p-S-PER1 [cytosol]
(R-HSA-400310)
p-S-PER1 [nucleoplasm]
(R-HSA-3325590)
PER1 [cytosol]
(R-HSA-400373)
Ub-p-S-PER1 [cytosol]
(R-HSA-517831)
0.837
8
UniProt:Q16625 OCLN
4
OCLN [plasma membrane]
(R-HSA-351846)
OCLN(321-522) [plasma membrane]
(R-HSA-351873)
OCLN(1-320) [plasma membrane]
(R-HSA-351854)
OCLN [cell junction]
(R-HSA-2160944)
0.835
10
UniProt:Q92997 DVL3
4
pp-DVL3 [cytosol]
(R-HSA-3772400)
p-DVL3 [cytosol]
(R-HSA-201680)
DVL3 [cytosol]
(R-HSA-201678)
ub-DVL3 [cytosol]
(R-HSA-4652688)
0.805
9
UniProt:Q16526 CRY1
4
Ub-p-S-CRY1 [nucleoplasm]
(R-HSA-517931)
CRY1 [cytosol]
(R-HSA-400247)
p-S-CRY1 [nucleoplasm]
(R-HSA-400340)
p-S-CRY1 [cytosol]
(R-HSA-400270)
0.788
7
UniProt:O14641 DVL2
5
DVL2 [cytosol]
(R-HSA-201694)
pp-DVL2 [cytosol]
(R-HSA-3772398)
p-DVL2 [cytosol]
(R-HSA-201706)
p-DVL2 [clathrin-coated endocytic vesicle]
(R-HSA-5138444)
ub-DVL2 [cytosol]
(R-HSA-4652689)
0.745
4
UniProt:P25054 APC
20
APC R213* [cytosol]
(R-HSA-9666924)
APC C1410* [cytosol]
(R-HSA-9666925)
APC K1310* [cytosol]
(R-HSA-9666926)
APC R499* [cytosol]
(R-HSA-9666927)
APC R1450* [cytosol]
(R-HSA-5251499)
APC G1357* [cytosol]
(R-HSA-9666940)
APC L1488* [cytosol]
(R-HSA-9666941)
APC S1400* [cytosol]
(R-HSA-9666942)
APC S1346* [cytosol]
(R-HSA-9666943)
APC R405* [cytosol]
(R-HSA-9666936)
APC S1281* [cytosol]
(R-HSA-9666937)
APC E1573* [cytosol]
(R-HSA-9666938)
APC R805* [cytosol]
(R-HSA-9666939)
APC R1386* [cytosol]
(R-HSA-9666932)
APC S1327* [cytosol]
(R-HSA-9666933)
APC E1209* [cytosol]
(R-HSA-9666934)
APC Q1469* [cytosol]
(R-HSA-9666935)
APC R564* [cytosol]
(R-HSA-9666928)
APC E1536* [cytosol]
(R-HSA-9666929)
APC G1288* [cytosol]
(R-HSA-9666930)
0.738
8
UniProt:Q1W6H9 F110C
0.738
4
UniProt:Q8TC76 F110B
0.725
4
UniProt:O15169 AXIN1
11
AXIN1 [cytosol]
(R-HSA-195249)
p-T481,S486,S493-AXIN1 [cytosol]
(R-HSA-206040)
ub-AXIN1 [cytosol]
(R-HSA-4641133)
RibC-AXIN1 [cytosol]
(R-HSA-3640841)
Ub-RibC-AXIN1 [cytosol]
(R-HSA-3640864)
AXIN1 P255S [cytosol]
(R-HSA-5251505)
AXIN1 P354L [cytosol]
(R-HSA-5251511)
AXIN1 W247* [cytosol]
(R-HSA-5251512)
AXIN1 E406* [cytosol]
(R-HSA-5251500)
AXIN1 Y346* [cytosol]
(R-HSA-4839753)
AXIN1 L396M [cytosol]
(R-HSA-5251503)
0.687
5
UniProt:Q9BQ89 F110A
0.667
3
UniProt:Q5T7W0 ZN618
0.666
7
UniProt:Q9UIM3 FKBPL
1
FKBPL [cytosol]
(R-HSA-8852374)
0.643
4
UniProt:Q49AN0 CRY2
4
p-S-CRY2 [cytosol]
(R-HSA-400305)
p-S-CRY2 [nucleoplasm]
(R-HSA-400328)
CRY2 [cytosol]
(R-HSA-400255)
Ub-p-S-CRY2 [nucleoplasm]
(R-HSA-517935)
0.643
5
UniProt:Q7Z7G8 VP13B
0.643
3
UniProt:Q6PEV8 F199X
0.643
4
UniProt:Q8WVL7 ANR49
0.643
4
UniProt:Q9Y343 SNX24
0.643
5
UniProt:Q9UJF2 RASAL2
1
RASAL2 [cytosol]
(R-HSA-5658224)
0.643
3
UniProt:Q14C86 GAPVD1
1
GAPVD1 [cytosol]
(R-HSA-8871123)
0.643
5
UniProt:Q5T0W9 FAM83B
1
FAM83B [cytosol]
(R-HSA-9715184)
0.643
5
UniProt:Q86UY5 FAM83A
1
FAM83A [cytosol]
(R-HSA-9851391)
0.642
5
UniProt:O14640 DVL1
4
ub-DVL1 [cytosol]
(R-HSA-4641157)
DVL1 [cytosol]
(R-HSA-201687)
p-S-DVL1 [cytosol]
(R-HSA-201700)
pp-DVL1 [cytosol]
(R-HSA-3772396)
0.639
6
UniProt:Q04917 YWHAH
1
YWHAH [cytosol]
(R-HSA-1445107)
0.604
3
UniProt:O70239
5
phospho-Axin1 [cytosol]
(R-RNO-3640864)
phospho-Axin1 [cytosol]
(R-RNO-3640841)
Axin1 [cytosol]
(R-RNO-4641133)
phospho-Axin1 [cytosol]
(R-RNO-206040)
Axin1 [cytosol]
(R-RNO-195249)
0.591
7
UniProt:O75382 TRIM3
1
TRIM3 [cytosol]
(R-HSA-5624344)
0.556
3
UniProt:Q9H4H8 FAM83D
1
FAM83D [cytosol]
(R-HSA-9852722)
0.547
2
UniProt:Q60838
5
Dvl2 [cytosol]
(R-MMU-4652689)
phospho-Dvl2 [clathrin-coated endocytic vesicle]
(R-MMU-5138444)
phospho-Dvl2 [cytosol]
(R-MMU-201706)
phospho-Dvl2 [cytosol]
(R-MMU-3772398)
Dvl2 [cytosol]
(R-MMU-201694)
0.544
3
UniProt:Q9UF02 CCG5
0.527
2
UniProt:P31323 PRKAR2B
2
PRKAR2B [ciliary base]
(R-HSA-5610414)
PRKAR2B [cytosol]
(R-HSA-57842)
0.527
3
UniProt:Q9H0C5 BTBD1
1
BTBD1 [cytosol]
(R-HSA-8851650)
0.527
2
UniProt:Q6PGQ1 DRIC1
0.527
2
UniProt:O15027 SEC16A
1
SEC16A [cytosol]
(R-HSA-5685728)
0.527
2
UniProt:P61964 WDR5
1
WDR5 [nucleoplasm]
(R-HSA-1629838)
0.527
2
UniProt:P11142 HSPA8
10
HSPA8 [cytosol]
(R-HSA-264476)
HSPA8 [lysosomal lumen]
(R-HSA-9625182)
HSPA8 [late endosome lumen]
(R-HSA-9631104)
HSPA8 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane]
(R-HSA-888599)
HSPA8 [plasma membrane]
(R-HSA-936508)
HSPA8 [nucleoplasm]
(R-HSA-5082380)
HSPA8 [secretory granule lumen]
(R-HSA-6801530)
HSPA8 [extracellular region]
(R-HSA-6805936)
HSPA8 [ficolin-1-rich granule lumen]
(R-HSA-6801494)
Me3K561-HSPA8 [nucleoplasm]
(R-HSA-8932217)
0.527
3
UniProt:O43865 AHCYL1
1
AHCYL1 [endoplasmic reticulum membrane]
(R-HSA-5215973)
0.527
2
UniProt:Q9Y698 CACNG2
2
CACNG2 [plasma membrane]
(R-HSA-210375)
CACNG2 [endocytic vesicle membrane]
(R-HSA-416846)
0.527
2
UniProt:Q9P2F5 STOX2
0.527
2
UniProt:Q8WWF3 SSMM1
0.527
2
UniProt:Q9Y343-2 SNX24
0.527
2
UniProt:Q9P2K6 KLHL42
1
KLHL42 [cytosol]
(R-HSA-8863204)
0.527
2
UniProt:P55735 SEC13
4
SEC13 [lysosomal membrane]
(R-HSA-9638246)
SEC13 [endoplasmic reticulum membrane]
(R-HSA-203994)
SEC13 [ER to Golgi transport vesicle membrane]
(R-HSA-204012)
SEC13 [cytosol]
(R-HSA-203981)
0.527
2
UniProt:O94887 FARP2
1
FARP2 [cytosol]
(R-HSA-396935)
0.527
2
UniProt:O75695 RP2
1
RP2 [cilium]
(R-HSA-5624052)
0.527
3
UniProt:P48729 CSNK1A1
2
CSNK1A1 [cilium]
(R-HSA-5632507)
CSNK1A1 [cytosol]
(R-HSA-195263)
0.527
2
UniProt:P48730 CSNK1D
3
CSNK1D [nucleoplasm]
(R-HSA-421305)
CSNK1D [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-HSA-5685717)
CSNK1D [cytosol]
(R-HSA-380315)
0.527
2
UniProt:A5A3E0 POTEF
0.527
2
UniProt:Q9H4B6 SAV1
2
p-SAV1 [cytosol]
(R-HSA-2028276)
SAV1 [cytosol]
(R-HSA-2028283)
0.527
2
UniProt:Q1RMZ1 BMT2
1
BMT2 [cytosol]
(R-HSA-9640251)
0.527
2
UniProt:Q93008 USP9X
1
USP9X [cytosol]
(R-HSA-870499)
0.527
2
UniProt:Q8IYU8 MICU2
1
MICU2 [mitochondrial inner membrane]
(R-HSA-8949166)
0.527
2
UniProt:A7E2V4 ZSWIM8
1
ZSWIM8 [cytosol]
(R-HSA-9011266)
0.527
2
UniProt:Q9GZY0 NXF2
2
NXF2 [cytosol]
(R-HSA-8932924)
NXF2 [nucleoplasm]
(R-HSA-8932926)
0.527
2
UniProt:Q00987 MDM2
11
p-S166,S188-MDM2 [nucleoplasm]
(R-HSA-6793669)
p-S166,S188-MDM2 [cytosol]
(R-HSA-198638)
MDM2 [cytosol]
(R-HSA-198644)
MDM2 [nucleoplasm]
(R-HSA-69486)
MDM2 [endocytic vesicle membrane]
(R-HSA-416849)
MDM2 [plasma membrane]
(R-HSA-416843)
PolyUb,p-S166,S188-MDM2 [nucleoplasm]
(R-HSA-6795669)
p-5S,T-MDM2 [nucleoplasm]
(R-HSA-6804954)
p-S166,S188,T218-MDM2 [nucleoplasm]
(R-HSA-6792862)
monoSUMO1-K182-MDM2 [nucleoplasm]
(R-HSA-3000408)
PolyUb-MDM2 [nucleoplasm]
(R-HSA-6782472)
0.524
3
UniProt:P08238 HSP90AB1
6
HSP90AB1 [lysosomal lumen]
(R-HSA-9622846)
HSP90AB1 [nucleoplasm]
(R-HSA-5082399)
HSP90AB1 [cytosol]
(R-HSA-419617)
HSP90AB1 [secretory granule lumen]
(R-HSA-6801477)
HSP90AB1 [extracellular region]
(R-HSA-6806463)
HSP90AB1 [ficolin-1-rich granule lumen]
(R-HSA-6801491)
0.524
2
UniProt:P62258 YWHAE
1
YWHAE [cytosol]
(R-HSA-194368)
0.499
3
UniProt:Q15154 PCM1
1
PCM1 [cytosol]
(R-HSA-380308)
0.483
2
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